메뉴 건너뛰기




Volumn 21, Issue 3, 2010, Pages 194-205

Differing short-term neuroprotective effects of the fibrates fenofibrate and bezafibrate in MPTP and 6-OHDA experimental models of Parkinson's disease

Author keywords

1 methyl 4 phenyl 1,2,3,6 tetrahydropyridine; 6 hydroxydopamine; Bezafibrate; Fenofibrate; Parkinson's disease; Peroxisome proliferator activated receptor

Indexed keywords

1,2,3,6 TETRAHYDRO 1 METHYL 4 PHENYLPYRIDINE; APOMORPHINE; BEZAFIBRATE; FENOFIBRATE; OXIDOPAMINE;

EID: 77953124810     PISSN: 09558810     EISSN: None     Source Type: Journal    
DOI: 10.1097/FBP.0b013e32833a5c81     Document Type: Article
Times cited : (21)

References (54)
  • 2
    • 27244452751 scopus 로고    scopus 로고
    • Fenofibrate, a peroxysome proliferator-activated receptor a agonist, exerts neuroprotec-tive effects in traumatic brain injury
    • Besson VC, Chen XR, Plotkine M, Marchand-Verrecchia C (2005). Fenofibrate, a peroxysome proliferator-activated receptor a agonist, exerts neuroprotec-tive effects in traumatic brain injury. Neurosci Lett 388:7-12.
    • (2005) Neurosci Lett , vol.388 , pp. 7-12
    • Besson, V.C.1    Chen, X.R.2    Plotkine, M.3    Marchand-Verrecchia, C.4
  • 3
    • 0034993599 scopus 로고    scopus 로고
    • Molecular pathway involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: Contribution to the apoptotic theory in Parkinson's disease
    • Blum D, Torch S, Lambeng N, Nissou M, Benabid AL, Sadoul R, Verna JM (2001). Molecular pathway involved in the neurotoxicity of 6-OHDA, dopamine and MPTP: contribution to the apoptotic theory in Parkinson's disease. Prog Neurobiol 65:135-172.
    • (2001) Prog Neurobiol , vol.65 , pp. 135-172
    • Blum, D.1    Torch, S.2    Lambeng, N.3    Nissou, M.4    Benabid, A.L.5    Sadoul, R.6    Verna, J.M.7
  • 4
    • 0030611777 scopus 로고    scopus 로고
    • Induction of dopamine D3 receptor expression as a mechanism of behavioral sensitization to levodopa
    • Bordet R, Ridray S, Carboni S, Diaz J, Sokoloff P, Schwartz JC (1997). Induction of dopamine D3 receptor expression as a mechanism of behavioral sensitization to levodopa. Proc Natl Acad Sci USA 94:3363-3367.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 3363-3367
    • Bordet, R.1    Ridray, S.2    Carboni, S.3    Diaz, J.4    Sokoloff, P.5    Schwartz, J.C.6
  • 5
    • 34147182536 scopus 로고    scopus 로고
    • PPAR: A new pharmacological target for neuroprotection in stroke and neuro-degenerative diseases
    • Bordet R, Ouk T, Petrault O, Gelé P, Gautier S, Laprais M, et al. (2006). PPAR: a new pharmacological target for neuroprotection in stroke and neuro-degenerative diseases. Biochem Soc Trans 34:1341-1346.
    • (2006) Biochem Soc Trans , vol.34 , pp. 1341-1346
    • Bordet, R.1    Ouk, T.2    Petrault, O.3    Gelé, P.4    Gautier, S.5    Laprais, M.6
  • 6
    • 26844505808 scopus 로고    scopus 로고
    • Toxin-induced models of Parkinson's disease
    • Bové J, Prou D, Perier C, Przedborski S (2005). Toxin-induced models of Parkinson's disease. NeuroRx 2:484-494.
    • (2005) NeuroRx , vol.2 , pp. 484-494
    • Bové, J.1    Prou, D.2    Perier, C.3    Przedborski, S.4
  • 7
    • 0036326074 scopus 로고    scopus 로고
    • Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease
    • Breidert T, Callebert J, Heneka MT, Landreth G, Launay JM, Hirsch EC (2002). Protective action of the peroxisome proliferator-activated receptor-gamma agonist pioglitazone in a mouse model of Parkinson's disease. J Neurochem 82:615-624.
