Influence of ibuprofen on bone healing around dental implants: A randomised double-blind placebo-controlled clinical study

European Journal of Oral Implantology

Volumn 2, Issue 3, 2009, Pages 185-199

  Alissa, Rami ^a   Sakka, Salah ^b   Oliver, Richard ^a   Horner, Keith ^a   Esposito, Marco ^a,c   Worthington, Helen V ^a   Coulthard, Paul ^a  

^a UNIVERSITY OF MANCHESTER   (United Kingdom)

^b University of Al Baath   (Syrian Arab Republic)

^c UNIVERSITY OF GOTHENBURG   (Sweden)

Author keywords

Dental implants; Ibuprofen; Marginal bone; Periapical radiograph; Placebo

Indexed keywords

IBUPROFEN; NONSTEROID ANTIINFLAMMATORY AGENT;

ADOLESCENT; ADULT; AGED; ALVEOLAR BONE LOSS; ARTICLE; BONE REGENERATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECT; FEMALE; HUMAN; MALE; METHODOLOGY; MIDDLE AGED; NONPARAMETRIC TEST; RADIOGRAPHY; RANDOMIZED CONTROLLED TRIAL; STATISTICAL MODEL; TOOTH IMPLANTATION; WOUND HEALING;

ADOLESCENT; ADULT; AGED; AGED, 80 AND OVER; ALVEOLAR BONE LOSS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; DENTAL IMPLANTATION, ENDOSSEOUS; DENTAL IMPLANTS; DOUBLE-BLIND METHOD; FEMALE; HUMANS; IBUPROFEN; LINEAR MODELS; MALE; MIDDLE AGED; OSSEOINTEGRATION; STATISTICS, NONPARAMETRIC; WOUND HEALING; YOUNG ADULT;

EID: 77953095604     PISSN: 17562406     EISSN: 17562414     Source Type: Journal    
DOI: None     Document Type: Article

References (72)

