Adenosine receptor subtypes in airways responses of sensitized guinea-pigs to inhaled ovalbumin

Pulmonary Pharmacology and Therapeutics

Volumn 23, Issue 4, 2010, Pages 355-364

  Smith, Nicola ^a   Broadley, Kenneth J ^a  

^a CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

Adenosine receptors; Airways hyperreactivity; EAR; Inflammatory cell influx; LAR; Ovalbumin; Sensitized guinea pigs

Indexed keywords

4 [2 [7 AMINO 2 (2 FURYL) 1,2,4 TRIAZOLO[2,3 A][1,3,5]TRIAZIN 5 YLAMINO]ETHYL]PHENOL; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; 9 CHLORO 2 (2 FURYL) 5 PHENYLACETYLAMINO 1,2,4 TRIAZOLO[1,5 C]QUINAZOLINE; ADENOSINE RECEPTOR; ADENOSINE RECEPTOR BLOCKING AGENT; DEXAMETHASONE; HISTAMINE; MRS 1706; OVALBUMIN; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ALLERGIC REACTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHUS REACTIVITY; CONTROLLED STUDY; DRUG RECEPTOR BINDING; GUINEA PIG; INFLAMMATORY CELL; LUNG LAVAGE; MALE; NONHUMAN; PLETHYSMOGRAPHY; PRIORITY JOURNAL; PROVOCATION TEST; SENSITIZATION;

ADENOSINE; ANIMALS; BRONCHIAL HYPERREACTIVITY; DEXAMETHASONE; GLUCOCORTICOIDS; GUINEA PIGS; MALE; OVALBUMIN; PLETHYSMOGRAPHY, WHOLE BODY; RECEPTOR, ADENOSINE A2B; RECEPTOR, ADENOSINE A3; RECEPTORS, PURINERGIC P1; TIME FACTORS;

EID: 77953120576     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2010.03.010     Document Type: Article

References (49)