    • (2002) J Neurochem , vol.82 , pp. 615-624
    • Breidert, T.1    Callebert, J.2    Heneka, M.T.3    Landreth, G.4    Launay, J.M.5    Hirsch, E.C.6
  • 8
    • 84944661914 scopus 로고
    • Rank transformations as a bridge between parametric and nonparametric statistics
    • Conover WJ, Iman RL (1981). Rank transformations as a bridge between parametric and nonparametric statistics. Am Stat 35:124-129.
    • (1981) Am Stat , vol.35 , pp. 124-129
    • Conover, W.J.1    Iman, R.L.2
  • 9
    • 0033578272 scopus 로고    scopus 로고
    • Behavioral phenotyping of transgenic and knockout mice: Experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests
    • Crawley JN (1999). Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests. Brain Res 835:18-26.
    • (1999) Brain Res , vol.835 , pp. 18-26
    • Crawley, J.N.1
  • 10
    • 0031930111 scopus 로고    scopus 로고
    • Distribution of mRNAs encoding the peroxysome proliferator-activated receptor a, b, and g and the retinoid X receptor a, b, and g in rat central nervous system
    • Cullingford TE, Bhakoo K, Peuchen S, Dolphin CT, Patel R, Clark JB (1998). Distribution of mRNAs encoding the peroxysome proliferator-activated receptor a, b, and g and the retinoid X receptor a, b, and g in rat central nervous system. J Neurochem 70:1366-1375.
    • (1998) J Neurochem , vol.70 , pp. 1366-1375
    • Cullingford, T.E.1    Bhakoo, K.2    Peuchen, S.3    Dolphin, C.T.4    Patel, R.5    Clark, J.B.6
  • 11
    • 33745309774 scopus 로고    scopus 로고
    • The role of the peroxysome proliferator-activated receptor-a (PPAR-a) in the regulation of acute inflammation
    • Cuzzocrea S, Mazzon E, Di Paola S, Peli A, Bonato A, Britti D, et al. (2006). The role of the peroxysome proliferator-activated receptor-a (PPAR-a) in the regulation of acute inflammation. J Leukocyte Biol 79:999-1010.
    • (2006) J Leukocyte Biol , vol.79 , pp. 999-1010
    • Cuzzocrea, S.1    Mazzon, E.2    Di Paola, S.3    Peli, A.4    Bonato, A.5    Britti, D.6
  • 12
    • 0347087323 scopus 로고    scopus 로고
    • Protection with pioglitazone in the MPTP model of Parkinson's disease correlates with i kappa B alpha induction and block of NF kappa B and iNOS activation
    • Dehmer T, Heneka MT, Sastre M, Dichgans J, Schulz JB (2004). Protection with pioglitazone in the MPTP model of Parkinson's disease correlates with I kappa B alpha induction and block of NF kappa B and iNOS activation. J Neurochem 88:494-501.
    • (2004) J Neurochem , vol.88 , pp. 494-501
    • Dehmer, T.1    Heneka, M.T.2    Sastre, M.3    Dichgans, J.4    Schulz, J.B.5
  • 13
    • 0033527569 scopus 로고    scopus 로고
    • Peroxysome proliferator-activated receptor alpha negatively regulates the inflammatory gene response by negative cross-talk with transcription factors NF-kB and AP-1
    • Delerive P, De Bosscher K, Besnard S, Vanden Berghe W, Peters JM, Gonzalez FJ, et al. (1999). Peroxysome proliferator-activated receptor alpha negatively regulates the inflammatory gene response by negative cross-talk with transcription factors NF-kB and AP-1. J Biol Chem 274:32048-32054.
    • (1999) J Biol Chem , vol.274 , pp. 32048-32054
    • Delerive, P.1    De Bosscher, K.2    Besnard, S.3    Vanden Berghe, W.4    Peters, J.M.5    Gonzalez, F.J.6
  • 14
    • 0038720453 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-a activation as a mechanism of preventive neuroprotection induced by chronic fenofibrate treatment
    • Deplanque D, Gelé P, P étrault O, Six I, Furman C, Bouly M, et al. (2003). Peroxisome proliferator-activated receptor-a activation as a mechanism of preventive neuroprotection induced by chronic fenofibrate treatment. J Neurosci 23:6264-6271.