1. Henry PJ. Oral implant restoration for enhanced oral function. Clin Exp Pharmacol Physiol 2005;32:123-127
2. Davis BK. Dental aesthetics and the aging patient. Facial Plast Surg 2006;22:154-160
3. Newman MG. The single-tooth implant as a standard of care. Int J Oral Maxillofac Implants 1999;14:621-622
4. Feine JS, Carlsson GE, Awad MA, Chehade A, Duncan WJ, Gizani S et al. The McGill consensus statement on overdentures. Mandibular two-implant overdentures as first choice standard of care for edentulous patients. Gerodontology 2002;19:3-4
5. Engquist B, Astrand P, Dahlgren S, Engquist E, Feldmann H, Grondahl K. Marginal bone reaction to oral implants: a prospective comparative study of Astra Tech and Branemark System implants. Clin Oral Implants Res 2002;13:30-37
6. Branemark PI. Osseointegration and its experimental background. J Prosthet Dent 1983;50:399-410
7. Kalyvas DG, Tarenidou M. Influence of nonsteroidal antiinflammatory drugs on osseointegration. J Oral Sci 2008;50:239-246
8. Celotti F, Laufer S. Anti-inflammatory drugs: new multitarget compounds to face an old problem. The dual inhibition concept. Pharmacol Res 2001;43:429-436
9. Ferreira SH. Peripheral analgesic sites of action of anti-inflammatory drugs. Int J Clin Pract 2002;128:2-10
10. Ong CK, Seymour RA. An evidence-based update of the use of analgesics in dentistry. Periodontol 2000 2008;46:143-164
11. Jeffcoat MK, Williams RC, Reddy MS, English R, Goldhaber P. Flurbiprofen treatment of human periodontitis: effect on alveolar bone height and metabolism. J Periodontal Res 1988;23:381-385
12. Williams RC, Jeffcoat MK, Howell TH, Rolla A, Stubbs D, Teoh KW et al. Altering the progression of human alveolar bone loss with the non-steroidal anti-inflammatory drug flurbiprofen. J Periodontol 1989;60:485-490
13. Jeffcoat MK, Page R, Reddy M, Wannawisute A, Waite P, Palcanis K et al. Use of digital radiography to demonstrate the potential of naproxen as an adjunct in the treatment of rapidly progressive periodontitis. J Periodontal Res 1991;26: 415-421
14. Reddy MS, Palcanis KG, Barnett ML, Haigh S, Charles CH, Jeffcoat MK. Efficacy of meclofenamate sodium (Meclomen) in the treatment of rapidly progressive periodontitis. J Clin Periodontol 1993;20:635-640
15. Jeffcoat MK, Reddy MS, Wang IC, Meuninghoff LA, Farmer JB, Koth DL. The effect of systemic flurbiprofen on bone supporting dental implants. J Am Dent Assoc 1995;126:305-311
16. Gerstenfeld LC, Thiede M, Seibert K, Mielke C, Phippard D, Svagr B et al. Differential inhibition of fracture healing by nonselective and cyclooxygenase-2 selective non-steroidal antiinflammatory drugs. J Orthop Res 2003;21:670-675
17. Beck A, Krischak G, Sorg T, Augat P, Farker K, Merkel U et al. Influence of diclofenac (group of nonsteroidal anti-inflammatory drugs) on fracture healing. Arch Orthop Trauma Surg 2003;123:327-332
18. Keller JC, Trancik TM, Young FA, St Mary E. Effects of indomethacin on bone ingrowth. J Orthop Res 1989;7:28-34
19. Trancik T, Mills W, Vinson N. The effect of indomethacin, aspirin, and ibuprofen on bone ingrowth into a porous-coated implant. Clin Orthop Relat Res 1989;249:113-121
20. Saudan M, Saudan P, Perneger T, Riand N, Keller A, Hoffmeyer P. Celecoxib versus ibuprofen in the prevention of heterotopic ossification following total hip replacement: a prospective randomised trial. J Bone Joint Surg 2007;89:155-159
21. Bek D, Beksac B, Della Valle AG, Sculco TP, Salvati EA. Aspirin decreases the prevalence and severity of heterotopic ossification after 1-stage bilateral total hip arthroplasty for osteoarthrosis. J Arthroplasty 2009;24:226-232
22. Stoltny T, Koczy B, Wawrzynek W, Miszczyk L. Heterotopic ossification in patients after total hip replacement. Ortop Traumatol Rehabil 2007;9:264-272
23. Reddy MS, Jeffcoat MK, Richardson RC. Assessment of adjunctive flurbiprofen therapy in root-form implant healing with digital subtraction radiography. J Oral Implantol 1990;16:272-276
