Reduced adenylyl cyclase immunolabeling and activity in postmortem temporal cortex of depressed suicide victims

Journal of Affective Disorders

Volumn 56, Issue 2-3, 1999, Pages 141-151

  Reiach, James S ^a   Li, Peter P ^b,c,d   Warsh, Jerry J ^b,c,d   Kish, Stephen J ^b,c,d   Young, L Trevor ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b CENTRE FOR ADDICTION AND MENTAL HEALTH   (Canada)

^c UNIVERSITY OF TORONTO   (Canada)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

Adenylyl cyclase; Bipolar affective disorder; Major depressive disorder; Signal transduction; Suicide; Temporal cortex

Indexed keywords

ADENYLATE CYCLASE; FORSKOLIN; GUANOSINE 5' O (3 THIOTRIPHOSPHATE); ISOENZYME;

ADULT; AGED; ANTIBODY LABELING; ARTICLE; AUTOPSY; CLINICAL ARTICLE; CONTROLLED STUDY; DEPRESSION; ENZYME ACTIVATION; ENZYME ANALYSIS; FEMALE; GEL ELECTROPHORESIS; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; MALE; MANIC DEPRESSIVE PSYCHOSIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; SUICIDE; TEMPORAL CORTEX; VICTIM;

ADENYLATE CYCLASE; ADOLESCENT; ADULT; AGED; AUTOPSY; BLOTTING, WESTERN; CYCLIC AMP; DEPRESSIVE DISORDER; FEMALE; HUMANS; MALE; MIDDLE AGED; PROTEIN ISOFORMS; SIGNAL TRANSDUCTION; SUICIDE; TEMPORAL LOBE;

EID: 0033399399     PISSN: 01650327     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0165-0327(99)00048-8     Document Type: Article

References (51)

