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Volumn 120, Issue 6, 2010, Pages 1981-1993

Cdc42 regulates bone modeling and remodeling in mice by modulating RANKL/M-CSF signaling and osteoclast polarization

Author keywords

[No Author keywords available]

Indexed keywords

BIM PROTEIN; CASPASE 3; COLONY STIMULATING FACTOR 1; CYCLIN D; GUANOSINE TRIPHOSPHATASE; OSTEOCLAST DIFFERENTIATION FACTOR; PROTEIN CDC42; RETINOBLASTOMA PROTEIN;

EID: 77953181212     PISSN: 00219738     EISSN: 15588238     Source Type: Journal    
DOI: 10.1172/JCI39650     Document Type: Article
Times cited : (108)

References (54)
  • 1
    • 34447132814 scopus 로고    scopus 로고
    • Skeletal remodeling in health and disease
    • Zaidi M. Skeletal remodeling in health and disease. Nat Med. 2007;13(7):791-801.
    • (2007) Nat Med , vol.13 , Issue.7 , pp. 791-801
    • Zaidi, M.1
  • 2
    • 0037673945 scopus 로고    scopus 로고
    • Osteoclast differentiation and activation
    • Boyle WJ, Simonet WS, Lacey DL. Osteoclast differentiation and activation. Nature. 2003;423(6937):337-342.
    • (2003) Nature , vol.423 , Issue.6937 , pp. 337-342
    • Boyle, W.J.1    Simonet, W.S.2    Lacey, D.L.3
  • 3
    • 0043267732 scopus 로고    scopus 로고
    • Genetic regulation of osteoclast development and function
    • DOI 10.1038/nrg1122
    • Teitelbaum SL, Ross FP. Genetic regulation of osteoclast development and function. Nat Rev Genet. 2003;4(8):638-649. (Pubitemid 36917505)
    • (2003) Nature Reviews Genetics , vol.4 , Issue.8 , pp. 638-649
    • Teitelbaum, S.L.1    Ross, F.P.2
  • 4
  • 5
    • 27944479854 scopus 로고    scopus 로고
    • Rho GTPases: Biochemistry and biology
    • Jaffe AB, Hall A. Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol. 2005;21:247-269.
    • (2005) Annu Rev Cell Dev Biol , vol.21 , pp. 247-269
    • Jaffe, A.B.1    Hall, A.2
  • 6
    • 27844604200 scopus 로고    scopus 로고
    • Rho GTPases and the control of cell behaviour
    • Hall A. Rho GTPases and the control of cell behaviour. Biochem Soc Trans. 2005;33(Pt 5):891-895.
    • (2005) Biochem Soc Trans , vol.33 , Issue.PART 5 , pp. 891-895
    • Hall, A.1
  • 7
    • 25444437569 scopus 로고    scopus 로고
    • Regulation of actin ring formation by rho GTPases in osteoclasts
    • Chellaiah MA. Regulation of actin ring formation by rho GTPases in osteoclasts. J Biol Chem. 2005;280(38):32930-32943.
    • (2005) J Biol Chem , vol.280 , Issue.38 , pp. 32930-32943
    • Chellaiah, M.A.1
  • 9
    • 0029012991 scopus 로고
    • The small GTP-binding protein, rho p21, is involved in bone resorption by regulating cytoskeletal organization in osteoclasts
    • Zhang D, et al. The small GTP-binding protein, rho p21, is involved in bone resorption by regulating cytoskeletal organization in osteoclasts. J Cell Sci. 1995;108(Pt 6):2285-2292.
    • (1995) J Cell Sci , vol.108 , Issue.PART 6 , pp. 2285-2292
    • Zhang, D.1
  • 10
    • 0034697358 scopus 로고    scopus 로고
    • Rho-A is critical for osteoclast podosome organization, motility, and bone resorption
    • Chellaiah MA, et al. Rho-A is critical for osteoclast podosome organization, motility, and bone resorption. J Biol Chem. 2000;275(16):11993- 12002.
