Induction of bystander response in human glioma cells using high-energy electrons: A role for TGF-β1

Radiation Research

Volumn 173, Issue 6, 2010, Pages 769-778

  Gow, M D ^b   Seymour, C B ^b   Ryan, L A ^b   Mothersill, C E ^a  

^a MCMASTER UNIVERSITY   (Canada)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; MONOCLONAL ANTIBODY; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA1;

ARTICLE; BYSTANDER EFFECT; CELL DEATH; CELL STRESS; CELL SURVIVAL; CULTURE MEDIUM; ELECTRON; ENERGY; GLIOMA CELL; HUMAN; HUMAN CELL; IRRADIATION; PRIORITY JOURNAL;

ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; BYSTANDER EFFECT; CELL DEATH; CELL LINE, TUMOR; CELL SURVIVAL; CULTURE MEDIA, CONDITIONED; DOSE-RESPONSE RELATIONSHIP, RADIATION; ELECTRONS; GLIOMA; HUMANS; TRANSFORMING GROWTH FACTOR ALPHA; TRANSFORMING GROWTH FACTOR BETA1;

EID: 77953141396     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.1667/RR1895.1     Document Type: Article

References (69)

1. E. J. Hall, The bystander effect. Health Phys. 85, 31-35 (2003).
2. T. K. Hei, H. Zhou, V. N. Ivanov, M. Hong, H. B. Lieberman, D. J. Brenner, S. A. Amundson and C. R. Geard, Mechanism of radiation-induced bystander effects: a unifying model. J. Pharm. Pharmacol. 60, 943-950 (2008).
3. J. B. Little, Cellular radiation effects and the bystander response. Mutat. Res. 597, 113-118 (2006).
4. C. Mothersill and C. Seymour, Radiation-induced bystander effects: are they good, bad or both? Med. Confl. Surviv. 21, 101-110 (2005).
5. S. A. Lorimore, M. A. Kadhim, D. A. Pocock, D. Papworth, D. L. Stevens, D. T. Goodhead and E. G. Wright, Chromosomal instability in the descendants of unirradiated surviving cells after a-particle irradiation. Proc. Natl. Acad. Sci. USA 95, 5730-5733 (1998).
6. C. Mothersill and C. Seymour, Medium from irradiated human epithelial cells but not human fibroblasts reduces the clonogenic survival of unirradiated cells. Int. J. Radiat. Biol. 71, 421-427 (1997).
7. C. Shao, M. Folkard, B. D. Michael and K. M. Prise, Bystander signalling between glioma cells and fibroblasts targeted with counted particles. Int. J. Cancer 116, 45-51 (2005).
8. H. Nagasawa and J. B. Little, Induction of sister chromatid exchanges by extremely low doses of a-particles. Cancer Res. 52, 6394-6396 (1992).
9. H. Nagasawa and J. B. Little, Unexpected sensitivity to the induction of mutations by very low doses of a-particle radiation: evidence for a bystander effect. Radiat. Res. 152, 552-557 (1999).
10. H. Zhou, G. Randers-Pehrson, C. A. Waldren, D. Vannais, E. J. Hall and T. K. Hei, Induction of a bystander mutagenic effect of a particles in mammalian cells. Proc. Natl. Acad. Sci. USA 97, 2099-2104 (2000).
11. O. V. Belyakov, S. A. Mitchell, D. Parikh, G. Randers-Pehrson, S. A. Marino, S. A. Amundson, C. R. Geard and D. J. Brenner, Biological effects in unirradiated human tissue induced by radiation damage up to 1 mm away. Proc. Natl. Acad. Sci. USA 102, 14203-14208 (2005).
12. K. M. Prise, O. V. Belyakov, M. Folkard and B. D. Michael, Studies of bystander effects in human fibroblasts using a charged particle microbeam. Int. J. Radiat. Biol. 74, 793-798 (1998).
13. C. Shao, M. Aoki and Y. Furusawa, Medium-mediated bystander effects on HSG cells co-cultivated with cells irradiated by X-rays or a 290 MeV/u carbon beam. J. Radiat. Res. (Tokyo) 42, 305-316 (2001).
14. S. A. Lorimore, P. J. Coates and E. G. Wright, Radiation-induced genomic instability and bystander effects: inter-related nontargeted effects of exposure to ionizing radiation. Oncogene 22, 7058-7069 (2003).
