Effects of UVA on TNF-α, IL-1β, and IL-10 expression levels in human keratinocytes and intervention studies with an antioxidant and a JNK inhibitor

Photodermatology Photoimmunology and Photomedicine

Volumn 26, Issue 1, 2010, Pages 28-35

  An, Li ^a   Dong, Guo Qing ^a   Gao, Qian ^a   Zhang, Ying ^a   Hu, Li Wen ^a   Li, Jing Hai ^a   Liu, Yang ^a  

^a CHINA MEDICAL UNIVERSITY   (China)

Author keywords

carotene; Cytokine; Keratinocyte; SP600125; Ultraviolet

Indexed keywords

ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; ANTIOXIDANT; BETA CAROTENE; INTERLEUKIN 10; INTERLEUKIN 1BETA; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TUMOR NECROSIS FACTOR ALPHA; ANTHRA(1,9 CD)PYRAZOL 6(2H) ONE; ANTHRA(1,9-CD)PYRAZOL-6(2H)-ONE; ANTHRACENE DERIVATIVE; IL10 PROTEIN, HUMAN; PROTEIN KINASE INHIBITOR; VITAMIN;

ARTICLE; CELL CULTURE; CELL LINE; CELL VIABILITY; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; GENETIC TRANSDUCTION; HUMAN; HUMAN CELL; IN VITRO STUDY; IRRADIATION; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; ULTRAVIOLET A RADIATION; UPREGULATION; BIOSYNTHESIS; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; PATHOLOGY; RADIATION EXPOSURE; ULTRAVIOLET RADIATION;

ANTHRACENES; ANTIOXIDANTS; BETA CAROTENE; CELL LINE, TRANSFORMED; HUMANS; INTERLEUKIN-10; INTERLEUKIN-1BETA; JNK MITOGEN-ACTIVATED PROTEIN KINASES; KERATINOCYTES; PROTEIN KINASE INHIBITORS; TUMOR NECROSIS FACTOR-ALPHA; ULTRAVIOLET RAYS; UP-REGULATION; VITAMINS;

EID: 77949891272     PISSN: 09054383     EISSN: 16000781     Source Type: Journal    
DOI: 10.1111/j.1600-0781.2009.00481.x     Document Type: Article

References (54)