    • (2003) J Neurosci , vol.23 , pp. 6264-6271
    • Deplanque, D.1    Gele, P.2    Petrault, O.3    Six, I.4    Furman, C.5    Bouly, M.6
  • 15
    • 0036283426 scopus 로고    scopus 로고
    • Modeling Parkinson's disease in rats: An evaluation of the 6-OHDA lesions of the nigrostriatal pathway
    • Deumens R, Blokland A, Prickaerts J (2002). Modeling Parkinson's disease in rats: an evaluation of the 6-OHDA lesions of the nigrostriatal pathway. Exp Neurol 175:303-317.
    • (2002) Exp Neurol , vol.175 , pp. 303-317
    • Deumens, R.1    Blokland, A.2    Prickaerts, J.3
  • 16
    • 0024585155 scopus 로고
    • Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease
    • Dexter DT, Carter CJ, Wells FR, Agid F, Agid Y, Lees A, et al. (1989). Basal lipid peroxidation in substantia nigra is increased in Parkinson's disease. J Neurochem 52:381-389.
    • (1989) J Neurochem , vol.52 , pp. 381-389
    • Dexter, D.T.1    Carter, C.J.2    Wells, F.R.3    Agid, F.4    Agid, Y.5    Lees, A.6
  • 17
    • 0026517010 scopus 로고
    • Control of peroxisomal beta-oxidation pathway by a novel family of nuclear receptors
    • Dreyer C, Krey G, Keller H, Givel F, Helftenbein G, Wahli W (1992). Control of peroxisomal beta-oxidation pathway by a novel family of nuclear receptors. Cell 68:879-887.
    • (1992) Cell , vol.68 , pp. 879-887
    • Dreyer, C.1    Krey, G.2    Keller, H.3    Givel, F.4    Helftenbein, G.5    Wahli, W.6
  • 18
    • 0032944412 scopus 로고    scopus 로고
    • Tolerance to a suprathreshold dose of L-Dopa in MPTP mice: Effects of glutamate antagonists
    • Frederiksson A, Palomo T, Chase T, Archer T (1999). Tolerance to a suprathreshold dose of L-Dopa in MPTP mice: effects of glutamate antagonists. J Neural Tr a n s m 106:283-300.
    • (1999) J Neural Transm , vol.106 , pp. 283-300
    • Frederiksson, A.1    Palomo, T.2    Chase, T.3    Archer, T.4
  • 19
    • 0032816777 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors regulate gene governing lipoprotein metabolism, vascular inflammation and atherosclerosis
    • Fruchart JC, Duriez P, Staels B (1999). Peroxisome proliferator-activated receptors regulate gene governing lipoprotein metabolism, vascular inflammation and atherosclerosis. Curr Opin Lipidol 10:245-257.
    • (1999) Curr Opin Lipidol , vol.10 , pp. 245-257
    • Fruchart, J.C.1    Duriez, P.2    Staels, B.3
  • 20
    • 40049088000 scopus 로고    scopus 로고
    • PPARalpha: Mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators
    • Gonzalez FJ, Shah YM (2008). PPARalpha: mechanism of species differences and hepatocarcinogenesis of peroxisome proliferators. Toxicology 246:2-8.
    • (2008) Toxicology , vol.246 , pp. 2-8
    • Gonzalez, F.J.1    Shah, Y.M.2
  • 22
    • 12944250987 scopus 로고    scopus 로고
    • Caspase 3: A vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease
    • Hartmann A, Hunot S, Michel PP, Muriel MP, Vyas S, Faucheux BA, et al. (2000). Caspase 3: a vulnerability factor and final effector in apoptotic death of dopaminergic neurons in Parkinson's disease. Proc Natl Acad Sci USA 97:2875-2880.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 2875-2880
    • Hartmann, A.1    Hunot, S.2    Michel, P.P.3    Muriel, M.P.4    Vyas, S.5    Faucheux, B.A.6
  • 23
    • 0035313071 scopus 로고    scopus 로고
    • Caspase-8 is an effector in apoptotic death of dopamine neurons in Parkinson's disease, but pathway inhibition results in neuronal necrosis
    • Hartmann A, Troadec JD, Hunot S, Kikly K, Faucheux BA, Mouatt-Prigent A, et al. (2001). Caspase-8 is an effector in apoptotic death of dopamine neurons in Parkinson's disease, but pathway inhibition results in neuronal necrosis. J Neurosci 21:2247-2255.