1. Harbinson P.L., MacLeod D., Hawksworth R., O'Toole S., Sullivan P.J., Heath P., et al. The effect of a novel orally active selective PDE4 isoenzyme inhibitor (CDP840) on allergen-induced responses in asthmatic subjects. Eur Resp J 10 (1997) 1008-1014
2. Larsen B.B., Nielsen L.P., Engelstatter R., Steinijans V., and Dahl R. Effect of ciclesonide on allergen challenge in subjects with bronchial asthma. Allergy 58 (2003) 207-212
3. Booij-Noord H., Oric N.G.M., and de Vries K. Immediate and late bronchial obstructive reactions to inhalation of house dust and protective effects of disodium cromoglycate and prednisolone. J Allergy Clin Immunol 48 (1971) 344-354
4. Toward T.J., and Broadley K.J. Early and late bronchoconstriction, airway hyperreactivity, leucocyte influx and lung histamine and nitric oxide after inhaled antigen: effects of dexamethasone and rolipram. Clin Exp Allergy 34 (2004) 91-102
5. Smith N., and Johnson F.J. Early and late phase bronchoconstriction, airway hyperreactivity and cell influx into the lungs, after 5′-AMP inhalation: comparison with ovalbumin. J Allergy Clin Immunol 35 (2005) 522-530
6. Blackburn M.R., Lee C.G., Young H.W.J., Zhu Z., Chunn J.L., Kang M.J., et al. Adenosine mediates IL-13-induced inflammation and remodeling in the lung and interacts in an IL-13-adenosine amplification pathway. J Clin Invest 112 (2003) 332-344
7. Driver A.G., Kukloy C.A., Ali S., and Mustafa S.J. Adenosine in bronchoalveolar lavage fluid in asthma. Am Rev Respir Dis 148 (1993) 91-97
8. Mann J.S., Holgate S.T., Renwick A.G., and Cushley M.J. Airway effects of purine nucleosides and nucleotides and release with bronchial provocation in asthma. J Appl Physiol 61 (1986) 1667-1676
9. Cushley M.J., Tattersfield A.E., and Holgate S.T. Inhaled adenosine and guanosine on airway resistance in normal and asthmatic subjects. Br J Clin Pharmacol 15 (1983) 161-165
10. Bjorck T., Gustafsson L.E., and Dahlen S.E. Isolated bronchi from asthmatics are hyperresponsive to adenosine, which apparently acts indirectly by liberation of leukotrienes and histamine. Am Rev Respir Dis 145 (1992) 1087-1091
11. Thorne J.R., and Broadley K.J. Adenosine-induced bronchoconstriction in conscious hyperresponsive and sensitized guinea-pigs. Am Respir Crit Care Med 149 (1994) 392-399
12. 3 receptors mediate rapid inflammatory cell influx into the lungs of sensitized guinea pigs. Clin Exp Allergy 31 (2001) 943-951
13. Smith N., and Broadley K.J. Adenosine receptors subtypes involved in the airways responses to 5′-AMP inhalation of sensitized guinea-pigs. Clin Exp Allergy 38 (2008) 1536-1547
14. Fredholm B.B., Arslan G., Halldner L., Kull B., Schulte G., and Wasserman W. Structure and function of adenosine receptors and their genes. Naunyn-Schmeidebergs Arch Pharmacol 362 (2000) 364-374
15. Smith N., and Broadley K.J. Optimisation of the ovalbumin sensitisation and challenge protocols in a model of asthma. Int Immunopharm 7 (2007) 183-190
16. Danahay H., and Broadley K.J. Effects of inhibitors of phosphodiesterase, on antigen-induced bronchial hyperreactivity in conscious sensitized guinea pigs and airway leukocyte infiltration. Br J Pharmacol 120 (1997) 289-297
17. Griffiths-Johnson D.A., Nicholls P.J., and McDermott M. Measurement of specific airways conductance in guinea pigs. A non-invasive method. J Pharmacol Methods 19 (1988) 233-248
18. Finney M.J., and Forsberg K.I. Quantification of nasal involvement in a guinea pig plethysmograph. J Appl Physiol 76 (1994) 1432-1438
19. Poucher S.M., Keddie J.R., Brooks R., Shaw G.R., and McKillop D. Pharmacodynamics of ZM241385, a potent A2a adenosine receptor antagonist, after enteric administration in rat, cat and dog. J Pharm Pharmacol 48 (1996) 601-606
20. Klotz K.N. Adenosine receptors and their ligands. Naunyn-Schmeidebergs Arch Pharmacol 362 (2000) 382-391
21. 2A receptor activation in murine models of respiratory disorders. Am J Physiol Lung Cell Mol Physiol 290 (2006) L1036-L1043
22. 2A receptor agonist, on allergic airways inflammation in the rat. Eur J Pharmacol 438 (2002) 183-188