    • (2000) J Biol Chem , vol.275 , Issue.16 , pp. 11993-12002
    • Chellaiah, M.A.1
  • 13
    • 1942456777 scopus 로고    scopus 로고
    • WASp deficiency in mice results in failure to form osteoclast sealing zones and defects in bone resorption
    • DOI 10.1182/blood-2003-04-1259
    • Calle Y, et al. WASp deficiency in mice results in failure to form osteoclast sealing zones and defects in bone resorption. Blood. 2004;103(9):3552-3561. (Pubitemid 38525693)
    • (2004) Blood , vol.103 , Issue.9 , pp. 3552-3561
    • Calle, Y.1    Jones, G.E.2    Jagger, C.3    Fuller, K.4    Blundell, M.P.5    Chow, J.6    Chambers, T.7    Thrasher, A.J.8
  • 14
    • 2942702354 scopus 로고    scopus 로고
    • Actin-related protein 2/3 complex is required for actin ring formation
    • DOI 10.1359/JBMR.0301238
    • Hurst IR, Zuo J, Jiang J, Holliday LS. Actin-related protein 2/3 complex is required for actin ring formation. J Bone Miner Res. 2004;19(3):499-506. (Pubitemid 38787406)
    • (2004) Journal of Bone and Mineral Research , vol.19 , Issue.3 , pp. 499-506
    • Hurst, I.R.1    Zuo, J.2    Jiang, J.3    Holliday, L.S.4
  • 15
    • 65249180600 scopus 로고    scopus 로고
    • Selective inhibition of RANK blocks osteoclast maturation and function and prevents bone loss in mice
    • Kim H, et al. Selective inhibition of RANK blocks osteoclast maturation and function and prevents bone loss in mice. J Clin Invest. 2009;119(4):813-825.
    • (2009) J Clin Invest , vol.119 , Issue.4 , pp. 813-825
    • Kim, H.1
  • 16
    • 33750493895 scopus 로고    scopus 로고
    • Gene targeting of Cdc42 and Cdc42GAP affirms the critical involvement of Cdc42 in filopodia induction, directed migration, and proliferation in primary mouse embryonic fibroblasts
    • DOI 10.1091/mbc.E06-05-0466
    • Yang L, Wang L, Zheng Y. Gene targeting of Cdc42 and Cdc42GAP affirms the critical involvement of Cdc42 in filopodia induction, directed migration, and proliferation in primary mouse embryonic fibroblasts. Mol Biol Cell. 2006;17(11):4675-4685. (Pubitemid 44665738)
    • (2006) Molecular Biology of the Cell , vol.17 , Issue.11 , pp. 4675-4685
    • Yang, L.1    Wang, L.2    Zheng, Y.3
  • 19
    • 42749095897 scopus 로고    scopus 로고
    • NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells
    • Bai S, et al. NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells. J Biol Chem. 2008;283(10):6509-6518.
    • (2008) J Biol Chem , vol.283 , Issue.10 , pp. 6509-6518
    • Bai, S.1
  • 20
    • 0027369641 scopus 로고
    • Cloning and expression of a human CDC42 GTPase-activating protein reveals a functional SH3-binding domain
    • Barfod ET, et al. Cloning and expression of a human CDC42 GTPase-activating protein reveals a functional SH3-binding domain. J Biol Chem. 1993;268(35):26059-26062.
    • (1993) J Biol Chem , vol.268 , Issue.35 , pp. 26059-26062
    • Barfod, E.T.1
  • 21
    • 33845431274 scopus 로고    scopus 로고
    • SHIP1 negatively regulates proliferation of osteoclast precursors via Akt-dependent alterations in D-type cyclins and p27
    • Zhou P, Kitaura H, Teitelbaum SL, Krystal G, Ross FP, Takeshita S. SHIP1 negatively regulates proliferation of osteoclast precursors via Akt-dependent alterations in D-type cyclins and p27. J Immunol 2006;177(12):8777-8784. (Pubitemid 44893844)
    • (2006) Journal of Immunology , vol.177 , Issue.12 , pp. 8777-8784
    • Zhou, P.1    Kitaura, H.2    Teitelbaum, S.L.3    Krystal, G.4    Ross, F.P.5    Takeshita, S.6
  • 22
    • 0034644508 scopus 로고    scopus 로고
    • Insights into programmed cell death through structural biology
    • Fesik SW. Insights into programmed cell death through structural biology. Cell. 2000; 103(2):273-282.
