Comparative metabolism and retention of iodine-125, yttrium-90, and indium-111 radioimmunoconjugates by cancer cells

Cancer Research

Volumn 56, Issue 9, 1996, Pages 2123-2129

  Press, Oliver W ^a,c,f   Shan, Daming ^a,e   Howell Clark, Janet ^a   Eary, Janet ^b   Appelbaum, Frederick R ^a,c   Matthews, Dana ^b,c   King, David J ^d   Haines, Adrian M R ^d   Hamann, Philip ^e   Hinman, Lois ^e,g   Shochat, Daniel ^a,e,h   Bernstein, Irwin D ^b,c  

^a UNIVERSITY OF WASHINGTON   (United States)

^b UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

^c Fred Hutchinson Cancer Research Center   (United States)

^d UCB PHARMA   (Belgium)

^e PFIZER INC   (United States)

^f UNIVERSITY OF WASHINGTON MEDICAL CENTER   (United States)

^g Immunomedics Inc   (United States)

^h NONE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INDIUM 111; IODINE 125; YTTRIUM 90;

ANTIGEN ANTIBODY REACTION; ARTICLE; CANCER CELL; CELL LYSATE; CELL METABOLISM; CELL ORGANELLE; ENDOCYTOSIS; GENE TARGETING; HUMAN; HUMAN CELL; INTERNALIZATION; LYSOSOME MEMBRANE; PRIORITY JOURNAL; RADIOACTIVITY; RADIOIODINATION;

ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; ANTIGENS, NEOPLASM; BREAST NEOPLASMS; CARCINOMA; COLORECTAL NEOPLASMS; DRUG CARRIERS; FEMALE; HL-60 CELLS; HUMANS; IMMUNOCONJUGATES; INDIUM RADIOISOTOPES; IODINE RADIOISOTOPES; LIPOSOMES; RADIOIMMUNOTHERAPY; YTTRIUM RADIOISOTOPES;

