Substitution of the Walker A lysine by arginine in the nucleotide-binding domains of sulphonylurea receptor SUR2B: Effects on ligand binding and channel activity

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 381, Issue 6, 2010, Pages 507-516

  Amann, Tobias ^a   Schell, Sophie ^a   Kühner, Petra ^a   Winkler, Marcus ^a   Schwanstecher, Mathias ^b   Russ, Ulrich ^a   Quast, Ulrich ^a  

^a UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^b TECHNICAL UNIVERSITY OF BRAUNSCHWEIG   (Germany)

Author keywords

Glibenclamide; Opener P1075; Recombinant vascular K ATP channel; Sulphonylurea receptor 2B; SUR ATPase states; Walker A mutation Lys Arg

Indexed keywords

2 CYANO 1 (1,1 DIMETHYLPROPYL) 3 (3 PYRIDYL)GUANIDINE; ADENOSINE TRIPHOSPHATE; ARGININE; BINDING PROTEIN; GLIBENCLAMIDE; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR6.1; LYSINE; SULPHONYLUREA RECEPTOR 2B; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG RECEPTOR BINDING; ELECTROPHYSIOLOGY; ENZYME INHIBITION; GENE MUTATION; HUMAN; HUMAN CELL; LIGAND BINDING; MOUSE; NONHUMAN; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN MOTIF; RAT;

ADENOSINE TRIPHOSPHATE; AMINO ACID MOTIFS; AMINO ACID SUBSTITUTION; ANIMALS; ARGININE; ATP-BINDING CASSETTE TRANSPORTERS; BINDING SITES; GLYBURIDE; GUANIDINES; HUMANS; HYPOGLYCEMIC AGENTS; LIGANDS; LYSINE; MICE; MUTATION; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN BINDING; PYRIDINES; RATS; RECEPTORS, DRUG;

EID: 77953229777     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-010-0510-0     Document Type: Article

References (52)

