메뉴 건너뛰기




Volumn 1, Issue 9, 2009, Pages 1723-1736

Drug repositioning using in silico compound profiling

Author keywords

[No Author keywords available]

Indexed keywords

ASTEMIZOLE; FINASTERIDE; METHADONE; RAPAMYCIN; SAQUINAVIR; SILDENAFIL; TELMISARTAN; THALIDOMIDE;

EID: 77953387346     PISSN: 17568919     EISSN: None     Source Type: Journal    
DOI: 10.4155/fmc.09.123     Document Type: Article
Times cited : (29)

References (60)
  • 1
    • 0019160035 scopus 로고
    • The treatment of lepra reaction in lepromatous leprosy. Fifteen years' experience with thalidomide
    • Sheskin J. The treatment of lepra reaction in lepromatous leprosy. Fifteen years' experience with thalidomide. Int. J. Dermatol. 19(6), 318-322 (1980).
    • (1980) Int. J. Dermatol. , vol.19 , Issue.6 , pp. 318-322
    • Sheskin, J.1
  • 2
    • 13844256192 scopus 로고    scopus 로고
    • Thalidomide as a novel therapeutic agent: New uses for an old product
    • Teo SK, Stirling DI, Zeldis JB. Thalidomide as a novel therapeutic agent: new uses for an old product. Drug Discov. Today 10(2), 107-114 (2005).
    • (2005) Drug Discov. Today , vol.10 , Issue.2 , pp. 107-114
    • Teo, S.K.1    Stirling, D.I.2    Zeldis, J.B.3
  • 3
    • 4344668661 scopus 로고    scopus 로고
    • Drug repositioning: Identifying and developing new uses for existing drugs
    • Ashburn TT, Thor KB. Drug repositioning: identifying and developing new uses for existing drugs. Nat. Rev. Drug Discov. 3(8), 673-683 (2004).
    • (2004) Nat. Rev. Drug Discov. , vol.3 , Issue.8 , pp. 673-683
    • Ashburn, T.T.1    Thor, K.B.2
  • 4
    • 22744433270 scopus 로고    scopus 로고
    • High lung PDE5: A strong basis for treating pulmonary hypertension with PDE5 inhibitors
    • Corbin JD, Beasley A, Blount MA, Francis SH. High lung PDE5: a strong basis for treating pulmonary hypertension with PDE5 inhibitors. Biochem. Biophys. Res. Commun. 334(3), 930-938 (2005).
    • (2005) Biochem. Biophys. Res. Commun. , vol.334 , Issue.3 , pp. 930-938
    • Corbin, J.D.1    Beasley, A.2    Blount, M.A.3    Francis, S.H.4
  • 5
    • 21544444144 scopus 로고    scopus 로고
    • Antiproliferative effects of phosphodiesterase type 5 inhibition in human pulmonary artery cells
    • Wharton J, Strange JW, Møller GM et al. Antiproliferative effects of phosphodiesterase type 5 inhibition in human pulmonary artery cells. Am. J. Respir. Crit. Care Med. 172(1), 105-113 (2005).
    • (2005) Am. J. Respir. Crit. Care Med. , vol.172 , Issue.1 , pp. 105-113
    • Wharton, J.1    Strange, J.W.2    Møller, G.M.3
  • 6
    • 29144470350 scopus 로고    scopus 로고
    • Differential effects of phosphodiesterase-5 inhibitors on hypoxic pulmonary vasoconstriction and pulmonary artery cytokine expression
    • Tsai BM, Turrentine MW, Sheridan BC et al. Differential effects of phosphodiesterase-5 inhibitors on hypoxic pulmonary vasoconstriction and pulmonary artery cytokine expression. Ann. Thorac. Surg. 81(1), 272-278 (2006).
    • (2006) Ann. Thorac. Surg. , vol.81 , Issue.1 , pp. 272-278
    • Tsai, B.M.1    Turrentine, M.W.2    Sheridan, B.C.3
  • 7
    • 36349033482 scopus 로고    scopus 로고
    • Phosphodiesterase type 5: Expanding roles in cardiovascular regulation
    • Kass DA, Champion HC, Beavo JA. Phosphodiesterase type 5: expanding roles in cardiovascular regulation. Circ. Res. 101(11), 1084-1095 (2007).