1. Bachelor MA, Bowden GT. UVA-mediated activation of signaling pathways involved in skin tumor promotion and progression. Semin Cancer Biol 2004, 14:131-138.
2. Armstrong BK, Kricker A. The epidemiology of UV induced skin cancer. J Photochem Photobiol B 2001, 63:8-18.
3. Wang SQ, Setlow R, Berwick M. Ultraviolet A and melanoma: a review. J Am Acad Dermatol 2001, 44:837-846.
4. Welss T, Basketter DA, Schröder KR. In vitro skin irritation: facts and future. State of the art review of mechanisms and models. Toxicol In Vitro 2004, 18:231-243.
5. Grone A. Keratinocytes and cytokines. Vet Immunol Immunopathol 2002, 88:1-12.
6. Kuchel JM, Barnetson RS, Halliday GM. Ultraviolet a augments solar-simulated ultraviolet radiation-induced local suppression of recall responses in humans. J Invest Dermatol 2002, 118:1032-1037.
7. Allanson M, Reeve VE. Immunoprotective UVA (320-400 nm) irradiation upregulates heme oxygenase-1 in the dermis and epidermis of hairless mouse skin. J Invest Dermatol 2004, 122:1030-1036.
8. Schieke SM, Ruwiedel K, Gers-Barlag H, Grether-Beck S, Krutmann J. Molecular crosstalk of the ultraviolet a and ultraviolet B signaling responses at the level of mitogen-activated protein kinases. J Invest Dermatol 2005, 124:857-859.
9. Halliday GM, Byrne SN, Kuchel JM, Poon TS, Barnetson RS. The suppression of immunity by ultraviolet radiation: UVA, nitric oxide and DNA damage. Photochem Photobiol Sci 2004, 3:736-740.
10. Iwai I, Hatao M, Naganuma M, Kumano Y, Ichihashi M. UVA-induced immune suppression through an oxidative pathway. J Invest Dermatol 1999, 112:19-24.
11. Grabbe S, Bruvers S, Gallo RL, Knisely TL, Nazareno R, Granstein RD. Tumor antigen presentation by murine epidermal cells. J Immunol 1991, 146:3656-3661.
12. Ullrich SE. Modulation of immunity by ultraviolet radiation: key effects on antigen presentation. J Invest Dermatol 1995, 105:30S-36S.
13. Ullrich SE. The role of epidermal cytokines in the generation of cutaneous immune reactions and ultraviolet radiation-induced immune suppression. Photochem Photobiol 1995, 62:389-401.
14. Schwarz T, Urbanski A, Luger TA. Ultraviolet light and epidermal cell derived cytokines. Epidermal growth factors and cytokines 1994, 303-363. Luger TA, Schwarz T, In, eds, New York, Marcel Dekker
15. Schwarz T. Mechanisms of UV-induced immunosuppression. Keio J Med 2005, 54:165-171.
16. Wang B, Amerio P, Sauder DN. Role of cytokines in epidermal Langerhans cell migration. J Leukoc Biol 1999, 66:33-39.
17. Moodycliffe AM, Kimber I, Norval M. Role of tumour necrosis factor-alpha in ultraviolet B light-induced dendritic cell migration and suppression of contact hypersensitivity. Immunology 1994, 81:79-84.
18. Kurimoto I, Streilein JW. Deleterious effects of cis-urocanic acid and UVB radiation on Langerhans cells and on induction of contact hypersensitivity are mediated by tumor necrosis factor-alpha. J Invest Dermatol 1992, 99:69S-70S.
19. Barr RM, Walker SL, Tsang W. Suppressed alloantigen presentation, increased TNF-alpha, IL-1, IL-1Ra, IL-10, and modulation of TNF-R in UV-irradiated human skin. J Invest Dermatol 1999, 112:692-698.
20. Rivas JM, Ullrich SE. Systemic suppression of delayed-type hypersensitivity by supernatants from UV-irradiated keratinocytes. An essential role for keratinocyte-derived IL-10. J Immunol 1992, 149:3865-3871.
21. Skiba B, Neill B, Diva TJ. Gene expression profiles of TNF-α, TACE, furin, IL-1β and matrilysin in UVA- and UVB-irradiated HaCaT cells. Photodermatol Photoimmunol Photomed 2005, 21:173-182.
22. Brink N, Szamel M, Young AR, Wittern KP, Bergemann J. Comparative quantification of IL-1beta, IL-10, IL-10r, TNF-alpha and IL-7 mRNA levels in UV-irradiated human skin in vivo. Inflamm Res 2000, 49:290-296.
23. Enk CD, Sredni D, Blauvelt A, Katz SI. Induction of IL-10 gene expression in human keratinocytes by UVB exposure in vivo and in vitro. J Immunol 1995, 154:4851-4856.
24. Kang K, Hammerberg C, Meunier L, Cooper KD. CD11b1 macrophages that infiltrate human epidermis after in vivo ultraviolet exposure potently produce IL-10 and represent the major secretory source of IL-10 protein. J Immunol 1994, 153:5256-5264.
25. Teunissen MB, Koomen CW, Jansen J. In contrast to their murine counterparts, normal human keratinocytes and human epidermoid cell lines A431 and HaCat fail to express IL-10 mRNA and protein. Clin Exp Immunol 1997, 107:213-223.
26. Enk AH, Katz SI. Identification and induction of keratinocyte-derived IL-10. J Immunol 1992, 149:92-95.
27. Skov L, Hansen H, Allen M. Contrasting effects of ultraviolet A1 and ultraviolet B exposure on the induction of tumour necrosis factor-alpha in human skin. Br J Dermatol 1998, 138:216-220.