    • (2001) J Neurosci , vol.21 , pp. 2247-2255
    • Hartmann, A.1    Troadec, J.D.2    Hunot, S.3    Kikly, K.4    Faucheux, B.A.5    Mouatt-Prigent, A.6
  • 24
    • 0033007231 scopus 로고    scopus 로고
    • Effect of peroxisome proliferator-activated receptor alpha activators on tumor necrosis factor expression in mice during endotoxemia
    • Hill MR, Clarke S, Rodgers K, Thornhill B, Peters JM, Gonzalez FJ, Gimble JM (1999). Effect of peroxisome proliferator-activated receptor alpha activators on tumor necrosis factor expression in mice during endotoxemia. Infect Immun 67:3488-3493.
    • (1999) Infect Immun , vol.67 , pp. 3488-3493
    • Hill, M.R.1    Clarke, S.2    Rodgers, K.3    Thornhill, B.4    Peters, J.M.5    Gonzalez, F.J.6    Gimble, J.M.7
  • 25
    • 0031715925 scopus 로고    scopus 로고
    • Glial cells and inflammation in Parkinson's disease: A role in neurodegeneration?
    • Hirsch EC, Hunot S, Damier P, Faucheux B (1998). Glial cells and inflammation in Parkinson's disease: a role in neurodegeneration?. Ann Neurol 44:S115-S120.
    • (1998) Ann Neurol , vol.44
    • Hirsch, E.C.1    Hunot, S.2    Damier, P.3    Faucheux, B.4
  • 26
    • 0035127181 scopus 로고    scopus 로고
    • Evidence for a dissociation between MPTP toxicity and tyrosinase activity based on congenic mouse strain susceptibility
    • Hofele K, Sedelis M, Auburger GW, Morgan S, Huston JP, Schwarting RK (2001). Evidence for a dissociation between MPTP toxicity and tyrosinase activity based on congenic mouse strain susceptibility. Exp Neurol 168:116-122.
    • (2001) Exp Neurol , vol.168 , pp. 116-122
    • Hofele, K.1    Sedelis, M.2    Auburger, G.W.3    Morgan, S.4    Huston, J.P.5    Schwarting, R.K.6
  • 29
    • 0028784523 scopus 로고
    • Time course and morphology of dopaminergic neuronal death caused by neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine
    • Jackson-Lewis V, Jakowec M, Burke RE, Przedborski S (1995). Time course and morphology of dopaminergic neuronal death caused by neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Neurodegeneration 4:257-269.
    • (1995) Neurodegeneration , vol.4 , pp. 257-269
    • Jackson-Lewis, V.1    Jakowec, M.2    Burke, R.E.3    Przedborski, S.4
  • 31
    • 33846641782 scopus 로고    scopus 로고
    • Lipid-lowering drugs in the MPTP mouse model of Parkinson's disease: Fenofibrate has a neuroprotective effect, whereas bezafibrate and HMG-CoA reductase inhibitors do not
    • Kreisler A, Gelé P, Wiart JF, Lhermitte M, Destée A, Bordet R (2007). Lipid-lowering drugs in the MPTP mouse model of Parkinson's disease: fenofibrate has a neuroprotective effect, whereas bezafibrate and HMG-CoA reductase inhibitors do not. Brain Res 1135:77-84.
    • (2007) Brain Res , vol.1135 , pp. 77-84
    • Kreisler, A.1    Gelé, P.2    Wiart, J.F.3    Lhermitte, M.4    Destée, A.5    Bordet, R.6
  • 32
    • 0030985318 scopus 로고    scopus 로고
    • Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxysome proliferator-activated receptors by coactivator-depen-dent receptor ligand assay
    • Krey G, Braissant O, L'Horset F, Kalkhoven E, Perroud M, Parker MG, Wahli W (1997). Fatty acids, eicosanoids, and hypolipidemic agents identified as ligands of peroxysome proliferator-activated receptors by coactivator-depen-dent receptor ligand assay. Mol Endocrinol 11:779-791.
