Bystander Effects Induced by Continuous Low-Dose-Rate 125I Seeds Potentiate the Killing Action of Irradiation on Human Lung Cancer Cells In Vitro

International Journal of Radiation Oncology Biology Physics

Volumn 72, Issue 5, 2008, Pages 1560-1566

  Chen, Hong H ^a   Jia, Rong F ^a   Yu, Lei ^a   Zhao, Mei J ^a   Shao, Chun L ^a   Cheng, Wen Y ^a  

^a FUDAN UNIVERSITY   (China)

Author keywords

H2AX; 125I seed; Bystander effect; Human lung cancer cells; Micronucleus

Indexed keywords

AGRICULTURAL PRODUCTS; ANIMAL CELL CULTURE; BIOLOGICAL ORGANS; CELL CULTURE; CELL DEATH; CYTOLOGY; DIMETHYL SULFOXIDE; IRRADIATION; MANGANESE COMPOUNDS; OXYGEN; RADIATION; RADIATION EFFECTS; SEED;

125I SEED; A549 CELLS; APOPTOSIS; BYSTANDER CELLS; BYSTANDER EFFECT; BYSTANDER EFFECTS; BYSTANDER RESPONSES; CELL LINES; FORMATION RATES; HUMAN LUNG CANCER CELLS; HUMAN LUNGS; IN VITRO; IRRADIATION DOSES; MICRONUCLEUS; NONIRRADIATED CELLS; NONUNIFORM DISTRIBUTIONS; RADIATION DOSAGES; REACTIVE OXYGEN SPECIES; TUMOR CELLS;

CELLS;

IODINE 125;

APOPTOSIS; ARTICLE; CANCER CELL; CELL PROLIFERATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; IN VITRO STUDY; IRRADIATION; LUNG CANCER; PRIORITY JOURNAL; RADIATION DOSE;

APOPTOSIS; BRACHYTHERAPY; BYSTANDER EFFECT; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CELL SURVIVAL; DOSE-RESPONSE RELATIONSHIP, RADIATION; HUMANS; IODINE RADIOISOTOPES; LUNG NEOPLASMS; RADIATION TOLERANCE;

EID: 56349136896     PISSN: 03603016     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2008.07.038     Document Type: Article

References (20)

1. Langley S.E., and Laing R.W. Iodine seed prostate brachytherapy: An alternative first-line choice for early prostate cancer. Prostate Cancer Prostatic Dis 7 (2004) 201-207
2. Nag S., DeHaan M., Scruggs G., et al. Long-term follow-up of patients of intrahepatic malignancies treated with iodine-125 brachytherapy. Int J Radiat Oncol Biol Phys 64 (2006) 736-744
3. 125I seed paraspinal brachytherapy for malignant tumors with spinal cord compression. Int J Radiat Oncol Biol Phys 54 (2002) 505-513
4. Mothersill C.E., Moriarty M.J., and Seymour C.B. Radiotherapy and the potential exploitation of bystander effects. Int J Radiat Oncol Biol Phys 58 (2004) 575-579
5. Sokolov M.V., Smilenov L.B., Hall E.J., et al. Ionizing radiation induces DNA double-strand breaks in bystander primary human fibroblasts. Oncogene 24 (2005) 7257-7265
6. Shao C., Folkard M., Michael B.D., et al. Targeted cytoplasmic irradiation induces bystander responses. Proc Natl Acad Sci U S A 101 (2004) 13495-13500
7. Boyd M., Ross S.C., Dorrens J., et al. Radiation-induced biologic bystander effect elicited in vitro by targeted radiopharmaceuticals labeled with alpha-, beta-, and auger electron-emitting radionuclides. J Nucl Med 47 (2006) 1007-1015
8. Xue L.Y., Butler N.J., Makrigiorgos G.M., et al. Bystander effect produced by radiolabeled tumor cells in vivo. Proc Natl Acad Sci U S A 99 (2002) 13765-13770
9. Kishikawa H., Wang K., Adelstein S.J., et al. Inhibitory and stimulatory bystander effects are differentially induced by Iodine-125 and Iodine-123. Radiat Res 165 (2006) 688-694
10. Aird E.G., Folkard M., Mayes C.R., et al. A purpose-built iodine-125 irradiation plaque for low dose rate low energy irradiation of cell lines in vitro. Br J Radiol 74 (2001) 56-61
11. 125I seed in vitro irradiation. Chin J Radiat Oncol 14 (2005) 435-438
12. Nath R., Anderson L.L., Luxton G., et al. Dosimetry of interstitial brachytherapy sources: recommendations of the AAPM Radiation Therapy Committee Task Group No. 43. American Association of Physicists in Medicine. Med Phys 22 (1995) 209-234
13. Burdak-Rothkamm S., Short S.C., Folkard M., et al. ATR-dependent radiation-induced gamma H2AX foci in bystander primary human astrocytes and glioma cells. Oncogene 26 (2007) 993-1002
14. Little J.B., Azzam E.I., de Toledo S.M., et al. Bystander effects: intercellular transmission of radiation damage signals. Radiat Prot Dosimetry 99 (2002) 159-162
15. Bishayee A., Hill H.Z., Stein D., et al. Free radical-initiated and gap junction-mediated bystander effect due to nonuniform distribution of incorporated radioactivity in a three-dimensional tissue culture model. Radiat Res 155 (2001) 335-344
16. Shao C., Stewart V., Folkard M., et al. Nitric oxide-mediated signaling in the bystander response of individually targeted glioma cells. Cancer Res 63 (2003) 8437-8442
17. Rothkamm K., and Lobrich M. Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses. Proc Natl Acad Sci U S A 100 (2003) 5057-5062
18. Ishizaki K., Hayashi Y., Nakamura H., et al. No induction of p53 phosphorylation and few focus formation of phosphorylated H2AX suggest efficient repair of DNA damage during chronic low-dose-rate irradiation in human cells. J Radiat Res (Tokyo) 45 (2004) 521-525
19. Iyer R., Lehnert B.E., and Svensson R. Factors underlying the cell growth-related bystander responses to alpha particles. Cancer Res 60 (2000) 1290-1298
20. Narayanan P.K., LaRue K.E., Goodwin E.H., et al. Alpha particles induce the production of interleukin-8 by human cells. Radiat Res 152 (1999) 57-63