    • (2007) Circ. Res. , vol.101 , Issue.11 , pp. 1084-1095
    • Kass, D.A.1    Champion, H.C.2    Beavo, J.A.3
  • 8
    • 38049132717 scopus 로고    scopus 로고
    • Sildenafil in hypoxic pulmonary hypertension potentiates a compensatory up-regulation of NO-cGMP signaling
    • Kirsch M, Kemp-Harper B, Weissmann N, Grimminger F, Schmidt HH. Sildenafil in hypoxic pulmonary hypertension potentiates a compensatory up-regulation of NO-cGMP signaling. FASEB J. 22(1), 30-40 (2008).
    • (2008) FASEB J , vol.22 , Issue.1 , pp. 30-40
    • Kirsch, M.1    Kemp-Harper, B.2    Weissmann, N.3    Grimminger, F.4    Schmidt, H.H.5
  • 9
    • 33746584053 scopus 로고    scopus 로고
    • Sildenafil: From angina to erectile dysfunction to pulmonary hypertension and beyond
    • Ghofrani HA, Osterloh IH, Grimminger F. Sildenafil: from angina to erectile dysfunction to pulmonary hypertension and beyond. Nat. Rev. Drug Discov. 5(8), 689-702 (2006).
    • (2006) Nat. Rev. Drug Discov. , vol.5 , Issue.8 , pp. 689-702
    • Ghofrani, H.A.1    Osterloh, I.H.2    Grimminger, F.3
  • 11
    • 0141654989 scopus 로고    scopus 로고
    • Erythrocyte G protein-coupled receptor signaling in malarial infection
    • Harrison T, Samuel BU, Akompong T et al. Erythrocyte G protein-coupled receptor signaling in malarial infection. Science. 301(5640), 1734-1736 (2003).
    • (2003) Science , vol.301 , Issue.5640 , pp. 1734-1736
    • Harrison, T.1    Samuel, B.U.2    Akompong, T.3
  • 12
    • 33746381549 scopus 로고    scopus 로고
    • A clinical drug library screen identifies astemizole as an antimalarial agent
    • Chong CR, Chen X, Shi L, Liu JO, Sullivan DJ Jr. A clinical drug library screen identifies astemizole as an antimalarial agent. Nat. Chem. Biol. 2(8), 415-416 (2006).
    • (2006) Nat. Chem. Biol. , vol.2 , Issue.8 , pp. 415-416
    • Chong, C.R.1    Chen, X.2    Shi, L.3    Liu, J.O.4    Sullivan Jr., D.J.5
  • 13
    • 48249095940 scopus 로고    scopus 로고
    • In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen
    • Plouffe D, Brinker A, McNamara C et al. In silico activity profiling reveals the mechanism of action of antimalarials discovered in a high-throughput screen. Proc. Natl Acad. Sci. USA 105(26), 9059-9064 (2008).
    • (2008) Proc. Natl Acad. Sci. USA , vol.105 , Issue.26 , pp. 9059-9064
    • Plouffe, D.1    Brinker, A.2    McNamara, C.3
  • 14
    • 34548304745 scopus 로고    scopus 로고
    • In silico pharmacology for drug discovery: Methods for virtual ligand screening and profiling
    • Ekins S, Mestres J, Testa B. In silico pharmacology for drug discovery: methods for virtual ligand screening and profiling. Br. J. Pharmacol. 152(1), 9-20 (2007).
    • (2007) Br. J. Pharmacol. , vol.152 , Issue.1 , pp. 9-20
    • Ekins, S.1    Mestres, J.2    Testa, B.3
  • 15
    • 34548319111 scopus 로고    scopus 로고
    • In silico pharmacology for drug discovery: Applications to targets and beyond
    • Ekins S, Mestres J, Testa B. In silico pharmacology for drug discovery: applications to targets and beyond. Br. J. Pharmacol. 152(1), 21-37 (2007).
    • (2007) Br. J. Pharmacol. , vol.152 , Issue.1 , pp. 21-37
    • Ekins, S.1    Mestres, J.2    Testa, B.3
  • 20
    • 41649105837 scopus 로고    scopus 로고
    • Kinase-likeness and kinaseprivileged fragments: Toward virtual polypharmacology
    • Aronov AM, McClain B, Moody CS, Murcko MA. Kinase-likeness and kinaseprivileged fragments: toward virtual polypharmacology. J. Med. Chem. 51(5), 1214-1222 (2008).
