Cell-cell contact during gamma irradiation is not required to induce a bystander effect in normal human keratinocytes: Evidence for release during irradiation of a signal controlling survival into the medium

Radiation Research

Volumn 149, Issue 3, 1998, Pages 256-262

  Mothersill, Carmel ^a   Seymour, C B ^a  

^a DUBLIN INSTITUTE OF TECHNOLOGY   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ARTICLE; CANCER CELL CULTURE; CELL DENSITY; CELL INTERACTION; CELL SURVIVAL; CONTROLLED STUDY; CULTURE MEDIUM; FIBROBLAST CULTURE; GAMMA IRRADIATION; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL; RADIATION DOSE; SIGNAL TRANSDUCTION;

APOPTOSIS; CELL COMMUNICATION; CELL SURVIVAL; CELLS, CULTURED; CLONE CELLS; COLD; CULTURE MEDIA; HUMANS; KERATINOCYTES; TETRADECANOYLPHORBOL ACETATE;

EID: 0031936163     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.2307/3579958     Document Type: Article

References (28)

1. C. Mothersill and C. B. Seymour, Medium from irradiated human epithelial cells but not from fibroblasts reduces the clonogenic survival of unirradiated cells. Int. J. Radiat. Biol. 71, 421-127 (1997).
2. C. B. Seymour and C. Mothersill, Delayed expression of lethal mutations and genomic instability in the progeny of human epithelial cells which survived in a bystander killing environment. Radiat. Oncol. Invest., in press.
3. H. Nagasawa and J. B. Little, Induction of sister-chromatid exchanges by extremely low doses of alpha particles. Cancer Res. 52, 6394-6396 (1992).
4. A. Deshpande, E. H. Goodwin, S. M. Bailey, B. L. Marrone and B. E. Lehnert, Alpha-particle-induced sister chromatid exchange in normal human lung fibroblasts: Evidence for an extra-nuclear target. Radiat. Res. 145, 260-267 (1996).
5. J. D. Pitts, Cancer gene therapy: A bystander effect using the gap junctional pathway. Mol. Carcinogen. 11, 127-130 (1994).
6. C. Mothersill and C. B. Seymour, Survival of human epithelial cells irradiated with cobalt 60 as microcolonies or single cells. Int. J. Radiat. Biol., in press.
7. W. E. Loewenstein, Junctional intercellular communication and the control of growth. Biochim. Biophys. Acta 560, 1-65 (1979).
8. L. J. Mills, S. M. Nelson and A. R. Malcolm, Effects of selected anti-tumour-promoting chemicals on metabolic cooperation between Chinese hamster V79 cells. Toxicol. Appl. Pharmacol. 126, 338-344 (1994).
9. P. Boukamp, E. J. Stanbridge, D. Y. Foo, P. A. Cerutti and N. E. Fusenig, c-Ha-ras oncogene expression in immortalized human keratinocytes (HaCaT) alters growth potential in vivo but lacks correlation with malignancy. Cancer Res. 50, 2840-2847 (1990).
10. T. T. Puck and P. I. Marcus, Action of X-rays on mammalian cells. J. Exp. Med. 103, 653-666 (1956).
11. M. H. El-Fouly, J. E. Trosko and C. C. Chang, Scrape loading and dye transfer: A rapid and simple technique to study gap junctional intercellular communication. Exp. Cell Res. 168, 422-430 (1987).
12. B. L. Upham, K. S. Kang, H-Y. Cho and J. E. Trosko, Hydrogen peroxide inhibits gap junctional intercellular communication in glutathione sufficient but not in glutathione deficient cells. Carcinogenesis 18, 37-42 (1997).
13. J. E. Trosko and C. C. Chang, Non-genotoxic mechanisms in carcinogenesis: Role of inhibited intercellular communication. In Carcinogen Risk Assessment: New Directions in Qualitative and Quantitative Aspects (R. W. Hart and F. G. Hoergen, Eds.), pp. 139-170. Banbury Report 31, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY, 1988.
14. M. C. Raff, Social controls on cell survival and cell death. Nature 356, 397-400 (1992).
15. L. Stryer, Biochemistry, 3rd ed., pp. 733-763. W. H. Freeman, New York, 1988.
16. G. Kroemer, N. Zamzami and S. A. Susin, Mitochondrial control of apoptosis. Immunol. Today 18, 44-51 (1997).
17. G. Kroemer, The proto-oncogene bcl-2 and its role in regulating apoptosis. Nat. Med. 3, 614-620 (1997).
18. S. M. Clutton, K. M. S. Townsend, C. Walker, J. D. Ansell and E. G. Wright, Radiation induced genomic instability and persisting oxidative stress in primary bone marrow cultures. Carcinogenesis 17, 1633-1639 (1996).
19. G. E. Watson, S. A. Lorimore, S. M. Clutton, M. A. Kadhim and E. G. Wright, Genetic factors influencing alpha-particle induced chromosomal instability. Int. J. Radiat. Biol. 71, 497-503 (1997).
20. M. Jamali and K-R. Trott, Increased micronucleus frequency in the progeny of irradiated Chinese hamster cells. Int. J. Radiat. Biol. 69, 301-307 (1996).
21. C. B. Seymour, C. Mothersill and T. Alper, High yields of lethal mutations in somatic mammalian cells that survive ionizing radiation. Int. J. Radial Biol 50, 167-169 (1986).
22. C. Mothersill and C. B. Seymour, Recovery of the radiation survival curve shoulder in repair proficient and repair deficient cell populations. Mutat. Res. 285, 259-266 (1993).
23. M. S. Mendonca, R. J. Antoniono and J. L. Redpath, Delayed heritable damage and epigenetics in radiation-induced neoplastic transformation of human hybrid cells. Radiat. Res. 134, 209-216 (1993).
24. W. P. Chang and J. B. Little, Delayed reproductive death as a dominant phenotype in cell clones surviving X-irradiation. Carcinogenesis 13, 923-928 (1992).
25. M. Kadhim, D. A. MacDonald, D. Goodhead, S. A. Lorimore, S. J. Marsden and E. G. Wright, Transmission of chromosomal instability after plutonium alpha-particle irradiation. Nature 355, 738-740 (1992).
26. B. A. Marder and W. F. Morgan, Delayed chromosomal instability induced by DNA damage. Mol Cell Biol. 13, 6667-6677 (1993).
27. W. F. Morgan, J. P. Day, M. I. Kaplan, E. M. McGee and C. L. Limoli, Genomic instability induced by ionizing radiation. Radiat. Res. 146, 247-258 (1996).
28. C. B. Seymour and C. Mothersill, Lethal mutations, the survival curve shoulder and split-dose recovery. Int. J. Radiat. Biol 56, 999-1010 (1989).