메뉴 건너뛰기




Volumn 323, Issue 1, 2010, Pages 55-61

Cell therapy for diabetes: Stem cells, progenitors or beta-cell replication?

Author keywords

Beta cells; Cell therapy; Diabetes; Pancreatic precursor cells; Pancreatic stem cells

Indexed keywords

ADULT STEM CELL; B LYMPHOCYTE; BREAST EPITHELIUM; CELL DIFFERENTIATION; CELL DIVISION; CELL REGENERATION; CELL THERAPY; CELL TRANSPLANTATION; EMBRYO DEVELOPMENT; EMBRYONIC STEM CELL; EX VIVO STUDY; HUMAN; IN VITRO STUDY; IN VIVO STUDY; INSULIN DEPENDENT DIABETES MELLITUS; LEUKOCYTE DISORDER; NONHUMAN; PANCREAS ISLET BETA CELL; PANCREAS ISLET TRANSPLANTATION; PRIORITY JOURNAL; REVIEW; TISSUE ENGINEERING; XENOGRAFT;

EID: 77952884646     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mce.2009.12.014     Document Type: Review
Times cited : (17)

References (91)
  • 1
  • 5
    • 53549107175 scopus 로고    scopus 로고
    • Production of beta-cells from human embryonic stem cells
    • Baetge E.E. Production of beta-cells from human embryonic stem cells. Diabetes Obes. Metab. 2008, 10(Suppl. 4):186-194.
    • (2008) Diabetes Obes. Metab. , vol.10 , Issue.SUPPL. 4 , pp. 186-194
    • Baetge, E.E.1
  • 6
    • 23844541266 scopus 로고    scopus 로고
    • Glucagon-like peptide-1 enhances production of insulin in insulin-producing cells from mouse embryonic stem cells
    • Bai L., Meredith G., Tuch B.E. Glucagon-like peptide-1 enhances production of insulin in insulin-producing cells from mouse embryonic stem cells. J. Endocrinol. 2005, 186:343-352.
    • (2005) J. Endocrinol. , vol.186 , pp. 343-352
    • Bai, L.1    Meredith, G.2    Tuch, B.E.3
  • 7
    • 44649139159 scopus 로고    scopus 로고
    • Embryonic stem cells to beta-cells by understanding pancreas development
    • Best M., Carroll M., Hanley N.A., Piper Hanley K. Embryonic stem cells to beta-cells by understanding pancreas development. Mol. Cell Endocrinol. 2008, 288:86-94.
    • (2008) Mol. Cell Endocrinol. , vol.288 , pp. 86-94
    • Best, M.1    Carroll, M.2    Hanley, N.A.3    Piper Hanley, K.4
  • 8
    • 0033770540 scopus 로고    scopus 로고
    • Life and death of the pancreatic beta cells
    • Bonner-Weir S. Life and death of the pancreatic beta cells. Trends Endocrinol. Metab. 2000, 11:375-378.
    • (2000) Trends Endocrinol. Metab. , vol.11 , pp. 375-378
    • Bonner-Weir, S.1
  • 9
    • 0027449197 scopus 로고
    • A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development
    • Bonner-Weir S., Baxter L.A., Schuppin G.T., Smith F.E. A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development. Diabetes 1993, 42:1715-1720.
    • (1993) Diabetes , vol.42 , pp. 1715-1720
    • Bonner-Weir, S.1    Baxter, L.A.2    Schuppin, G.T.3    Smith, F.E.4
  • 12
    • 34250858628 scopus 로고    scopus 로고
    • All beta cells contribute equally to islet growth and maintenance
    • Brennand K., Huangfu D., Melton D. All beta cells contribute equally to islet growth and maintenance. PLoS Biol. 2007, 5:e163.
    • (2007) PLoS Biol. , vol.5
    • Brennand, K.1    Huangfu, D.2    Melton, D.3
  • 13
    • 33645514001 scopus 로고    scopus 로고
    • A side order of stem cells: the SP phenotype
    • Challen G.A., Little M.H. A side order of stem cells: the SP phenotype. Stem Cells 2006, 24:3-12.
