Structures of dihydrofolate reductase-thymidylate synthase of trypanosoma cruzi in the folate-free state and in complex with two antifolate drugs, trimetrexate and methotrexate

Acta Crystallographica Section D: Biological Crystallography

Volumn 65, Issue 7, 2009, Pages 704-716

  Senkovich, Olga ^a   Schormann, Norbert ^a   Chattopadhyay, Debasish ^a,b  

^a UNIVERSITY OF ALABAMA AT BIRMINGHAM   (United States)

^b and Clinical Center   (United States)

Author keywords

Chagas disease; Dihydrofolate reductase thymidylate synthase; Drug design; Parasites

Indexed keywords

DIHYDROFOLATE REDUCTASE; FOLIC ACID ANTAGONIST; METHOTREXATE; MULTIENZYME COMPLEX; THYMIDYLATE SYNTHASE; THYMIDYLATE SYNTHASE DIHYDROFOLATE REDUCTASE; THYMIDYLATE SYNTHASE-DIHYDROFOLATE REDUCTASE; TRIMETREXATE;

ANIMAL; ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; ENZYME ACTIVE SITE; ENZYME SPECIFICITY; ENZYMOLOGY; ESCHERICHIA COLI; HUMAN; METABOLISM; PROTEIN BINDING; PROTEIN QUATERNARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; STRUCTURAL HOMOLOGY; TRYPANOSOMA CRUZI; X RAY CRYSTALLOGRAPHY;

ANIMALS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; ESCHERICHIA COLI; FOLIC ACID ANTAGONISTS; HUMANS; METHOTREXATE; MODELS, MOLECULAR; MULTIENZYME COMPLEXES; PROTEIN BINDING; PROTEIN STRUCTURE, QUATERNARY; PROTEIN STRUCTURE, TERTIARY; STRUCTURAL HOMOLOGY, PROTEIN; SUBSTRATE SPECIFICITY; TETRAHYDROFOLATE DEHYDROGENASE; THYMIDYLATE SYNTHASE; TRIMETREXATE; TRYPANOSOMA CRUZI;

CRYPTOSPORIDIUM HOMINIS; HEXAPODA; MASTIGOPHORA (FLAGELLATES); PLASMODIUM FALCIPARUM; PROTOZOA; TRYPANOSOMA CRUZI;

EID: 68149165443     PISSN: 09074449     EISSN: 13990047     Source Type: Journal    
DOI: 10.1107/S090744490901230X     Document Type: Article

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