    • (2008) J. Med. Chem. , vol.51 , Issue.5 , pp. 1214-1222
    • Aronov, A.M.1    McClain, B.2    Moody, C.S.3    Murcko, M.A.4
  • 21
    • 34547522758 scopus 로고    scopus 로고
    • Discovery of anti-androgen activity of nonsteroidal scaffolds of marketed drugs
    • Bisson WH, Cheltsov AV, Bruey-Sedano N et al. Discovery of anti-androgen activity of nonsteroidal scaffolds of marketed drugs. Proc. Natl Acad. Sci. USA 104(29), 11927-11932 (2007).
    • (2007) Proc. Natl Acad. Sci. USA , vol.104 , Issue.29 , pp. 11927-11932
    • Bisson, W.H.1    Cheltsov, A.V.2    Bruey-Sedano, N.3
  • 22
    • 37049020280 scopus 로고    scopus 로고
    • Discovery of the first nonpeptidic, small-molecule, highly selective somatostatin receptor subtype 5 antagonists: A chemogenomics approach
    • Martin RE, Green LG, Guba W, Kratochwil N, Christ A. Discovery of the first nonpeptidic, small-molecule, highly selective somatostatin receptor subtype 5 antagonists: a chemogenomics approach. J. Med. Chem. 50(25), 6291-6294 (2007).
    • (2007) J. Med. Chem. , vol.50 , Issue.25 , pp. 6291-6294
    • Martin, R.E.1    Green, L.G.2    Guba, W.3    Kratochwil, N.4    Christ, A.5
  • 26
    • 0034041222 scopus 로고    scopus 로고
    • The use of NMDA-receptor antagonists in the treatment of chronic pain
    • Hewitt DJ. The use of NMDA-receptor antagonists in the treatment of chronic pain. Clin. J. Pain. 16(Suppl. 2), S73-S79 (2000).
    • (2000) Clin. J. Pain. , vol.16 , Issue.SUPPL. 2
    • Hewitt, D.J.1
  • 27
    • 0035377463 scopus 로고    scopus 로고
    • Selective muscarinic receptor antagonists for airway diseases
    • Lee AM, Jacoby DB, Fryer AD. Selective muscarinic receptor antagonists for airway diseases. Curr. Opin. Pharmacol. 1(3), 223-229 (2001).
    • (2001) Curr. Opin. Pharmacol. , vol.1 , Issue.3 , pp. 223-229
    • Lee, A.M.1    Jacoby, D.B.2    Fryer, A.D.3
  • 28
    • 13844318259 scopus 로고    scopus 로고
    • The role of anticholinergics in chronic obstructive pulmonary disease
    • Barnes PJ. The role of anticholinergics in chronic obstructive pulmonary disease. Am. J. Med. 117(Suppl. 12A), S24-S32 (2004).
    • (2004) Am. J. Med. , vol.117 , Issue.SUPPL. 12A
    • Barnes, P.J.1
  • 29
    • 4243936277 scopus 로고    scopus 로고
    • Non-antimicrobial activities of macrolides
    • Williams JD. Non-antimicrobial activities of macrolides. Int. J. Antimicrob. Agents. 18(Suppl. 1), S89-S91 (2001).
    • (2001) Int. J. Antimicrob. Agents. , vol.18 , Issue.SUPPL. 1
    • Williams, J.D.1
  • 30
    • 27644447574 scopus 로고    scopus 로고
    • The mammalian target of the rapamycin (mTOR) kinase pathway: Its role in tumourigenesis and targeted antitumour therapy
    • Janus A, Robak T, Smolewski P. The mammalian target of the rapamycin (mTOR) kinase pathway: its role in tumourigenesis and targeted antitumour therapy. Cell. Mol. Biol. Lett. 10(3), 479-498 (2005).
    • (2005) Cell. Mol. Biol. Lett. , vol.10 , Issue.3 , pp. 479-498
    • Janus, A.1    Robak, T.2    Smolewski, P.3
  • 32
    • 33847147689 scopus 로고    scopus 로고
    • Sirolimus causes relaxation of human vascular smooth muscle: A novel action of sirolimus mediated via ATP-sensitive potassium channels
    • Ghatta S, Tunstall RR, Kareem S, Rahman M, O'Rourke ST. Sirolimus causes relaxation of human vascular smooth muscle: a novel action of sirolimus mediated via ATP-sensitive potassium channels. J. Pharmacol. Exp. Ther. 320(3), 1204-1208 (2007).
    • (2007) J. Pharmacol. Exp. Ther. , vol.320 , Issue.3 , pp. 1204-1208
    • Ghatta, S.1    Tunstall, R.R.2    Kareem, S.3    Rahman, M.4    O'Rourke, S.T.5
  • 34
    • 0035991938 scopus 로고    scopus 로고
    • In vitro evaluation of motilin agonism by macrolide immunosuppressive drugs
    • Van Vlem B, Schoonjans R, Vanholder R et al. In vitro evaluation of motilin agonism by macrolide immunosuppressive drugs. Nephrol. Dial. Transplant. 17(6), 973-977 (2002).
