Effects of ketoprofen and ibuprofen on platelet aggregation and prostanoid formation in man

European Journal of Clinical Pharmacology

Volumn 51, Issue 3-4, 1996, Pages 231-234

  Stichtenoth, D O ^a   Tsikas, D ^a   Gutzki, F M ^a   Frolich J C ^a  

^a HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

ibuprofen; cyclooxygenase; ketoprofen; PGE M; platelet aggregation; TXB2

Indexed keywords

IBUPROFEN; KETOPROFEN; PROSTAGLANDIN E2; PROSTANOID; THROMBOXANE B2;

ADULT; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; FEMALE; GAS CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; MASS SPECTROMETRY; NORMAL HUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; RANDOMIZED CONTROLLED TRIAL; THROMBOCYTE AGGREGATION; VOLUNTEER;

ADULT; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CROSS-OVER STUDIES; FEMALE; HUMANS; IBUPROFEN; KETOPROFEN; PLATELET AGGREGATION; PLATELET AGGREGATION INHIBITORS; PROSTAGLANDINS; THROMBOXANE B2;

EID: 0030472460     PISSN: 00316970     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002280050189     Document Type: Article

References (19)

1. Williams RL, Upton RA (1988) The clinical pharmacology of ketoprofen. J Clin Pharmacol 28:S13-S22
2. Davies EF, Avery GS (1971) Ibuprofen: a review of its pharmacological properties and therapeutic efficacy in rheumatic disorders. Drugs 2:416-446
3. Meade EA, Smith WL, DeWitt DL (1993) Differential inhibition of prostaglandin endoperoxide synthase (cyclooxygenase) isozymes by aspirin and other nonsteroidal anti-inflammatory drugs. J Biol Chem 268:6610-6614
4. Panara MR, Greco A, Santini G, et al (1995) Effects of the novel anti-inflammatory compounds, N-[2-(cyclohexyloxy)-4-nitrophenyl] methanesulphonamide (NS-398) and 5-methanesulphonamido-6-(2,4-difluorothiophenyl)-1-indanone (L-745 337), on the cyclo-oxygenase activity of human blood prostaglandin endoperoxide synthases. Br J Pharmacol 116:2429-2434
5. Funk CD, Funk LB, Kennedy ME, Pong AS, Fitzgerald GA (1991) Human platelet/erythroleukemia cell prostaglandin G/H synthase: cDNA cloning, expression, and gene chromosomal assignment. FASEB J 5:2304-2312
6. Seyberth HW, Sweetman BJ, Frölich JC, Oates JA (1976) Quantification of the major urinary metabolite of the E-prostaglandins by mass spectrometry: evaluation of the method's application to clinical studies. Prostaglandins 11:381-397
7. Ferretti A, Flanagan VP, Reeves VB (1987) Stable isotope dilution assay for prostaglandin E metabolite: 24-hour urinary output in healthy male subjects. Anal Biochem 167:174-180
8. Böger RH, Bode-Böger SM, Gutzki F-M, Tsikas D, Weskott H-P, Frölich JC (1993) Rapid and selective inhibition of platelet aggregation and thromboxane formation by intravenous low dose aspirin in man. Clin Sci 84:517-524
9. Born GVR, Cross MJ (1963) The aggregation of blood platelets. J Physiol 168:178-195
10. Fauler J, Tsikas D, Mayatepek E, Keppler D, Frölich JC (1994) Impaired degradation of prostaglandins and thromboxane in Zellweger syndrome. Pediatr Res 36:449-455
11. Cooper SA, Berrie R, Cohn P (1988) Comparison of ketoprofen, ibuprofen and placebo in a dental surgery pain model. Adv Ther 5:43-53
12. Arnold JD (1990) Ketoprofen, ibuprofen, and placebo in the relief of postoperative pain. Adv Ther 7:264-275
13. Robbins D, Taylor MAH, Brown MD, McIlwain H (1990) Ketoprofen versus ibuprofen for acute sports injuries: are there differences between nonsteroidal anti-inflammatory drugs? Curr Ther Res 48:780-789
14. O'Neill GP, Ford-Hutchinson AW (1993) Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues. FEBS Lett 330:156-160
15. Frölich JC (1995) Prostaglandin endoperoxide synthetase isoenzymes: the clinical relevance of selective inhibition. Ann Rheum Dis 54:942-943
16. Vane JR, Botting RM (1996) Overview - mechanisms of action of anti-inflammatory drugs. In: Vane J, Botting J, Botting R (eds) Improved non-steroid antiinflammatory drugs. Kluwer Academic Publishers and William Harvey Press, London, pp 1-27
17. Garcia Rodriguez LA, Jick H (1994) Risk of upper gastrointestinal bleeding and perforation associated with individual non-steroidal anti-inflammatory drugs. Lancet 343:769-772
18. Langman MJS, Weil J, Wainwright P, et al (1994) Risks of bleeding peptic ulcer associated with individual non-steroidal anti-inflammatory drugs. Lancet 343:1075-1078
19. Savage RL, Moller PW, Ballantyne CL, Wells JE (1993) Variation in the risk of peptic ulcer complications with non-steroidal antiinflammatory drug therapy. Arthritis Rheum 36:84-90