Mechanism of adenosine-induced airways obstruction in allergic guinea pigs

British Journal of Pharmacology

Volumn 147, Issue 7, 2006, Pages 720-728

  Keir, Sandra ^a   Boswell Smith, Victoria ^a   Spina, Domenico ^a   Page, Clive ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

Adenosine 5 monophosphate; Airway; Capsaicin; N 6 cyclopentyladenosine; Passive sensitisation; Sensory nerves; Vagotomy

Indexed keywords

2 [4 (2 CARBOXYETHYL)PHENETHYLAMINO]ADENOSINE 5' (N ETHYLCARBOXAMIDE); 6 N (3 IODOBENZYL)ADENOSINE 5' N METHYLCARBOXAMIDE; 8 CYCLOPENTYL 1,3 DIPROPYLXANTHINE; ADENOSINE; ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE A2A RECEPTOR AGONIST; ADENOSINE A3 RECEPTOR AGONIST; ADENOSINE PHOSPHATE; ADENOSINE RECEPTOR STIMULATING AGENT; ATROPINE; CAPSAICIN; HISTAMINE; HISTAMINE H1 RECEPTOR ANTAGONIST; MEPYRAMINE; METHACHOLINE; N 6 CYCLOPENTYLADENOSINE; OVALBUMIN; UNCLASSIFIED DRUG;

AGONIST; AIRWAY OBSTRUCTION; ALLERGIC REACTION; ALLERGY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BRONCHOSPASM; BRONCHUS HYPERREACTIVITY; CHRONIC DRUG ADMINISTRATION; CONTROLLED STUDY; DRUG MECHANISM; DRUG SENSITIZATION; GUINEA PIG; HISTAMINE RELEASE; LUNG LAVAGE; LUNG RESISTANCE; MALE; MAST CELL; NONHUMAN; PRIORITY JOURNAL; SPECIES COMPARISON; VAGOTOMY;

ADENOSINE; AIRWAY OBSTRUCTION; AIRWAY RESISTANCE; ANESTHESIA; ANIMALS; BRONCHOALVEOLAR LAVAGE FLUID; CAPSAICIN; CYCLIC AMP; GUINEA PIGS; HISTAMINE H1 ANTAGONISTS; LUNG; MALE; NEURAL PATHWAYS; OVALBUMIN; PYRILAMINE; RECEPTOR, ADENOSINE A1; RECEPTOR, ADENOSINE A2A; RESPIRATORY FUNCTION TESTS; RESPIRATORY HYPERSENSITIVITY; VAGOTOMY; XANTHINES;

EID: 33645534129     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1038/sj.bjp.0706663     Document Type: Article

References (47)

