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Volumn 10, Issue SUPPL. 4, 2008, Pages 186-194

Production of β-cells from human embryonic stem cells

Author keywords

Beta cell (b cell); C peptide; Definitive endoderm (DE); Foregut endoderm; Glucose stimulated insulin secretion (GSIS); Human embryonic stem cell (hESCs); Pancreatic endoderm

Indexed keywords

ACTIVIN; BASIC FIBROBLAST GROWTH FACTOR; CHEMOKINE RECEPTOR CXCR4; FIBROBLAST GROWTH FACTOR 10; HEPATOCYTE NUCLEAR FACTOR 3BETA; KERATINOCYTE GROWTH FACTOR; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN NODAL; SOMATOMEDIN; TRANSCRIPTION FACTOR SOX17;

EID: 53549107175     PISSN: 14628902     EISSN: 14631326     Source Type: Journal    
DOI: 10.1111/j.1463-1326.2008.00956.x     Document Type: Conference Paper
Times cited : (51)

References (66)
  • 1
    • 2342424743 scopus 로고    scopus 로고
    • Development of definitive endoderm from embryonic stem cells in culture
    • Kubo A, Shinozaki K, Shannon JM et al. Development of definitive endoderm from embryonic stem cells in culture. Development 2004; 131: 1651-1662.
    • (2004) Development , vol.131 , pp. 1651-1662
    • Kubo, A.1    Shinozaki, K.2    Shannon, J.M.3
  • 3
    • 33750846133 scopus 로고    scopus 로고
    • Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells
    • D'Amour KA, Bang AG, Eliazer S et al. Production of pancreatic hormone-expressing endocrine cells from human embryonic stem cells. Nat Biotechnol 2006; 24: 1392-1401.
    • (2006) Nat Biotechnol , vol.24 , pp. 1392-1401
    • D'Amour, K.A.1    Bang, A.G.2    Eliazer, S.3
  • 4
    • 34547857040 scopus 로고    scopus 로고
    • Generation of insulin-producing islet-like clusters from human embryonic stem cells
    • Jiang J, Au M, Lu K, Eshpeter A et al. Generation of insulin-producing islet-like clusters from human embryonic stem cells. Stem Cells 2007; 25: 1940-1953.
    • (2007) Stem Cells , vol.25 , pp. 1940-1953
    • Jiang, J.1    Au, M.2    Lu, K.3    Eshpeter, A.4
  • 5
    • 0026699762 scopus 로고
    • Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture
    • Matsui Y, Zsebo K, Hogan BL. Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture. Cell 1992; 70: 841-847.
    • (1992) Cell , vol.70 , pp. 841-847
    • Matsui, Y.1    Zsebo, K.2    Hogan, B.L.3
  • 7
    • 19944385908 scopus 로고    scopus 로고
    • Generation of pluripotent stem cells from neonatal mouse testis
    • Kanatsu-Shinohara M, Inoue K, Lee J et al. Generation of pluripotent stem cells from neonatal mouse testis. Cell 2004; 119: 1001-1102.
    • (2004) Cell , vol.119 , pp. 1001-1102
    • Kanatsu-Shinohara, M.1    Inoue, K.2    Lee, J.3
  • 8
    • 41549134120 scopus 로고    scopus 로고
    • Pluripotency of a single spermatogonial stem cell in mice
    • Kanatsu-Shinohara M, Lee J, Inoue K et al. Pluripotency of a single spermatogonial stem cell in mice. Biol Reprod 2008; 78: 681-687.
    • (2008) Biol Reprod , vol.78 , pp. 681-687
    • Kanatsu-Shinohara, M.1    Lee, J.2    Inoue, K.3
  • 9
    • 33646336640 scopus 로고    scopus 로고
    • Pluripotency of spermatogonial stem cells from adult mouse testis
    • Guan K, Nayernia K, Maier LS et al. Pluripotency of spermatogonial stem cells from adult mouse testis. Nature 2006; 440: 1199-1203.
    • (2006) Nature , vol.440 , pp. 1199-1203
    • Guan, K.1    Nayernia, K.2    Maier, L.S.3
  • 10
    • 0037019337 scopus 로고    scopus 로고
    • Pluripotency of mesenchymal stem cells derived from adult marrow
    • Jiang Y, Jahagirdar BN, Reinhardt RL et al. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 2002; 418: 41-49.