    • (2000) Cell , vol.103 , Issue.2 , pp. 273-282
    • Fesik, S.W.1
  • 24
    • 0037192784 scopus 로고    scopus 로고
    • Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-kappaB ligand signaling
    • DOI 10.1074/jbc.M111696200
    • Mansky KC, Sankar U, Han J, Ostrowski MC. Microphthalmia transcription factor is a target of the p38 MAPK pathway in response to receptor activator of NF-kappa B ligand signaling. J Biol Chem. 2002;277(13):11077-11083. (Pubitemid 34952867)
    • (2002) Journal of Biological Chemistry , vol.277 , Issue.13 , pp. 11077-11083
    • Mansky, K.C.1    Sankar, U.2    Han, J.3    Ostrowski, M.C.4
  • 25
    • 0031042493 scopus 로고    scopus 로고
    • Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton
    • DOI 10.1016/S0955-0674(97)80156-1
    • Tapon N, Hall A. Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton. Curr Opin Cell Biol. 1997;9(1):86-92. (Pubitemid 27065113)
    • (1997) Current Opinion in Cell Biology , vol.9 , Issue.1 , pp. 86-92
    • Tapon, N.1    Hall, A.2
  • 26
    • 33644950260 scopus 로고    scopus 로고
    • Podosome and sealing zone: Specificity of the osteoclast model
    • Jurdic P, Saltel F, Chabadel A, Destaing O. Podosome and sealing zone: specificity of the osteoclast model. Eur J Cell Biol. 2006;85(3-4):195-202.
    • (2006) Eur J Cell Biol , vol.85 , Issue.3-4 , pp. 195-202
    • Jurdic, P.1    Saltel, F.2    Chabadel, A.3    Destaing, O.4
  • 28
    • 0000202186 scopus 로고    scopus 로고
    • A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity
    • Lin D, Edwards AS, Fawcett JP, Mbamalu G, Scott JD, Pawson T. A mammalian PAR-3-PAR-6 complex implicated in Cdc42/Rac1 and aPKC signalling and cell polarity. Nat Cell Biol. 2000;2(8):540-547.
    • (2000) Nat Cell Biol , vol.2 , Issue.8 , pp. 540-547
    • Lin, D.1    Edwards, A.S.2    Fawcett, J.P.3    Mbamalu, G.4    Scott, J.D.5    Pawson, T.6
  • 29
    • 0034253536 scopus 로고    scopus 로고
    • The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42
    • Joberty G, Petersen C, Gao L, Macara IG. The cell-polarity protein Par6 links Par3 and atypical protein kinase C to Cdc42. Nat Cell Biol. 2000;2(8):531-539.
    • (2000) Nat Cell Biol , vol.2 , Issue.8 , pp. 531-539
    • Joberty, G.1    Petersen, C.2    Gao, L.3    Macara, I.G.4
  • 31
    • 0037385561 scopus 로고    scopus 로고
    • A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl
    • Plant PJ, et al. A polarity complex of mPar-6 and atypical PKC binds, phosphorylates and regulates mammalian Lgl. Nat Cell Biol. 2003;5(4):301-308.
    • (2003) Nat Cell Biol , vol.5 , Issue.4 , pp. 301-308
    • Plant, P.J.1
  • 32
    • 33645746316 scopus 로고    scopus 로고
    • The PAR-aPKC system: Lessons in polarity
    • Suzuki A, Ohno S. The PAR-aPKC system: lessons in polarity. J Cell Sci. 2006;119(Pt 6):979-987.
    • (2006) J Cell Sci , vol.119 , Issue.PART 6 , pp. 979-987
    • Suzuki, A.1    Ohno, S.2
  • 33
    • 0037287298 scopus 로고    scopus 로고
    • Protein kinase C λ/ι PKCλ/ι: A PKC isotype essential for the development of multicellular organisms
    • DOI 10.1093/jb/mvg018
    • Suzuki A, Akimoto K, Ohno S. Protein kinase C λ/ι (PKCλ/ι): a PKC isotype essential for the development of multicellular organisms. J Biochem. 2003;133(1):9-16. (Pubitemid 36240973)
    • (2003) Journal of Biochemistry , vol.133 , Issue.1 , pp. 9-16
    • Suzuki, A.1    Akimoto, K.2    Ohno, S.3
  • 34
    • 0642376906 scopus 로고    scopus 로고
    • Protein kinase Cζ (PKCζ): Activation mechanisms and cellular functions
    • DOI 10.1093/jb/mvg017
    • Hirai T, Chida K. Protein kinase Cζ (PKCζ): activation mechanisms and cellular functions. J Biochem. 2003;133(1):1-7. (Pubitemid 36240972)
    • (2003) Journal of Biochemistry , vol.133 , Issue.1 , pp. 1-7
    • Hirai, T.1    Chida, K.2
  • 35
    • 0035313804 scopus 로고    scopus 로고
    • Multiple roles for Cdc42 in cell regulation
    • Erickson JW, Cerione RA. Multiple roles for Cdc42 in cell regulation. Curr Opin Cell Biol. 2001;13(2):153-157.
