The effect of aspirin on gingival crevicular fluid levels of inflammatory and anti-inflammatory mediators in patients with gingivitis

Journal of Periodontology

Volumn 78, Issue 8, 2007, Pages 1620-1626

  Kim, David M ^a   Koszeghy, Kristian L ^a,b   Badovinac, Rachel L ^c   Kawai, Toshihisa ^a   Hosokawa, Ikuko ^a   Howell, T Howard ^a   Karimbux, Nadeem Y ^a  

^a HARVARD SCHOOL OF DENTAL MEDICINE   (United States)

^b The Forsyth Institute ^*

^c FORSYTH INSTITUTE   (United States)

Author keywords

Aspirin; Gingival crevicular fluid; Gingivitis

Indexed keywords

EID: 34548095611     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2007.070011     Document Type: Article

References (17)

1. American Academy of Periodontology. Modulation of the host response in periodontal therapy (position paper). J Periodontol 2002;73:460-470.
2. Salvi GE, Lang NP. Host response modulation in the management of periodontal disease. J Clin Periodontol 2005;32:108-129.
3. Feldman RS, Szeto B, Chauncey HH, Goldhaber P. Non-steroidal anti-inflammatory drugs in the reduction of human alveolar bone loss. J Clin Periodontol 1983; 10:131-136.
4. Williams RC, Jeffcoat MK, Howell TH, et al. Altering the progression of human alveolar bone loss with nonsteroidal anti-inflammatory drug flurbiprofen. J Periodontol 1989;60:485-490.
5. Jeffcoat MK, Page R, Reddy M, et al. Use of digital radiography to demonstrate the potential of naproxen as an adjunct in the treatment of rapidly progressive periodontitis. J Periodontal Res 1991;26:415-421.
6. Haffajee AD, Dibart S, Kent RL Jr., Socransky SS. Clinical and microbiological changes associated with the use of 4 adjunctive systemically administered agents in the treatment of periodontal infections. J Clin Periodontol 1995;22:618-627.
7. Jeffcoat MK, Reddy MS, Haigh S, et al. A comparison of topical ketorolac, systemic flurbiprofen, and placebo for the inhibition of bone loss in adult periodontitis. J Periodontol 1995;66:329-338.
8. Ng VW, Bissada NF. Clinical evaluation of systemic doxycycline and ibuprofen administration as an adjunctive treatment of adult periodontitis. J Periodontol 1998;69:772-776.
9. Drouganis A, Hirsch R. Low-dose aspirin therapy and periodontal attachment loss in ex- and non-smokers. J Clin Periodontol 2001;28:38-45.
10. Schrodi J, Recio L, Fiorellini J, Howell H, Goodson M, Karimbux N. The effect of aspirin on the periodontal parameter bleeding on probing. J Periodontol 2002; 73:871-876.
11. Royzman D, Recio L, Badovinac RL, et al. The effect of aspirin intake on bleeding on probing in patients with gingivitis. J Periodontol 2004;75:679-684.
12. Serhan CN. Lipoxins and aspirin-triggered 15-epi-lipoxins are the first lipid mediators of endogenous anti-inflammation and resolution. Prostaglandins Leukot Essent Fatty Acids 2005;73:141-162.
13. Chiang N, Hurwitz S, Ridker PM, Serhan CN. Aspirin has a gender-dependent impact on antiinflammatory 15-epi-lipoxin A4 formation: A randomized human trial. Arterioscler Thromb Vasc Biol 2006;26: e14-17.
14. Sodin-Semrl S, Taddeo B, Tseng D, Varga J, Fiore S. Lipoxin A4 inhibits IL-1 beta-induced IL-6, IL-8, and matrix metalloproteinase-3 production in human synovial fibroblasts and enhances synthesis of tissue inhibitors of metalloproteinases. J Immunol 2000;164: 2660-2666.
15. von der Weid PY, Hollenberg MD, Fiorucci S, Wallace JL. Aspirin-triggered, cyclooxygenase-2-dependent lipoxin synthesis modulates vascular tone. Circulation 2004; 110:1320-1325.
16. Love WD, Ramirez JM, Fultz RP. An oral hygiene measurement system for possible research and clinical use. J Public Health Dent 1975;35:227-230.
17. Goodson JM. Gingival crevice fluid flow. Periodontol 2000 2003;31:43-54.