메뉴 건너뛰기




Volumn 16, Issue 6, 2010, Pages 277-286

Virus-host interactions in hepatitis C virus infection: implications for molecular pathogenesis and antiviral strategies

Author keywords

[No Author keywords available]

Indexed keywords

CYCLOPHILIN; HLA ANTIGEN; INTERFERON; INTERFERON LAMBDA 3; INTERLEUKIN 28; INTERLEUKIN 28B; LIPOPROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN; MICRORNA; MICRORNA 122; PEGINTERFERON ALPHA; PROTEIN ZO1; RIBAVIRIN; STAT PROTEIN; TOLL LIKE RECEPTOR; UNCLASSIFIED DRUG;

EID: 77953290422     PISSN: 14714914     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molmed.2010.04.003     Document Type: Review
Times cited : (59)

References (93)
  • 1
    • 23944506014 scopus 로고    scopus 로고
    • Global epidemiology of hepatitis C virus infection
    • Shepard C.W., et al. Global epidemiology of hepatitis C virus infection. Lancet Infect. Dis. 5 (2005) 558-567
    • (2005) Lancet Infect. Dis. , vol.5 , pp. 558-567
    • Shepard, C.W.1
  • 2
    • 33645729182 scopus 로고    scopus 로고
    • Immunobiology and pathogenesis of viral hepatitis
    • Guidotti L.G., and Chisari F.V. Immunobiology and pathogenesis of viral hepatitis. Annu. Rev. Pathol. 1 (2006) 23-61
    • (2006) Annu. Rev. Pathol. , vol.1 , pp. 23-61
    • Guidotti, L.G.1    Chisari, F.V.2
  • 3
    • 0345188811 scopus 로고    scopus 로고
    • Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line
    • Lohmann V., et al. Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line. Science 285 (1999) 110-113
    • (1999) Science , vol.285 , pp. 110-113
    • Lohmann, V.1
  • 4
    • 0037416146 scopus 로고    scopus 로고
    • Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes
    • Bartosch B., et al. Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes. J. Exp. Med. 197 (2003) 633-642
    • (2003) J. Exp. Med. , vol.197 , pp. 633-642
    • Bartosch, B.1
  • 5
    • 0038471344 scopus 로고    scopus 로고
    • Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles
    • Hsu M., et al. Hepatitis C virus glycoproteins mediate pH-dependent cell entry of pseudotyped retroviral particles. Proc. Natl. Acad. Sci. U. S. A. 100 (2003) 7271-7276
    • (2003) Proc. Natl. Acad. Sci. U. S. A. , vol.100 , pp. 7271-7276
    • Hsu, M.1
  • 6
    • 0031977996 scopus 로고    scopus 로고
    • Hepatitis C virus structural proteins assemble into viruslike particles in insect cells
    • Baumert T.F., et al. Hepatitis C virus structural proteins assemble into viruslike particles in insect cells. J. Virol. 72 (1998) 3827-3836
    • (1998) J. Virol. , vol.72 , pp. 3827-3836
    • Baumert, T.F.1
  • 7
    • 22544470874 scopus 로고    scopus 로고
    • Production of infectious hepatitis C virus in tissue culture from a cloned viral genome
    • Wakita T., et al. Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat. Med. 11 (2005) 791-796
    • (2005) Nat. Med. , vol.11 , pp. 791-796
    • Wakita, T.1
  • 8
    • 21544440397 scopus 로고    scopus 로고
    • Robust hepatitis C virus infection in vitro
    • Zhong J., et al. Robust hepatitis C virus infection in vitro. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 9294-9299
    • (2005) Proc. Natl. Acad. Sci. U. S. A. , vol.102 , pp. 9294-9299
    • Zhong, J.1
  • 9
    • 23044437222 scopus 로고    scopus 로고
    • Complete replication of hepatitis C virus in cell culture
    • Lindenbach B.D., et al. Complete replication of hepatitis C virus in cell culture. Science 309 (2005) 623-626
    • (2005) Science , vol.309 , pp. 623-626
    • Lindenbach, B.D.1
  • 10
    • 17944379233 scopus 로고    scopus 로고
    • Hepatitis C virus replication in mice with chimeric human livers
    • Mercer D.F., et al. Hepatitis C virus replication in mice with chimeric human livers. Nat. Med. 7 (2001) 927-933
    • (2001) Nat. Med. , vol.7 , pp. 927-933
    • Mercer, D.F.1
  • 11
    • 44649093803 scopus 로고    scopus 로고
    • Mouse models for the study of HCV infection and virus-host interactions
    • Barth H., et al. Mouse models for the study of HCV infection and virus-host interactions. J. Hepatol. 49 (2008) 134-142
    • (2008) J. Hepatol. , vol.49 , pp. 134-142
    • Barth, H.1
  • 12
    • 77949725830 scopus 로고    scopus 로고
    • Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment
    • Bissig K.D., et al. Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment. J. Clin. Invest. 120 (2010) 924-930
    • (2010) J. Clin. Invest. , vol.120 , pp. 924-930
    • Bissig, K.D.1
  • 13
    • 34249024924 scopus 로고    scopus 로고
    • Replication of hepatitis C virus
    • Moradpour D., et al. Replication of hepatitis C virus. Nat. Rev. Microbiol. 5 (2007) 453-463
    • (2007) Nat. Rev. Microbiol. , vol.5 , pp. 453-463
    • Moradpour, D.1
  • 14
    • 0034646996 scopus 로고    scopus 로고
    • The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies
    • Farci P., et al. The outcome of acute hepatitis C predicted by the evolution of the viral quasispecies. Science 288 (2000) 339-344
    • (2000) Science , vol.288 , pp. 339-344
    • Farci, P.1
  • 15
    • 33748933183 scopus 로고    scopus 로고
    • Hepatitis C virus entry: molecular biology and clinical implications
    • Barth H., et al. Hepatitis C virus entry: molecular biology and clinical implications. Hepatology 44 (2006) 527-535
    • (2006) Hepatology , vol.44 , pp. 527-535
    • Barth, H.1
  • 16
    • 17044457135 scopus 로고    scopus 로고
    • Cellular binding of hepatitis C virus envelope glycoprotein E2 requires cell surface heparan sulfate
    • Barth H., et al. Cellular binding of hepatitis C virus envelope glycoprotein E2 requires cell surface heparan sulfate. J. Biol. Chem. 278 (2003) 41003-41012
    • (2003) J. Biol. Chem. , vol.278 , pp. 41003-41012
    • Barth, H.1
  • 17
    • 33846576292 scopus 로고    scopus 로고
    • The low-density lipoprotein receptor plays a role in the infection of primary human hepatocytes by hepatitis C virus
    • Molina S., et al. The low-density lipoprotein receptor plays a role in the infection of primary human hepatocytes by hepatitis C virus. J. Hepatol. 46 (2007) 411-419
    • (2007) J. Hepatol. , vol.46 , pp. 411-419
    • Molina, S.1
  • 18
    • 0032582538 scopus 로고    scopus 로고
    • Binding of hepatitis C virus to CD81
    • Pileri P., et al. Binding of hepatitis C virus to CD81. Science 282 (1998) 938-941
    • (1998) Science , vol.282 , pp. 938-941
    • Pileri, P.1
  • 19
    • 18644378971 scopus 로고    scopus 로고
    • The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus
    • Scarselli E., et al. The human scavenger receptor class B type I is a novel candidate receptor for the hepatitis C virus. EMBO J. 21 (2002) 5017-5025
    • (2002) EMBO J. , vol.21 , pp. 5017-5025
    • Scarselli, E.1
  • 20
    • 34147219730 scopus 로고    scopus 로고
    • Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry
    • Evans M.J., et al. Claudin-1 is a hepatitis C virus co-receptor required for a late step in entry. Nature 446 (2007) 801-805
    • (2007) Nature , vol.446 , pp. 801-805
    • Evans, M.J.1
  • 21
    • 60149090028 scopus 로고    scopus 로고
    • Human occludin is a hepatitis C virus entry factor required for infection of mouse cells
    • Ploss A., et al. Human occludin is a hepatitis C virus entry factor required for infection of mouse cells. Nature 457 (2009) 882-886
    • (2009) Nature , vol.457 , pp. 882-886
    • Ploss, A.1
  • 22
    • 24644483623 scopus 로고    scopus 로고
    • Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA
    • Jopling C.L., et al. Modulation of hepatitis C virus RNA abundance by a liver-specific MicroRNA. Science 309 (2005) 1577-1581
    • (2005) Science , vol.309 , pp. 1577-1581
    • Jopling, C.L.1
  • 23
    • 58049217312 scopus 로고    scopus 로고
    • microRNA-122 stimulates translation of hepatitis C virus RNA
    • Henke J.I., et al. microRNA-122 stimulates translation of hepatitis C virus RNA. EMBO J. 27 (2008) 3300-3310
    • (2008) EMBO J. , vol.27 , pp. 3300-3310
    • Henke, J.I.1
  • 24
    • 69549135689 scopus 로고    scopus 로고
    • The autophagy machinery is required to initiate hepatitis C virus replication
    • Dreux M., et al. The autophagy machinery is required to initiate hepatitis C virus replication. Proc. Natl. Acad. Sci. U. S. A. 106 (2009) 14046-14051
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 14046-14051
    • Dreux, M.1
  • 25
    • 70049096419 scopus 로고    scopus 로고
    • Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics
    • Kaul A., et al. Essential role of cyclophilin A for hepatitis C virus replication and virus production and possible link to polyprotein cleavage kinetics. PLoS Pathog. 5 (2009) e1000546
    • (2009) PLoS Pathog. , vol.5
    • Kaul, A.1
  • 26
    • 34548316984 scopus 로고    scopus 로고
    • The lipid droplet is an important organelle for hepatitis C virus production
    • Miyanari Y., et al. The lipid droplet is an important organelle for hepatitis C virus production. Nat. Cell Biol. 9 (2007) 1089-1097
    • (2007) Nat. Cell Biol. , vol.9 , pp. 1089-1097
    • Miyanari, Y.1
  • 27
    • 34547616693 scopus 로고    scopus 로고
    • Hepatitis C virus p7 protein is crucial for assembly and release of infectious virions
    • Steinmann E., et al. Hepatitis C virus p7 protein is crucial for assembly and release of infectious virions. PLoS Pathog. 3 (2007) e103
    • (2007) PLoS Pathog. , vol.3
    • Steinmann, E.1
  • 28
    • 73449126883 scopus 로고    scopus 로고
    • Apolipoprotein E interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles
    • Benga W.J., et al. Apolipoprotein E interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles. Hepatology 51 (2010) 43-53
    • (2010) Hepatology , vol.51 , pp. 43-53
    • Benga, W.J.1
  • 29
    • 39749098739 scopus 로고    scopus 로고
    • Cellular determinants of hepatitis C virus assembly, maturation, degradation, and secretion
    • Gastaminza P., et al. Cellular determinants of hepatitis C virus assembly, maturation, degradation, and secretion. J. Virol. 82 (2008) 2120-2129
    • (2008) J. Virol. , vol.82 , pp. 2120-2129
    • Gastaminza, P.1
  • 30
    • 61849160363 scopus 로고    scopus 로고
    • A functional genomic screen identifies cellular cofactors of hepatitis C virus replication
    • Tai A.W., et al. A functional genomic screen identifies cellular cofactors of hepatitis C virus replication. Cell Host Microbe 5 (2009) 298-307
    • (2009) Cell Host Microbe , vol.5 , pp. 298-307
    • Tai, A.W.1
  • 31
    • 70349513508 scopus 로고    scopus 로고
    • A genome-wide genetic screen for host factors required for hepatitis C virus propagation
    • Li Q., et al. A genome-wide genetic screen for host factors required for hepatitis C virus propagation. Proc. Natl. Acad. Sci. U. S. A. 106 (2009) 16410-16415
    • (2009) Proc. Natl. Acad. Sci. U. S. A. , vol.106 , pp. 16410-16415
    • Li, Q.1
  • 32
    • 68849111675 scopus 로고    scopus 로고
    • Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence
    • Rehermann B. Hepatitis C virus versus innate and adaptive immune responses: a tale of coevolution and coexistence. J. Clin. Invest. 119 (2009) 1745-1754
    • (2009) J. Clin. Invest. , vol.119 , pp. 1745-1754
    • Rehermann, B.1
  • 33
    • 47149098765 scopus 로고    scopus 로고
    • Host neutralizing responses and pathogenesis of hepatitis C virus infection
    • Zeisel M.B., et al. Host neutralizing responses and pathogenesis of hepatitis C virus infection. Hepatology 48 (2008) 299-307
    • (2008) Hepatology , vol.48 , pp. 299-307
    • Zeisel, M.B.1
  • 34
    • 77951094286 scopus 로고    scopus 로고
    • A look behind closed doors: interaction of persistent viruses with dendritic cells
    • Lambotin M., et al. A look behind closed doors: interaction of persistent viruses with dendritic cells. Nat. Rev. Microbiol. 8 (2010) 350-360
    • (2010) Nat. Rev. Microbiol. , vol.8 , pp. 350-360
    • Lambotin, M.1
  • 35
    • 58049202272 scopus 로고    scopus 로고
    • Innate immunity to virus infection
    • Takeuchi O., and Akira S. Innate immunity to virus infection. Immunol. Rev. 227 (2009) 75-86
    • (2009) Immunol. Rev. , vol.227 , pp. 75-86
    • Takeuchi, O.1    Akira, S.2
  • 36
    • 56749133272 scopus 로고    scopus 로고
    • Viral evasion and subversion of pattern-recognition receptor signalling
    • Bowie A.G., and Unterholzner L. Viral evasion and subversion of pattern-recognition receptor signalling. Nat. Rev. Immunol. 8 (2008) 911-922
    • (2008) Nat. Rev. Immunol. , vol.8 , pp. 911-922
    • Bowie, A.G.1    Unterholzner, L.2
  • 37
    • 17144382003 scopus 로고    scopus 로고
    • Hepatitis C virus expression suppresses interferon signaling by degrading STAT1
    • Lin W., et al. Hepatitis C virus expression suppresses interferon signaling by degrading STAT1. Gastroenterology 128 (2005) 1034-1041