    • (2002) Nature , vol.418 , pp. 41-49
    • Jiang, Y.1    Jahagirdar, B.N.2    Reinhardt, R.L.3
  • 11
    • 33846120651 scopus 로고    scopus 로고
    • Isolation of amniotic stem cell lines with potential for therapy
    • De Coppi P, Bartsch G Jr, Siddiqui MM et al. Isolation of amniotic stem cell lines with potential for therapy. Nat Biotechnol 2007; 25: 100-106.
    • (2007) Nat Biotechnol , vol.25 , pp. 100-106
    • De Coppi, P.1    Bartsch Jr., G.2    Siddiqui, M.M.3
  • 12
    • 41849151748 scopus 로고    scopus 로고
    • Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo
    • Kroon E, Martinson LA, Kadoya K et al. Pancreatic endoderm derived from human embryonic stem cells generates glucose-responsive insulin-secreting cells in vivo. Nat Biotechnol 2008; 26: 443-452.
    • (2008) Nat Biotechnol , vol.26 , pp. 443-452
    • Kroon, E.1    Martinson, L.A.2    Kadoya, K.3
  • 13
    • 33845996144 scopus 로고    scopus 로고
    • Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed
    • McLean AB, D'Amour KA, Jones KL et al. Activin a efficiently specifies definitive endoderm from human embryonic stem cells only when phosphatidylinositol 3-kinase signaling is suppressed. Stem Cells 2007; 25: 29-38.
    • (2007) Stem Cells , vol.25 , pp. 29-38
    • McLean, A.B.1    D'Amour, K.A.2    Jones, K.L.3
  • 14
    • 0033568470 scopus 로고    scopus 로고
    • Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4
    • McGrath KE, Koniski AD, Maltby KM, McGann JK, Palis J. Embryonic expression and function of the chemokine SDF-1 and its receptor, CXCR4. Dev Biol 1999; 213: 442-456.
    • (1999) Dev Biol , vol.213 , pp. 442-456
    • McGrath, K.E.1    Koniski, A.D.2    Maltby, K.M.3    McGann, J.K.4    Palis, J.5
  • 15
    • 28644442419 scopus 로고    scopus 로고
    • Induction and monitoring of definitive and visceral endoderm differentiation of mouse ES cells
    • Yasunaga M, Tada S, Torikai-Nishikawa S et al. Induction and monitoring of definitive and visceral endoderm differentiation of mouse ES cells. Nat Biotechnol 2005; 23: 1542-1550.
    • (2005) Nat Biotechnol , vol.23 , pp. 1542-1550
    • Yasunaga, M.1    Tada, S.2    Torikai-Nishikawa, S.3
  • 16
    • 0033961133 scopus 로고    scopus 로고
    • An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis
    • De Moerlooze L, Spencer-Dene B, Revest J, Hajihosseini M, Rosewell I, Dickson C. An important role for the IIIb isoform of fibroblast growth factor receptor 2 (FGFR2) in mesenchymal-epithelial signalling during mouse organogenesis. Development 2000; 127: 483-492.
    • (2000) Development , vol.127 , pp. 483-492
    • De Moerlooze, L.1    Spencer-Dene, B.2    Revest, J.3    Hajihosseini, M.4    Rosewell, I.5    Dickson, C.6
  • 17
    • 0034865012 scopus 로고    scopus 로고
    • Basic mechanisms of lung development: Eighth Woods Hole Conference on Lung Cell Biology 2000
    • Cardoso WV, Williams MC. Basic mechanisms of lung development: Eighth Woods Hole Conference on Lung Cell Biology 2000. Am J Respir Cell Mol Biol 2001; 25: 137-140.
    • (2001) Am J Respir Cell Mol Biol , vol.25 , pp. 137-140
    • Cardoso, W.V.1    Williams, M.C.2
  • 18
    • 0035694459 scopus 로고    scopus 로고
    • Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis
    • Bhushan A, Itoh N, Kato S et al. Fgf10 is essential for maintaining the proliferative capacity of epithelial progenitor cells during early pancreatic organogenesis. Development 2001; 128: 5109-5117.
