A novel Entamoeba histolytica cysteine proteinase, EhCP4, is key for invasive amebiasis and a therapeutic target

Journal of Biological Chemistry

Volumn 285, Issue 24, 2010, Pages 18516-18527

  He, Chen ^a   Nora, George P ^b   Schneider, Eric L ^c   Kerr, Iain D ^d   Hansell, Elizabeth ^c   Hirata, Ken ^a   Gonzalez, David ^a   Sajid, Mohammed ^c,e   Boyd, Sarah E ^f   Hruz, Petr ^g   Cobo, Eduardo R ^a   Le, Christine ^g   Liu, Wei Ting ^a   Eckmann, Lars ^g   Dorrestein, Pieter C ^a   Houpt, Eric R ^h   Brinen, Linda S ^d   Craik, Charles S ^c   Roush, William R ^b   McKerrow, James ^c   Reeda, Sharon L ^a   more..

^a UNIVERSITY OF CALIFORNIA   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^f LA TROBE UNIVERSITY   (Australia)

^g UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

^h UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDIC PH; BIOCHEMICAL PROPERTIES; COCULTURE; CYSTEINE PROTEINASE; CYTOPLASMIC VESICLES; DRUG DESIGN; ENDOPLASMIC RETICULUM; ENTAMOEBA HISTOLYTICA; EPITHELIAL BARRIER; EXPRESSION PATTERNS; HOMOLOGY MODELING; HOST IMMUNE RESPONSE; IN-VITRO; IN-VIVO; NEUTRAL PH; PARASITE-; PROTEOLYTIC ACTIVITIES; RECOMBINANT ENZYMES; SUBSTRATE SPECIFICITY; THERAPEUTIC TARGETS; UP-REGULATION; VINYL SULFONES;

AMINO ACIDS; ENZYME ACTIVITY;

CELL CULTURE;

ANTIPARASITIC AGENT; ARGININE; CYSTEINE PROTEINASE; ENTAMOEBA HISTOLYTICA CYSTEINE PROTEINASE 4; ISOLEUCINE; RECOMBINANT ENZYME; UNCLASSIFIED DRUG; VALINE; WRR 483; WRR 605;

ACIDITY; AMEBIASIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATALYSIS; CELL VACUOLE; CONTROLLED STUDY; CYTOPLASM; DRUG SYNTHESIS; ENDOPLASMIC RETICULUM; ENTAMOEBA HISTOLYTICA; ENZYME ACTIVATION; ENZYME INHIBITION; ENZYME LOCALIZATION; ENZYME RELEASE; ENZYME SPECIFICITY; HUMAN; HUMAN CELL; INTESTINE CELL; MALE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN TARGETING; SEQUENCE HOMOLOGY; TYPHLITIS;

AMEBIASIS; ANIMALS; CELL LINE, TUMOR; CYSTEINE PROTEASES; DRUG DESIGN; ENTAMOEBA HISTOLYTICA; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HUMANS; HYDROGEN-ION CONCENTRATION; KINETICS; MASS SPECTROMETRY; MICE; MICE, INBRED C3H; PEPTIDE HYDROLASES; PROTEASE INHIBITORS; RECOMBINANT PROTEINS; THIOREDOXINS;

ENTAMOEBA HISTOLYTICA; PROTOZOA;

EID: 77953310153     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M109.086181     Document Type: Article

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