1. Altshuler L.L., Conrad A., Hauser P., Li X., Guze B.H., Denikoff K., Tourtellotte W., Post R. Reduction of temporal lobe volume in bipolar disorder: A preliminary report of magnetic resonance imaging. Arch. Gen. Psych. 48:1991;482-483.
2. 2 and β-adrenergic receptor binding sites in the brain of suicide victims. Arch. Gen. Psych. 47:1990;1038-1047.
3. Avissar S., Barki-Harrington L., Nechamkin Y., Roitman G., Schreiber G. Reduced β-adrenergic receptor-coupled Gs protein function and Gsα immunoreactivity in mononuclear leukocytes of patients with depression. Biol. Psychiatry. 39:1996;755-760.
4. Avissar S., Nechamkin Y., Barki-Harrington L., Roitman G., Schreiber G. Differential G protein measures in mononuclear leukocytes of patients with bipolar mood disorder are state dependent. J. Affect. Disord. 43:1997;85-93.
5. Bakalyar H.A., Reed R.R. Identification of a specialized adenylyl cyclase that may mediate odorant detection. Science. 250:1990;1403-1406.
6. Birnbaumer L., Abramowitz J., Brown A.M. Receptor-effector coupling by G proteins. Biochim. Biophys. Acta. 1031:1990;163-224.
7. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72:1976;248-252.
8. 2+/calmodulin-stimulated enzyme expressed in discrete regions of rat brain. J. Biol. Chem. 269:(16):1994;12190-12195.
9. Castets F., Baillat G., Mirzoeva S., Mabrouk K., Garin J., d'Alayer J., Monneron A. A brain synaptosomal adenylyl cyclase of high specific activity is photolabeled with azide-ATP. Biochemistry. 33:1994;5063-5069.
10. Chen J., Rasenick M.M. Chronic antidepressant treatment facilitates G protein activation of adenylyl cyclase without altering G protein content. J. Pharmacol. Exp. Thera. 275:(1):1995;509-517.
11. Chen J., Rasenick M.M. Chronic treatment of C6 Glioma cells with antidepressant drugs increases functional coupling between a G protein (Gs) and adenylyl cyclase. J. Neurochem. 64:1995;724-732.
12. Cowburn R.F., Marcusson J.O., Eriksson A., Wiehager B., O'Neill C. Adenylyl cyclase activity and G-protein subunit levels in postmortem frontal cortex of suicide victims. Brain Res. 633:1994;297-304.
13. DePaermentier F., Mauger J.M., Lowther S., Crompton M.R., Katona C.L.E., Horton R.W. Brain α-adrenoceptors in depressed suicides. Brain. Res. 757:1997;60-68.
14. Duman R.S., Strada S.J., Enna S.J. Effect of imipramine and adrenocorticotropin administration on the rat brain norepinephrine-coupled cyclic nucleotide generating system: alterations in alpha and beta adrenergic components. J. Pharmacol. Exp. Ther. 234:1985;409-414.
15. Extein I., Tallman J., Smith C.C., Goodwin F.K. Change in lymphocyte β-adrenergic receptors in depression and mania. Psychiatry Res. 1:1979;191-197.
16. Friedman E., Wang H.-Y. Receptor-mediated activation of G proteins is increased in postmortem brains of bipolar affective disorder subjects. J. Neurochem. 67:1996;1145-1152.
17. Gao B., Gilman A.G. Cloning and expression of a widely distributed (type IV) adenylyl cyclase. Proc. Natl. Acad. Sci. USA. 88:1991;10178-10182.
18. 1-noradrenergic receptors in the human brain postmortem. Arch. Gen. Psych. 47:1990;1049-1053.
19. Halper J.P., Brown R.P., Sweeney J.A., Koscis J., Peters A., Mann J. Blunted β-adrenergic responsivity of peripheral blood cells in endogenous depression. Arch. Gen. Psychiatry. 45:1988;241-244.
20. Hashimoto E., Frölich L., Ozawa H., Saito T., Maurer K., Böning J., Takahata N., Riederer P. Reduced immunoreactivity of type I adenylyl cyclase in the postmortem brains of alcoholics. Alcohol Clin. Exp. Res. 22:(3):1998;88S-92S.
21. Hudson C.J., Young L.T., Li P.P., Warsh J.J. CNS signal transduction in the pathophysiology and pharmacotherapy of affective disorders and schizophrenia. Synapse. 13:1993;278-293.
22. 2-adrenoceptor: Evidence that adenylate cyclase is the limiting component for receptor-mediated stimulation of adenylate cyclase activity. Biochem. J. 318:(Pt3):1996;1033-1039.
23. Manji H.K. G proteins: Implications for psychiatry. Am. J. Psychiatry. 149:1992;746-760.
24. Manji H.K., Chen G., Shimon H., Hsiao J.K., Potter W.Z., Belmaker R.H. Guanine nucleotide-binding proteins in bipolar affective disorder. Arch. Gen. Psychiatry. 52:1995;135-144.
25. Mann J.J., Halper J.P., Wilner P.J., Sweeney J.A., Mieczkowski J.A., Chen J.-S., Stokes P.E., Brown R.P. Subsensitivity of adenylyl cyclase-coupled receptors on mononuclear leukocytes from drug-free inpatients with a major depressive episode. Biol Psychiatry. 42:1997;859-870.
26. Mann J.J., Brown R.P., Halper J.P., Sweeney J.A., Kocsis J.H., Stokes P.E., Bilezikian J.P. Reduced sensitivity of lymphocyte β-adrenergic receptors in patients with endogenous depression and psychomotor agitation. N. Eng. J. Med. 313:1985;715-720.