    • (2001) Development , vol.128 , pp. 5109-5117
    • Bhushan, A.1    Itoh, N.2    Kato, S.3
  • 19
    • 0037133681 scopus 로고    scopus 로고
    • Role for FGFR2IIIb-mediated signals in controlling pancreatic endocrine progenitor cell proliferation
    • Elghazi L, Cras-Meneur C, Czernichow P, Scharfmann R. Role for FGFR2IIIb-mediated signals in controlling pancreatic endocrine progenitor cell proliferation. Proc Natl Acad Sci USA 2002; 99: 3884-3889.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 3884-3889
    • Elghazi, L.1    Cras-Meneur, C.2    Czernichow, P.3    Scharfmann, R.4
  • 20
    • 0037309058 scopus 로고    scopus 로고
    • The IIIb isoform of fibroblast growth factor receptor 2 is required for proper growth and branching of pancreatic ductal epithelium but not for differentiation of exocrine or endocrine cells
    • Pulkkinen MA, Spencer-Dene B, Dickson C, Otonkoski T. The IIIb isoform of fibroblast growth factor receptor 2 is required for proper growth and branching of pancreatic ductal epithelium but not for differentiation of exocrine or endocrine cells. Mech Dev 2003; 120: 167-175.
    • (2003) Mech Dev , vol.120 , pp. 167-175
    • Pulkkinen, M.A.1    Spencer-Dene, B.2    Dickson, C.3    Otonkoski, T.4
  • 22
    • 33847245306 scopus 로고    scopus 로고
    • Fgf10 regulates hepatopancreatic ductal system patterning and differentiation
    • Dong PD, Munson CA, Norton W et al. Fgf10 regulates hepatopancreatic ductal system patterning and differentiation. Nat Genet 2007; 39: 397-402.
    • (2007) Nat Genet , vol.39 , pp. 397-402
    • Dong, P.D.1    Munson, C.A.2    Norton, W.3
  • 23
    • 17444378574 scopus 로고    scopus 로고
    • Fibroblast growth factors 7 and 10 are expressed in the human embryonic pancreatic mesenchyme and promote the proliferation of embryonic pancreatic epithelial cells
    • Ye F, Duvillie B, Scharfmann R. Fibroblast growth factors 7 and 10 are expressed in the human embryonic pancreatic mesenchyme and promote the proliferation of embryonic pancreatic epithelial cells. Diabetologia 2005; 48: 277-281.
    • (2005) Diabetologia , vol.48 , pp. 277-281
    • Ye, F.1    Duvillie, B.2    Scharfmann, R.3
  • 24
    • 0034025536 scopus 로고    scopus 로고
    • The effect of retinoic acid on the proportion of insulin cells in the developing chick pancreas
    • Penny C, Kramer B. The effect of retinoic acid on the proportion of insulin cells in the developing chick pancreas. In Vitro Cell Dev Biol Anim 2000; 36: 14
    • (2000) In Vitro Cell Dev Biol Anim , vol.36 , pp. 14
    • Penny, C.1    Kramer, B.2
  • 25
    • 2942542776 scopus 로고    scopus 로고
    • Retinoic acid signaling is essential for pancreas development and promotes endocrine at the expense of exocrine cell differentiation in Xenopus
    • Chen Y, Pan FC, Brandes N, Afelik S, Solter M, Pieler T. Retinoic acid signaling is essential for pancreas development and promotes endocrine at the expense of exocrine cell differentiation in Xenopus. Dev Biol 2004; 271: 144-160.
    • (2004) Dev Biol , vol.271 , pp. 144-160
    • Chen, Y.1    Pan, F.C.2    Brandes, N.3    Afelik, S.4    Solter, M.5    Pieler, T.6
  • 26
    • 0037162287 scopus 로고    scopus 로고
    • Retinoic acid signaling is required for a critical early step in zebrafish pancreatic development
    • Stafford D, Prince VE. Retinoic acid signaling is required for a critical early step in zebrafish pancreatic development. Curr Biol 2002; 12: 1215-1220.
