Differential inhibition of fracture healing by non-selective and cyclooxygenase-2 selective non-steroidal anti-inflammatory drugs

Journal of Orthopaedic Research

Volumn 21, Issue 4, 2003, Pages 670-675

  Gerstenfeld, Louis C ^a   Thiede, Mark ^b   Siebert, Karen ^b   Mielke, Cindy ^b   Phippard, Deborah ^b   Svagr, Bohus ^a   Cullinane, Dennis ^a   Einhorn, Thomas A ^a  

^a BOSTON UNIVERSITY MEDICAL CENTER   (United States)

^b PFIZER INC   (United States)

Author keywords

Cox enzymes; Fracture repair; NSAIDs

Indexed keywords

CATALYST ACTIVITY; DRUG PRODUCTS; ENZYMES; RNA; STIFFNESS; STRENGTH OF MATERIALS;

FRACTURE HEALING;

ORTHOPEDICS;

CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; KETOROLAC; MESSENGER RNA; NONSTEROID ANTIINFLAMMATORY AGENT; PARECOXIB; RNA; VALDECOXIB;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BIOMECHANICS; BONE STRENGTH; CALLUS; CARTILAGE; CONTROLLED STUDY; DOSE RESPONSE; DRUG MEGADOSE; DRUG SELECTIVITY; FEMUR FRACTURE; FRACTURE HEALING; FRACTURE NONUNION; HISTOPATHOLOGY; LOW DRUG DOSE; MALE; NONHUMAN; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; PROSTAGLANDIN SYNTHESIS; PROTEIN EXPRESSION; RAT STRAIN; RIGIDITY; STATISTICAL SIGNIFICANCE; TOXICITY TESTING;

EID: 0012429950     PISSN: 07360266     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0736-0266(03)00003-2     Document Type: Article

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