    • (2006) Stem Cells , vol.24 , pp. 3-12
    • Challen, G.A.1    Little, M.H.2
  • 16
    • 0024458020 scopus 로고
    • Pancreatic beta cell proliferation in rabbits demonstrated by bromodeoxyuridine labeling
    • Davidson P.M., Campbell I.L., Oxbrow L., Hutson J.M., Harrison L.C. Pancreatic beta cell proliferation in rabbits demonstrated by bromodeoxyuridine labeling. Pancreas 1989, 4:594-600.
    • (1989) Pancreas , vol.4 , pp. 594-600
    • Davidson, P.M.1    Campbell, I.L.2    Oxbrow, L.3    Hutson, J.M.4    Harrison, L.C.5
  • 17
    • 36749056212 scopus 로고    scopus 로고
    • Formation and regeneration of the endocrine pancreas
    • Dhawan S., Georgia S., Bhushan A. Formation and regeneration of the endocrine pancreas. Curr. Opin. Cell Biol. 2007, 19:634-645.
    • (2007) Curr. Opin. Cell Biol. , vol.19 , pp. 634-645
    • Dhawan, S.1    Georgia, S.2    Bhushan, A.3
  • 18
    • 2342510386 scopus 로고    scopus 로고
    • Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation
    • Dor Y., Brown J., Martinez O.I., Melton D.A. Adult pancreatic beta-cells are formed by self-duplication rather than stem-cell differentiation. Nature 2004, 429:41-46.
    • (2004) Nature , vol.429 , pp. 41-46
    • Dor, Y.1    Brown, J.2    Martinez, O.I.3    Melton, D.A.4
  • 19
    • 0035433196 scopus 로고    scopus 로고
    • Complete protection of islets against allorejection and autoimmunity by a simple barium-alginate membrane
    • Duvivier-Kali V.F., Omer A., Parent R.J., O'Neil J.J., Weir G.C. Complete protection of islets against allorejection and autoimmunity by a simple barium-alginate membrane. Diabetes 2001, 50:1698-1705.
    • (2001) Diabetes , vol.50 , pp. 1698-1705
    • Duvivier-Kali, V.F.1    Omer, A.2    Parent, R.J.3    O'Neil, J.J.4    Weir, G.C.5
  • 20
    • 0022826388 scopus 로고
    • Time course and cellular source of pancreatic regeneration following acute pancreatitis in the rat
    • Elsasser H.P., Adler G., Kern H.F. Time course and cellular source of pancreatic regeneration following acute pancreatitis in the rat. Pancreas 1986, 1:421-429.
    • (1986) Pancreas , vol.1 , pp. 421-429
    • Elsasser, H.P.1    Adler, G.2    Kern, H.F.3
  • 21
    • 33750628012 scopus 로고    scopus 로고
    • Isolation and characterization of residual undifferentiated mouse embryonic stem cells from embryoid body cultures by fluorescence tracking
    • Ensenat-Waser R., Santana A., Vicente-Salar N., Cigudosa J.C., Roche E., Soria B., Reig J.A. Isolation and characterization of residual undifferentiated mouse embryonic stem cells from embryoid body cultures by fluorescence tracking. In Vitro Cell Dev. Biol. Anim. 2006, 42:115-123.
    • (2006) In Vitro Cell Dev. Biol. Anim. , vol.42 , pp. 115-123
    • Ensenat-Waser, R.1    Santana, A.2    Vicente-Salar, N.3    Cigudosa, J.C.4    Roche, E.5    Soria, B.6    Reig, J.A.7
  • 23
    • 0033045376 scopus 로고    scopus 로고
    • Prior streptozotocin treatment does not inhibit pancreas regeneration after 90% pancreatectomy in rats
    • Finegood D.T., Weir G.C., Bonner-Weir S. Prior streptozotocin treatment does not inhibit pancreas regeneration after 90% pancreatectomy in rats. Am. J. Physiol. 1999, 276:E822-R827.