    • (2005) Gastroenterology , vol.128 , pp. 1034-1041
    • Lin, W.1
  • 38
    • 0036717295 scopus 로고    scopus 로고
    • Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation
    • Yoshida T., et al. Activation of STAT3 by the hepatitis C virus core protein leads to cellular transformation. J. Exp. Med. 196 (2002) 641-653
    • (2002) J. Exp. Med. , vol.196 , pp. 641-653
    • Yoshida, T.1
  • 39
    • 0346100572 scopus 로고    scopus 로고
    • Hepatitis C virus inhibits interferon signaling through up-regulation of protein phosphatase 2A
    • Duong F.H., et al. Hepatitis C virus inhibits interferon signaling through up-regulation of protein phosphatase 2A. Gastroenterology 126 (2004) 263-277
    • (2004) Gastroenterology , vol.126 , pp. 263-277
    • Duong, F.H.1
  • 40
    • 13344282731 scopus 로고    scopus 로고
    • Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway
    • Meraz M.A., et al. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell 84 (1996) 431-442
    • (1996) Cell , vol.84 , pp. 431-442
    • Meraz, M.A.1
  • 41
    • 0030024563 scopus 로고    scopus 로고
    • Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease
    • Durbin J.E., et al. Targeted disruption of the mouse Stat1 gene results in compromised innate immunity to viral disease. Cell 84 (1996) 443-450
    • (1996) Cell , vol.84 , pp. 443-450
    • Durbin, J.E.1
  • 42
    • 44349109098 scopus 로고    scopus 로고
    • Interferon signaling and treatment outcome in chronic hepatitis C
    • Sarasin-Filipowicz M., et al. Interferon signaling and treatment outcome in chronic hepatitis C. Proc. Natl. Acad. Sci. U. S. A. 105 (2008) 7034-7039
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 7034-7039
    • Sarasin-Filipowicz, M.1
  • 43
    • 7644226241 scopus 로고    scopus 로고
    • Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation
    • Dolganiuc A., et al. Hepatitis C core and nonstructural 3 proteins trigger toll-like receptor 2-mediated pathways and inflammatory activation. Gastroenterology 127 (2004) 1513-1524
    • (2004) Gastroenterology , vol.127 , pp. 1513-1524
    • Dolganiuc, A.1
  • 44
    • 77953286248 scopus 로고    scopus 로고
    • Toll-like receptor 2 senses hepatitis C virus core protein but not infectious viral particles
    • Hoffmann M., et al. Toll-like receptor 2 senses hepatitis C virus core protein but not infectious viral particles. J. Innate Immun. 1 (2009) 446-454
    • (2009) J. Innate Immun. , vol.1 , pp. 446-454
    • Hoffmann, M.1
  • 45
    • 0038108598 scopus 로고    scopus 로고
    • Upregulation of major histocompatibility complex class I on liver cells by hepatitis C virus core protein via p53 and TAP1 impairs natural killer cell cytotoxicity
    • Herzer K., et al. Upregulation of major histocompatibility complex class I on liver cells by hepatitis C virus core protein via p53 and TAP1 impairs natural killer cell cytotoxicity. J. Virol. 77 (2003) 8299-8309
    • (2003) J. Virol. , vol.77 , pp. 8299-8309
    • Herzer, K.1
  • 46
    • 72549104093 scopus 로고    scopus 로고
    • Natural killer cells are polarized toward cytotoxicity in chronic hepatitis C in an interferon-alfa-dependent manner
    • 325-335
    • Ahlenstiel G., et al. Natural killer cells are polarized toward cytotoxicity in chronic hepatitis C in an interferon-alfa-dependent manner. Gastroenterology 138 (2010) 325-335
    • (2010) Gastroenterology , vol.138
    • Ahlenstiel, G.1
  • 47
    • 77951861128 scopus 로고    scopus 로고
    • Interferon-alpha-induced TRAIL on natural killer cells is associated with control of hepatitis C virus infection
    • Stegmann K.A., et al. Interferon-alpha-induced TRAIL on natural killer cells is associated with control of hepatitis C virus infection. Gastroenterology 138 (2010) 1885-1897
    • (2010) Gastroenterology , vol.138 , pp. 1885-1897
    • Stegmann, K.A.1
  • 48
    • 0037033363 scopus 로고    scopus 로고
    • Binding of the hepatitis C virus envelope protein E2 to CD81 inhibits natural killer cell functions
    • Tseng C.T., and Klimpel G.R. Binding of the hepatitis C virus envelope protein E2 to CD81 inhibits natural killer cell functions. J. Exp. Med. 195 (2002) 43-49
    • (2002) J. Exp. Med. , vol.195 , pp. 43-49
    • Tseng, C.T.1    Klimpel, G.R.2
