Neurotransmitter receptor-mediated activation of G-proteins in brains of suicide victims with mood disorders: Selective supersensitivity of α2A-adrenoceptors

Molecular Psychiatry

Volumn 7, Issue 7, 2002, Pages 755-767

  Gonzalez Maeso J ^a   Rodriguez Puertas R ^a   Meana, J J ^a,b   Garcia Sevilla J A ^b   Guimon J ^b  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

G proteins; Guanosine 5 O (3 thiotriphosphate); Human brain; Mood disorders; Suicide; 35S GTP S binding; 2A adrenoceptors

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; 4 AMINOBUTYRIC ACID B RECEPTOR STIMULATING AGENT; ALPHA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; ALPHA 2A ADRENERGIC RECEPTOR; BACLOFEN; BRAIN PROTEIN; BRIMONIDINE; CARBACHOL; ENKEPHALIN[2 DEXTRO ALANINE 4 METHYLPHENYLALANINE 5 GLYCINE]; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); MASTOPARAN; MU OPIATE RECEPTOR AGONIST; MUSCARINIC AGENT; NEUROTRANSMITTER RECEPTOR; SEROTONIN 1A AGONIST; SEROTONIN 1A RECEPTOR; SULFUR 35;

ADULT; AFFECTIVE NEUROSIS; AGED; ARTICLE; AUTOPSY; CLINICAL ARTICLE; CONTROLLED STUDY; DENSITY; DEPRESSION; FEMALE; FRONTAL CORTEX; HUMAN; HUMAN TISSUE; IMMUNOREACTIVITY; MALE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN FUNCTION; RECEPTOR SENSITIVITY; SUICIDE; SUPERSENSITIVITY;

ADULT; AGED; BRAIN; FEMALE; GTP-BINDING PROTEIN ALPHA SUBUNITS, GI-GO; GUANOSINE 5'-O-(3-THIOTRIPHOSPHATE); HETEROTRIMERIC GTP-BINDING PROTEINS; HUMANS; MALE; MIDDLE AGED; MOOD DISORDERS; PSYCHOTROPIC DRUGS; RADIOLIGAND ASSAY; RECEPTORS, ADRENERGIC, ALPHA-2; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; SUICIDE; SULFUR RADIOISOTOPES; TUBULIN;

EID: 0036373345     PISSN: 13594184     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.mp.4001067     Document Type: Article

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