    • (1999) Am. J. Physiol. , vol.276
    • Finegood, D.T.1    Weir, G.C.2    Bonner-Weir, S.3
  • 24
    • 0015804548 scopus 로고
    • Self-regulation of growth in three dimensions
    • Folkman J., Hochberg M. Self-regulation of growth in three dimensions. J. Exp. Med. 1973, 138:745-753.
    • (1973) J. Exp. Med. , vol.138 , pp. 745-753
    • Folkman, J.1    Hochberg, M.2
  • 25
    • 34250613861 scopus 로고    scopus 로고
    • Differentiation of transplanted microencapsulated fetal pancreatic cells
    • Foster J.L., Williams G., Williams L.J., Tuch B.E. Differentiation of transplanted microencapsulated fetal pancreatic cells. Transplantation 2007, 83:1440-1448.
    • (2007) Transplantation , vol.83 , pp. 1440-1448
    • Foster, J.L.1    Williams, G.2    Williams, L.J.3    Tuch, B.E.4
  • 26
    • 19544386310 scopus 로고    scopus 로고
    • Teratoma formation leads to failure of treatment for type I diabetes using embryonic stem cell-derived insulin-producing cells
    • Fujikawa T., Oh S.H., Pi L., Hatch H.M., Shupe T., Petersen B.E. Teratoma formation leads to failure of treatment for type I diabetes using embryonic stem cell-derived insulin-producing cells. Am. J. Pathol. 2005, 166:1781-1791.
    • (2005) Am. J. Pathol. , vol.166 , pp. 1781-1791
    • Fujikawa, T.1    Oh, S.H.2    Pi, L.3    Hatch, H.M.4    Shupe, T.5    Petersen, B.E.6
  • 27
    • 54749140900 scopus 로고    scopus 로고
    • Absence of transmission of potentially xenotic viruses in a prospective pig to primate islet xenotransplantation study
    • Garkavenko O., Dieckhoff B., Wynyard S., Denner J., Elliott R.B., Tan P.L., Croxson M.C. Absence of transmission of potentially xenotic viruses in a prospective pig to primate islet xenotransplantation study. J. Med. Virol. 2008, 80:2046-2052.
    • (2008) J. Med. Virol. , vol.80 , pp. 2046-2052
    • Garkavenko, O.1    Dieckhoff, B.2    Wynyard, S.3    Denner, J.4    Elliott, R.B.5    Tan, P.L.6    Croxson, M.C.7
  • 28
    • 76549198972 scopus 로고
    • Pathologic anatomy of the pancreas in juvenile diabetes mellitus
    • Gepts W. Pathologic anatomy of the pancreas in juvenile diabetes mellitus. Diabetes 1965, 14:619-633.
    • (1965) Diabetes , vol.14 , pp. 619-633
    • Gepts, W.1
  • 29
    • 0026518591 scopus 로고
    • Onset of cell-specific gene expression in the developing mouse pancreas
    • Gittes G.K., Rutter W.J. Onset of cell-specific gene expression in the developing mouse pancreas. Proc. Natl. Acad. Sci. U.S.A. 1992, 89:1128-1132.
    • (1992) Proc. Natl. Acad. Sci. U.S.A. , vol.89 , pp. 1128-1132
    • Gittes, G.K.1    Rutter, W.J.2
  • 31
    • 0034652287 scopus 로고    scopus 로고
    • Neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
    • Gradwohl G., Dierich A., LeMeur M., Guillemot F. neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:1607-1611.