    • (2002) Curr Biol , vol.12 , pp. 1215-1220
    • Stafford, D.1    Prince, V.E.2
  • 27
    • 5744240610 scopus 로고    scopus 로고
    • A conserved role for retinoid signaling in vertebrate pancreas development
    • Stafford D, Hornbruch A, Mueller PR, Prince VE. A conserved role for retinoid signaling in vertebrate pancreas development. Dev Genes Evol 2004; 214: 432-441.
    • (2004) Dev Genes Evol , vol.214 , pp. 432-441
    • Stafford, D.1    Hornbruch, A.2    Mueller, P.R.3    Prince, V.E.4
  • 29
    • 0036789023 scopus 로고    scopus 로고
    • Retinoid signaling controls mouse pancreatic exocrine lineage selection through epithelial-mesenchymal interactions
    • Kobayashi H, Spilde TL, Bhatia AM, et al. Retinoid signaling controls mouse pancreatic exocrine lineage selection through epithelial-mesenchymal interactions. Gastroenterology 2002; 123: 1331-1340.
    • (2002) Gastroenterology , vol.123 , pp. 1331-1340
    • Kobayashi, H.1    Spilde, T.L.2    Bhatia, A.M.3
  • 30
    • 0037221180 scopus 로고    scopus 로고
    • All-trans retinoic acid induces differentiation of ducts and endocrine cells by mesenchymal/epithelial interactions in embryonic pancreas
    • Tulachan SS, Doi R, Kawaguchi Y et al. All-trans retinoic acid induces differentiation of ducts and endocrine cells by mesenchymal/epithelial interactions in embryonic pancreas. Diabetes 2003; 52: 76-84.
    • (2003) Diabetes , vol.52 , pp. 76-84
    • Tulachan, S.S.1    Doi, R.2    Kawaguchi, Y.3
  • 31
    • 33846269275 scopus 로고    scopus 로고
    • All-trans retinoic acid suppresses exocrine differentiation and branching morphogenesis in the embryonic pancreas
    • Shen CN, Marguerie A, Chien CY, Dickson C, Slack JM, Tosh D. All-trans retinoic acid suppresses exocrine differentiation and branching morphogenesis in the embryonic pancreas. Differentiation 2007; 75: 62-74.
    • (2007) Differentiation , vol.75 , pp. 62-74
    • Shen, C.N.1    Marguerie, A.2    Chien, C.Y.3    Dickson, C.4    Slack, J.M.5    Tosh, D.6
  • 32
    • 23944453381 scopus 로고    scopus 로고
    • Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice
    • Martin M, Gallego-Llamas J, Ribes V et al. Dorsal pancreas agenesis in retinoic acid-deficient Raldh2 mutant mice. Dev Biol 2005; 284: 399-411.
    • (2005) Dev Biol , vol.284 , pp. 399-411
    • Martin, M.1    Gallego-Llamas, J.2    Ribes, V.3
  • 33
    • 16244406880 scopus 로고    scopus 로고
    • Retinoic acid generated by Raldh2 in mesoderm is required for mouse dorsal endodermal pancreas development
    • Molotkov A, Molotkova N, Duester G. Retinoic acid generated by Raldh2 in mesoderm is required for mouse dorsal endodermal pancreas development. Dev Dyn 2005; 232: 950-957.
    • (2005) Dev Dyn , vol.232 , pp. 950-957
    • Molotkov, A.1    Molotkova, N.2    Duester, G.3
  • 34
    • 0037212983 scopus 로고    scopus 로고
    • Hedgehog signaling in pancreas development
    • Hebrok M. Hedgehog signaling in pancreas development. Mech Dev 2003; 120: 45-57.
    • (2003) Mech Dev , vol.120 , pp. 45-57
    • Hebrok, M.1
  • 35
    • 38849196910 scopus 로고    scopus 로고
    • Hedgehog signals in pancreatic differentiation from embryonic stem cells: Revisiting the neglected
    • Mfopou JK, Bouwens L. Hedgehog signals in pancreatic differentiation from embryonic stem cells: Revisiting the neglected. Differentiation 2008; 76: 107-117.