15. 2 cells in vitro can be initiated in the unirradiated neighbors of irradiated cells. Radiat. Res. 155, 397-401 (2001).
16. Z. Liu, C. E. Mothersill, F. E. McNeill, F. M. Lyng, S. H. Byun, C. B. Seymour and W. V. Prestwich, A dose threshold for a medium transfer bystander effect for a human skin cell line. Radiat. Res. 166, 19-23 (2006).
17. C. Mothersill, R. J. Seymour and C. B. Seymour, Bystander effects in repair-deficient cell lines. Radiat. Res. 161, 256-263 (2004).
18. C. Mothersill and C. B. Seymour, Cell-cell contact during c irradiation is not required to induce a bystander effect in normal human keratinocytes: evidence for release during irradiation of a signal controlling survival into the medium. Radiat. Res. 149, 256-262 (1998).
19. S. G. Sawant, W. Zheng, K. M. Hopkins, G. Randers-Pehrson, H. B. Lieberman and E. J. Hall, The radiation-induced bystander effect for clonogenic survival. Radiat. Res. 157, 361-364 (2002).
20. F. M. Lyng, P. Maguire, N. Kilmurray, C. Mothersill, C. Shao, M. Folkard and K. M. Prise, Apoptosis is initiated in human keratinocytes exposed to signalling factors from microbeam irradiated cells. Int. J. Radiat. Biol. 82, 393-399 (2006).
21. J. McIlrath, S. A. Lorimore, P. J. Coates and E. G. Wright, Radiation-induced genomic instability in immortalized haemopoietic stem cells. Int. J. Radiat. Biol. 79, 27-34 (2003).
22. C. Mothersill and C. Seymour, Radiation-induced bystander effects: past history and future directions. Radiat. Res. 155, 759-767 (2001).
23. C. Shao, M. Folkard, B. D. Michael and K. M. Prise, Targeted cytoplasmic irradiation induces bystander responses. Proc. Natl. Acad. Sci. USA 101, 13495-13500 (2004).
24. C. Mothersill, C. B. Seymour and M. C. Joiner, Relationship between radiation-induced low-dose hypersensitivity and the bystander effect. Radiat. Res. 157, 526-532 (2002).
25. R. C. Poon, N. Agnihotri, C. Seymour and C. Mothersill, Bystander effects of ionizing radiation can be modulated by signaling amines. Environ. Res. 105, 200-211 (2007).
26. A. Bishayee, H. Z. Hill, D. Stein, D. V. Rao and R. W. Howell, Free radical-initiated and gap junction-mediated bystander effect due to nonuniform distribution of incorporated radioactivity in a three-dimensional tissue culture model. Radiat. Res. 155, 335-344 (2001).
27. C. Shao, Y. Furusawa, M. Aoki and K. Ando, Role of gap junctional intercellular communication in radiation-induced bystander effects in human fibroblasts. Radiat. Res. 160, 318-323 (2003).
28. S. Burdak-Rothkamm, S. C. Short, M. Folkard, K. Rothkamm and K. M. Prise, ATR-dependent radiation-induced cH2AX foci in bystander primary human astrocytes and glioma cells. Oncogene 26, 993-1002 (2007).
29. T. K. Hei, Cyclooxygenase-2 as a signaling molecule in radiation-induced bystander effect. Mol. Carcinog. 45, 455-460 (2006).
30. R. Iyer, B. E. Lehnert and R. Svensson, Factors underlying the cell growth-related bystander responses to a particles. Cancer Res. 60, 1290-1298 (2000).
31. E. I. Azzam, S. M. de Toledo, D. R. Spitz and J. B. Little, Oxidative metabolism modulates signal transduction and micronucleus formation in bystander cells from a-particle-irradiated normal human fibroblast cultures. Cancer Res. 62, 5436-5442 (2002).
32. F. M. Lyng, C. B. Seymour and C. Mothersill, Production of a signal by irradiated cells which leads to a response in unirradiated cells characteristic of initiation of apoptosis Br. J. Cancer 83, 1223-1230 (2000).
33. F. M. Lyng, C. B. Seymour and C. Mothersill, Initiation of apoptosis in cells exposed to medium from the progeny of irradiated cells: a possible mechanism for bystander-induced genomic instability? Radiat. Res. 157, 365-370 (2002).