24. Jeffcoat MK, Reddy MS, Haigh S, Buchanan W, Doyle MJ, Meredith MP et al. A comparison of topical ketorolac, systemic flurbiprofen, and placebo for the inhibition of bone loss in adult periodontitis. J Periodontol 1995;66:329-338
25. National Radiological Protection Board. Guidance notes for dental practitioners on the safe use of X-ray equipment. NRPB, Department of Health, Chilton, UK:NRPB, 2001
26. Wennstrom JL, Ekestubbe A, Grondahl K, Karlsson S, Lindhe J. Implant-supported single-tooth restorations: a 5-year prospective study. J Clin Periodontol 2005;32:567-574
27. Reddy MS, Wang IC. Radiographic determinants of implant performance. Adv Dent Res 1999;13:136-145
28. Wakoh M, Harada T, Otonari T, Otonari-Yamamoto M, Ohkubo M, Kousuge Y et al. Reliability of linear distance measurement for dental implant length with standardized periapical radiographs. Bull Tokyo Dent Coll 2006;47: 105-115
29. Ostman PO, Hellman M, Albrektsson T, Sennerby L. Direct loading of Nobel Direct and Nobel Perfect one-piece implants: a 1-year prospective clinical and radiographic study. Clin Oral Implants Res 2007;18:409-418
30. Mangano C, Mangano F, Piattelli A, Iezzi G, Mangano A, La Colla L. Prospective clinical evaluation of 1920 Morse taper connection implants: results after 4 years of functional loading. Clin Oral Implants Res 2009;20:254-261
31. Sakka S, Al-ani Z, Kasioumis T, Worthington H, Coulthard P. Inter-examiner and intra-examiner reliability of the measurement of marginal bone loss around oral implants. Implant Dent 2005;14:386-388
32. Blance A, Tu YK, Baelum V, Gilthorpe MS. Statistical issues on the analysis of change in follow-up studies in dental research. Community Dent Oral Epidemiol 2007;35:412-420
33. Jeffcoat MK, Reddy MS, Moreland LW, Koopman WJ. Effects of nonsteroidal antiinflammatory drugs on bone loss in chronic inflammatory disease. Ann N Y Acad Sci 1993; 30:292-302
34. Weber HP, Buser D, Fiorellini JP, Williams RC. Radiographic evaluation of crestal bone levels adjacent to nonsubmerged titanium implants. Clin Oral Implants Res 1992;3:181-188
35. Bittar-Cortez JA, Passeri LA, de Almeida SM, Haiter-Neto F. Comparison of peri-implant bone level assessment in digitized conventional radiographs and digital subtraction images. Dentomaxillofac Radiol 2006;35:258-262
36. Jemt T. Implant treatment in elderly patients. Int J Prosthodont 1993;6:456-461
37. Zarb GA, Schmitt A. Osseointegration for elderly patients: the Toronto study. J Prosthet Dent 1994;72:559-568
38. Cordioli G, Majzoub Z, Castagna S. Mandibular overdentures anchored to single implants: a five-year prospective study. J Prosthet Dent 1997;78:159-165
39. Montes CC, Pereira FA, Thome G, Alves ED, Acedo RV, de Souza JR et al. Failing factors associated with osseointegrated dental implant loss. Implant Dent 2007;16:404-412
40. Ahlqvist J, Borg K, Gunne J, Nilson H, Olsson M, Astrand P. Osseointegrated implants in edentulous jaws: a 2-year longitudinal study. Int J Oral Maxillofac Implants 1990;5: 155-163
41. Strietzel FP, Lange KP, Svegar M, Hartmann HJ, Kuchler I. Retrospective evaluation of the success of oral rehabilitation using the Frialit-2 implant system. Part 1: Influence of topographic and surgical parameters. Int J Prosthodont 2004; 17:187-194
42. Attard NJ, Zarb GA. Long-term treatment outcomes in edentulous patients with implant overdentures: the Toronto study. Int J Prosthodont 2004;17:425-433
43. Garnero P, Sornay-Rendu E, Delmas PD. Decreased bone turnover in oral contraceptive users. Bone 1995;16:499-503
44. Gorai I, Chaki O, Nakayama M, Minaguchi H. Urinary biochemical markers for bone resorption during the menstrual cycle. Calcif Tissue Int 1995;57:100-104
45. Ebeling PR, Atley LM, Guthrie JR, Burger HG, Dennerstein L, Hopper JL et al. Bone turnover markers and bone density across the menopausal transition. J Clin Endocrinol Metab 1996;81:3366-3371
46. Fiorellini JP, Chen PK, Nevins M, Nevins ML. A retrospective study of dental implants in diabetic patients. Int J Periodontics Restorative Dent 2000;20:366-373