    • (2008) Differentiation , vol.76 , pp. 107-117
    • Mfopou, J.K.1    Bouwens, L.2
  • 36
    • 0348047628 scopus 로고    scopus 로고
    • Gene regulatory factors in pancreatic development
    • Jensen J. Gene regulatory factors in pancreatic development. Dev Dyn 2004; 229: 176-200.
    • (2004) Dev Dyn , vol.229 , pp. 176-200
    • Jensen, J.1
  • 37
    • 34047181087 scopus 로고    scopus 로고
    • Molecular basis of vertebrate endoderm development
    • Zorn AM, Wells JM. Molecular basis of vertebrate endoderm development. Int Rev Cytol 2007; 259: 49-111.
    • (2007) Int Rev Cytol , vol.259 , pp. 49-111
    • Zorn, A.M.1    Wells, J.M.2
  • 38
    • 33847402673 scopus 로고    scopus 로고
    • Pancreas and beta-cell development: From the actual to the possible
    • Murtaugh LC. Pancreas and beta-cell development: From the actual to the possible. Development 2007; 134: 427-438.
    • (2007) Development , vol.134 , pp. 427-438
    • Murtaugh, L.C.1
  • 39
    • 37249066122 scopus 로고    scopus 로고
    • Translational embryology: Using embryonic principles to generate pancreatic endocrine cells from embryonic stem cells
    • Spence JR, Wells JM. Translational embryology: Using embryonic principles to generate pancreatic endocrine cells from embryonic stem cells. Dev Dyn 2007; 236: 3218-3227.
    • (2007) Dev Dyn , vol.236 , pp. 3218-3227
    • Spence, J.R.1    Wells, J.M.2
  • 41
    • 21044433282 scopus 로고    scopus 로고
    • The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells
    • Schisler JC, Jensen PB, Taylor DG et al. The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells. Proc Natl Acad Sci USA 2005; 102: 7297-7302.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 7297-7302
    • Schisler, J.C.1    Jensen, P.B.2    Taylor, D.G.3
  • 42
    • 33646194560 scopus 로고    scopus 로고
    • A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells
    • Nishimura W, Kondo T, Salameh T et al. A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells. Dev Biol 2006; 293: 526-539.
    • (2006) Dev Biol , vol.293 , pp. 526-539
    • Nishimura, W.1    Kondo, T.2    Salameh, T.3
  • 43
    • 20344368579 scopus 로고    scopus 로고
    • MafA is a key regulator of glucose-stimulated insulin secretion
    • Zhang C, Moriguchi T, Kajihara M et al. MafA is a key regulator of glucose-stimulated insulin secretion. Mol Cell Biol 2005; 25: 4969-4976.
    • (2005) Mol Cell Biol , vol.25 , pp. 4969-4976
    • Zhang, C.1    Moriguchi, T.2    Kajihara, M.3
  • 44
    • 34247898958 scopus 로고    scopus 로고
    • Directed differentiation of human embryonic stem cells towards a pancreatic cell fate
    • Shim JH, Kim SE, Woo DH et al. Directed differentiation of human embryonic stem cells towards a pancreatic cell fate. Diabetologia 2007; 50: 1228-1238.
    • (2007) Diabetologia , vol.50 , pp. 1228-1238
    • Shim, J.H.1    Kim, S.E.2    Woo, D.H.3
  • 45
    • 2942687863 scopus 로고    scopus 로고
    • Human islet graft function in NOD-SCID mice predicts clinical response in islet transplant recipients
    • Gaber AO, Fraga D, Kotb M, Lo A, Sabek O, Latif K. Human islet graft function in NOD-SCID mice predicts clinical response in islet transplant recipients. Transplant Proc 2004; 36: 1108-1110.
    • (2004) Transplant Proc , vol.36 , pp. 1108-1110
    • Gaber, A.O.1    Fraga, D.2    Kotb, M.3    Lo, A.4    Sabek, O.5    Latif, K.6
  • 46
    • 34247353657 scopus 로고    scopus 로고
    • In vitro derivation of functional insulin-producing cells from human embryonic stem cells
    • Jiang W, Shi Y, Zhao D et al. In vitro derivation of functional insulin-producing cells from human embryonic stem cells. Cell Res 2007; 17: 333-344.