  • 49
    • 14944375587 scopus 로고    scopus 로고
    • Immunology of hepatitis B virus and hepatitis C virus infection
    • Rehermann B., and Nascimbeni M. Immunology of hepatitis B virus and hepatitis C virus infection. Nat. Rev. Immunol. 5 (2005) 215-229
    • (2005) Nat. Rev. Immunol. , vol.5 , pp. 215-229
    • Rehermann, B.1    Nascimbeni, M.2
  • 50
    • 0029151623 scopus 로고
    • Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection
    • Diepolder H.M., et al. Possible mechanism involving T-lymphocyte response to non-structural protein 3 in viral clearance in acute hepatitis C virus infection. Lancet 346 (1995) 1006-1007
    • (1995) Lancet , vol.346 , pp. 1006-1007
    • Diepolder, H.M.1
  • 51
    • 0035914925 scopus 로고    scopus 로고
    • Determinants of viral clearance and persistence during acute hepatitis C virus infection
    • Thimme R., et al. Determinants of viral clearance and persistence during acute hepatitis C virus infection. J. Exp. Med. 194 (2001) 1395-1406
    • (2001) J. Exp. Med. , vol.194 , pp. 1395-1406
    • Thimme, R.1
  • 52
    • 10244225383 scopus 로고    scopus 로고
    • Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response
    • Missale G., et al. Different clinical behaviors of acute hepatitis C virus infection are associated with different vigor of the anti-viral cell-mediated immune response. J. Clin. Invest. 98 (1996) 706-714
    • (1996) J. Clin. Invest. , vol.98 , pp. 706-714
    • Missale, G.1
  • 53
    • 34347230939 scopus 로고    scopus 로고
    • Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C
    • Pestka J.M., et al. Rapid induction of virus-neutralizing antibodies and viral clearance in a single-source outbreak of hepatitis C. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 6025-6030
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 6025-6030
    • Pestka, J.M.1
  • 54
    • 20944449916 scopus 로고    scopus 로고
    • Human serum facilitates hepatitis C virus infection, and neutralizing responses inversely correlate with viral replication kinetics at the acute phase of hepatitis C virus infection
    • Lavillette D., et al. Human serum facilitates hepatitis C virus infection, and neutralizing responses inversely correlate with viral replication kinetics at the acute phase of hepatitis C virus infection. J. Virol. 79 (2005) 6023-6034
    • (2005) J. Virol. , vol.79 , pp. 6023-6034
    • Lavillette, D.1
  • 55
    • 0034030136 scopus 로고    scopus 로고
    • Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C
    • Takaki A., et al. Cellular immune responses persist and humoral responses decrease two decades after recovery from a single-source outbreak of hepatitis C. Nat. Med. 6 (2000) 578-582
    • (2000) Nat. Med. , vol.6 , pp. 578-582
    • Takaki, A.1
  • 56
    • 33847015308 scopus 로고    scopus 로고
    • Hepatitis C virus continuously escapes from neutralizing antibody and T-cell responses during chronic infection in vivo
    • von Hahn T., et al. Hepatitis C virus continuously escapes from neutralizing antibody and T-cell responses during chronic infection in vivo. Gastroenterology 132 (2007) 667-678
    • (2007) Gastroenterology , vol.132 , pp. 667-678
    • von Hahn, T.1
  • 57
    • 66149119738 scopus 로고    scopus 로고
    • Selection pressure from neutralizing antibodies drives sequence evolution during acute infection with hepatitis C virus
    • Dowd K.A., et al. Selection pressure from neutralizing antibodies drives sequence evolution during acute infection with hepatitis C virus. Gastroenterology 136 (2009) 2377-2386
    • (2009) Gastroenterology , vol.136 , pp. 2377-2386
    • Dowd, K.A.1
  • 58
    • 45749102096 scopus 로고    scopus 로고
    • Hepatitis C virus (HCV)-induced immunoglobulin hypermutation reduces the affinity and neutralizing activities of antibodies against HCV envelope protein
    • Machida K., et al. Hepatitis C virus (HCV)-induced immunoglobulin hypermutation reduces the affinity and neutralizing activities of antibodies against HCV envelope protein. J. Virol. 82 (2008) 6711-6720
    • (2008) J. Virol. , vol.82 , pp. 6711-6720
    • Machida, K.1
  • 59
    • 66349121862 scopus 로고    scopus 로고
    • The HapMap and genome-wide association studies in diagnosis and therapy