    • (2000) Proc. Natl. Acad. Sci. U.S.A. , vol.97 , pp. 1607-1611
    • Gradwohl, G.1    Dierich, A.2    LeMeur, M.3    Guillemot, F.4
  • 32
    • 0030782731 scopus 로고    scopus 로고
    • Endocrine/exocrine intermediate cells in streptozotocin-treated Ins-IFN-gamma transgenic mice
    • Gu D., Arnush M., Sarvetnick N. Endocrine/exocrine intermediate cells in streptozotocin-treated Ins-IFN-gamma transgenic mice. Pancreas 1997, 15:246-250.
    • (1997) Pancreas , vol.15 , pp. 246-250
    • Gu, D.1    Arnush, M.2    Sarvetnick, N.3
  • 33
    • 0036340074 scopus 로고    scopus 로고
    • Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors
    • Gu G., Dubauskaite J., Melton D.A. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 2002, 129:2447-2457.
    • (2002) Development , vol.129 , pp. 2447-2457
    • Gu, G.1    Dubauskaite, J.2    Melton, D.A.3
  • 34
    • 14244266611 scopus 로고    scopus 로고
    • Minireview: transcriptional regulation in pancreatic development
    • Habener J.F., Kemp D.M., Thomas M.K. Minireview: transcriptional regulation in pancreatic development. Endocrinology 2005, 146:1025-1034.
    • (2005) Endocrinology , vol.146 , pp. 1025-1034
    • Habener, J.F.1    Kemp, D.M.2    Thomas, M.K.3
  • 35
    • 10744233137 scopus 로고    scopus 로고
    • Benefits and risks of solitary islet transplantation for type 1 diabetes using steroid-sparing immunosuppression: the National Institutes of Health experience
    • Hirshberg B., Rother K.I., Digon B.J., Lee J., Gaglia J.L., Hines K., Read E.J., Chang R., Wood B.J., Harlan D.M. Benefits and risks of solitary islet transplantation for type 1 diabetes using steroid-sparing immunosuppression: the National Institutes of Health experience. Diabetes Care 2003, 26:3288-3295.
    • (2003) Diabetes Care , vol.26 , pp. 3288-3295
    • Hirshberg, B.1    Rother, K.I.2    Digon, B.J.3    Lee, J.4    Gaglia, J.L.5    Hines, K.6    Read, E.J.7    Chang, R.8    Wood, B.J.9    Harlan, D.M.10
  • 38
    • 24144479748 scopus 로고    scopus 로고
    • Conditional expression demonstrates the role of the homeodomain transcription factor Pdx1 in maintenance and regeneration of beta-cells in the adult pancreas
    • Holland A.M., Gonez L.J., Naselli G., Macdonald R.J., Harrison L.C. Conditional expression demonstrates the role of the homeodomain transcription factor Pdx1 in maintenance and regeneration of beta-cells in the adult pancreas. Diabetes 2005, 54:2586-2595.
    • (2005) Diabetes , vol.54 , pp. 2586-2595
    • Holland, A.M.1    Gonez, L.J.2    Naselli, G.3    Macdonald, R.J.4    Harrison, L.C.5
  • 41
    • 0348047628 scopus 로고    scopus 로고
    • Gene regulatory factors in pancreatic development
    • Jensen J. Gene regulatory factors in pancreatic development. Dev. Dyn. 2004, 229:176-200.
    • (2004) Dev. Dyn. , vol.229 , pp. 176-200
    • Jensen, J.1
  • 45
    • 33750209164 scopus 로고    scopus 로고
    • Adult pancreatic stem/progenitor cells spontaneously differentiate in vitro into multiple cell lineages and form teratoma-like structures
    • Kruse C., Kajahn J., Petschnik A.E., Maass A., Klink E., Rapoport D.H., Wedel T. Adult pancreatic stem/progenitor cells spontaneously differentiate in vitro into multiple cell lineages and form teratoma-like structures. Ann. Anat. 2006, 188:503-517.
    • (2006) Ann. Anat. , vol.188 , pp. 503-517
    • Kruse, C.1    Kajahn, J.2    Petschnik, A.E.3    Maass, A.4    Klink, E.5    Rapoport, D.H.6    Wedel, T.7
  • 46
    • 0027595948 scopus 로고
    • Tissue engineering
    • Langer R., Vacanti J.P. Tissue engineering. Science 1993, 260:920-926.