34. H. Matsumoto, S. Hayashi, M. Hatashita, K. Ohnishi, H. Shioura, T. Ohtsubo, R. Kitai, T. Ohnishi and E. Kano, Induction of radioresistance by a nitric oxide-mediated bystander effect. Radiat. Res. 155, 387-396 (2001).
35. F. M. Lyng, P. Maguire, B. McClean, C. Seymour and C. Mothersill, The involvement of calcium and MAP kinase signaling pathways in the production of radiation-induced bystander effects. Radiat. Res. 165, 400-409 (2006).
36. M. D. Gow, C. B. Seymour, S. H. Byun and C. E. Mothersill, Effect of dose rate on the radiation-induced bystander response. Phys. Med. Biol. 53, 119-132 (2008).
37. L. A. Ryan, R. W. Smith, C. B. Seymour and C. E. Mothersill, Dilution of irradiated cell conditioned medium and the bystander effect. Radiat. Res. 169, 188-196 (2008).
38. C. Shao, V. Stewart, M. Folkard, B. D. Michael and K. M. Prise, Nitric oxide-mediated signaling in the bystander response of individually targeted glioma cells. Cancer Res. 63, 8437-8442 (2003).
39. C. Shao, F. M. Lyng, M. Folkard and K. M. Prise, Calcium fluxes modulate the radiation-induced bystander responses in targeted glioma and fibroblast cells. Radiat. Res. 166, 479-487 (2006).
40. J. Baselga, J. Mendelsohn, Y. M. Kim and A. Pandiella, Autocrine regulation of membrane transforming growth factor-a cleavage. J. Biol. Chem. 271, 3279-3284 (1996).
41. P. Dent, D. B. Reardon, J. S. Park, G. Bowers, C. Logsdon, K. Valerie and R. Schmidt-Ullrich, Radiation-induced release of transforming growth factor a activates the epidermal growth factor receptor and mitogen-activated protein kinase pathway in carcinoma cells, leading to increased proliferation and protection from radiation-induced cell death. Mol. Biol. Cell. 10, 2493-2506 (1999).
42. R. K. Schmidt-Ullrich, K. Valerie, W. Chan, D. E. Wazer and P. S. Lin, Expression of oestrogen receptor and transforming growth factor-a in MCF-7 cells after exposure to fractionated irradiation. Int. J. Radiat. Biol. 61, 405-415 (1992).
43. M. Rubenstein, R. Glick, T. Lichtor, Y. Mirochnik, P. Chou and P. Guinan, Treatment of the T98G glioblastoma cell line with antisense oligonucleotides directed toward mRNA encoding transforming growth factor-a and the epidermal growth factor receptor. Med. Oncol. 18, 121-130 (2001).
44. J. Massague and R. R. Gomis, The logic of TGFb signalling. FEBS Lett. 580, 2811-2820 (2006).
45. M. H. Barcellos-Hoff and T. A. Dix, Redox-mediated activation of latent transforming growth factor-b1. Mol. Endocrinol. 10, 1077-1083 (1996).
46. C. Shao, M. Folkard and K. M. Prise, Role of TGF-b1 and nitric oxide in the bystander response of irradiated glioma cells. Oncogene 27, 434-440 (2008).
47. C. Shao, K. M. Prise and M. Folkard, Signaling factors for irradiated glioma cells induced bystander responses in fibroblasts. Mutat. Res. 638, 139-145 (2008).
48. P. Lambin, B. Fertil, E. P. Malaise and M. C. Joiner, Multiphasic survival curves for cells of human tumor cell lines: induced repair or hypersensitive subpopulation? Radiat. Res. 138 (Suppl.), S32-S36 (1994).
49. L. Pirisi, K. E. Creek, J. Doniger and J. A. DiPaolo, Continuous cell lines with altered growth and differentiation properties originate after transfection of human keratinocytes with human papillomavirus type 16 DNA. Carcinogenesis 9, 1573-1579 (1998).
50. C. Mothersill, D. Rea, E. G. Wright, S. A. Lorimore, D. Murphy, C. B. Seymour and K. O'Malley, Individual variation in the production of a 'bystander signal' following irradiation of primary cultures of normal human urothelium. Carcinogenesis 22, 1465-1471 (2001).