    • Manolio T.A., and Collins F.S. The HapMap and genome-wide association studies in diagnosis and therapy. Annu. Rev. Med. 60 (2009) 443-456
    • (2009) Annu. Rev. Med. , vol.60 , pp. 443-456
    • Manolio, T.A.1    Collins, F.S.2
  • 60
    • 33846486344 scopus 로고    scopus 로고
    • A functional SNP of interferon-gamma gene is important for interferon-alpha-induced and spontaneous recovery from hepatitis C virus infection
    • Huang Y., et al. A functional SNP of interferon-gamma gene is important for interferon-alpha-induced and spontaneous recovery from hepatitis C virus infection. Proc. Natl. Acad. Sci. U. S. A. 104 (2007) 985-990
    • (2007) Proc. Natl. Acad. Sci. U. S. A. , vol.104 , pp. 985-990
    • Huang, Y.1
  • 61
    • 33646341219 scopus 로고    scopus 로고
    • Association of transforming growth factor-beta 1 functional polymorphisms with natural clearance of hepatitis C virus
    • Kimura T., et al. Association of transforming growth factor-beta 1 functional polymorphisms with natural clearance of hepatitis C virus. J. Infect. Dis. 193 (2006) 1371-1374
    • (2006) J. Infect. Dis. , vol.193 , pp. 1371-1374
    • Kimura, T.1
  • 62
    • 0141889852 scopus 로고    scopus 로고
    • Interleukin-10 promoter polymorphisms and the outcome of hepatitis C virus infection
    • Knapp S., et al. Interleukin-10 promoter polymorphisms and the outcome of hepatitis C virus infection. Immunogenetics 55 (2003) 362-369
    • (2003) Immunogenetics , vol.55 , pp. 362-369
    • Knapp, S.1
  • 63
    • 1642359820 scopus 로고    scopus 로고
    • Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR
    • Knapp S., et al. Polymorphisms in interferon-induced genes and the outcome of hepatitis C virus infection: roles of MxA, OAS-1 and PKR. Genes Immun. 4 (2003) 411-419
    • (2003) Genes Immun. , vol.4 , pp. 411-419
    • Knapp, S.1
  • 64
    • 2142698141 scopus 로고    scopus 로고
    • Genetic variants in the CCR gene cluster and spontaneous viral elimination in hepatitis C-infected patients
    • Mascheretti S., et al. Genetic variants in the CCR gene cluster and spontaneous viral elimination in hepatitis C-infected patients. Clin. Exp. Immunol. 136 (2004) 328-333
    • (2004) Clin. Exp. Immunol. , vol.136 , pp. 328-333
    • Mascheretti, S.1
  • 65
    • 3242778542 scopus 로고    scopus 로고
    • Inducible nitric oxide synthase gene (NOS2A) haplotypes and the outcome of hepatitis C virus infection
    • Yee L.J., et al. Inducible nitric oxide synthase gene (NOS2A) haplotypes and the outcome of hepatitis C virus infection. Genes Immun. 5 (2004) 183-187
    • (2004) Genes Immun. , vol.5 , pp. 183-187
    • Yee, L.J.1
  • 66
    • 19044361835 scopus 로고    scopus 로고
    • Hepatic gene expression discriminates responders and nonresponders in treatment of chronic hepatitis C viral infection
    • Chen L., et al. Hepatic gene expression discriminates responders and nonresponders in treatment of chronic hepatitis C viral infection. Gastroenterology 128 (2005) 1437-1444
    • (2005) Gastroenterology , vol.128 , pp. 1437-1444
    • Chen, L.1
  • 67
    • 3042715432 scopus 로고    scopus 로고
    • Distinct MHC class I and II alleles are associated with hepatitis C viral clearance, originating from a single source
    • McKiernan S.M., et al. Distinct MHC class I and II alleles are associated with hepatitis C viral clearance, originating from a single source. Hepatology 40 (2004) 108-114
    • (2004) Hepatology , vol.40 , pp. 108-114
    • McKiernan, S.M.1
  • 68
    • 34247574266 scopus 로고    scopus 로고
    • Impact of the genetic restriction of virus-specific T-cell responses in hepatitis C virus infection
    • Neumann-Haefelin C., and Thimme R. Impact of the genetic restriction of virus-specific T-cell responses in hepatitis C virus infection. Genes Immun. 8 (2007) 181-192
    • (2007) Genes Immun. , vol.8 , pp. 181-192
    • Neumann-Haefelin, C.1    Thimme, R.2
  • 69
    • 3843075120 scopus 로고    scopus 로고
    • HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection
    • Khakoo S.I., et al. HLA and NK cell inhibitory receptor genes in resolving hepatitis C virus infection. Science 305 (2004) 872-874
    • (2004) Science , vol.305 , pp. 872-874
    • Khakoo, S.I.1
  • 70