23. Livingston M., Heaney L.G., and Ennis M. Adenosine, inflammation and asthma - a review. Inflamm Res 53 (2004) 171-178
24. Haynes Jr. J., Obiako B., Thompson W.J., and Downey J. Adenosine-induced vasodilation: receptor characterisation in pulmonary circulation. Am J Physiol 268 (1995) H1862-H1868
25. Wardlaw A.J., Dunnette S., Gleich G.J., Collins J.V., and Kay A.B. Eosinophils and mast cells in bronchoalveolar lavage fluid in subjects with mild asthma. Relationship to bronchial hyperreactivity. Am Rev Respir Dis 137 (1988) 62-69
26. Rosewich M., Rose M.A., Eickmeier O., Travaci M., Kitz R., and Zielen S. Montelukast as an add-on therapy to β-agonists and late airway response. Eur Resp J 30 (2007) 56-61
27. 2B adenosine receptor antagonist on adenosine agonist AMP and allergen-induced airway responsiveness and cellular influx in a mouse model of asthma. J Pharmacol Exp Ther 320 (2007) 1246-1251
28. Rafferty P., Beasley R., and Holgate S.T. The contribution of histamine to immediate bronchoconstriction provoked by inhaled allergen and adenosine 5′-monophosphate in atopic asthma. Am Rev Respir Dis 136 (1987) 369-373
29. 2B receptors. Pharmacol Rev 49 (1997) 381-402
30. 2B adenosine receptor. J Exp Med 204 (2007) 117-128
31. 3 receptors promote degranulation of rat mast cells both in vitro and in vivo. Inflamm Res 46 (1997) 180-184
32. Thorne J.R., Danahay H., and Broadley K.J. Analysis of the bronchoconstrictor responses to adenosine receptor agonists in sensitized guinea pig lungs and trachea. Eur J Pharmacol 316 (1996) 263-271
33. Martin T.J., and Broadley K.J. Contractile responses to adenosine, R-PIA and ovalbumin in passively sensitized guinea-pig isolated airways. Br J Pharmacol 137 (2002) 729-738
34. Zhong H., Chunn J.L., Volmer J.B., Fozard J.R., and Blackburn M.R. Adenosine-mediated mast cell degranulation in adenosine deaminase deficient mice. J Pharmacol Exp Ther 298 (2001) 433-440
35. 3 receptor expression and function in eosinophils. Am J Respir Cell Mol Biol 16 (1997) 531-537
36. Jordan J.E., Thourani V.H., Auchampach J.A., Robinson J.A., Wang N.P., and Vinten-Johansen J. A(3) adensoine receptor activation attenuates neutrophil function and neutrophil-mediated reperfusion injury. Am J Physiol 277 (1999) H1895-H1905
37. Fozard J.R., and Hannon J.P. Adenosine receptor ligands: potential as therapeutic agents in asthma and COPD. Pulm Pharmacol Therap 12 (1999) 111-114
38. 1 receptor in bronchial biopsy specimens from asthmatic subjects. Eur Respir J 31 (2008) 311-319
39. Farmer S.G., Canning B.J., and Wilkins D.E. Adenosine receptor mediated contraction and relaxation of guinea pig isolated tracheal smooth muscle: effects of adenosine antagonists. Br J Pharmacol 95 (1988) 371-378
40. Keir S., Boswell-Smith V., Spina D., and Page C. Mechanism of adenosine-induced airways obstruction in allergic guinea pigs. Br J Pharmacol 147 (2006) 720-728
41. 1 receptors-dependent mechanism. J Appl Physiol 105 (2008) 187-196
42. Church M.K., and Holgate S.T. Adenosine-induced bronchoconstriction and its inhibition by nedocromil sodium. J Allergy Clin Immunol 92 (1993) 190-194
43. 1 adenosine receptors and neural pathways in adenosine-induced bronchoconstriction in mice. Am J Physiol Lung Cell Mol Physiol 293 (2007) L25-L32
44. British Thoracic Society. Scottish intercollegiate guidelines network. British guidelines on asthma management. Thorax 53 (2003) I1-I94
45. Global Initiative for Asthma. Global strategy for asthma management and prevention (1995), National Heart, Lung and Blood Institute, USA
46. Barnes P.J. The mode of action of corticosteroids in asthma. Res Immunol 149 (1998) 225-226
47. 3 receptor-mediated hypotension and mast cell degranulation in the rat by dexamethasone. J Pharmacol Exp Ther 302 (2002) 725-730
48. Fan M., Qin W., and Mustafa S.J. Characterization of adenosine receptors(s) involved in adenosine-induced bronchoconstriction in an allergic mouse model. Am J Physiol Lung Cell Mol Physiol 284 (2003) L1012-L1019
49. 3 antagonist does not attenuate AMP challenge in subjects with asthma. Am J Respir Crit Care Med 175 (2007) A682