27. Menkes D.B., Rasenick M.M., Wheeler M.A., Bitensky M.W. Guanosine triphosphate activation of brain adenylate cyclase: enhancement by long-term antidepressant treatment. Science. 219:1983;65-67.
28. Menninger J.A., Tabakoff B. Forskolin-stimulated platelet adenylyl cyclase activity is lower in persons with major depression. Biol. Psychiatry. 42:1997;30-38.
29. Mollner S., Simmoteit R., Palm D., Pfeuffer T. Monoclonal antibodies against various forms of the adenylyl cyclase catalytic subunit and associated proteins. Eur. J. Biochem. 195:1991;281-286.
30. Mons N., Harry A., Dubourg P., Premont R.T., Iyengar R., Cooper D.M.F. Immunohistochemical localization of adenylyl cyclase in rat brain indicates a highly selective concentration at synapses. Proc. Natl. Acad. Sci. USA. 92:1995;8473-8477.
31. Mooney J.J., Schatzberg A.F., Cole J.O., Samson J.A., Watermaux C., Gerson B., Pappalardo K.M., Schildkraut J. Rapid antidepressant response to alprazolam in depressed patients with high catecholamine output and heterologous desensitization of platelet adenylate cyclase. Biol. Psychiatry. 23:1988;543-559.
32. Newman M.E., Solomon H., Lerer B. Electroconvulsive shock and cyclic AMP signal transduction: effects distal to the receptor. J. Neurochem. 46:1986;1667-1669.
33. Ozawa H., Rasenick M.M. Coupling of the stimulatory GTP-binding protein Gs to rat synaptic membrane adenylate cyclase is enhanced subsequent to chronic antidepressant treatment. Mol. Pharmacol. 36:1989;803-808.
34. Ozawa H., Rasenick M.M. Chronic electroconvulsive treatment augments coupling of the GTP-binding protein Gs to the catalytic moiety of adenylyl cyclase in a manner similar to that seen with chronic antidepressant drugs. J. Neurochem. 56:1991;330-338.
35. Ozawa H., Gsell W., Frolich L., Zochling R., Pantucek F., Bechmann H., Riederer P. Imbalance of the Gs and Gi/o function in post-mortem human brain of depressed patients. J. Neural. Transm. [GenSect]. 94:1993;63-69.
36. Pacheco M.A., Stockmeier C., Meltzer H.Y., Overholser J.C., Dilley G.E., Jope R.S. Alterations in phosphoinositide signaling and G-protein levels in depressed suicide brain. Brain Res. 723:1996;37-45.
37. Pandey G.N., Dysken M.W., Garver D.L., Davis J. Changes in lymphocyte β-adrenergic receptor function in affective illness. Am. J. Psychiatry. 136:1979;675-678.
38. Premont R.T., Matsuoka I., Mattei M.G., Pouille Y., Defer N., Hanoune J. Identification and characterization of a widely expressed form of adenylyl cyclase. J. Biol. Chem. 271:(23):1996;13900-13907.
39. 3H cAMP binding in postmortem brain from subjects with bipolar affective disorder. J. Neurochem. 68:1997;297-304.
40. Schreiber G., Avissar S., Danon A., Belmaker R.H. Hyperfunctional G proteins in mononuclear leukocytes of patients with mania. Biol. Psychiatry. 29:1991;273-280.
41. Shichinohe S., Ozawa H., Saito T., Hashimoto E., Lang C., Riederer P., Takahata N. Differential alteration of adenylyl cyclase subtypes I, II, and V/VI in postmortem human brains of heroin addicts. Alcohol Clin. Exp. Res. 22:(3):1998;84S-87S.
42. Soares J.C., Mann J.J. The anatomy of mood disorders - Review of structural neuroimaging studies. Biol. Psychiatry. 41:1997;86-106.
43. Tang W.J., Krupinski J., Gilman A.G. Expression and characterization of calmodulin-activated (Type I) adenylyl cyclase. J. Biol. Chem. 266:1991;8595-8603.
44. Taussig R., Gilman A.G. Mammalian membrane-bound adenylyl cyclase. J. Biol. Chem. 270:1995;1-4.
45. Warsh J.J., Li P.P. Second messenger systems and mood disorders. Curr. Opin. Psychiatry. 9:1996;23-29.
46. 2+/CaM-sensitive adenylyl cyclase activity is decreased in the Alzheimer's brain: Possible relation to type I adenylyl cyclase. J. Neural Transm. 104:1997;721-732.
47. Yamamoto M., Ozawa H., Saito T., Frölich L., Riederer P., Takahata N. Reduced immunoreactivity of adenylyl cyclase in dementia of the Alzheimer type. Neuroreport. 7:1996;2965-2970.
48. s alpha subunit levels are elevated in bipolar affective disorder. Brain Res. 553:1991;323-326.
49. sα protein levels and forskolin-stimulated cyclic AMP formations are increased in bipolar affective disorder. J. Neurochem. 61:1993;890-898.
50. Young L.T., Li P.P., Kamble A., Siu K.P., Warsh J.J. Mononuclear leukocyte levels of G proteins in depressed patients with bipolar disorder or major depressive disorder. Am. J. Psychiatry. 151:(4):1994;594-596.
51. Young L.T., Li P.P., Kish S.J., Warsh J.J. Cerebral cortex β-adrenoceptor binding in bipolar affective disorder. J. Affect. Disord. 30:(2):1994;89-92.