    • 72849120234 scopus 로고    scopus 로고
    • Effect of killer immunoglobulin-like receptors in the response to combined treatment in patients with chronic hepatitis C virus infection
    • Vidal-Castineira J.R., et al. Effect of killer immunoglobulin-like receptors in the response to combined treatment in patients with chronic hepatitis C virus infection. J. Virol. 84 (2010) 475-481
    • (2010) J. Virol. , vol.84 , pp. 475-481
    • Vidal-Castineira, J.R.1
  • 71
    • 65949104586 scopus 로고    scopus 로고
    • Genomewide association studies and human disease
    • Hardy J., and Singleton A. Genomewide association studies and human disease. N. Engl. J. Med. 360 (2009) 1759-1768
    • (2009) N. Engl. J. Med. , vol.360 , pp. 1759-1768
    • Hardy, J.1    Singleton, A.2
  • 72
    • 70349292099 scopus 로고    scopus 로고
    • Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance
    • Ge D., et al. Genetic variation in IL28B predicts hepatitis C treatment-induced viral clearance. Nature 461 (2009) 399-401
    • (2009) Nature , vol.461 , pp. 399-401
    • Ge, D.1
  • 73
    • 70349548852 scopus 로고    scopus 로고
    • IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy
    • Suppiah V., et al. IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy. Nat. Genet 41 (2009) 1100-1104
    • (2009) Nat. Genet , vol.41 , pp. 1100-1104
    • Suppiah, V.1
  • 74
    • 70349533037 scopus 로고    scopus 로고
    • Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C
    • Tanaka Y., et al. Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C. Nat. Genet 41 (2009) 1105-1109
    • (2009) Nat. Genet , vol.41 , pp. 1105-1109
    • Tanaka, Y.1
  • 75
    • 77949831342 scopus 로고    scopus 로고
    • Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure - a genome-wide association study
    • Rauch A., et al. Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure - a genome-wide association study. Gastroenterology 41 (2010) 1338-1345
    • (2010) Gastroenterology , vol.41 , pp. 1338-1345
    • Rauch, A.1
  • 76
    • 70349966196 scopus 로고    scopus 로고
    • Genetic variation in IL28B and spontaneous clearance of hepatitis C virus
    • Thomas D.L., et al. Genetic variation in IL28B and spontaneous clearance of hepatitis C virus. Nature 461 (2009) 798-801
    • (2009) Nature , vol.461 , pp. 798-801
    • Thomas, D.L.1
  • 77
    • 0037236826 scopus 로고    scopus 로고
    • IL-28, IL-29 and their class II cytokine receptor IL-28R
    • Sheppard P., et al. IL-28, IL-29 and their class II cytokine receptor IL-28R. Nat. Immunol. 4 (2003) 63-68
    • (2003) Nat. Immunol. , vol.4 , pp. 63-68
    • Sheppard, P.1
  • 78
    • 34147161091 scopus 로고    scopus 로고
    • Viral infections activate types I and III interferon genes through a common mechanism
    • Onoguchi K., et al. Viral infections activate types I and III interferon genes through a common mechanism. J. Biol. Chem. 282 (2007) 7576-7581
    • (2007) J. Biol. Chem. , vol.282 , pp. 7576-7581
    • Onoguchi, K.1
  • 79
    • 42949160129 scopus 로고    scopus 로고
    • IFN-lambda (IFN-lambda) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo
    • Sommereyns C., et al. IFN-lambda (IFN-lambda) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo. PLoS Pathog. 4 (2008) e1000017
    • (2008) PLoS Pathog. , vol.4
    • Sommereyns, C.1
  • 80
    • 77649274843 scopus 로고    scopus 로고
    • The cell biology of hepatitis C virus
    • Joyce M.A., and Tyrrell D.L. The cell biology of hepatitis C virus. Microbes Infect. 12 (2010) 263-271
    • (2010) Microbes Infect. , vol.12 , pp. 263-271
    • Joyce, M.A.1    Tyrrell, D.L.2
  • 81
    • 65449171953 scopus 로고    scopus 로고
    • Telaprevir and peginterferon with or without ribavirin for chronic HCV infection
    • Hezode C., et al. Telaprevir and peginterferon with or without ribavirin for chronic HCV infection. N. Engl. J. Med. 360 (2009) 1839-1850
    • (2009) N. Engl. J. Med. , vol.360 , pp. 1839-1850
    • Hezode, C.1
  • 82
    • 65449152185 scopus 로고    scopus 로고
    • Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection
    • McHutchison J.G., et al. Telaprevir with peginterferon and ribavirin for chronic HCV genotype 1 infection. N. Engl. J. Med. 360 (2009) 1827-1838
    • (2009) N. Engl. J. Med. , vol.360 , pp. 1827-1838
