Expression and function of protein phosphatase PP2A in malignant testicular germ cell tumours

Journal of Pathology

Volumn 213, Issue 1, 2007, Pages 72-81

  Schweyer, S ^a   Bachem, A ^a   Bremmer, F ^a   Steinfelder, H J ^a   Soruri, A ^a   Wagner, W ^b   Pottek, T ^b   Thelen, P ^a   Hopker, W W ^c   Radzun, H J ^a   Fayyazi, A ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b Bundeswehrkrankenhaus Hamburg   (Germany)

^c ASKLEPIOS HOSPITAL BARMBEK   (Germany)

Author keywords

Apoptosis; Immunohistochemistry; MEK ERK; PP2A; Real time PCR; Testis; TGCT

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; CASPASE 3; MITOGEN ACTIVATED PROTEIN KINASE; OKADAIC ACID; PHOSPHOPROTEIN PHOSPHATASE 2A; PHOSPHOPROTEIN PHOSPHATASE INHIBITOR;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ASSAY; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; GERM CELL TUMOR; HUMAN; HUMAN CELL; IMMUNOHISTOCHEMISTRY; MALE; ORCHIECTOMY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN FUNCTION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TESTIS CANCER; TUMOR CELL; WESTERN BLOTTING;

ADULT; AGED; APOPTOSIS; BLOTTING, WESTERN; CANTHARIDIN; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FLAVONOIDS; HUMANS; IMMUNOHISTOCHEMISTRY; MALE; MIDDLE AGED; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOGEN-ACTIVATED PROTEIN KINASES; NEOPLASMS, GERM CELL AND EMBRYONAL; OKADAIC ACID; PHOSPHORYLATION; PROTEIN PHOSPHATASE 2; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; STAINING AND LABELING; TESTICULAR NEOPLASMS;

EID: 34548461719     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.2203     Document Type: Article

References (38)