    • (2002) Nephrol. Dial. Transplant. , vol.17 , Issue.6 , pp. 973-977
    • Van Vlem, B.1    Schoonjans, R.2    Vanholder, R.3
  • 35
    • 67349240884 scopus 로고    scopus 로고
    • Motilides: A long and winding road: Lessons from mitemcinal (GM-611) on diabetic gastroparesis
    • Takanashi H, Cynshi O. Motilides: a long and winding road: lessons from mitemcinal (GM-611) on diabetic gastroparesis. Regul. Pept. 155(1-3), 18-23 (2009).
    • (2009) Regul. Pept. , vol.155 , Issue.1-3 , pp. 18-23
    • Takanashi, H.1    Cynshi, O.2
  • 36
    • 36248969694 scopus 로고    scopus 로고
    • Inhibitors of HIV-1 protease: Current state of the art 10 years after their introduction. from antiretroviral drugs to antifungal, antibacterial and antitumor agents based on aspartic protease inhibitors
    • Mastrolorenzo A, Rusconi S, Scozzafava A, Barbaro G, Supuran CT. Inhibitors of HIV-1 protease: current state of the art 10 years after their introduction. From antiretroviral drugs to antifungal, antibacterial and antitumor agents based on aspartic protease inhibitors. Curr. Med. Chem. 14(26), 2734-2748 (2007).
    • (2007) Curr. Med. Chem. , vol.14 , Issue.26 , pp. 2734-2748
    • Mastrolorenzo, A.1    Rusconi, S.2    Scozzafava, A.3    Barbaro, G.4    Supuran, C.T.5
  • 37
    • 0035840866 scopus 로고    scopus 로고
    • Peripheral tachykinin receptors as targets for new drugs
    • Patacchini R, Maggi CA. Peripheral tachykinin receptors as targets for new drugs. Eur. J. Pharmacol. 429(1-3), 13-21 (2001).
    • (2001) Eur. J. Pharmacol. , vol.429 , Issue.1-3 , pp. 13-21
    • Patacchini, R.1    Maggi, C.A.2
  • 38
    • 8544251308 scopus 로고    scopus 로고
    • Telmisartan - Killing two birds with one stone
    • Doggrell SA. Telmisartan - killing two birds with one stone. Expert Opin. Pharmacother. 5(11), 2397-2400 (2004).
    • (2004) Expert Opin. Pharmacother. , vol.5 , Issue.11 , pp. 2397-2400
    • Doggrell, S.A.1
  • 39
    • 54449092429 scopus 로고    scopus 로고
    • Inhibiting angiotensin type 1 receptors as a target for diabetes
    • Kintscher U, Foryst-Ludwig A, Unger T. Inhibiting angiotensin type 1 receptors as a target for diabetes. Expert Opin. Ther. Targets 12(10), 1257-1263 (2008).
    • (2008) Expert Opin. Ther. Targets , vol.12 , Issue.10 , pp. 1257-1263
    • Kintscher, U.1    Foryst-Ludwig, A.2    Unger, T.3
  • 41
    • 34548046776 scopus 로고    scopus 로고
    • Telmisartan enhances cholesterol efflux from THP-1 macrophages by activating PPARg
    • Nakaya K, Ayaori M, Hisada T et al. Telmisartan enhances cholesterol efflux from THP-1 macrophages by activating PPARg. J. Atheroscler. Thromb. 14(3), 133-141 (2007).
    • (2007) J. Atheroscler. Thromb. , vol.14 , Issue.3 , pp. 133-141
    • Nakaya, K.1    Ayaori, M.2    Hisada, T.3
  • 43
    • 0344081893 scopus 로고    scopus 로고
    • Plateletactivating factor, a pleiotrophic mediator of physiological and pathological processes
    • Stafforini DM, McIntyre TM, Zimmerman GA, Prescott SM. Plateletactivating factor, a pleiotrophic mediator of physiological and pathological processes. Crit. Rev. Clin. Lab. Sci. 40(6), 643-672 (2003).
