Mucoadhesive drug delivery systems

Brazilian Journal of Pharmaceutical Sciences

Volumn 46, Issue 1, 2010, Pages 1-17

  Carvalho, Flávia Chiva ^a   Bruschi, Marcos Luciano ^b   Evangelista, Raul Cesar ^a   Gremião, Maria Palmira Daflon ^a  

^a SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

^b STATE UNIVERSITY OF MARINGÁ   (Brazil)

Author keywords

Bioadhesion; Drugs delivery; Mucoadhesion; Mucoadhesive systems

Indexed keywords

ADHESIVE AGENT; ALGINIC ACID; CARBOMER; CARBOXYMETHYLCELLULOSE; CELLULOSE DERIVATIVE; CHITOSAN; INSULIN; LECTIN; LIPOSOME; POLYACRYLIC ACID; POLYCARBOPHIL; POLYMER; MUCIN;

ADSORPTION KINETICS; ATOMIC FORCE MICROSCOPY; CONCEPTUAL FRAMEWORK; CONFOCAL LASER MICROSCOPY; DIFFUSION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG MECHANISM; DRUG RELEASE; DRUG TRANSPORT; ELECTRON MICROSCOPY; ELECTRONICS; FLOW KINETICS; HUMAN; HYDROGEL; HYDROGEN BOND; HYDROPHILICITY; IN VIVO STUDY; LIPOPHILICITY; METHODOLOGY; MOLECULAR INTERACTION; MOLECULAR MECHANICS; MUCOADHESION; MUCOSA; NONHUMAN; REVIEW; SHEAR STRENGTH; STOMATITIS; TABLET; EX VIVO STUDY; GASTROINTESTINAL TRANSIT; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; INTESTINE; MATHEMATICAL ANALYSIS; TENSILE STRENGTH;

EID: 77953254889     PISSN: 19848250     EISSN: 21759790     Source Type: Journal    
DOI: 10.1590/S1984-82502010000100002     Document Type: Review

References (50)