    • (2001) Curr Opin Cell Biol , vol.13 , Issue.2 , pp. 153-157
    • Erickson, J.W.1    Cerione, R.A.2
  • 36
    • 38949160556 scopus 로고    scopus 로고
    • Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival
    • Krum SA, et al. Estrogen protects bone by inducing Fas ligand in osteoblasts to regulate osteoclast survival. EMBO J. 2008;27(3):535-545.
    • (2008) EMBO J , vol.27 , Issue.3 , pp. 535-545
    • Krum, S.A.1
  • 37
    • 0344394236 scopus 로고    scopus 로고
    • Osteoclast Apoptosis: The Role of Fas in Vivo and in Vitro
    • DOI 10.1210/en.2003-0296
    • Wu X, McKenna MA, Feng X, Nagy TR, McDonald JM. Osteoclast apoptosis: the role of Fas in vivo and in vitro. Endocrinology. 2003;144(12):5545-5555. (Pubitemid 37476084)
    • (2003) Endocrinology , vol.144 , Issue.12 , pp. 5545-5555
    • Wu, X.1    McKenna, M.A.2    Feng, X.U.3    Nagy, T.R.4    McDonald, J.M.5
  • 38
    • 14844317695 scopus 로고    scopus 로고
    • 3 integrin regulates osteoclast apoptosis by transmitting a positive death signal
    • DOI 10.1210/me.2004-0161
    • Zhao H, Ross FP, Teitelbaum SL. Unoccupied αvβ3 integrin regulates osteoclast apoptosis by transmitting a positive death signal. Mol Endocrinol. 2005;19(3):771-780. (Pubitemid 40349447)
    • (2005) Molecular Endocrinology , vol.19 , Issue.3 , pp. 771-780
    • Zhao, H.1    Ross, F.P.2    Teitelbaum, S.L.3
  • 39
    • 0035957986 scopus 로고    scopus 로고
    • The Serine/Threonine Kinase PAK4 Prevents Caspase Activation and Protects Cells from Apoptosis
    • Gnesutta N, Qu J, Minden A. The serine/threonine kinase PAK4 prevents caspase activation and protects cells from apoptosis. J Biol Chem. 2001;276(17):14414-14419. (Pubitemid 37391833)
    • (2001) Journal of Biological Chemistry , vol.276 , Issue.17 , pp. 14414-14419
    • Gnesutta, N.1    Qu, J.2    Minden, A.3
  • 40
    • 54049156872 scopus 로고    scopus 로고
    • PAK1 is a novel MEK-independent raf target controlling expression of the IAP survivin in M-CSF-mediated osteoclast survival
    • Bradley EW, Ruan MM, Oursler MJ. PAK1 is a novel MEK-independent raf target controlling expression of the IAP survivin in M-CSF-mediated osteoclast survival. J Cell Physiol. 2008;217(3):752-758.
    • (2008) J Cell Physiol , vol.217 , Issue.3 , pp. 752-758
    • Bradley, E.W.1    Ruan, M.M.2    Oursler, M.J.3
  • 41
    • 34447508339 scopus 로고    scopus 로고
    • MITF and PU.1 recruit p38 MAPK and NFATc1 to target genes during osteoclast differentiation
    • Sharma SM, et al. MITF and PU.1 recruit p38 MAPK and NFATc1 to target genes during osteoclast differentiation. J Biol Chem. 2007;282(21):15921-15929.
    • (2007) J Biol Chem , vol.282 , Issue.21 , pp. 15921-15929
    • Sharma, S.M.1
  • 42
    • 0038706164 scopus 로고    scopus 로고
    • Signal transduction by receptor activator of nuclear factor kappa B in osteoclasts
    • DOI 10.1016/S0006-291X(03)00695-8
    • Lee ZH, Kim HH. Signal transduction by receptor activator of nuclear factor kappa B in osteoclasts. Biochem Biophys Res Commun. 2003;305(2):211-214. (Pubitemid 36555454)
    • (2003) Biochemical and Biophysical Research Communications , vol.305 , Issue.2 , pp. 211-214
    • Lee, Z.H.1    Kim, H.-H.2
  • 44
    • 49049118735 scopus 로고    scopus 로고
    • Actin cytoskeletal organisation in osteoclasts: A model to decipher transmigration and matrix degradation
    • Saltel F, Chabadel A, Bonnelye E, Jurdic P. Actin cytoskeletal organisation in osteoclasts: a model to decipher transmigration and matrix degradation. Eur J Cell Biol. 2008;87(8-9):459-468.