    • (2007) Cell Res , vol.17 , pp. 333-344
    • Jiang, W.1    Shi, Y.2    Zhao, D.3
  • 47
    • 0032844643 scopus 로고    scopus 로고
    • Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9
    • Li H, Arber S, Jessell TM, Edlund H. Selective agenesis of the dorsal pancreas in mice lacking homeobox gene Hlxb9. Nat Genet 1999; 23: 67-70.
    • (1999) Nat Genet , vol.23 , pp. 67-70
    • Li, H.1    Arber, S.2    Jessell, T.M.3    Edlund, H.4
  • 48
    • 0028869514 scopus 로고
    • Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny
    • Guz Y, Montminy MR, Stein R et al. Expression of murine STF-1, a putative insulin gene transcription factor, in beta cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny. Development 1995; 121: 11-18.
    • (1995) Development , vol.121 , pp. 11-18
    • Guz, Y.1    Montminy, M.R.2    Stein, R.3
  • 49
    • 0028149890 scopus 로고
    • Insulin-promoter-factor 1 is required for pancreas development in mice
    • Jonsson J, Carlsson L, Edlund T, Edlund H. Insulin-promoter-factor 1 is required for pancreas development in mice. Nature 1994; 371: 606-609.
    • (1994) Nature , vol.371 , pp. 606-609
    • Jonsson, J.1    Carlsson, L.2    Edlund, T.3    Edlund, H.4
  • 50
    • 0028031296 scopus 로고
    • Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst
    • Duncan SA, Manova K, Chen WS et al. Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst. Proc Natl Acad Sci USA 1994; 91: 7598-7602.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 7598-7602
    • Duncan, S.A.1    Manova, K.2    Chen, W.S.3
  • 51
    • 0029868156 scopus 로고    scopus 로고
    • PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum
    • Offield MF, Jetton TL, Labosky PA et al. PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. Development 1996; 122: 983-995.
    • (1996) Development , vol.122 , pp. 983-995
    • Offield, M.F.1    Jetton, T.L.2    Labosky, P.A.3
  • 52
    • 0034652287 scopus 로고    scopus 로고
    • neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas
    • Gradwohl G, Dierich A, LeMeur M, Guillemot F. neurogenin3 is required for the development of the four endocrine cell lineages of the pancreas. Proc Natl Acad Sci USA 2000; 97: 1607-1611.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 1607-1611
    • Gradwohl, G.1    Dierich, A.2    LeMeur, M.3    Guillemot, F.4
  • 53
    • 0036340074 scopus 로고    scopus 로고
    • Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors
    • Gu G, Dubauskaite J, Melton DA. Direct evidence for the pancreatic lineage: NGN3+ cells are islet progenitors and are distinct from duct progenitors. Development 2002; 129: 2447-2457.
    • (2002) Development , vol.129 , pp. 2447-2457
    • Gu, G.1    Dubauskaite, J.2    Melton, D.A.3
  • 54
    • 4644222526 scopus 로고    scopus 로고
    • Artifactual insulin release from differentiated embryonic stem cells
    • Hansson M, Tonning A, Frandsen U et al. Artifactual insulin release from differentiated embryonic stem cells. Diabetes 2004; 53: 2603-2609.
    • (2004) Diabetes , vol.53 , pp. 2603-2609
    • Hansson, M.1    Tonning, A.2    Frandsen, U.3
  • 56
    • 2942615532 scopus 로고    scopus 로고
    • Differentiation of human embryonic stem cells into insulin-producing clusters
    • Segev H, Fishman B, Ziskind A, Shulman M, Itskovitz-Eldor J. Differentiation of human embryonic stem cells into insulin-producing clusters. Stem Cells 2004; 22: 265-274.
    • (2004) Stem Cells , vol.22 , pp. 265-274
    • Segev, H.1    Fishman, B.2    Ziskind, A.3    Shulman, M.4    Itskovitz-Eldor, J.5
  • 57
    • 25844454068 scopus 로고    scopus 로고
    • Signals from the embryonic mouse pancreas induce differentiation of human embryonic stem cells into insulin-producing beta-cell-like cells
    • Brolen GK, Heins N, Edsbagge J, Semb H. Signals from the embryonic mouse pancreas induce differentiation of human embryonic stem cells into insulin-producing beta-cell-like cells. Diabetes 2005; 54: 2867-2874.