EID: 9244224115     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Press, O. W., Eary, J F , Appelbaum, F. R., Martin, P. J , Badger, C C., Nelp, W. B., Glenn, S., Butchko, G., Fisher, D., Porter, B , Matthews, D. C., Fisher, L D., and Bernstein, I. D. Radiolabeled-antibody therapy of B-cell lymphoma with autologous bone marrow support. N. Engl. J. Med., 329: 1219-1224, 1993.
2. Preis, O W , Eary, J F., Appelbaum, F. R , Martin, P. J., Nelp, W. B., Glenn, S., Fisher, D. R., Porter, B., Matthews, D., Gooley, T., and Bernstein, I D. A Phase II trial of 131I-B1 (anti-CD20) antibody therapy with autologous stem cell transplantation for relapsed B cell lymphomas. Lancet, 346. 336-340, 1995.
3. 131I-labeled anti-CD45 antibody, combined with cyclophosphamide and total body irradiation. Blood, 88: 1122-1131, 1995.
4. 131I -anti-B1 (anti-CD20) antibody. N. Engl. J. Med. 329: 459-465, 1993.
5. Goldenberg, D. M New developments in monoclonal antibodies for cancer detection and therapy. CA: A Cancer J. Clin., 44: 43-64, 1994.
6. Jurcic, J. G., and Scheinberg, D. A. Recent developments in the radioimmunotherapy of cancer. Curr Opin. Immunol., 6. 15-21, 1994.
7. Geissler, F., Anderson, S. K., and Press, O. W. Intracellular catabolism of radiolabeled anti-CD3 antibodies by leukemic T cells Cell Immunol., 137: 96-110, 1991
8. Geissler, F , Anderson, S. K., Venkatesan, P., and Press, O W. Intracellular catabolism of radiolabeled anti-μ antibodies by malignant B cells. Cancer Res , 52 2907-2915, 1992.
9. Motta-Hennessy, C., Sharkey, R. M., and Goldenberg, D. M. Metabolism of indium-111-labeled murine monoclonal antibody in tumor and normal tissue of the athymic mouse. J. Nucl. Med., 31: 1510-1519, 1990.
10. Mattes, M. J , Griffiths, G. L., Diril, H., Goldenberg, D. M., Ong, G. L., and Shih, L B. Processing of antibody-radioisotope conjugates after binding to the surface of tumor cells. Cancer (Phila ), 73: 787-793, 1994.
11. Duncan, J. R , and Welch, M. J. Intracellular metabolism of indium-111-DTPA labeled receptor targeted proteins. J. Nucl Med., 34: 1728-1738, 1993.
12. Stein, R., Goldenberg, D. M., Thorpe, S. R , Basu, A., and Mattes, M. J. Effects of radiolabeling monoclonal antibodies with a residulaizing iodine radiolabel on the accretion of radioisotope in tumors Cancer Res., 55: 3132-3139, 1995.
13. 125I radiolabeled T101 anti-CD5 monoclonal antibody Nucl. Med. Biol., 17 201-207, 1990.
14. Vriesendorp, H. M., Quadri, S. M., Stinson, R. L., Onyekwere, O. C., Shao, Y , Klein, J. L., Leichner, P. K., and Williams, J. R Selection of reagents for human radioimmunotherapy. J. Radiat. Oncol. Biol. Phys., 22: 37-45, 1991
15. Wessels, B. W., and Rogus, R. D. Radionuclide selection and model absorbed dose calculations for radiolabeled tumor associated antibodies. Med. Phys., 11. 638-644, 1984.
16. Yorke, E. D., Beaumier, P. L., Wessels, B. W., Fritzberg, A R., and Morgan, A. C Optimal antibody-radionuclide combinations for clinical radioimmunotherapy: a predictive model based on mouse pharmacokinetics. Int. J. Radiat. Appl. Instrum Part B, 8: 827-835, 1991
17. 90Y-anti-CD20 monoclonal antibody therapy (IDEC-Y2B8) for recurrent B cell lymphoma. J Immunother , 16: 161, 1994.
18. Shih, L. B., Thorpe, S. R., Griffiths, G. L., Diril, H., Ong, L. Hansen, H. J., Goldenberg, D. M., and Mattes, M. J The processing and fate of antibodies and their radiolabels bound to the surface of tumor cells in vitro: a comparison of nine radiolabels. J. Nucl. Med , 35: 899-908, 1994
19. Mattes, M. J., Griffiths, G. L., Diril, H , Goldenberg, D M , Ong, G L., and Shih, L. B. Processing of antibody radioisotope conjugates after binding to the surface of tumor cells. Cancer (Phila.), 73: 787-793, 1994.
20. Raubitschek, A. A. Yttrium-90 labeled T101 in the treatment of hematologic malignancies. Proceedings of the Fifth International Conference on Monoclonal Antibody Conjugates for Cancer, p 17, 1990.