    • (1997) Mol Endocrinol , vol.11 , pp. 779-791
    • Krey, G.1    Braissant, O.2    L'Horset, F.3    Kalkhoven, E.4    Perroud, M.5    Parker, M.G.6    Wahli, W.7
  • 33
    • 19544388947 scopus 로고    scopus 로고
    • PPAR-alpha activators suppress STAT1 inflammatory signaling in lipopolysaccharide-activated rat glia
    • Lee JH, Joe EH, Jou I (2005). PPAR-alpha activators suppress STAT1 inflammatory signaling in lipopolysaccharide-activated rat glia. Neuroreport 16:829-833.
    • (2005) Neuroreport , vol.16 , pp. 829-833
    • Lee, J.H.1    Joe, E.H.2    Jou, I.3
  • 34
    • 1942437619 scopus 로고    scopus 로고
    • Stereospecific regulation of tyrosine hydroxylase and proenkephalin genes by short-chain fatty acids in rat PC12 cells
    • Mally P, Mishra R, Gandhi S, Decastro MH, Nankova BB, Lagamma EF (2004). Stereospecific regulation of tyrosine hydroxylase and proenkephalin genes by short-chain fatty acids in rat PC12 cells. Pediatr Res 55: 847-854.
    • (2004) Pediatr Res , vol.55 , pp. 847-854
    • Mally, P.1    Mishra, R.2    Gandhi, S.3    Decastro, M.H.4    Nankova, B.B.5    Lagamma, E.F.6
  • 35
    • 0033594810 scopus 로고    scopus 로고
    • PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells
    • Marx N, Sukhova GK, Collins T, Libby P, Plutzky J (1999). PPARalpha activators inhibit cytokine-induced vascular cell adhesion molecule-1 expression in human endothelial cells. Circulation 99:3125-3131.
    • (1999) Circulation , vol.99 , pp. 3125-3131
    • Marx, N.1    Sukhova, G.K.2    Collins, T.3    Libby, P.4    Plutzky, J.5
  • 36
    • 0023789193 scopus 로고
    • Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains
    • McGeer PL, Itagaki S, Boyes BE, McGeer EG (1988). Reactive microglia are positive for HLA-DR in the substantia nigra of Parkinson's and Alzheimer's disease brains. Neurology 38:1285-1291.
    • (1988) Neurology , vol.38 , pp. 1285-1291
    • McGeer, P.L.1    Itagaki, S.2    Boyes, B.E.3    McGeer, E.G.4
  • 37
    • 58149392527 scopus 로고    scopus 로고
    • Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic dopamine neurons through nuclear receptors
    • Melis M, Pillolla G, Luchicchi A, Muntoni AL, Yasar S, Goldberg SR, Pistis M (2008). Endogenous fatty acid ethanolamides suppress nicotine-induced activation of mesolimbic dopamine neurons through nuclear receptors. J Neurosci 28:13985-13994.
    • (2008) J Neurosci , vol.28 , pp. 13985-13994
    • Melis, M.1    Pillolla, G.2    Luchicchi, A.3    Muntoni, A.L.4    Yasar, S.5    Goldberg, S.R.6    Pistis, M.7
  • 38
    • 67349156640 scopus 로고    scopus 로고
    • Lipid-lowering drugs are associated with delayed onset and slower course of Parkinson's disease
    • Mutez E, Duhamel A, Defebvre L, Bordet R, Destée A, Kreisler A (2009). Lipid-lowering drugs are associated with delayed onset and slower course of Parkinson's disease. Pharmacol Res 60:41-45.
    • (2009) Pharmacol Res , vol.60 , pp. 41-45
    • Mutez, E.1    Duhamel, A.2    Defebvre, L.3    Bordet, R.4    Destée, A.5    Kreisler, A.6
  • 39
    • 0037195866 scopus 로고    scopus 로고
    • Gemfibrozil, a lipid-lowering drug, inhibits the induction of nitric-oxide synthase in human astrocytes
    • Pahan K, Jana M, Liu X, Taylor BS, Wood C, Fischer SM (2002). Gemfibrozil, a lipid-lowering drug, inhibits the induction of nitric-oxide synthase in human astrocytes. J Biol Chem 277:45984-45991.