    • (1993) Science , vol.260 , pp. 920-926
    • Langer, R.1    Vacanti, J.P.2
  • 48
    • 0017179001 scopus 로고
    • Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus
    • Like A.A., Rossini A.A. Streptozotocin-induced pancreatic insulitis: new model of diabetes mellitus. Science 1976, 193:415-417.
    • (1976) Science , vol.193 , pp. 415-417
    • Like, A.A.1    Rossini, A.A.2
  • 52
    • 0033106488 scopus 로고    scopus 로고
    • Growing new organs
    • Mooney D.J., Mikos A.G. Growing new organs. Sci. Am. 1999, 280:60-65.
    • (1999) Sci. Am. , vol.280 , pp. 60-65
    • Mooney, D.J.1    Mikos, A.G.2
  • 54
    • 15744381397 scopus 로고    scopus 로고
    • Pancreatic islet transplantation
    • quiz e75
    • Naftanel M.A., Harlan D.M. Pancreatic islet transplantation. PLoS Med. 2004, 1:e58. quiz e75.
    • (2004) PLoS Med. , vol.1
    • Naftanel, M.A.1    Harlan, D.M.2
  • 55
    • 34848887156 scopus 로고    scopus 로고
    • Recovery from diabetes in mice by beta cell regeneration
    • Nir T., Melton D.A., Dor Y. Recovery from diabetes in mice by beta cell regeneration. J. Clin. Invest. 2007, 117:2553-2561.
    • (2007) J. Clin. Invest. , vol.117 , pp. 2553-2561
    • Nir, T.1    Melton, D.A.2    Dor, Y.3
  • 59
    • 38449113938 scopus 로고    scopus 로고
    • Blood into beta cells: can adult stem cells be used as a therapy for Type 1 diabetes?
    • Palma C.A., Lindeman R., Tuch B.E. Blood into beta cells: can adult stem cells be used as a therapy for Type 1 diabetes?. Regen. Med. 2008, 3:33-47.
    • (2008) Regen. Med. , vol.3 , pp. 33-47
    • Palma, C.A.1    Lindeman, R.2    Tuch, B.E.3
  • 60
    • 0030912531 scopus 로고    scopus 로고
    • Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters
    • Rafaeloff R., Pittenger G.L., Barlow S.W., Qin X.F., Yan B., Rosenberg L., Duguid W.P., Vinik A.I. Cloning and sequencing of the pancreatic islet neogenesis associated protein (INGAP) gene and its expression in islet neogenesis in hamsters. J. Clin. Invest. 1997, 99:2100-2109.
    • (1997) J. Clin. Invest. , vol.99 , pp. 2100-2109
    • Rafaeloff, R.1    Pittenger, G.L.2    Barlow, S.W.3    Qin, X.F.4    Yan, B.5    Rosenberg, L.6    Duguid, W.P.7    Vinik, A.I.8
  • 61
    • 0029166144 scopus 로고
    • In vivo cell transformation: neogenesis of beta cells from pancreatic ductal cells
    • Rosenberg L. In vivo cell transformation: neogenesis of beta cells from pancreatic ductal cells. Cell Transplant. 1995, 4:371-383.
    • (1995) Cell Transplant. , vol.4 , pp. 371-383
    • Rosenberg, L.1
  • 62
    • 0032533453 scopus 로고    scopus 로고
    • Induction of islet cell neogenesis in the adult pancreas: the partial duct obstruction model
    • Rosenberg L. Induction of islet cell neogenesis in the adult pancreas: the partial duct obstruction model. Microsc. Res. Tech. 1998, 43:337-346.
    • (1998) Microsc. Res. Tech. , vol.43 , pp. 337-346
    • Rosenberg, L.1
  • 64
    • 0030927342 scopus 로고    scopus 로고
    • The β cell transcription factors and development of the pancreas
    • Sander M., German M.S. The β cell transcription factors and development of the pancreas. J. Mol. Med. 1997, 75:327-340.