21. Roselli, M., Schlom, J , Gansow, O. A., Raubitschek, A., Mirzadeh, S., Brechbiel, M. W , and Colcher, D. Comparative biodistribution of yttrium- and indium-labeled monoclonal anubody B72 3 in athymic mice bearing human colon carcinoma xenografts. J Nucl. Med , 30: 672-682, 1989
22. Camera, L , Kinuya, S., Garmestani, K., Brechbiel, M. W , Wu, C., Pai, L. H , McMurry, T J., Gansow, O. A., Pastan, I , and Paik, C. H Comparative biodistribution of indium and yttrium-labeled B3 monoclonal antibody conjugated to either 2-(p-SCN-Bz.)-6-methyl-DTPA (1B4M-DTPA) or 2-(p-SCN-Bz)-1,4,7,10-tetraazacyclododecane tetraacetic acid (2B-DOTA) Eur J Nucl. Med , 21: 640-646, 1994
23. Appelbaum, F. R , Matthews, D , Eary, J. F., Badger, C. C , Kellogg, M., Press, O. W., Martin, P. J., Fisher, D , Nelp, W. B., Thomas, E. D , and Bernstein, I. D. The use of radiolabeled anti-CD33 antibody to augment marrow irradiation prior to marrow transplantation for acute myelogenous leukemia. Transplantation, 54 829-833, 1992
24. Van der Jagt, R. H C., Badger, C. C , Appelbaum, F. R., Press, O. W., Matthews, D. C , Eary, J. F , Krohn, K. A , and Bernstein, I. D. Localization of radiolabeled antimyeloid antibodies in a human acute leukemia xenograft tumor model. Cancer Res., 52: 89-94, 1992.
25. Carter, P , Kelley, R F., Rodrigues, M. L., Snedecor, B., Covarrubias, M., Velligan, M D., Wong, W. L. T., Rowland, A M , Kotts, C E., Carver, M. E., Yang, M , Bourell, J H., Shepard, H. M., and Henner, D. High level Escherichia coli expression and production of a bivalent humanized antibody fragment. Biotechnology, 10 163-167, 1992.
26. Baker, T. S., Bose, C. C., Caskey-Finney, H. M. King, D. J., Lawson, A. D G , Lyons, A , Mountain, A., Owens, R J , Rolfe, M. R., Sehdev, M., Yarranton, G T , and Adair, J. R Humanization of anti-mucin antibody for breast and ovarian cancer therapy. In: R L. Ceriani (ed.), Antigen and Antibody Molecular Engineering in Breast Cancer Diagnosis and Treatment, pp. 61-82. New York: Plenum Publishing Corp., 1994.
27. King, D. J., Antoniw, P , Owens, R. J., Adair, J. R., Haines, A. M. R., Farnsworth, A P. H., Finney, H , Lawson, A D G., Lyons, A , Baker, T. S , Baldock, D , Mackintosh, J , Gofton, C., Yarranion, G T., McWilliams, W., Shochat, D., Leichner, P. K., Welt, S., Old, L. J., and Mountain, A Preparation and preclinical evaluation of humanised A33 immunoconjugates for radioimmunotherapy. Br. J. Cancer, 72 1364-1372, 1995.
28. Turner, A , King, D J , Farnsworth, A P., Rhind, S K., Pedley, R. B., Boden, J , Boden, R., Millican, T. A., Millar, K., Boyce, B., Beeley, N. R., Eaton, M A., and Parker, D. Comparative biodistribution of indium-111-labeled macrocycte chimeric b72.3 antibody conjugates in tumor-bearing mice Br. J. Cancer, 70. 35-41, 1994.
29. King, D. J , Turner, A., Farnsworth, A. P. H , Adair, J. R., Owens, R. J., Fedley, R. B., Baldock, D., Proudfoot, K A., Lawson, A. D. G., Beeley, N. R. A., Millar, K., Millican, T. A., Boyce, B. A., Antoniw, P., Mountain, A., Begent, R. H J., Shochat, D., and Yarranton, G T. Improved tumor targeting with chemically cross-linked recombinant antibody fragments Cancer Res., 54; 6176-6185, 1994.
30. Lindmo, T., Boven, E., Cuttitta, F., Fedorko, J., and Bunn, P. A. Determination of the immunoreactive fraction of radiolabeled monoclonal antibodies by linear extrapolation to binding at infinite antigen excess. J. Immunol. Methods, 72: 77-89, 1974.
31. Badger, C. C., Krohn, K. A., and Bernstein, I. D. In vitro measurement of avidity of radioiodinated antibodies. Nucl. Med. Biol., 14: 605-610, 1987
32. Press, O. W., Hansen, J. A., Farr, A , and Martin, P. J Endocytosis and degradation of murine anti-human CD3 monoclonal antibodies by normal and malignant T-lymphocytes. Cancer Res., 48. 2249-2257, 1988.