1. Power DA, Brown RS, Brock CS, Payne HA, Majeed A, Babb P. Trends in testicular carcinomas in England and Wales 1971-1999. BJU Int 2001;87:361-365.
2. McGlynn KA, Devesa SS, Sigurdson AJ, Brown LM, Tsao L, Tarone RE. Trends in the incidence of the testicular germ cell tumors in the United States. Cancer 2003;97:63-70.
3. Chaganti RS, Houldsworth J. Genetics and biology of adult human male germ cell tumors. Cancer Res 2000;60:1475-1482.
4. Janssens V, Goris J. Protein phosphatases 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling. Biochem J 2001;353:417-439.
5. Kennelly PJ. Protein phosphatases - a phylogenetic perspective. Chem Rev 2001;101:2291-312.
6. Mayer-Jaekel RE, Hemmings BA. Protein phosphatases 2A - a 'menage à trois'. Trends Cell Biol 1994;4:287-291.
7. Cohen P. The structure and regulation of protein phosphatases. Anna Rev Biochem 1989;58:453-508.
8. Green DD, Yang SI, Mumby MC. Molecular cloning and sequence analysis of the catalytic subunit of bovine type 2A protein phosphatase. Proc Natl Acad Sci USA 1987;84:4880-4884.
9. Stone SR, Hofsteenge J, Hemmings BA. Molecular cloning of cDNAs encoding two isoforms of the catalytic subunit of protein phosphatase 2A. Biochemistry 1987;26:7215-7220.
10. Khew-Goodall Y, Hemmings BA. Tissue-specific expression of mRNAs encoding α- and β-catalytic subunits of protein phosphatase 2A. FEBS Lett 1998;238:265-268.
11. Lee TH, Turck C, Kirschner MW. Inhibition of cdc2 activation by INH/ PP2A. Mol Biol Cell 1994;5:323-338.
12. Santoro MF, Armand RR, Robertson mM, Peng YW, Brady MJ, Mankovich JA, et al. Regulation of protein phosphatase 2A activity by caspase-3 during apoptosis. J Biol Chem 1998;273:13119-13128.
13. Li H, Zhoa LL, Funder JW, Liu JP. Protein phosphatase 2A inhibits nuclear telomerase activity in human breast cancer cells. J Biol Chem 1997;272:16729-16732.
14. Yan Y, Shay JW, Wright WE, Mumby MC. Inhibition of protein phosphatase activity induces p53-dependent apoptosis in the absence of p53 transactivation. J Biol Chem 1997;272:15220-15226.
15. Francia G, Poulsom R, Hanby AM, Mitchel SD, Williams G, McKee P, et al. Identification by differential display of protein phosphatase-2A regulatory subunit preferentially expressed in malignant melanoma cells. Int J Cancer 1999;82:709-713.
16. von Zezschwitz C, Vorwerk H, Tergau F, Steinfelder HJ. Apoptosis induction by inhibitors of Ser/thr phosphatases 1 and 2A is associated with transgluta minase activation in two different human epithelial tumour lines. FEBS Lett 1997;413:147-151.
17. Grzmil M, Kaulfuss S, Thelen P, Hemmerlein B, Schweyer S, Obenauer S, et al. Expression and functional analysis of bax inhibitor-1 in human breast cancer cells. J Pathol 2006;208:340-349.
18. Geladopoulos TP, Sotiroudis TG, Evanelopoulos A.E. A malachite green colorimetric assay for protein phosphatase activity. Anal Biochem 1991;192:112-116.
19. Fahti AR, Krautheim A, Lucke S, Becker K, Steinfelder HJ. Nonradioactive technique to measure protein phosphatase 2A-like activity and its inhibition by drugs in cell extracts. Anal Biochem 2002; 310:208-214.
20. Krautheim A, Brechlin P, Becker K, Winkler M; Steinfelder HJ. Hamster pancreatic β cell lines with altered sensitivity towards apoptotic signalling by phosphatase inhibitors. Br J Pharmacol 2000; 129:687-694.
21. Schweyer S, Soruri A, Meschter O, Heintze A, Zschunke F, Miosge N, et al. Cisplatin-induced apoptosis in human malignant testicular germ cell lines depends on MEK-ERK activation. Br J Cancer 2004; 91:589-598.
22. Schweyer S, Soruri A, Heintze A, Radzun HJ, Fayyazi A. The role of reactive oxygen species in cisplatin-induced apoptosis in human malignant testicular germ cell lines. Int J Oncol 2004; 25:1671-1676.
23. Millward TA, Zolnierowicz; S, Hemmings BA. Regulation of protein kinase cascades by protein phosphatase 2A. Trends Biochem Sci 1999; 24:186-191.
24. Gause KC, Homma MK, Licciardi KA, Seger R, Ahn NG, Peterson MJ, et al. Effects of phorbol ester on mitogen-activated protein kinase activity in wild-type and phorbol ester-resistant EL4 thymoma. cells. J Biol Chem 1993;268:1624-1629.
25. Sonoda Y, Kasahara T, Yamaguchi Y, Kuno K, Matsushima K, Mukaida. N. Stimulation of interleukin-8 production by okadaic acid and vanadate in a human promyelocyte cell line, an HL-60 subline. Possible role of mitogen-activated protein kinase on the okadaic acid-induced NF-κB activation. J Biol Chem 1997;272:15366-15372.
26. Sugiyama M, Imai A, Furui T, Tamaya T. Membrane-associated serine/ threonine protein phosphatase in endometrial cancer. Am J Obstet Gynecol 2003;189:1666-1669.
27. Prowatke I, Devens F, Benner A, Grone EF, Mertens D, Grone HJ, et al. Expression analysis of imbalanced genes in prostate carcinoma using tissue microarrays. Br J Cancer 2007;96:82-88.
28. Chatfield K, Eastman A. Inhibitors of protein phosphatases 1 and 2A differentially prevent intrinsic and extrinsic apoptosis pathways. Biochem Biophys Res Commun 2004;323:1313-1320.
29. Laidley CW, Cohen E, Casida JE. Protein phosphatase in neuroblastoma cells: [3H] cantharidin binding site in relation to cytotoxicity. J Pharmacol Exp Ther 1997;280:1152-1158.
30. Morana SJ, Wolf CM, Li J, Reynolds JE, Brown MK, Eastman A. The involvement of protein phosphatases in the activation of ICE/CED-3 protease, intracellular acidification, DNA digestion, and apoptosis. J Biol Chem 1996;271:18263-18271.
31. Wolf CM, Eastman A. The temporal relationship between protein phosphatase, mitochondrial cytochrome c release and caspase activation in apoptosis. Exp Cell Res 1999;247:505-513.
32. Nakielny S, Campbell DG, Cohen P. MAP kinase kinase from rabbit skeletal muscle. A novel dual specificity enzyme showing homology to yeast protein kinases involved in pheromone-dependent signal transduction. FEBS Lett 1992;308:183-189.
33. Peyssonnaux C, Eychene A. The Raf/MEK-ERK pathway: new concepts of activation. Biol Cell 2001;93:53-62.
34. Djeu JY, Jiang K, Wei S. A view to a kill: signals triggering cytotoxicity. Clin Cancer Res 2002;8:636-640.
35. Lee JT Jr, McCubrey JA. The Raf/MEK-ERK signal transduction cascade as a target for chemotherapeutic intervention in leukemia. Leukemia 2002;16:486-507.
36. Fung MK, Cheung HW, Ling MT, Cheung AL, Wong YC, Wang X. Role of MEK-ERK pathway in the MAD2-mediated cisplatin sensitivity in testicular germ cell tumour cells. Br J Cancer 2006;95:475-484.
37. Persons DL, Yazlovitskaya EM, Cui W, Pelling JC. Cisplatin-induced activation of mitogen-activated protein kinases in ovarian carcinoma cells: inhibition of extracellular signal-regulated kinase activity increases sensitivity to cisplatin. Clin Cancer Res 1999; 5:1007-1014.
38. Wang X, Martindale JL, Holbrook NJ. Requirement for ERK activation in cisplatin-induced apoptosis. J Biol Chem 2000; 275:39435-39443.