    • (2005) Diabetes , vol.54 , pp. 2867-2874
    • Brolen, G.K.1    Heins, N.2    Edsbagge, J.3    Semb, H.4
  • 58
    • 33745629848 scopus 로고    scopus 로고
    • Endoderm and pancreatic islet lineage differentiation from human embryonic stem cells
    • Xu X, Kahan B, Forgianni A et al. Endoderm and pancreatic islet lineage differentiation from human embryonic stem cells. Cloning Stem Cells 2006; 8: 96-107.
    • (2006) Cloning Stem Cells , vol.8 , pp. 96-107
    • Xu, X.1    Kahan, B.2    Forgianni, A.3
  • 59
    • 33744832001 scopus 로고    scopus 로고
    • Generation of insulin-secreting cells from human embryonic stem cells
    • Baharvand H, Jafary H, Massumi M, Ashtiani SK. Generation of insulin-secreting cells from human embryonic stem cells. Dev Growth Differ 2006; 48: 323-332.
    • (2006) Dev Growth Differ , vol.48 , pp. 323-332
    • Baharvand, H.1    Jafary, H.2    Massumi, M.3    Ashtiani, S.K.4
  • 60
    • 0037312345 scopus 로고    scopus 로고
    • Differentiation and genetic manipulation of human embryonic stem cells and the analysis of the cardiovascular system
    • Lavon N, Benvenisty N. Differentiation and genetic manipulation of human embryonic stem cells and the analysis of the cardiovascular system. Trends Cardiovasc Med 2003; 13: 47-52.
    • (2003) Trends Cardiovasc Med , vol.13 , pp. 47-52
    • Lavon, N.1    Benvenisty, N.2
  • 61
    • 34548507937 scopus 로고    scopus 로고
    • Directed differentiation of human embryonic stem cells into the pancreatic endocrine lineage
    • Phillips BW, Hentze H, Rust WL et al. Directed differentiation of human embryonic stem cells into the pancreatic endocrine lineage. Stem Cells Dev 2007; 16: 561-578.
    • (2007) Stem Cells Dev , vol.16 , pp. 561-578
    • Phillips, B.W.1    Hentze, H.2    Rust, W.L.3
  • 62
    • 37349034589 scopus 로고    scopus 로고
    • Betacellulin and nicotinamide sustain PDX1 expression and induce pancreatic beta-cell differentiation in human embryonic stem cells
    • Cho YM, Lim JM, Yoo DH et al. Betacellulin and nicotinamide sustain PDX1 expression and induce pancreatic beta-cell differentiation in human embryonic stem cells. Biochem Biophys Res Commun 2008; 366: 129-134.
    • (2008) Biochem Biophys Res Commun , vol.366 , pp. 129-134
    • Cho, Y.M.1    Lim, J.M.2    Yoo, D.H.3
  • 63
    • 0035913986 scopus 로고    scopus 로고
    • Induction of pancreatic differentiation by signals from blood vessels
    • Lammert E, Cleaver O, Melton D. Induction of pancreatic differentiation by signals from blood vessels. Science 2001; 294: 564-567.
    • (2001) Science 564-567. , vol.294 , pp. 564-567
    • Lammert, E.1    Cleaver, O.2    Melton, D.3
  • 64
    • 16644394457 scopus 로고    scopus 로고
    • Blood vessel signals during development and beyond
    • Cleaver O. Blood vessel signals during development and beyond. Curr Top Dev Biol 2004; 62: 1-36.
    • (2004) Curr Top Dev Biol , vol.62 , pp. 1-36
    • Cleaver, O.1
  • 65
  • 66
    • 34147163066 scopus 로고    scopus 로고
    • EphA-Ephrin-A-mediated beta cell communication regulates insulin secretion from pancreatic islets
    • Konstantinova I, Nikolova G, Ohara-Imaizumi M et al. EphA-Ephrin-A-mediated beta cell communication regulates insulin secretion from pancreatic islets. Cell 2007; 129: 359-370.
    • (2007) Cell , vol.129 , pp. 359-370
    • Konstantinova, I.1    Nikolova, G.2    Ohara-Imaizumi, M.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.