1. L Aguilar-Bryan CG Nichols SW Wechsler JP Clement IV AE Boyd III G Gonzáles H Herrera-Soza K Nguy J Bryan DA Nelson 1995 Cloning of the β cell high-affinity sulfonylurea receptor: a regulator of insulin secretion Science 268 423 426 10.1126/science.7716547 1:CAS:528: DyaK2MXltFKktbw%3D 7716547
2. ATP channel Diabetes 48 1341 1347 10.2337/diabetes.48.6.1341 1:CAS:528: DyaK1MXjsFSgt7w%3D 10342826 (Pubitemid 29241036)
3. ATP channels "vingt ans apres": ATG to PDB to mechanism J Mol Cell Cardiol 39 79 98 10.1016/j.yjmcc.2004.12.004 1:CAS:528:DC%2BD2MXlsFGgtbk%3D 15978905 (Pubitemid 40836046)
4. ATP channels J Biol Chem 276 49083 49092 10.1074/jbc.M108763200 1:CAS:528:DC%2BD38XktlentQ%3D%3D 11673467
5. ATP channels FEBS Lett 445 131 136 10.1016/S0014-5793(99)00102-7 1:CAS:528:DyaK1MXht1Ogsrg%3D 10069387 (Pubitemid 29101548)
6. ATP channel closure FEBS Lett 459 367 376 10.1016/S0014-5793(99)01215-6 1:CAS:528:DyaK1MXmvVKjsL4%3D 10526167 (Pubitemid 29467370)
7. + channel openers J Biol Chem 275 717 720 10.1074/jbc.275.2.717 1:CAS:528: DC%2BD3cXntlaktg%3D%3D 10625598 (Pubitemid 30051106)
8. C Berkower S Michaelis 1991 Mutational analysis of the yeast a-factor transporter STE6, a member of the ATP binding cassette (ABC) protein superfamily EMBO J 10 3777 3785 1:CAS:528:DyaK38Xltl2gtQ%3D%3D 1935899
9. ATP channel complex FASEB J 14 1943 1952 10.1096/fj.00-0027com 1:CAS:528:DC%2BD3MXhtF2rsLg%3D 11023978
10. + channel openers in rat aorta J Biol Chem 267 11689 11692 1:CAS:528:DyaK38XltVerur4%3D 1601843
11. + channels Diabetes 53 S104 S112 10.2337/diabetes.53.suppl-3.S104 1:CAS:528:DC%2BD2cXhtVOls73F 15561897 (Pubitemid 39564531)
12. JD Campbell MSP Sansom FM Ashcroft 2003 Potassium channel regulation EMBO Rep 4 1038 1042 10.1038/sj.embor.7400003 1:CAS:528:DC%2BD3sXosFajtL8%3D 14593442 (Pubitemid 37527420)
13. A Christopoulos 1998 Assessing the distribution of parameters in models of ligand-receptor interaction: to log or not to log Trends Pharmacol Sci 19 351 357 10.1016/S0165-6147(98)01240-1 1:CAS:528:DyaK1cXmsVegsbg%3D 9786022 (Pubitemid 29011723)
14. H de Wet MV Mikhailov C Fotinou M Dreger TJ Craig C Vénien-Bryan FM Ashcroft 2007 Studies of the ATPase activity of the ABC protein SUR1 FEBS J 274 3532 3544 10.1111/j.1742-4658.2007.05879.x 17561960 (Pubitemid 47052393)
15. A Frelet M Klein 2006 Insight in eukaryotic ABC transporter function by mutation analysis FEBS Lett 580 1064 1084 10.1016/j.febslet.2006.01.024 1:CAS:528:DC%2BD28XhtFejtLY%3D 16442101 (Pubitemid 43185287)
16. LC Groop 1992 Sulfonylureas in NIDDM Diabetes Care 15 737 754 10.2337/diacare.15.6.737 1:STN:280:DyaK383ovFCitg%3D%3D 1600834
17. ATP channel modulator binding to the recombinant sulphonylurea receptor, SUR2B Br J Pharmacol 125 577 583 10.1038/sj.bjp.0702109 1:CAS:528:DyaK1cXmvVSqt7s%3D 9806343 (Pubitemid 28451498)
18. A Hambrock C Löffler-Walz U Russ U Lange U Quast 2001 Characterization of a mutant sulfonylurea receptor SUR2B with high affinity for sulfonylureas and openers: differences in the coupling to Kir6.x subtypes Mol Pharmacol 60 190 199 1:CAS:528:DC%2BD3MXks1Crtbw%3D 11408614
19. A Hambrock C Löffler-Walz U Quast 2002 Glibenclamide binding to sulphonylurea receptor subtypes: dependence on adenine nucleotides Br J Pharmacol 136 995 1004 10.1038/sj.bjp.0704801 1:CAS:528:DC%2BD38XmtF2kur0%3D 12145099