    • McHutchison, J.G.1
  • 83
    • 58149384511 scopus 로고    scopus 로고
    • Anti-CD81 antibodies can prevent a hepatitis C virus infection in vivo
    • Meuleman P., et al. Anti-CD81 antibodies can prevent a hepatitis C virus infection in vivo. Hepatology 48 (2008) 1761-1768
    • (2008) Hepatology , vol.48 , pp. 1761-1768
    • Meuleman, P.1
  • 84
    • 77950613333 scopus 로고    scopus 로고
    • Inhibition of hepatitis C virus infection by anti-claudin-1 antibodies is mediated by neutralization of E2-CD81-Claudin-1 associations
    • Krieger S.E., et al. Inhibition of hepatitis C virus infection by anti-claudin-1 antibodies is mediated by neutralization of E2-CD81-Claudin-1 associations. Hepatology 51 (2010) 1144-1157
    • (2010) Hepatology , vol.51 , pp. 1144-1157
    • Krieger, S.E.1
  • 85
    • 66149129922 scopus 로고    scopus 로고
    • The cyclophilin inhibitor Debio 025 combined with PEG IFNalpha2a significantly reduces viral load in treatment-naive hepatitis C patients
    • Flisiak R., et al. The cyclophilin inhibitor Debio 025 combined with PEG IFNalpha2a significantly reduces viral load in treatment-naive hepatitis C patients. Hepatology 49 (2009) 1460-1468
    • (2009) Hepatology , vol.49 , pp. 1460-1468
    • Flisiak, R.1
  • 86
    • 74249112787 scopus 로고    scopus 로고
    • Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection
    • Lanford R.E., et al. Therapeutic silencing of microRNA-122 in primates with chronic hepatitis C virus infection. Science 327 (2010) 198-201
    • (2010) Science , vol.327 , pp. 198-201
    • Lanford, R.E.1
  • 87
    • 58849095096 scopus 로고    scopus 로고
    • Development of novel treatments for hepatitis C
    • Webster D.P., et al. Development of novel treatments for hepatitis C. Lancet Infect. Dis. 9 (2009) 108-117
    • (2009) Lancet Infect. Dis. , vol.9 , pp. 108-117
    • Webster, D.P.1
  • 88
    • 70349295416 scopus 로고    scopus 로고
    • PEG-IFN-λ: Antiviral activity and safety profile in a 4-week phase 1B study in relapsed genotype 1 Hepatitis C infection
    • Shiffmann M., et al. PEG-IFN-λ: Antiviral activity and safety profile in a 4-week phase 1B study in relapsed genotype 1 Hepatitis C infection. J. Hepatol. 50 Supplement 1 (2009) S237
    • (2009) J. Hepatol. , vol.50 , Issue.SUPPL. 1
    • Shiffmann, M.1
  • 89
    • 39149105299 scopus 로고    scopus 로고
    • RNAi: a powerful tool to unravel hepatitis C virus-host interactions within the infectious life cycle
    • Lupberger J., et al. RNAi: a powerful tool to unravel hepatitis C virus-host interactions within the infectious life cycle. J. Hepatol. 48 (2008) 523-525
    • (2008) J. Hepatol. , vol.48 , pp. 523-525
    • Lupberger, J.1
  • 90
    • 33644862356 scopus 로고    scopus 로고
    • Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro
    • Lindenbach B.D., et al. Cell culture-grown hepatitis C virus is infectious in vivo and can be recultured in vitro. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 3805-3809
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 3805-3809
    • Lindenbach, B.D.1
  • 91
    • 76349104162 scopus 로고    scopus 로고
    • Jones, C.T. et al. (2010) Real-time imaging of hepatitis C virus infection using a fluorescent cell-based reporter system. Nat. Biotechnol. 28, 167-171
    • Jones, C.T. et al. (2010) Real-time imaging of hepatitis C virus infection using a fluorescent cell-based reporter system. Nat. Biotechnol. 28, 167-171
  • 92
    • 33646556662 scopus 로고    scopus 로고
    • Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras
    • Pietschmann T., et al. Construction and characterization of infectious intragenotypic and intergenotypic hepatitis C virus chimeras. Proc. Natl. Acad. Sci. U. S. A. 103 (2006) 7408-7413
    • (2006) Proc. Natl. Acad. Sci. U. S. A. , vol.103 , pp. 7408-7413
    • Pietschmann, T.1
  • 93
    • 77649262300 scopus 로고    scopus 로고
    • Ploss, A. et al. (2010) Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures. Proc. Natl. Acad. Sci. U. S. A. 107, 3141-3145
    • Ploss, A. et al. (2010) Persistent hepatitis C virus infection in microscale primary human hepatocyte cultures. Proc. Natl. Acad. Sci. U. S. A. 107, 3141-3145


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.