1. BJORCK, T., GUSTAFSSON, L.E. & DAHLEN, S.E. (1992). Isolated bronchi from asthmatics are hyperresponsive to adenosine, which apparently acts indirectly by liberation of leukotrienes and histamine. Am. Rev. Respir. Dis., 145, 1087-1091.
2. BROWN, R.A., CLARKE, G.W.H.M.J., DENYER, J.C., SAVAGE, T.J., RATOFF, J.C., LEDBETTER, C.L., MURDOCH, R.H., O'CONNOR, B.J., PAGE, C.P. & SPINA, D. (2005). Immunolocalisation of adenosine A1 receptors in asthmatic bronchial biopsy sections. Am. J. Respir Crit. Care Med., 171, A805.
3. BURKI, N.K., DALE, W.J. & LEE, L.Y. (2005). Intravenous adenosine and dyspnea in humans. J. Appl. Physiol., 98, 180-185.
4. CHUAYCHOO, B., MACGLASHAN, D.W., LEE, M.-G. & UNDEM, B.J. (2005). Effect of adensoine on subtypes of vagal afferent nerves. Am. J. Respir Crit. Care Med., 170, A831.
5. CLARKE, H., CUSHLEY, M.J., PERSSON, C.G. & HOLGATE, S.T. (1989). The protective effects of intravenous theophylline and enprofylline against histamine- and adenosine 5′-monophosphate-provoked bronchoconstriction: implications for the mechanisms of action of xanthine derivatives in asthma. Pulm. Pharmacol., 2, 147-154.
6. CLARKE, P.S., JARRETT, R.G. & HALL, G.J. (1982). The protective effect of ipratropium bromide aerosol against bronchospasm induced by hyperventilation and the inhalation of allergen, methacholine and histamine. Ann. Allergy, 48, 180-183.
7. COCKCROFT, D.W., MURDOCK, K.Y., GORE, B.P., O'BYRNE, P.M. & MANNING, P. (1989). Theophylline does not inhibit allergen-induced increase in airway responsiveness to methacholine. J. Allergy Clin. Immunol., 83, 913-920.
8. CRUMMY, F., LIVINGSTON, M., ENNIS, M. & HEANEY, L.G. (2004). Mast cell mediator release in nonasthmatic subjects after endobronchial adenosine challenge. J. Allergy Clin. Immunol., 114, 34-39.
9. CUSHLEY, M.J., TATTERSFIELD, A.E. & HOLGATE, S.T. (1983). Inhaled adenosine and guanosine on airway resistance in normal and asthmatic subjects. Br. J. Clin. Pharmacol., 15, 161-165.
10. DAFFONCHIO, L., LEES, I.W., PAYNE, A.N. & WHITTLE, B.J. (1987). Pharmacological modulation of bronchial anaphylaxis induced by aerosol challenge in anaesthetized guinea-pigs. Br. J. Pharmacol., 91, 701-708.
11. EL-HASHIM, A., D'AGOSTINO, B., MATERA, M.G. & PAGE, C.P. (1996). Characterization of adenosine receptors involved in adenosine-induced bronchoconstriction in allergic rabbits. Br. J. Pharmacol., 119, 1262-1268.
12. FAN, M. & MUSTAFA, S.J. (2002). Adenosine-mediated bronchoconstriction and lung inflammation in an allergic mouse model. Pulm. Pharmacol. Ther., 15, 147-155.
13. FEOKTISTOV, I. & BIAGGIONI, I. (1995). Adenosine A2b receptors evoke interleukin-8 secretion in human mast cells. An enprofylline-sensitive mechanism with implications for asthma. J. Clin. Invest., 96, 1979-1986.
14. FOZARD, J.R. & HANNON, J.P. (2000). Species differences in adenosine receptor-mediated bronchoconstrictor responses. Clin. Exp. Allergy, 30, 1213-1220.
15. HANNON, J.P., TIGANI, B., WILLIAMS, I., MAZZONI, L. & FOZARD, J.R. (2001). Mechanism of airway hyperresponsiveness to adenosine induced by allergen challenge in actively sensitized Brown Norway rats. Br. J. Pharmacol., 132, 1509-1523.
16. HOLGATE, S.T. (2005). The quintiles prize lecture 2004: the identification of the adenosine A(2B) receptor as a novel therapeutic target in asthma. Br. J. Pharmacol., 145, 1009-1015.
17. 1 receptors. J. Physiol., 508, 109-118.
18. HOSHIKO, K. & MORLEY, J. (1993). Allergic bronchospasm and airway hyperreactivity in the guinea pig. Jpn. J. Pharmacol, 63, 151-157.
19. HOWARTH, P.H., DURHAM, S.R., LEE, T.H., KAY, A.B., CHURCH, M.K. & HOLGATE, S.T. (1985). Influence of albuterol, cromolyn sodium and ipratropium bromide on the airway and circulating mediator responses to allergen bronchial provocation in asthma. Am. Rev. Respir Dis., 132, 986-992.
20. INGENITO, E.P., PLISS, L.B., MARTINS, M.A. & INGRAM JR., R.H. (1991). Effects of capsaicin on mechanical, cellular, and mediator responses to antigen in sensitized guinea pigs. Am. Rev. Respir. Dis., 143, 572-577.
21. JAFFAR, Z.H., SULLIVAN, P., PAGE, C. & COSTELLO, J. (1996). Low-dose theophylline modulates T-lymphocyte activation in allergen-challenged asthmatics. Eur. Respir. J., 9, 456-462.
22. KALLOS, P. & KALLOS, L. (1984). Experimental asthma in guinea pigs revisited. Int. Arch. Allergy Appl. Immunol., 73, 77-85.
23. KEIR, S., PAGE, C. & SPINA, D. (2002). Bronchial hyperresponsiveness induced by chronic treatment with albuterol: role of sensory nerves. J. Allergy Clin. Immunol., 110, 388-394.