20. ATP channels-functional coupling of Kir6.2 and SUR1 subunits J Gen Physiol 114 203 213 10.1085/jgp.114.2.203 1:CAS:528:DyaK1MXltlOju7o%3D 10435998 (Pubitemid 29380150)
21. ATP channel modulators with sulfonylurea receptor SUR2B: implication for tetramer formation and allosteric coupling of subunits Mol Pharmacol 61 407 414 10.1124/mol.61.2.407 11809866 (Pubitemid 34112816)
22. OH Lowry NJ Rosebrough AL Farr RJ Randall 1951 Protein measurement with the folin phenol reagent J Biol Chem 193 265 275 1:CAS:528:DyaG38XhsVyrsw%3D%3D 14907713
23. ATP channels by SUR1 and SUR2A J Mol Cell Cardiol 39 491 501 10.1016/j.yjmcc.2005.03.009 1:CAS:528:DC%2BD2MXosVCrsLY%3D 15893323 (Pubitemid 41133734)
24. M Matsuo N Kioka T Amachi K Ueda 1999 ATP binding properties of the nucleotide-binding folds of SUR1 J Biol Chem 274 37479 37482 10.1074/jbc.274.52.37479 1:CAS:528:DC%2BD3cXpsFGg 10601323 (Pubitemid 30016837)
25. ATP channel openers Mol Pharmacol 67 1026 1033 10.1124/mol.104.008698 1:CAS:528:DC%2BD2MXjtFWmsr8%3D 15615694 (Pubitemid 40410405)
26. ATP channel openers J Mol Cell Cardiol 38 951 963 10.1016/j.yjmcc.2004.11.030 1:CAS:528:DC%2BD2MXks1ejsrc%3D 15910880 (Pubitemid 40725943)
27. ATP channels as molecular sensors of cellular metabolism Nature 440 470 476 10.1038/nature04711 1:CAS:528: DC%2BD28Xis1OlsLg%3D 16554807
28. + channel subtype selectivity of insulin secretagogues for the coronary vasculature and the myocardium Diabetes 53 S156 S164 10.2337/diabetes.53.suppl-3.S156 1:CAS:528:DC%2BD2cXhtVOls7rK 15561904 (Pubitemid 39564538)
29. DC Rees E Johnson O Lewinson 2009 ABC transporters: the power to change Nat Rev Mol Cell Biol 10 218 227 10.1038/nrm2646 1:CAS:528:DC%2BD1MXitFKlsL0%3D 19234479
30. F Reimann SJ Tucker P Proks FM Ashcroft 1999 Involvement of the N-terminus of Kir6.2 in coupling to the sulphonylurea receptor J Physiol 518 325 336 10.1111/j.1469-7793.1999.0325p.x 1:CAS:528:DyaK1MXmtVWgsbc%3D 10381582 (Pubitemid 29366732)
31. ATP) channels by Mg-nucleotides J Physiol 547 159 168 10.1113/jphysiol.2002.031625 1:CAS:528:DC%2BD3sXivFSkt7k%3D 12562963 (Pubitemid 36285171)
32. + channel Kir6.1 increases the affinity of the vascular sulfonylurea receptor SUR2B for glibenclamide Mol Pharmacol 56 955 961 1:CAS:528:DyaK1MXntV2mu7g%3D 10531400
33. 2+ Br J Pharmacol 139 368 380 10.1038/sj.bjp.0705238 1:CAS:528:DC%2BD3sXkvFCltrY%3D 12770942 (Pubitemid 36760369)
34. M Saraste PR Sibbald A Wittinghofer 1990 The P-loop-a common motif in ATP-and GTP-binding proteins Trends Biochem Sci 15 430 434 10.1016/0968-0004(90) 90281-F 2126155
35. E Satoh M Yamada C Kondo VP Repunte Y Horio T Iijima Y Kurachi 1998 Intracellular nucleotide-mediated gating of SUR/Kir6.0 complex potassium channels expressed in a mammalian cell line and its modification by pinacidil J Physiol 511 663 674 10.1111/j.1469-7793.1998.663bg.x 1:CAS:528: DyaK1cXmvVOrtLk%3D 9714850 (Pubitemid 28456897)
36. E Schneider S Hunke 1998 ATP-binding-cassette (ABC) transport systems: functional and structural aspects of the ATP-hydrolyzing subunits/domains FEMS Microbiol Rev 22 1 20 10.1111/j.1574-6976.1998.tb00358.x 1:CAS:528: DyaK1cXjtVKitLo%3D 9640644