51. C. Mothersill, F. Lyng, C. Seymour, P. Maguire, S. Lorimore and E. Wright, Genetic factors influencing bystander signaling in murine bladder epithelium after low-dose irradiation in vivo. Radiat. Res. 163, 391-399 (2005).
52. B. Cooper, S. Schneider, J. Bohl, Y. Jiang, A. Beaudet and P. S. Vande, Requirement of E6AP and the features of human papillomavirus E6 necessary to support degradation of p53. Virology 306, 87-99 (2003).
53. C. B. Seymour and C. Mothersill, Relative contribution of bystander and targeted cell killing to the low-dose region of the radiation dose-response curve. Radiat. Res. 153, 508-511 (2000).
54. T. T. Puck and P. I. Marcus, Action of X-rays on mammalian cells. J. Exp. Med. 103, 653-666 (1956).
55. H. E. Johns and J. R. Cunningham, The Physics of Radiology, 4th ed. Charles C Thomas, Springfield, IL, 1983.
56. 125I seeds potentiate the killing action of irradiation on human lung cancer cells in vitro. Int. J. Radiat. Oncol. Biol. Phys. 72, 1560-1566 (2008)
57. T. Groesser, B. Cooper and B. Rydberg, Lack of bystander effects from high-LET radiation for early cytogenetic end points. Radiat. Res. 170, 794-802 (2008).
58. Y. Shi and J. Massague, Mechanisms of TGF-b signalling from cell membrane to the nucleus. Cell 113, 685-700 (2003).
59. K. E. Bachman and B. H. Park, Duel nature of TGF-b signaling: tumor suppressor vs. tumor promoter. Curr. Opin. Oncol. 17, 49-54 (2004).
60. M. Dziembowska, M. Danilkiewicz, A. Wesolowska, A. Zupanska, S. Chouaib and B. Kaminska, Cross-talk between Smad and p38 MAPK signalling in transforming growth factor b signal transduction in human glioblastoma cells. Biochem. Biophys. Res. Commun. 354, 1101-1106 (2007).
61. J. N. Rich, M. Zhang, M. B. Datto, D. D. Bigner and X. F. Wang, Transforming growth factor-b-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines. J. Biol. Chem. 274, 35053-35058 (1999).
62. K. Dano, P. A. Andreasen, J. Grondahl-Hansen, P. Kristensen, L. S. Nielsen and L. Skriver, Plasminogen activators, tissue degradation, and cancer. Adv. Cancer Res. 44, 139-266 (1985).
63. Y. Hasui, J. Suzumiya, K. Marutsuka, A. Sumiyoshi, S. Hashida and E. Ishikawa, Comparative study of plasminogen activators in cancers and normal mucosae of human urinary bladder. Cancer Res. 49, 1067-1070 (1989).
64. M. Laiho and J. Keski-Oja, Growth factors in the regulation of pericellular proteolysis: a review. Cancer Res. 49, 2533-2553 (1989).
65. D. C. Rijken and D. Collen, Purification and characterization of the plasminogen activator secreted by human melanoma cells in culture. J. Biol. Chem. 256, 7035-7041 (1981).
66. R. Flaumenhaft, M. Abe, P. Mignatti and D. B. Rifkin, Basic fibroblast growth factor-induced activation of latent transforming growth factor b in endothelial cells: regulation of plasminogen activator activity. J. Cell Biol. 118, 901-909 (1992).
67. J. Taipale, K. Miyazono, C. H. Heldin and J. Keski-Oja, Latent transforming growth factor-b 1 associates to fibroblast extracellular matrix via latent TGF-b binding protein. J. Cell Biol. 124, 171-181 (1994).
68. D. A. Boothman, M. Wang and S. W. Lee, Induction of tissue-type plasminogen activator by ionizing radiation in human malignant melanoma cells. Cancer Res. 51, 5587-5595 (1991).
69. N. Fukunaga, H. L. Burrows, M. Meyers, R. A. Schea and D. A. Boothman, Enhanced induction of tissue-type plasminogen activator in normal human cells compared to cancer-prone cells following ionizing radiation. Int. J. Radiat. Oncol. Biol. Phys. 24, 949-957 (1992).