The structure-based design and synthesis of selective inhibitors of Trypanosoma cruzi dihydrofolate reductase

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 10, 1999, Pages 1463-1468

  Zuccotto, Fabio ^a   Brun, Reto ^b   Gonzalez Pacanowska, Dolores ^c   Ruiz Perez, Luis M ^c   Gilbert, Ian H ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

^b SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^c INSTITUTO DE PARASITOLOGÍA Y BIOMEDICINA LÓPEZ NEYRA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; DIHYDROFOLATE REDUCTASE; DIHYDROFOLATE REDUCTASE INHIBITOR; METHOTREXATE; METHOTREXATE DERIVATIVE;

ANTIBACTERIAL ACTIVITY; ARTICLE; CHAGAS DISEASE; DRUG DESIGN; DRUG STRUCTURE; ENZYME INHIBITION; MODEL; REACTION ANALYSIS; TRYPANOSOMA CRUZI;

ANIMALS; BINDING SITES; CELL LINE; DRUG DESIGN; ENZYME INHIBITORS; FOLIC ACID ANTAGONISTS; HUMANS; MICE; MOLECULAR STRUCTURE; RECOMBINANT PROTEINS; TETRAHYDROFOLATE DEHYDROGENASE; TRYPANOSOMA CRUZI;

EID: 0033577778     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00213-9     Document Type: Article

References (12)

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10. Acknowledgement to Dr R. Ridley, Roche Pharmaceuticals for supplying recombinant human enzyme.
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