    • (2003) Crit. Rev. Clin. Lab. Sci. , vol.40 , Issue.6 , pp. 643-672
    • Stafforini, D.M.1    McIntyre, T.M.2    Zimmerman, G.A.3    Prescott, S.M.4
  • 44
    • 40849086262 scopus 로고    scopus 로고
    • Platelet activating factor as a mediator and therapeutic approach in bronchial asthma
    • Kasperska-Zajac A, Brzoza Z, Rogala B. Platelet activating factor as a mediator and therapeutic approach in bronchial asthma. Inflammation 31(2), 112-120 (2008).
    • (2008) Inflammation , vol.31 , Issue.2 , pp. 112-120
    • Kasperska-Zajac, A.1    Brzoza, Z.2    Rogala, B.3
  • 45
    • 36048992504 scopus 로고    scopus 로고
    • Chemogenomic data analysis: Prediction of small-molecule targets and the advent of biological fingerprint
    • Bender A, Young DW, Jenkins JL et al. Chemogenomic data analysis: prediction of small-molecule targets and the advent of biological fingerprint. Comb. Chem. High Throughput Screen. 10(8), 719-731 (2007).
    • (2007) Comb. Chem. High Throughput Screen. , vol.10 , Issue.8 , pp. 719-731
    • Bender, A.1    Young, D.W.2    Jenkins, J.L.3
  • 46
    • 53349142711 scopus 로고    scopus 로고
    • Enhancing drug discovery through in silico screening: Strategies to increase true positives retrieval rates
    • Kirchmair J, Distinto S, Schuster D, Spitzer G, Langer T, Wolber G. Enhancing drug discovery through in silico screening: strategies to increase true positives retrieval rates. Curr. Med. Chem. 15(20), 2040-2053 (2008).
    • (2008) Curr. Med. Chem. , vol.15 , Issue.20 , pp. 2040-2053
    • Kirchmair, J.1    Distinto, S.2    Schuster, D.3    Spitzer, G.4    Langer, T.5    Wolber, G.6
  • 47
    • 77953422573 scopus 로고    scopus 로고
    • Use of broad biological profiling as relevant descriptor to describe and differentiate compounds: Structure-in vitro (pharmacology-ADME)-in vivo (safety) relationships
    • Vaz RJ, Klabunde T (Eds). Wiley-VCH Verlag GmbH & Co., Weinheim, Germany
    • Mason JS, Migeon J, Dupuis P, Otto-Buc A. Use of broad biological profiling as relevant descriptor to describe and differentiate compounds: structure-in vitro (pharmacology-ADME)-in vivo (safety) relationships. In: Methods and Principles in Medicinal Chemistry: Antitargets (Volume 38). Vaz RJ, Klabunde T (Eds). Wiley-VCH Verlag GmbH & Co., Weinheim, Germany, 23-52 (2008).
    • (2008) Methods and Principles in Medicinal Chemistry: Antitargets , vol.38 , pp. 23-52
    • Mason, J.S.1    Migeon, J.2    Dupuis, P.3    Otto-Buc, A.4
  • 48
    • 0037068532 scopus 로고    scopus 로고
    • Do structurally similar molecules have similar biological activity?
    • Martin YC, Kofron JL, Traphagen LM. Do structurally similar molecules have similar biological activity? J. Med. Chem. 45(19), 4350-4358 (2002).
    • (2002) J. Med. Chem. , vol.45 , Issue.19 , pp. 4350-4358
    • Martin, Y.C.1    Kofron, J.L.2    Traphagen, L.M.3
  • 49
    • 33745391215 scopus 로고    scopus 로고
    • Prediction of biological targets for compounds using multiple-category Bayesian models trained on chemogenomics databases
    • Nidhi, Glick M, Davies JW, Jenkins JL. Prediction of biological targets for compounds using multiple-category Bayesian models trained on chemogenomics databases. J. Chem. Inf. Model. 46(3), 1124-1133 (2006).
    • (2006) J. Chem. Inf. Model. , vol.46 , Issue.3 , pp. 1124-1133
    • Nidhi Glick, M.1    Davies, J.W.2    Jenkins, J.L.3
  • 50
    • 34548317031 scopus 로고    scopus 로고
    • Chemogenomic approaches to rational drug design
    • Rognan D. Chemogenomic approaches to rational drug design. Br. J. Pharmacol. 152(1), 38-52 (2007).
    • (2007) Br. J. Pharmacol. , vol.152 , Issue.1 , pp. 38-52
    • Rognan, D.1
  • 51
    • 51349130206 scopus 로고    scopus 로고
    • A ligand-based approach to mining the chemogenomic space of drugs
    • Gregori-Puigjané E, Mestres J. A ligand-based approach to mining the chemogenomic space of drugs. Comb. Chem. High Throughput Screen. 11(8), 669-676 (2008).
