Advantage of residualizing radiolabels for an internalizing antibody against the B-cell lymphoma antigen, CD22

Cancer Immunology Immunotherapy

Volumn 44, Issue 3, 1997, Pages 179-188

  Sharkey, Robert M ^a   Behr, Thomas M ^a   Mattes, M Jules ^a   Stein, Rhona ^a   Griffiths, Gary L ^b   Shih, Lisa B ^b   Hansen, Hans J ^b   Blumenthal, Rosalyn D ^a   Dunn, Robert M ^a   Juweid, Malik E ^a   Goldenberg, David M ^a  

^a GARDEN STATE CANCER CENTER   (United States)

^b IMMUNOMEDICS INC   (United States)

Author keywords

Anti CD22 monoclonal antibody; B cell non Hodgkin's lymphoma; Internalization; Radioactive metals; Radioimmunodetection; Radioimmunotherapy; Residualizing iodine label

Indexed keywords

CD20 ANTIGEN; CD22 ANTIGEN; IMMUNOGLOBULIN F(AB) FRAGMENT; IMMUNOGLOBULIN G2A; INDIUM 111; IODINE 125; IODINE 131; MONOCLONAL ANTIBODY; RADIOACTIVE IODINE; TOSYLCHLORAMIDE SODIUM; TYRAMINE; YTTRIUM 90;

ANIMAL CELL; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; B CELL LYMPHOMA; CATABOLISM; DRUG DISTRIBUTION; FEMALE; FLOW CYTOMETRY; IMMUNOFLUORESCENCE TEST; INTERNALIZATION; INTRAVENOUS DRUG ADMINISTRATION; MOUSE; NONHODGKIN LYMPHOMA; NONHUMAN; PRIORITY JOURNAL; RADIATION DOSE; TUMOR VOLUME;

ANIMALS; ANTIBODIES, MONOCLONAL; ANTIGENS, CD; ANTIGENS, CD22; ANTIGENS, DIFFERENTIATION, B-LYMPHOCYTE; ANTIGENS, NEOPLASM; CELL ADHESION MOLECULES; HUMANS; INDIUM RADIOISOTOPES; LECTINS; LYMPHOMA, B-CELL; MICE; MICE, NUDE; NEOPLASMS, EXPERIMENTAL; RADIOIMMUNOTHERAPY; TUMOR CELLS, CULTURED;

EID: 8544267259     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620050371     Document Type: Article

References (47)