47. Van Steenberghe D, Quirynen M, Naert I, Maffei G, Jacobs R. Marginal bone loss around implants retaining hinging mandibular overdentures, at 4-, 8-and 12-years follow-up. J Clin Periodontol 2001;28:628-633
48. Beikler T, Flemmig TF. Implants in the medically compromised patient. Crit Rev Oral Biol Med 2003;14:305-316
49. Park H S, Lee YJ, Jeong S H, Kwon TG. Density of the alveolar and basal bones of the maxilla and the mandible. Am J Orthod Dentofacial Orthop 2008;133:30-37
50. Devlin H, Horner K, Ledgerton D. A comparison of maxillary and mandibular bone mineral densities. J Prosthet Dent 1998;79:323-327
51. Adell R, Lekholm U, Rockler B, Branemark PI. A 15-year study of osseointegrated implants in the treatment of the edentulous jaw. Int J Oral Surg 1981;10:387-416
52. Friberg B, Jemt T, Lekholm U. Early failures in 4,641 consecutively placed Branemark dental implants: a study from stage 1 surgery to the connection of completed prostheses. Int J Oral Maxillofac Implants 1991;6:142-146
53. Carlsson GE, Lindquist LW, Jemt T. Long-term marginal periimplant bone loss in edentulous patients. Int J Prosthodont 2000;13;295-302
54. Tawil G, Mawla M, Gottlow J. Clinical and radiographic evaluation of the 5-mm diameter regular-platform Branemark fixture: 2-to 5-year follow-up. Clin Implant Dent Relat Res 2002;4:16-26
55. Kumar A, Jaffin RA, Berman C. The effect of smoking on achieving osseointegration of surface-modified implants: a clinical report. Int J Oral Maxillofac Implants 2002;17:816-819
56. Penarrocha M, Palomar M, Sanchis JM, Guarinos J, Balaguer J. Radiologic study of marginal bone loss around 108 dental implants and its relationship to smoking, implant location, and morphology. Int J Oral Maxillofac Implants 2004;19:861-867
57. Albrektsson T, Zarb G, Worthington P, Eriksson AR. The longterm efficacy of currently used dental implants: a review and proposed criteria of success. Int J Oral Maxillofac Implants 1986;1:11-25
58. Smith DE, Zarb GA. Criteria for success of osseointegrated endosseous implants. J Prosthet Dent 1989;62:567-572
59. Gomez-Roman G. Influence of flap design on peri-implant interproximal crestal bone loss around single-tooth implants. Int J Oral Maxillofac Implants 2001;16:61-67
60. Broggini N, McManus LM, Hermann JS, Medina R, Schenk RK, Buser D et al. Peri-implant inflammation defined by the implant-abutment interface. J Dent Res 2006;85:473-478
61. Isidor F. Influence of forces on peri-implant bone. Clin Oral Implants Res 2006;17:8-18
62. Kemppainen P, Eskola S, Ylipaavalniemi P. A comparative prospective clinical study of two single-tooth implants: a preliminary report of 102 implants. J Prosthet Dent 1997;77: 382-387
63. Steveling H, Roos J, Rasmusson L. Maxillary implants loaded at 3 months after insertion: results with Astra Tech implants after up to 5 years. Clin Implant Dent Relat Res 2001;3: 120-124
64. Rainsford KD. Anti-inflammatory drugs in the 21st century. Subcell Biochem 2007;42:3-27
65. Warner TD, Mitchell JA. Cyclooxygenases: new forms, new inhibitors, and lessons from the clinic. Faseb J 2004;18: 790-804
66. Kim DM, Koszeghy KL, Badovinac RL, Kawai T, Hosokawa I, Howell TH et al. The effect of aspirin on gingival crevicular fluid levels of inflammatory and anti-inflammatory mediators in patients with gingivitis. J Periodontol 2007;78: 1620-1626
67. 2 levels as a predictor of periodontal attachment loss. J Periodontal Res 1986;21:101-112
68. 2 production by osteoblast plays a critical role in lipopolysaccharide-induced bone loss associated with inflammation. J Immunol 2006;177:1879-1885
69. Pilbeam CC, Harrison JR, Raisz LG. Prostaglandins and bone metabolism. In: Bilezikian JP, Raisz LG, Rodan DA (eds). Principles of Bone Biology. San Diego, CA: Academic Press, 1996:715-728
70. 2 enhances alveolar bone formation in the rat mandible. Bone 2004;35:1361-1368
71. Stichtenoth DO, Tsikas D, Gutzki FM, Frolich JC. Effects of ketoprofen and ibuprofen on platelet aggregation and prostanoid formation in man. Eur J Clin Pharmacol 1996; 51:231-234
72. 2 synthesis and the degree and rate of orthodontic tooth movement. Angle Orthod 1996;66:339-349