    • (2008) Comb. Chem. High Throughput Screen. , vol.11 , Issue.8 , pp. 669-676
    • Gregori-Puigjané, E.1    Mestres, J.2
  • 52
    • 58149099516 scopus 로고    scopus 로고
    • In silico functional profiling of small molecules and its applications
    • Sato T, Matsuo Y, Honma T, Yokoyama S. In silico functional profiling of small molecules and its applications. J. Med. Chem. 51(24), 7705-7716 (2008).
    • (2008) J. Med. Chem. , vol.51 , Issue.24 , pp. 7705-7716
    • Sato, T.1    Matsuo, Y.2    Honma, T.3    Yokoyama, S.4
  • 53
    • 33750994920 scopus 로고    scopus 로고
    • Bridging chemical and biological space: 'Target fishing' using 2D and 3D molecular descriptors
    • Nettles JH, Jenkins JL, Bender A, Deng Z, Davies JW, Glick M. Bridging chemical and biological space: 'target fishing' using 2D and 3D molecular descriptors. J. Med. Chem. 49(23), 6802-6810 (2006).
    • (2006) J. Med. Chem. , vol.49 , Issue.23 , pp. 6802-6810
    • Nettles, J.H.1    Jenkins, J.L.2    Bender, A.3    Deng, Z.4    Davies, J.W.5    Glick, M.6
  • 54
    • 26944446576 scopus 로고    scopus 로고
    • In vitro safety pharmacology profiling: An essential tool for successful drug development
    • Whitebread S, Hamon J, Bojanic D, Urban L. In vitro safety pharmacology profiling: an essential tool for successful drug development. Drug Discov. Today. 10(21), 1421-1433 (2005).
    • (2005) Drug Discov. Today. , vol.10 , Issue.21 , pp. 1421-1433
    • Whitebread, S.1    Hamon, J.2    Bojanic, D.3    Urban, L.4
  • 56
    • 36849084612 scopus 로고    scopus 로고
    • Predictive models for HERG channel blockers: Ligand-based and structure-based approaches
    • Thai KM, Ecker GF. Predictive models for HERG channel blockers: ligand-based and structure-based approaches. Curr. Med. Chem. 14(28), 3003-3026 (2007).
    • (2007) Curr. Med. Chem. , vol.14 , Issue.28 , pp. 3003-3026
    • Thai, K.M.1    Ecker, G.F.2
  • 57
    • 47249146126 scopus 로고    scopus 로고
    • Drug target identification using side-effect similarity
    • Campillos M, Kuhn M, Gavin AC, Jensen LJ, Bork P. Drug target identification using side-effect similarity. Science 321(5886), 263-266 (2008).
    • (2008) Science , vol.321 , Issue.5886 , pp. 263-266
    • Campillos, M.1    Kuhn, M.2    Gavin, A.C.3    Jensen, L.J.4    Bork, P.5
  • 58
    • 40049100210 scopus 로고    scopus 로고
    • Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure
    • Bender A, Scheiber J, Glick M et al. Analysis of pharmacology data and the prediction of adverse drug reactions and off-target effects from chemical structure. ChemMedChem. 2(6), 861-873 (2007).
    • (2007) Chem Med Chem , vol.2 , Issue.6 , pp. 861-873
    • Bender, A.1    Scheiber, J.2    Glick, M.3
  • 59
    • 65249092595 scopus 로고    scopus 로고
    • Gaining insight into off-target mediated effects of drug candidates with a comprehensive systems chemical biology analysis
    • Scheiber J, Chen B, Milik M et al. Gaining insight into off-target mediated effects of drug candidates with a comprehensive systems chemical biology analysis. J. Chem. Inf. Model. 49(2), 308-317 (2009).
    • (2009) J. Chem. Inf. Model. , vol.49 , Issue.2 , pp. 308-317
    • Scheiber, J.1    Chen, B.2    Milik, M.3
  • 60
    • 65649093070 scopus 로고    scopus 로고
    • Mapping adverse drug reactions in chemical space
    • Scheiber J, Jenkins JL, Sukuru SC et al. Mapping adverse drug reactions in chemical space. J. Med. Chem. 52(9), 3103-3107 (2009).
    • (2009) J. Med. Chem. , vol.52 , Issue.9 , pp. 3103-3107
    • Scheiber, J.1    Jenkins, J.L.2    Sukuru, S.C.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.