1. 99m-labeled LL2 monoclonal antibody fragment in the radioimmunodetection of B-cell lymphoma. Cancer [Supp]73: 896-899
2. 99m-labelled LL2-Fab′-fragments (anti-CD22) in the staging of B-cell-non-Hodgkin's lymphoma (NHL). Cancer Res 55 [Supp]: 5771-5773
3. Behr TM, Goldenberg DM (1996) Improved prospects for cancer therapy with radiolabeled antibody fragments and peptides? J Nucl Med 37: 834-836
4. Behr TM, Sharkey RM, Juweid ME, Blumenthal RD, Dunn RM, Griffiths GL, Bair HJ, Wolf FG, Becker WS, Goldenberg DM (1995) Reduction of the renal uptake of radiolabeled monoclonal antibody fragments by cationic amino acids and their derivatives. CancerRes 55: 3825-3834
5. Behr TM, Sharkey RM, Juweid ME, Aninipot R, Mattes MJ, Stein R, Griffiths GL, Goldenberg DM (1995) Residualizing (indium, yttrium) versus released (iodine) isotopes in radioimmunodetection and therapy with internalizing antibodies (abstract 71). J Nucl Med 36: 20P
6. Behr TM, Sharkey RM, Blumenthal RD, Sgouros G, Dunn RM, Alisauskus R, Griffiths G, Goldenberg DM (1996) Overcoming nephrotoxicity in therapy with radiometal-conjugated fragments and peptides: improvement of their therapeutic efficacy. (abstract 374) J Nucl Med 37: 96P
7. Behr TM, Sharkey RM, Juweid ME, Dunn RM, Vagg RC, Swayne LC, Siegel JA, Goldenberg DM (1997) Phase I/II clinical radioimmunotherapy with an 131I-labeled anti-CEA murine IgG monoclonal antibody. J Nucl Med (in press)
8. 99mTc-labeled LL2 monoclonal antibody fragment. Cancer Res 55: 5764s-5770s
9. Carrasquillo JA, Kramer B, Fleisher T, Perentesis P, Boland CJ, Foss F, Rotman M, Reynolds RC, Mulshine JL, Camera L, Frincke J, Lollo C, Neumann RD, Larson SM, Raubitschek A (1991) In-111 versus Y-90 T101 biodistribution in patients with hematopoietic malignancies. J Nucl Med 32: 970
10. Cox JD (1994) Lymphomas and leukemia. In: Cox JD (ed) Moss' radiation oncology - rationale, technique, results, 7th edn. Mosby - Year Book, St Louis, pp 795-826
11. DeNardo SJ, DeNardo GL, O'Grady LF, Macey DJ, Mills SL, Epstein AL, Peng J-S, McGahan JP (1987) Treatment of a patient with B-cell lymphoma by I-131 Lym-1 monoclonal antibodies. Int J Biol Markers 2: 49-53
12. Duncan JR, Welch MJ (1993) Intracellular metabolsim of indium-111 DTPA labeled receptor targeted proteins. J Nucl Med 34: 1728-1738
13. 111In-DTPA-ε-lysine as the primary metabolic and secretory product. Nucl Med Biol 21: 1023-1034
14. Geissler F, Anderson SK, Venkatesan P, Press O (1992). Intracellular catabolism of radiolabeled anti-μ antibodies by malignant B-cells. Cancer Res 52: 2907-2915
15. Goldenberg DM (ed) (1990) Cancer imaging with radiolabeled antibodies. Kluwer, Boston, Mass
16. Goldenberg DM (ed) (1995) Cancer therapy with radiolabeled antibodies. CRC, Boca Raton, Fla.
17. Goldenberg DM, DeLand F, Kim E, Bennett S, Primus FJ, van Nagell JR, Estes N, De Simone P, Rayburn P (1978) Use of radiolabeled antibodies to carcinoembryonic antigen for the detection and localization of diverse cancers by external photoscanning. N Engl J Med 298: 1384-1388
18. 131-labeled LL2 monoclonal antibody. J Clin Oncol 9: 548-564
19. Griffiths GL (1995) Radiochemistry of therapeutic radionuclides. In: Goldenberg DM (ed) Cancer therapy with radiolabeled antibodies. CRC, Boca Raton, Fla.
20. Hanna R, Ong GL, Mattes MJ (1996) Processing of antibodies bound to B-cell lymphomas and other hematological malignancies. Cancer Res 56: 3062-3068
21. Juweid M, Sharkey RM, Markowitz A, Behr T, Swayne LC, Hansen HJ, Shevitz J, Leung S, Rubin AD, Herskovic T, Hanley D, Goldenberg DM (1995) Treatment of non-Hodgkin's lymphoma with radiolabeled murine, chimeric, or humanized LL2, an anti-CD22 monoclonal antibody. Cancer Res 55: 5899s-5907s
22. 131I]anti-B1 (anti-CD20) antibody. N Engl J Med 329: 459-465
23. Kyriakos RJ, Shih LB, Ong GL, Patel K, Goldenberg DM, Mattes MJ (1992) The fate of antibodies bound to the surface of tumor cells in vitro. Cancer Res 52: 835-842
24. Leung S-O, Goldenberg DM, Dion AS, Pellegrini MC, Shevitz J, Shih LB, Hansen HJ (1995) Construction and characterization of a humanized, internalizing, B-cell (CD22)-specific leukemia/lymphoma antibody, LL2. Mol Immunol 32: 1413-1427