28. Kock A, Schwarz T, Kirnbauer R. Human keratinocytes are a source for tumor necrosis factor alpha: evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light. J Exp Med 1990, 172:1609-1614.
29. Groves RW, Allen MH, Ross EL, Barker JN, MacDonald DM. Tumour necrosis factor α is proinflammatory in normal human skin and modulates cutaneous adhesion molecule expression. Br J Dermatol 1995, 132:345-352.
30. Cumberbatch M, Dearman RJ, Kimber I. Interleukin 1 beta and the stimulation of Langerhans cell migration: comparisons with tumour necrosis factor alpha. Arch Dermatol Res 1997, 289:277-284.
31. Seité S, Colige A, Deroanne C. Changes in matrix gene and protein expressions after single or repeated exposure to one minimal erythemal dose of solar-simulated radiation in human skin in vivo. Photochem Photobiol 2004, 79:265-271.
32. Murphy GM, Dowd PM, Hudspith BN, Brostoff J, Greaves MW. Local increase in interleukin-1-like activity following UVB irradiation of human skin in vivo. Photodermatol 1989, 6:268-274.
33. Tournier C, Dong C, Turner TK, Jones SN, Flavell RA, Davis RJ. MKK7 is an essential component of the JNK signal transduction pathway activated by proinflammatory cytokines. Genes Dev 2001, 15:1419-1426.
34. Katagiri C, Negishi K, Hibino T. c-JUN N-terminal kinase-1 (JNK1) but not JNK2 or JNK3 is involved in UV signal transduction in human epidermis. J Dermatol Sci 2006, 43:171-179.
35. Englaro W, Dérijard B, Ortonne JP, Ballotti R. Solar ultraviolet light activates extra-cellular signal-regulated kinases and the ternary complex factor in human normal keratinocytes. Oncogene 1998, 16:661-664.
36. Davis RJ. Signal transduction by the JNK group of MAP kinases. Cell 2000, 103:239-252.
37. Whitmarsh AJ, Davis RJ. Transcription factor AP-1 regulation by mitogen-activated protein kinase signal transduction pathways. J Mol Med 1996, 74:589-607.
38. Schaeffer HJ, Weber MJ. Mitogen-activated protein kinases: specific messages from ubiquitous messengers. Mol Cell Biol 1999, 19:2435-2444.
39. Chen W, Borchers AH, Dong Z, Powell MB, Bowden GT. UVB irradiation-induced activator protein-1 activation correlates with increased c-fos gene expression in a human keratinocyte cell line. J Biol Chem 1998, 273:32176-32181.
40. Silvers AL, Bowden GT. UVA irradiation-induced activation of activator protein-1 is correlated with induced expression of AP-1 family members in the human keratinocyte cell line HaCaT. Photochem Photobio 2002, 75:302-310.
41. Bennett BL, Sasaki DT, Murray BW. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase. Proc Natl Acad Sci USA 2001, 98:13681-13686.
42. Lee JC, Laydon JT, McDonnell PC. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature 1994, 372:739-746.
43. Dripps DJ, Brandhuber BJ, Thompson RC, Eisenberg SP. Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction. J Biol Chem 1991, 266:10331-10336.
44. Hirao T, Aoki H, Ichikawa H, Sato Y. Characterization of an interleukin 1 receptor antagonist protein released from ultraviolet-irradiated epidermal sheet. Dermatol Sci 1997, 14:189-198.
45. Fialkow L, Chan CK, Rotin D, Grinstein S, Downey GP. Activation of the mitogen-activated protein kinase signaling pathway in neutrophils. Role of oxidants. J Biol Chem 1994, 269:31234-31242.
46. Xing YX, Li P, Miao YX, Du W, Wang CB. Involvement of ROS/ASMase/JNK signalling pathway in inhibiting UVA-induced apoptosis of HaCaT cells by polypeptide from Chlamys farreri. Free Radic Res 2008, 42:12-19.
47. Gao MQ, Guo SB, Chen XH, Du W, Wang CB. Molecular mechanisms of polypeptide from Chlamys farreri protecting HaCaT cells from apoptosis induced by UVA plus UVB. Acta Pharmacol Sin 2007, 28:1007-1014.
48. Ding M, Li J, Leonard SS. Differential role of hydrogen peroxide in UV-induced signal transduction. Mol Cell Biochem 2002, 234-235:81-90.
49. Thannickal VJ, Fanburg BL. Reactive oxygen species in cell signaling. Am J Physiol Lung Cell Mol Physiol 2000, 279:L1005-L1028.
50. Finkel T. Oxygen radicals and signaling. Curr Opin Cell Biol 1998, 10:248-253.
51. Rhee SG. Redox signaling: hydrogen peroxide as intracellular messenger. Exp Mol Med 1999, 31:53-59.
52. Grether-Beck S, Bonizzi G, Schmitt-Brenden H. Non-enzymatic triggering of the ceramide signalling cascade by solar UVA radiation. EMBO J 2000, 19:5793-5800.
53. Darr D, Fridovich I. Free radicals in cutaneous biology. J Invest Dermatol 1994, 102:671-675.
54. Djavaheri-Mergny M, Dubertret L. UV-A-induced AP-1 activation requires the Raf/ERK pathway in human NCTC 2544 keratinocytes. Exp Dermatol 2001, 10:204-210.