24. KIM, S.A., MARSHALL, M.A., MELMAN, N., KIM, H.S., MULLER, C.E., LINDEN, J. & JACOBSON, K.A. (2002). Structure-activity relationships at human and rat A2B adenosine receptors of xanthine derivatives substituted at the 1-, 3-, 7-, and 8-positions. J. Med. Chem., 45, 2131-2138.
25. MARTIN, T.J. & BROADLEY, K.J. (2002). Mediators of adenosine- and ovalbumin-induced bronchoconstriction of sensitized guinea-pig isolated airways. Eur. J. Pharmacol., 451, 89-99.
26. MCNAMARA, N., GALLUP, M., KHONG, A., SUCHER, A., MALTSEVA, I., FAHY, J. & BASBAUM, C. (2004). Adenosine up-regulation of the mucin gene, MUC2, in asthma. FASEB J., 18, 1770-1772.
27. MEADE, C.J., DUMONT, I. & WORRALL, L. (2001). Why do asthmatic subjects respond so strongly to inhaled adenosine? Life Sci., 69, 1225-1240.
28. MILLS, J.E. & WIDDICOMBE, J.G. (1970). Role of the vagus nerves in anaphylaxis and histamine-induced bronchoconstrictions in guinea-pigs. Br. J. Pharmacol., 39, 724-731.
29. MYERS, A.C. & UNDEM, B.J. (1995). Antigen depolarizes guinea pig bronchial parasympathetic ganglion neurons by activation of histamine H1 receptors. Am. J. Physiol., 268, L879-L884.
30. O'CONNOR, B.J., CROWTHER, S.D., COSTELLO, J.F. & MORLEY, J. (1999). Selective airway responsiveness in asthma. Trends Pharmacol. Sci., 20, 9-11.
31. PAUWELS, R., VAN, R.D., VAN DER, S.M., JOHANNESSON, N. & PERSSON, C.G. (1985). The effect of theophylline and enprofylline on allergen-induced bronchoconstriction. J. Allergy Clin. Immunol., 76, 583-590.
32. PEACHELL, P.T., LICHTENSTEIN, L.M. & SCHLEIMER, R.P. (1989). Inhibition by adenosine of histamine and leukotriene release from human basophils. Biochem. Pharmacol., 38, 1717-1725.
33. POLOSA, R., CIAMARRA, I., MANGANO, G., PROSPERINI, G., PISTORIO, M.P., VANCHERI, C. & CRIMI, N. (2000). Bronchial hyperresponsiveness and airway inflammation markers in nonasthmatics with allergic rhinitis. Eur. Respir. J., 15, 30-35.
34. POLOSA, R., NG, W.H., CRIMI, N., VANCHERI, C., HOLGATE, S.T., CHURCH, M.K. & MISTRETTA, A. (1995). Release of mast-cell derived mediators after endobronchial adenosine challenge in asthma. Am. J. Respir. Crit. Care Med., 151, 624-629.
35. RAFFERTY, P., BEASLEY, R., SOUTHGATE, P. & HOLGATE, S. (1987). The role of histamine in allergen and adenosine-induced bronchoconstriction. Int. Arch. Allergy Appl. Immunol., 82, 292-294.
36. REYNOLDS, S.M., SPINA, D. & PAGE, C.P. (2004). Adenosine stimulates reflex cholinergic mediated contraction of tracheal smooth muscle in situ in normal and passively immunized guinea-pigs. Am. J. Respir. Crit. Care Med., 169, A181.
37. RICCIO, M.M., MYERS, A.C. & UNDEM, B.J. (1996). Immunomodulation of afferent neurones in guinea-pig isolated airways. J. Physiol., 491, 499-509.
38. RICHARDS, I.M., EADY, R.P., JACKSON, D.M., ORR, T.S., PRITCHARD, D.I., VENDY, K. & WELLS, E. (1983). Ascaris-induced bronchoconstriction in primates experimentally infected with Ascaris suum ova. Clin. Exp. Immunol., 54, 461-468.
39. SPINA, D. & PAGE, C.P. (2002). Asthma - a need for a rethink? Trends Pharmacol. Sci., 23, 311-315.
40. SPRUNTULIS, L.M. & BROADLEY, K.J. (2001). A3 receptors mediate rapid inflammatory cell influx into the lungs of sensitized guinea-pigs. Clin. Exp. Allergy, 31, 943-951.
41. TAKAHASHI, Y., MIZUNO, H., OHNO, H. & MISAWA, M. (1997). Neural reflex-mediated tracheal response during bronchoconstriction induced by ovalbumin antigen in guinea pigs. Gen. Pharmacol., 28, 399-404.
42. THORNE, J.R. & BROADLEY, K.J. (1992). Adenosine-induced bronchoconstriction of isolated lung and trachea from sensitized guinea-pigs. Br. J. Pharmacol., 106, 978-985.
43. THORNE, J.R. & BROADLEY, K.J. (1994). Adenosine-induced bronchoconstriction in conscious hyperresponsive and sensitized guinea pigs. Am. J. Respir. Crit. Care Med., 149, 392-399.
44. THORNE, J.R., DANAHAY, H. & BROADLEY, K.J. (1996). Analysis of the bronchoconstrictor responses to adenosine receptor agonists in sensitized guinea-pig lungs and trachea. Eur. J. Pharmacol., 316, 263-271.
45. VAN SCHOOR, J., JOOS, G.F. & PAUWELS, R.A. (2000). Indirect bronchial hyperresponsiveness in asthma: mechanisms, pharmacology and implications for clinical research. Eur. Respir. J., 16, 514-533.
46. WOOLCOCK, A.J., SALOME, C.M. & YAN, K. (1984). The shape of the dose-response curve to histamine in asthmatic and normal subjects. Am. Rev. Respir. Dis., 130, 71-75.
47. WYSS, D., BONNEAU, O. & TRIFILIEFF, A. (2005). Mast cell involvement in the adenosine mediated airway hyper-reactivity in a murine model of ovalbumin-induced lung inflammation. Br. J. Pharmacol., 145, 845-852.