    • (2008) Eur J Cell Biol , vol.87 , Issue.8-9 , pp. 459-468
    • Saltel, F.1    Chabadel, A.2    Bonnelye, E.3    Jurdic, P.4
  • 46
    • 0142026447 scopus 로고    scopus 로고
    • Regulation of Actin Dynamics by WASP Family Proteins
    • DOI 10.1093/jb/mvg146
    • Miki H, Takenawa T. Regulation of actin dynamics by WASP family proteins. J Biochem. 2003;134(3):309-313. (Pubitemid 37288327)
    • (2003) Journal of Biochemistry , vol.134 , Issue.3 , pp. 309-313
    • Miki, H.1    Takenawa, T.2
  • 47
    • 30844466190 scopus 로고    scopus 로고
    • Protein complexes regulating Arp2/3-mediated actin assembly
    • DOI 10.1016/j.ceb.2005.12.003, PII S0955067405001845, Cell Structure and Dynamics
    • Stradal TE, Scita G. Protein complexes regulating Arp2/3-mediated actin assembly. Curr Opin Cell Biol. 2006;18(1):4-10. (Pubitemid 43107601)
    • (2006) Current Opinion in Cell Biology , vol.18 , Issue.1 , pp. 4-10
    • Stradal, T.E.1    Scita, G.2
  • 48
    • 2642579936 scopus 로고    scopus 로고
    • Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex
    • Millard TH, Sharp SJ, Machesky LM. Signalling to actin assembly via the WASP (Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex. Biochem J. 2004;380(Pt 1):1-17.
    • (2004) Biochem J , vol.380 , Issue.PART 1 , pp. 1-17
    • Millard, T.H.1    Sharp, S.J.2    Machesky, L.M.3
  • 49
    • 36749082817 scopus 로고    scopus 로고
    • Identification of a bipartite focal adhesion localization signal in RhoU/Wrch-1, a Rho family GTPase that regulates cell adhesion and migration
    • DOI 10.1042/BC20070058
    • Ory S, Brazier H, Blangy A. Identification of a bipartite focal adhesion localization signal in RhoU/Wrch-1, a Rho family GTPase that regulates cell adhesion and migration. Biol Cell. 2007;99(12):701-716. (Pubitemid 350201920)
    • (2007) Biology of the Cell , vol.99 , Issue.12 , pp. 701-716
    • Ory, S.1    Brazier, H.2    Blangy, A.3
  • 50
    • 30144446099 scopus 로고    scopus 로고
    • Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/progenitor cell survival, adhesion, and engraftment
    • DOI 10.1182/blood-2005-05-2171
    • Wang L, Yang L, Filippi MD, Williams DA, Zheng Y. Genetic deletion of Cdc42GAP reveals a role of Cdc42 in erythropoiesis and hematopoietic stem/ progenitor cell survival, adhesion, and engraftment. Blood. 2006;107(1):98-105. (Pubitemid 43053529)
    • (2006) Blood , vol.107 , Issue.1 , pp. 98-105
    • Wang, L.1    Yang, L.2    Filippi, M.-D.3    Williams, D.A.4    Zheng, Y.5
  • 52
    • 44449175502 scopus 로고    scopus 로고
    • Synaptotagmin VII Regulates Bone Remodeling by Modulating Osteoclast and Osteoblast Secretion
    • DOI 10.1016/j.devcel.2008.03.022, PII S1534580708001330
    • Zhao H, Ito Y, Chappel J, Andrews NW, Teitelbaum SL, Ross FP. Synaptotagmin VII regulates bone remodeling by modulating osteoclast and osteoblast secretion. Dev Cell. 2008;14(6):914-925. (Pubitemid 351757201)
    • (2008) Developmental Cell , vol.14 , Issue.6 , pp. 914-925
    • Zhao, H.1    Ito, Y.2    Chappel, J.3    Andrews, N.W.4    Teitelbaum, S.L.5    Ross, F.P.6
  • 53
    • 0033940801 scopus 로고    scopus 로고
    • Identification and characterization of the new osteoclast progenitor with macrophage phenotypes being able to differentiate into mature osteoclasts
    • Takeshita S, Kaji K, Kudo A. Identification and characterization of the new osteoclast progenitor with macrophage phenotypes being able to differentiate into mature osteoclasts. J Bone Miner Res. 2000;15(8):1477-1488. (Pubitemid 30484517)
    • (2000) Journal of Bone and Mineral Research , vol.15 , Issue.8 , pp. 1477-1488
    • Takeshita, S.1    Kaji, K.2    Kudo, A.3


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