    • (2002) J Biol Chem , vol.277 , pp. 45984-45991
    • Pahan, K.1    Jana, M.2    Liu, X.3    Taylor, B.S.4    Wood, C.5    Fischer, S.M.6
  • 41
    • 0033180560 scopus 로고    scopus 로고
    • Age-associated alterations in splenic iNOS regulation: Influence of constitutively expressed IFN-gamma and correction following supplementation with PPARalpha activators or vitamin e
    • Poynter ME, Daynes RA (1999). Age-associated alterations in splenic iNOS regulation: influence of constitutively expressed IFN-gamma and correction following supplementation with PPARalpha activators or vitamin E. Cell Immunol 195:127-136.
    • (1999) Cell Immunol , vol.195 , pp. 127-136
    • Poynter, M.E.1    Daynes, R.A.2
  • 42
    • 0031895005 scopus 로고    scopus 로고
    • Mechanisms of MPTP toxicity
    • Przedborski S, Jackson-Lewis V (1998). Mechanisms of MPTP toxicity. Mov Disord 13 (Suppl 1):35-38.
    • (1998) Mov Disord , vol.13 , Issue.SUPPL. 1 , pp. 35-38
    • Przedborski, S.1    Jackson-Lewis, V.2
  • 43
    • 0031819433 scopus 로고    scopus 로고
    • Evidence for the suppression of apoptosis by the peroxisome proliferator activated receptor alpha (PPAR alpha
    • Roberts RA, James NH, Woodyatt NJ, Macdonald N, Tugwood JD (1998). Evidence for the suppression of apoptosis by the peroxisome proliferator activated receptor alpha (PPAR alpha). Carcinogenesis 19:43-48.
    • (1998) Carcinogenesis , vol.19 , pp. 43-48
    • Roberts, R.A.1    James, N.H.2    Woodyatt, N.J.3    MacDonald, N.4    Tugwood, J.D.5
  • 44
    • 0002352476 scopus 로고    scopus 로고
    • Strain-dependent recovery of open-field behavior and striatal dopamine deficiency in the mouse MPTP model of Parkinson's disease
    • Schwarting RK, Sedelis M, Hofele K, Auburger GW, Huston JP (1999). Strain-dependent recovery of open-field behavior and striatal dopamine deficiency in the mouse MPTP model of Parkinson's disease. Neurotox Res 1:41-56.
    • (1999) Neurotox Res , vol.1 , pp. 41-56
    • Schwarting, R.K.1    Sedelis, M.2    Hofele, K.3    Auburger, G.W.4    Huston, J.P.5
  • 45
    • 0033749345 scopus 로고    scopus 로고
    • MPTP susceptibility in the mouse: Behavioral, neurochemical, and histological analysis of gender and strain differences
    • Sedelis M, Hofele K, Auburger GW, Morgan S, Huston JP, Schwarting RK (2000a). MPTP susceptibility in the mouse: behavioral, neurochemical, and histological analysis of gender and strain differences. Behav Genet 30:1 71-182.
    • (2000) Behav Genet , vol.30 , Issue.1 , pp. 71-182
    • Sedelis, M.1    Hofele, K.2    Auburger, G.W.3    Morgan, S.4    Huston, J.P.5    Schwarting, R.K.6
  • 46
    • 0034615837 scopus 로고    scopus 로고
    • Evidence for resistance to MPTP in C57BL/6 x BALB/c F1 hybrids as compared with their progenitor strains
    • Sedelis M, Hofele K, Auburger GW, Morgan S, Huston JP, Schwarting RK (2000b). Evidence for resistance to MPTP in C57BL/6 x BALB/c F1 hybrids as compared with their progenitor strains. Neuroreport 11:1093-1096.
    • (2000) Neuroreport , vol.11 , pp. 1093-1096
    • Sedelis, M.1    Hofele, K.2    Auburger, G.W.3    Morgan, S.4    Huston, J.P.5    Schwarting, R.K.6
  • 47
    • 0035829368 scopus 로고    scopus 로고
    • Behavioral phenotyping of the MPTP mouse model of Parkinson's disease
    • Sedelis M, Schwarting RKW, Huston JP (2001). Behavioral phenotyping of the MPTP mouse model of Parkinson's disease. Behav Brain Res 125:109-122.