1. AHUJA, A.; KHAR, R. K.; ALI, J. Mucoadhesive drug delivery systems. Drug Dev. Ind. Pharm., v.23, n.5, p.489-515, 1997.
2. ANDREWS, G. P.; JONES, D. S. Rheological characterization of bioadhesive binary polymeric systems designed as platforms for drug delivery implants. Biomacromol., v.7, p.899-906, 2006.
3. ANDREWS, G. P.; LAVERTY, T. P.; JONES, D. S. Mucoadhesive polymeric platforms for controlled drug delivery, Eur. J. Pharm. Biopharm., v.71, n.3, p.505-518, 2008.
4. BOCATAJ, M.; VOVK, T.; KEREC, M.; DIMNIK, A. D.; GRABNAR, I.; MRHAR, A. The correlation between zeta potential and mucoadhesion strength on pig vesical mucosa. Biol. Pharm. Bull,. v.26, n.5, p.743-746, 2003.
5. BRAVO-OSUNA, I.; VAUTHIER, C.; FARABOLLINI, A.; PALMIERI, G. F.; PONCHEL, G. Mucoadhesion mechanism of chitosan and thiolated chitosan-poly(isobutiyl cyanoacrylate) core-shell nanoparticles. Biomaterials, v.28, n.13, p.2233-2243, 2007.
6. BROMBERG, L.; TEMCHENKO, M.; ALAKHOV, V.; HATTON, T. A. Bioadhesive properties and rheology of polyether-modified poly(acrylic acid) hydrogels. Int. J. Pharm., v.282, n.1, p.45-60, 2004.
7. BRUSCHI, M. L. Desenvolvimento e caracterização de sistemas de liberação de própolis intrabolsa periodontal. Ribeirão Preto, 2006. 238 p. [Tese de Doutorado. Faculdade de Ciências Farmacêuticas de Ribeirão Preto. Universidade de são Paulo].
8. BRUSCHI, M. L.; FREITAS, O. Oral bioadhesive drug delivery systems. Drug Ind. Pharm., v.31, n.3, p.293-310, 2005.
9. BRUSCHI, M. L.; JONES, D. S.; PANZERI, H.; GREMIÃO, M. P. D.; FREITAS, O.; LARA, E. H. G. Semisolid systems containing propolis for the treatment of periodontal disease: in vitro release kinetics, syringeability, rheological, textural, and mucoadhesive properties. J. Pharm. Sci., v.96, n.8, p.2074-2089, 2007.
10. BRUSCHI, M. L.; JONES, D. S.; PANZERI, H.; GREMIÃO, M. P. D.; FREITAS, O.; LARA, E. H. G. Development and characterization of precursor of liquid crystalline phase with propolis-containing microparticles for use in the treatment of periodontal disease. Drug Develop. Ind. Pharm., v.34, n.3, p.267-278, 2008.
11. CALLENS, C.; CEULEMANS, J.; LUDWIG, A.; FOREMAN, P.; REMON, J. P. Rheological study on mucoadhesivity of some nasal powder formulations. Eur. J. Pharm. Biopharm., v.55, n.3, p.323-328, 2003.
12. CEULEMANS, J.; VINCKIER, I.; LUDWIG, A. The use of xantan gum in an ophthalmic liquid dosage form: rheological characterization of the interaction with mucin. J. Pharm. Sci., v.91, n.4, p.1117-1127, 2002.
13. CHOWDARY, C. P. R.; RAO, Y. S. Mucoadhesive microspheres for controlled drug delivery. Biol. Pharm. Bull., v.27, n.11, p.1717-1724, 2004.
14. CLEARY, J.; BROMBERG, L.; MAGNER, E. Adhesion of Polyether-Modified Poly(acrylic acid) to Mucin. Langmuir, v.20, n.22, p.9755-9762, 2004.
15. EVANGELISTA, R. C. Sistemas de liberação controlada de fármacos. Araraquara, 2006. 345 f. [Tese de Livre Docência em Farmacotécnica. Faculdade de Ciências Farmacêuticas. Universidade Estadual Paulista "Júlio de Mesquita Filho"].
16. FORMARIZ, T. P.; URBAN, M. C. C.; SILVA JUNIOR, A. A.; GREMIÃO, M. P. D; OLIVEIRA, A. G. Microemulsões e fases líquidas cristalinas como sistemas de liberação de fármacos. Rev. Bras. Ciênc. Farm., v.41, n.3, p.301-313, 2005.
17. GOTO, T.; MORISHITA, M.; KAVIMANDAN, N. J.; TAKAYAMA, K.; PEPPAS, N. A. Gastrointestinal transit and mucoadhesive characteristics of complexation hydrogels in rats. J. Pharm. Sci., v.95, n.2, p.462-469, 2006.
18. GRABOVAC, V.; GUGGI, D.; BERNKOP-SCHNÜRCH, A. Comparison of the mucoadhesive properties of varios polymers. Adv. Drug Del. Rev., v.57, n.11, p.1713-1723, 2005.
19. HÄGERSTRÖM, H. Polymer gels as pharmaceutical dosage forms: rheological performance and physicochemical interactions at the gel-mucus interface for formulations intended for mucosal drug delivery. Uppsala, 2003. 76 f. [Dissertation for the degree of Doctor of Philosophy in Pharmaceutics. Uppsala University]
20. HÄGERSTRÖM, H.; EDSMAN, K.; STRØ;MME, M. Low-Frequency Dielectric Spectroscopy as a Tool for Studying the Compatibility between Pharmaceutical Gels and Mucus Tissue. J. Pharm. Sci., v.92, n.9, p.1869-1881, 2003.
21. HASSAN, E. E.; GALLO, J. M. A simple rheological method for the in vitro assessment of mucin-polymer bioadhesive bond strength. Pharm. Res., v.7, n.5, p.491-495, 1990.
22. HUANG, Y.; LEOBANDUNG, W.; FOSS, A.; PEPPAS, N. A. Molecular aspects of muco- and bioadhesion: Tetheres structures and site-specific surfaces. J. Control. Release, v.65, n.1, p.63-71, 2000.
23. JUNGINGER, H. E.; THANOU, M.; VERHOEF, J. C. Drug Delivery: Mucoadhesive Hydrogels. Encyclopedia of Pharmaceutical Technology (3.ed.). Available at: 〈http://www.informaworld.com/smpp/content~db=all~content=a758558230~tab= conten〉. Accessed on: 31 out. 2007.