37. M Schwanstecher S Löser Ch Brandt K Scheffer F Rosenberger U Panten 1992 Adenine nucleotide-induced inhibition of binding of sulphonylureas to their receptor in pancreatic islets Br J Pharmacol 105 531 534 1:CAS:528: DyaK38XitVOls7s%3D 1628141
38. M Schwanstecher C Sieverding H Dörschner I Gross L Aguilar-Bryan C Schwanstecher J Bryan 1998 Potassium channel openers require ATP to bind to and act through sulfonylurea receptors EMBO J 17 5529 5535 10.1093/emboj/17.19.5529 1:CAS:528:DyaK1cXmvVyjsrg%3D 9755153 (Pubitemid 28445964)
39. + channels Prog Biophys Mol Biol 81 133 176 10.1016/S0079-6107(02)00053-6 1:CAS:528:DC%2BD3sXotlOhsA%3D%3D 12565699 (Pubitemid 36141258)
40. ATP channel activity by diazoxide and MgADP. Distinct functions of the two nucleotide binding folds of the sulfonylurea receptor J Gen Physiol 110 643 654 10.1085/jgp.110.6.643 1:CAS:528:DyaK2sXnvFGhs74%3D 9382893 (Pubitemid 27524605)
41. D Stephan E Stau U Lange H Felsch C Löffler-Walz A Hambrock U Russ U Quast 2005 The mutation Y1206S increases the affinity of the sulphonylurea receptor SUR2A for glibenclamide and enhances the effects of coexpression with Kir6.2 Br J Pharmacol 144 1078 1088 10.1038/sj.bjp.0706142 1:CAS:528: DC%2BD2MXjtlaksrs%3D 15711591 (Pubitemid 40593006)
42. + channel J Physiol 512 395 406 10.1111/j.1469-7793.1998.395be.x 1:CAS:528:DyaK1cXnsVKntrk%3D 9763630 (Pubitemid 28486886)
43. + channels in the absence of the sulphonylurea receptor Nature 387 179 183 10.1038/387179a0 1:CAS:528: DyaK2sXjtF2gs7Y%3D 9144288 (Pubitemid 27209432)
44. 2+- independent ATP binding of the sulfonylurea receptor SUR1 J Biol Chem 272 22983 22986 10.1074/jbc.272.37.22983 1:CAS:528:DyaK2sXmt1WjtLw%3D 9287292 (Pubitemid 27392419)
45. I Uhde A Toman I Gross C Schwanstecher M Schwanstecher 1999 Identification of the potassium channel opener site on sulfonylurea receptors J Biol Chem 274 28079 28082 10.1074/jbc.274.40.28079 1:CAS:528:DyaK1MXmsFWgsb8%3D 10497157 (Pubitemid 29472920)
46. IL Urbatsch L Beaudet I Carrier P Gros 1998 Mutations in either nucleotide-binding site of P-glycoprotein (Mdr3) prevent vanadate trapping of nucleotide at both sites Biochem 37 4592 4602 10.1021/bi9728001 1:CAS:528:DyaK1cXhs1Wgt7k%3D (Pubitemid 28217177)
47. JE Walker M Saraste MJ Runswick NJ Gay 1982 Distantly related sequences in the α-and β-subunits of ATP synthase, myosin, kinases and other ATP-requiring enzymes and a common nucleotide binding fold EMBO J 1 945 951 1:CAS:528:DyaL3sXhtVensbY%3D 6329717
48. M Winkler D Stephan S Bieger P Kühner F Wolff U Quast 2007 Testing the bipartite model of the sulfonylurea receptor binding site: binding of A-, B-, and A+B-site ligands J Pharmacol Exp Ther 322 701 708 10.1124/jpet.107. 123224 1:CAS:528:DC%2BD2sXoslSjur8%3D 17495126 (Pubitemid 47105784)
49. M Winkler R Lutz U Russ U Quast J Bryan 2009 Analysis of two KCNJ11 neonatal diabetes mutations, V59G and V59A, and the analogous KCNJ8 I60G substitution: differences between the channel subtypes formed with SUR1 J Biol Chem 284 6752 6762 10.1074/jbc.M805435200 1:CAS:528:DC%2BD1MXislWrtbg%3D 19139106
50. + channel J Physiol 499 715 720 1:CAS:528: DyaK2sXislejsrg%3D 9130167
51. + conductance Neuron 31 233 245 10.1016/S0896-6273(01)00356-7 1:CAS:528:DC%2BD3MXlvFelt7o%3D 11502255 (Pubitemid 32762977)
52. + channels J Biol Chem 277 14206 14210 10.1074/jbc.M109452200 1:CAS:528:DC%2BD38XjsFWntbw%3D 11825892 (Pubitemid 34968033)