    • (2001) Behav Brain Res , vol.125 , pp. 109-122
    • Sedelis, M.1    Schwarting, R.K.W.2    Huston, J.P.3
  • 48
    • 0033966851 scopus 로고    scopus 로고
    • Regulation of locomotor activity by metabo-tropic glutamate receptors in the nucleus accumbens and ventral tegmental area
    • Swanson CJ, Kalivas PW (2000). Regulation of locomotor activity by metabo-tropic glutamate receptors in the nucleus accumbens and ventral tegmental area. J Pharmacol Exp Ther 292:406-414.
    • (2000) J Pharmacol Exp Ther , vol.292 , pp. 406-414
    • Swanson, C.J.1    Kalivas, P.W.2
  • 49
    • 5444228135 scopus 로고    scopus 로고
    • Cellular pathology of Parkinson's disease: Astrocytes, microglia and inflammation
    • Teismann P, Schulz JB (2004). Cellular pathology of Parkinson's disease: astrocytes, microglia and inflammation. Cell Tissue Res 318:149-161.
    • (2004) Cell Tissue Res , vol.318 , pp. 149-161
    • Teismann, P.1    Schulz, J.B.2
  • 50
    • 0015184103 scopus 로고
    • Postsynaptic supersensitivity after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system
    • Ungerstedt U (1971). Postsynaptic supersensitivity after 6-hydroxydopamine induced degeneration of the nigro-striatal dopamine system. Acta Physiol Scand Suppl 367:69-91.
    • (1971) Acta Physiol Scand , vol.367 , Issue.SUPPL. , pp. 69-91
    • Ungerstedt, U.1
  • 51
    • 0036314839 scopus 로고    scopus 로고
    • Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarction size
    • Wayman NS, Hattori Y, McDonald MC, Mota-Filipe H, Cuzzocrea S, Pisano B, et al. (2002). Ligands of the peroxisome proliferator-activated receptors (PPAR-gamma and PPAR-alpha) reduce myocardial infarction size. FASEB 16:1027-1040.
    • (2002) FASEB , vol.16 , pp. 1027-1040
    • Wayman, N.S.1    Hattori, Y.2    McDonald, M.C.3    Mota-Filipe, H.4    Cuzzocrea, S.5    Pisano, B.6
  • 52
    • 25444528680 scopus 로고    scopus 로고
    • Agonists for the peroxysome proliferator-activated receptor-a and the retinoid X receptor inhibit inflammatory responses of microglia
    • Xu J, Storer PD, Chavis JA, Racke MK, Drew PD (2005). Agonists for the peroxysome proliferator-activated receptor-a and the retinoid X receptor inhibit inflammatory responses of microglia. J Neurosci Res 81:403-411.
    • (2005) J Neurosci Res , vol.81 , pp. 403-411
    • Xu, J.1    Storer, P.D.2    Chavis, J.A.3    Racke, M.K.4    Drew, P.D.5
  • 53
    • 33746079214 scopus 로고    scopus 로고
    • Peroxysome proliferator-activated receptor-a and retinoid X receptor agonists inhibit inflammatory response of astrocytes
    • Xu J, Chavis JA, Racke MK, Drew PD (2006). Peroxysome proliferator-activated receptor-a and retinoid X receptor agonists inhibit inflammatory response of astrocytes. J Neuroimmunol 176:95-105.
    • (2006) J Neuroimmunol , vol.176 , pp. 95-105
    • Xu, J.1    Chavis, J.A.2    Racke, M.K.3    Drew, P.D.4
  • 54
    • 0033961676 scopus 로고    scopus 로고
    • An integrative neuroanatomical perspective on some subcortical substrates of adaptive responding with emphasis on the nucleus accumbens
    • Zahm DS (2000). An integrative neuroanatomical perspective on some subcortical substrates of adaptive responding with emphasis on the nucleus accumbens. Neurosci Biobehav R 24:8-105.
    • (2000) Neurosci Biobehav R , vol.24 , pp. 8-105
    • Zahm, D.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.