24. KEELY, S.; RULLAY, A.; WILSON, C.; CARMICHAEL, A.; CARRINGTON, S.; CORFIELD, A.; HADDLETON, D. M.; BRAYDEN, D. J. In vitro and ex vivo intestinal tissue models to measure mucoadhesion of poly (methacrylate) and N-trimethylated chitosan polymers. Pharm. Res., v.22, n.1, p.38-49, 2005.
25. KOCKISCH, S.; REES, G. D.; YOUNG, S. A; TSIBOUKLIS, J.; SMART, J. D. A direct-staining method to evaluate the mucoadhesion of polymers from aqueous dispersion. J. Control. Release, v.77, n.1, p.1-6, 2001.
26. LEE, J. W.; PARK, J. H.; ROBINSON, J. R. Bioadhesive-based dosage forms: The next generation. J. Pharm. Sci., v.89, n.7, p.850-866, 2000.
27. LEHR, C. M. Lectin-mediated drug delivery: The second generation of bioadhesives. J. Control. Release, v.65, n.1, p.19-29, 2000.
28. LEUNG, S. H. S.; ROBINSON, J. R. Polymer structure features contributing to mucoadhesion II. J. Control. Release, v.12, n.3, p.187-194, 1990.
29. MALMSTEN, M. Surfactants and polymers in drug delivery. Drugs and the pharmaceutical Sciences. New York: Marcel Dekker, 2002. 348 p.
30. MATHIOWITZ, E.; CHICKERING, D. E.; LEHR, C. M. (Eds.). Bioadhesive drug delivery systems: fundamentals, novel approaches, and development. Drugs and the Pharmaceutical Sciences. New York: Marcel Dekker, 1999. 696 p.
31. MORTAZAVI, S. A.; MOGHIMI, H. R. Effect of Surfactant Type and Concentration on the Duration of Mucoadhesion of Carbopol 934 and HPMC Solid Compacts. Ir. J. Pharm. Res., v.2, n.4, p.191-199, 2003.
32. NAGAI, T. Adhesive topical drug delivery system. J. Control. Release, v.2, p.121-134, p.121-134, 1985.
33. NAGAI, T.; NISHIMOTO, Y.; NAMBU, N.; SUZUKI, Y.; SEKINE, K. Powder dosage form of insulin for nasal administration. J. Control. Release, v.1, n.1, p.15-22, 1984.
34. NIELSEN, L. S.; SCHUBERT, L.; HANSEN, J. Bioadhesive drug delivery systems. I. Characterization of mucoadhesive properties of systems based on glyceryl mono-oleate and glyceryl monolinoleate. Eur. J. Pharm. Sci., v.6, n.3, p.231-239, 1998.
35. PARK, J. S.; OH, Y. K.; JUNG, H. Y.; KIM, J. M.; KIM, C. K. In situ gelling and mucoadhesive polymer vehicles for controlled intranasal delivery of plasmid DNA. J. Biomed. Master Res., v.59, n.3, p.144-151, 2001.
36. PEPPAS, N. A.; HUANG, Y. Nanoscale technology of mucoadhesive interactions. Adv. Drug Del. Rev., v.56, n.11, p.1675-1687, 2004.
37. PEPPAS, N. A.; SAHLIN, J. J. Hydrogels as mucoadhesive and bioadhesive materials: a review. Biomaterials, v.17, n.11, p.1553-1561, 1996.
38. QIU, Y.; PARK, K. Environment-sensitive hydrogels for drug delivery. Adv. Drug Del. Rev., v.53, n.3, p.321-339, 2001.
39. RANGO RAO, K. V.; BURI, P. A novel in situ method to test polymers and coated microparticles for bioadhesion. Int. J. Pharm., v.52, n.3, p.265-270, 1989.
40. SÄKKINEN, M.; MARVOLA, J.; KANERVA, H.; LINDEVALL, K.; MARTTI MARVOLA, A. A. Are chitosan formulations mucoadhesive in the human small intestine? An evaluation based on gamma scintigraphy. Int. J. Pharm., v.307, v.307, n.2, p.285-291, 2006.
41. SANTOS, C. A.; JACOB, J. S.; HERTZOG, B. A.; FREESMAN, B. D.; PRESS, D. L.; HARNPICHARNCHAI, P.; MATHIOWITZ, E. Correlation of two bioadhesion assays: the everted sac technique and the CAHN microbalance. J. Control. Rel., v.61, n.2, p.113-122, 1999.
42. SHIN, S. C.; LEE, J. W.; YANG, K. H.; LEE, C. H. Preparation and evaluation of bioadhesive benzocainegels for enhanced local anesthetic effects. Int. J. Pharm., v.260, n.1, p.77-81, 2003.
43. SIGURDSSON, H. H.; LOFTSSON, T.; LEHR, C. M. Assessment of mucoadhesion by a resonant mirror biosensor. Int. J. Pharm., v.325, n.1, p.75-81, 2006.
44. SMART, J. D. The basics and underlying mechanisms of mucoadhesion. Adv.Drug Del. Rev., v.57, n.11, p.1556-1568, 2005.
45. TAKEUCHI, H.; THONGBORISUTE, J.; MATSUI, Y.; SUGIHARA, H.; YAMAMOTO, H. H.; KAMASHIMA, Y. Novel mucoadhesion tests for polymers and polymer-coated particles to design optimal mucoadhesive drug delivery systems. Adv. Drug Del. Rev., v.57, n.11, p.1583-1594, 2005.
46. VYAS, T. K.; BABBAR, A. K.; SHARMA, R. K.; SINGH, S., MISRA, A.; Preliminary brain-targeting studies on intranasal mucoadhesive microemulsion of sumatriptan. AAPS Pharm. Sci. Tech., v.7, n.1, p.E1-E9, 2006.
47. WISE, D. L. Handbook of pharmaceutical controlled release technology. New York: Marcel Dekker, 2000. 890 p.
48. WITTAYA-AREEKUL, S.; KRUENATE, J.; PRAHSARN, C. Preparation and in vitro evaluation of mucoadhesive properties of alginate/chitosan microparticles containing prednisolone. Int. J. Pharm., v.312, n.1, p.113-118, 2006.
49. WONG, C. F.; YUEN, K. H.; PEH, K. K. An in-vitro method for buccal adhesion studies: importance of instrument variables. Int. J. Pharm., v.180, n.1, p.47-57, 1999.
50. WOODLEY, J. Bioadhesion, new possibilities for drug administration? Clin. Pharmacokinet., v.40, n.2, p.77-84, 2001.