    • (1997) J. Mol. Med. , vol.75 , pp. 327-340
    • Sander, M.1    German, M.S.2
  • 65
    • 0025297086 scopus 로고
    • Overexpression of TGF alpha in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast
    • Sandgren E.P., Luetteke N.C., Palmiter R.D., Brinster R.L., Lee D.C. Overexpression of TGF alpha in transgenic mice: induction of epithelial hyperplasia, pancreatic metaplasia, and carcinoma of the breast. Cell 1990, 61:1121-1135.
    • (1990) Cell , vol.61 , pp. 1121-1135
    • Sandgren, E.P.1    Luetteke, N.C.2    Palmiter, R.D.3    Brinster, R.L.4    Lee, D.C.5
  • 69
    • 33644669226 scopus 로고    scopus 로고
    • An overview on the development of a bio-artificial pancreas as a treatment of insulin-dependent diabetes mellitus
    • Silva A.I., de Matos A.N., Brons I.G., Mateus M. An overview on the development of a bio-artificial pancreas as a treatment of insulin-dependent diabetes mellitus. Med. Res. Rev. 2006, 26:181-222.
    • (2006) Med. Res. Rev. , vol.26 , pp. 181-222
    • Silva, A.I.1    de Matos, A.N.2    Brons, I.G.3    Mateus, M.4
  • 70
    • 0029027780 scopus 로고
    • Developmental biology of the pancreas
    • Slack J.M. Developmental biology of the pancreas. Development 1995, 121:1569-1580.
    • (1995) Development , vol.121 , pp. 1569-1580
    • Slack, J.M.1
  • 71
    • 0033979603 scopus 로고    scopus 로고
    • Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice
    • Soria B., Roche E., Berna G., Leon-Quinto T., Reig J.A., Martin F. Insulin-secreting cells derived from embryonic stem cells normalize glycemia in streptozotocin-induced diabetic mice. Diabetes 2000, 49:157-162.
    • (2000) Diabetes , vol.49 , pp. 157-162
    • Soria, B.1    Roche, E.2    Berna, G.3    Leon-Quinto, T.4    Reig, J.A.5    Martin, F.6
  • 73
    • 45449094570 scopus 로고    scopus 로고
    • Reprogramming of pancreatic beta cells into induced pluripotent stem cells
    • Stadtfeld M., Brennand K., Hochedlinger K. Reprogramming of pancreatic beta cells into induced pluripotent stem cells. Curr. Biol. 2008, 18:890-894.
    • (2008) Curr. Biol. , vol.18 , pp. 890-894
    • Stadtfeld, M.1    Brennand, K.2    Hochedlinger, K.3
  • 75
    • 52049103091 scopus 로고    scopus 로고
    • Pancreas islets in metabolic signaling-focus on the beta-cell
    • Suckale J., Solimena M. Pancreas islets in metabolic signaling-focus on the beta-cell. Front. Biosci. 2008, 13:7156-7171.
    • (2008) Front. Biosci. , vol.13 , pp. 7156-7171
    • Suckale, J.1    Solimena, M.2
  • 76
    • 33846091092 scopus 로고    scopus 로고
    • Conserved markers of fetal pancreatic epithelium permit prospective isolation of islet progenitor cells by FACS
    • Sugiyama T., Rodriguez R.T., McLean G.W., Kim S.K. Conserved markers of fetal pancreatic epithelium permit prospective isolation of islet progenitor cells by FACS. Proc. Natl. Acad. Sci. U.S.A. 2007, 104:175-180.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 175-180
    • Sugiyama, T.1    Rodriguez, R.T.2    McLean, G.W.3    Kim, S.K.4
  • 77
    • 33747195353 scopus 로고    scopus 로고
    • Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors
    • Takahashi K., Yamanaka S. Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 2006, 126:663-676.