33. Dickson, R B., Hanover, J. A., Willingham, M. C., and Pastan, I Prelysosomal divergence of transferrin and epidermal growth factor during receptor-mediated endocytosis Biochemistry, 22: 5667-5674, 1983.
34. Laemmli, U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (Lond.), 227: 680-685, 1970.
35. Welt, S., Divgi, C. R., Kemeny, N., Finn, R. D., Scott, A M., Graham, M , St. Germain, J , Richards, E C., Larson, S. M., Oettgen, H F., and Old, L J. Phase I/II study of iodine 131-labeled monoclonal antibody A33 in patients with advanced colon cancer. J. Clin. Oncol., 12. 1561-1571, 1994
36. Yokoyama, K., Carrasquillo, J A., Chang, A. E., Colcher, D , Roselli, M., Sugarbaker, P , Sindelar, W., Reynolds, J. C , Perentesis, P., and Gansow, O. A Differences in biodistribution of indium-111 and iodine-131-labeled B72.3 monoclonal antibodies in patients with colorectal cancer. J. Nucl Med., 10: 320-327, 1989.
37. Buraggi, G. L., Gasparini, M., Seregni, E., Bombardieri, E., Regalia, E., and Maffioli, L Pilot, multicenter and prospective trials with an anti-CEA antibody. Int. J. Biol. Markers, 7: 189-192, 1992.
38. Novak-Hofer, I., Amstutz, H. P., Macke, H. R., Schwarzbach, R., Zimmermann, K., Morgenthaler, J. J., and Schubiger, P. A. Cellular processing of copper-67-labeled monoclonal antibody chCE7 by human neuroblastoma cells Cancer Res., 565: 46-50, 1995.
39. 125I-labeled monoclonal antibodies in osteogenic sarcoma xenografts in nude mice. Cancer Res., 49: 1752-1757, 1989.
40. Sharkey, R. M , Motta-Hennnessy, C , Pawlyk, D., Siegel, J. A., and Goldenberg, D. M. Biodistribution and radiation dose estimates for yttrium and iodine-labeled monoclonal antibody IgG and fragments in nude mice bearing human colonic tumor xenografts. Cancer Res., 50: 2330-2336, 1990
41. Kozak, R W., Raubitschek, A. A., Mirzadeh, S., Brechbiel, M. W., Junghaus, R , Gansow, O. A., and Waldmann, T. A. Nature of the bifunctional chelating agent used for radioimmunotherapy with yttrium-90 monoclonal antibodies: critical factors in determining in vivo survival and organ toxicity. Cancer Res., 49: 2639-2644, 1989
42. 111In-labeled T101 monoclonal antibody. N. Engl. J. Med , 315: 673-680, 1986.
43. Carrasquilio, J. A., Mulshine, J. L., Bunn, P. A., Jr., Reynolds, J. C., Foon, K. A , Schroff, R. W., Perentesis, P., Steis, R. G., Keenan, A. M., Horowitz, M., and Larson, S. M. Indium-111 T101 monoclonal antibody is superior to iodine-131 T101 in imaging of cutaneous T-cell lymphoma. J. Nucl. Med., 28. 281-287, 1987
44. Press, O. W., Howell-Clark, J., Anderson, S., and Bernstein, I. Retention of B-cell-specific monoclonal antibodies by human lymphoma cells. Blood. 83: 1390-1397, 1994.
45. Ali, S. A., Warren, S. D., Richter, K. Y. Badger, C. C , Eary, J. E., Press, O. W., Krohn, K. A., Bernstein, I. D., and Nelp, W. B. Improving the tumor retention of radioiodinated antibody: aryl carbohydrates adducts. Cancer Res., 50: 783s-788s, 1990
46. Pittman, R. C., Carew, T. E., Glass, C. K., Green, S. R., Taylor, C. A., Jr., and Attie, A. D. A radioiodinated, intracellularly trapped ligand for determining the sites of plasma protein degradation in vivo. Biochem. J., 212: 791-800, 1983.
47. Zalutsky, M. R., Noska, M. A , Colapinto, E. V., Garg, P K., Bigner, D. D. Enhanced rumor localization and in vivo stability of a monoclonal antibody radioiodinated using N-succinimidyl 3 (tri-n-butylstannyl)benzoate. Cancer Res., 49: 5543-5549, 1989.
48. Press, O. W., DeSantes, K. D., Anderson, S. K., and Geissler, F. Inhibition of catabolism of radiolabeled antibodies by tumor cells using lysosomotropic amines and carboxylic ionophores. Cancer Res., 50: 1243-1250, 1990.
49. Eary, J. F., Press, O. W., Badger C. C , Durack, L. D., Richter, K. Y., Adison, S. J., Krohn, K. A., Fisher, D. R., Porter, B. A., and Williams, D L. Imaging and treatment of B-cell lymphoma. J. Nucl. Med , 31. 1257-1268, 1990