    • (2006) Cell , vol.126 , pp. 663-676
    • Takahashi, K.1    Yamanaka, S.2
  • 78
    • 0033978152 scopus 로고    scopus 로고
    • Generation of an autologous tissue (matrix) flap by combining an arteriovenous shunt loop with artificial skin in rats: preliminary report
    • Tanaka Y., Tsutsumi A., Crowe D.M., Tajima S., Morrison W.A. Generation of an autologous tissue (matrix) flap by combining an arteriovenous shunt loop with artificial skin in rats: preliminary report. Br. J. Plast. Surg. 2000, 53:51-57.
    • (2000) Br. J. Plast. Surg. , vol.53 , pp. 51-57
    • Tanaka, Y.1    Tsutsumi, A.2    Crowe, D.M.3    Tajima, S.4    Morrison, W.A.5
  • 79
    • 34247644369 scopus 로고    scopus 로고
    • Growth and regeneration of adult beta cells does not involve specialized progenitors
    • Teta M., Rankin M.M., Long S.Y., Stein G.M., Kushner J.A. Growth and regeneration of adult beta cells does not involve specialized progenitors. Dev. Cell 2007, 12:817-826.
    • (2007) Dev. Cell , vol.12 , pp. 817-826
    • Teta, M.1    Rankin, M.M.2    Long, S.Y.3    Stein, G.M.4    Kushner, J.A.5
  • 80
    • 39449120582 scopus 로고    scopus 로고
    • Thomas, et al. Int. J. Obesity 2008, 32:239-248.
    • (2008) Int. J. Obesity , vol.32 , pp. 239-248
    • Thomas1
  • 82
    • 0034614576 scopus 로고    scopus 로고
    • Stem cells: units of development, units of regeneration, and units in evolution
    • Weissman I.L. Stem cells: units of development, units of regeneration, and units in evolution. Cell 2000, 100:157-168.
    • (2000) Cell , vol.100 , pp. 157-168
    • Weissman, I.L.1
  • 84
    • 2342466734 scopus 로고    scopus 로고
    • Global prevalence of diabetes: estimates for the year 2000 and projections for 2030
    • Wild S., Roglic G., Green A., Sicree R., King H. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004, 27:1047-1053.
    • (2004) Diabetes Care , vol.27 , pp. 1047-1053
    • Wild, S.1    Roglic, G.2    Green, A.3    Sicree, R.4    King, H.5
  • 85
    • 0029927506 scopus 로고    scopus 로고
    • The non-human primate endocrine pancreas: development, regeneration potential and metaplasia
    • Wolfe-Coote S., Louw J., Woodroof C., Du Toit D.F. The non-human primate endocrine pancreas: development, regeneration potential and metaplasia. Cell Biol. Int. 1996, 20:95-101.
    • (1996) Cell Biol. Int. , vol.20 , pp. 95-101
    • Wolfe-Coote, S.1    Louw, J.2    Woodroof, C.3    Du Toit, D.F.4
  • 87
    • 34249863603 scopus 로고    scopus 로고
    • Strategies and new developments in the generation of patient-specific pluripotent stem cells
    • Yamanaka S. Strategies and new developments in the generation of patient-specific pluripotent stem cells. Cell Stem Cell 2007, 1:39-49.
    • (2007) Cell Stem Cell , vol.1 , pp. 39-49
    • Yamanaka, S.1
  • 91
    • 53349178722 scopus 로고    scopus 로고
    • In vivo reprogramming of adult pancreatic exocrine cells to beta-cells
    • Zhou Q., Brown J., Kanarek A., Rajagopal J., Melton D.A. In vivo reprogramming of adult pancreatic exocrine cells to beta-cells. Nature 2008, 455:627-632.
    • (2008) Nature , vol.455 , pp. 627-632
    • Zhou, Q.1    Brown, J.2    Kanarek, A.3    Rajagopal, J.4    Melton, D.A.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.