25. Losman MJ, Leung SO, Shevitz J, Shukla R, Haraga L, Shih LB, Goldenberg DM, Hansen HJ (1995) Development and evaluation of the specificity of a rat monoclonal anti-1d antibody, WN, to an anti-B-cell lymphoma monoclonal antibody, murine LL2. Cancer Res 55: 5978-5982
26. Moshakis V, McIlhinney RAJ, Raghaven D, Neville AM (1981) Localization of human tumor xenografts after i.v. administration of radiolabelled monoclonal antibodies. Br J Cancer 44: 91-99
27. Motta-Hennessy C, Sharkey RM, Goldenberg DM (1990) Metabolism of indium-111-labeled murine monoclonal antibody in tumor and normal tissue of the athymic mouse. J Nucl Med 31: 1510-1519
28. Murthy S, Sharkey RM, Goldenberg DM, Lee RE, Pinsky CM, Hansen HJ, Burger K, Swayne LC (1992) Lymphoma imaging with a new technetium-99m labelled antibody, LL2. Eur J Nucl Med 19: 394-401
29. 125I radiolabeled anti-CD5 monoclonal antibody. Nucl Med Biol 17: 201-207
30. Pawlak-Byczkowska EJ, Hansen HJ, Dion AS, Goldenberg DM (1989) Two new monoclonal antibodies, EPB-1 and EPB-2, reactive with human lymphoma. Cancer Res 49: 4568-4577
31. Pimm MV, Perkins AC, Baldwin RW (1985) Differences in tumour and normal tissue concentrations of iodine- and indium-labelled monoclonal antibody. II. Biodistribution studies in mice and human tumour xenografts. Eur J Nucl Med 11: 300-304
32. Press OW, FarrAG, Borroz KI, Anderson SK, Martin PJ (1989) Endocytosis and degradation of monoclonal antibodies targeting human B-cell malignancies. Cancer Res 49: 4906-4912
33. 131I-B1 (anti-CD20) antibody therapy with autologous stem cell transplantation for relapsed B cell lymphoma. Lancet 346: 336-340
34. Press OW, Eary JF, Appelbaum FR, Bernstein ID (1995) Treatment of relapsed B cell lymphomas with high dose radioimmunotherapy and bone marrow transplantation. In: Goldenberg DM (ed) Cancer therapy with radiolabeled antibodies. CRC, Boca Raton, Fla, p 229
35. Press OW, Shan D, Howell-Clark J, Eary J, Appelbaum FR, Matthews D, King DJ, Haines AMR, Hamann P, Hinman L, Shochat D, Bernstein ID (1996) Comparative metabolism and retention of iodine-125, yttrium-90, and indium-111 radioimmunoconjugates by cancer cells. Cancer Res 56: 2123-2129
36. Reist CJ, Archer GE, Kurpad SN, Wikstrand CJ, Vaidyanathan G, Willingham MC, Moscatello DK, Wong AJ, Bigner DD, Zalutsky MR (1995) Tumor-specific anti-epidermal growth factor receptor variant III monoclonal antibodies: use of the tyramine-cellobiose radioiodination method enhances cellular retention and uptake in tumor xenografts. Cancer Res 55: 4375-43821
37. Schmid J, Möller P, Moldenhauer G, Dörken B, Bihl H, Matzku S (1993) Monoclonal antibody uptake in B-cell lymphomas: experimental studies in nude mouse xenografts. Cancer Immunol Immunother 36: 274-280
38. Sharkey RM, Primus FJ, Goldenberg DM (1987) Antibody protein dose and radioimmunodetection of GW-39 human colon tumor xenografts. Int J Cancer 39: 611-617
39. Sharkey RM, Motta-Hennessy C, Pawlyk D, Siegel JA, Goldenberg DM (1990) Biodistribution and radiation dose estimates for yttrium- and iodine-labeled monoclonal antibodies IgG and fragments in nude mice bearing human colonic tumor xenografts. Cancer Res 50: 2330-2336
40. Sharkey RM, Natale A, Goldenberg DM, Mattes MJ (1991) Rapid blood clearance of immunoglobulin G2a in nude mice. Cancer Res 51: 3102-3107
41. Sharkey RM, BehrT, Mattes MJ, Stein R, Shih LB, Goldenberg DM (1995) Enhanced retention of a radiometal-labeled internalizing antibody for cancer radioimmunotherapy (abstract 2911). Proc Am Assoc Cancer Res 36: 489
42. Shih LB, Lu HHZ, Xuan H, Goldenberg DM (1994) Internalization and intracellular processing of an anti-B-cell lymphoma monoclonal antibody, LL2. Int J Cancer 56: 538-545
43. Shih LB, Thorpe SR, Grifffiths GL, Diril H, Ong GL, Hansen HJ, Goldenberg DM, Mattes MJ (1994) The processing and fate of antibodies and their radiolabels bound to the surface of tumor cells in vitro: a comparison of nine radiolabels. J Nucl Med 35: 899-908
44. Stein R, Belisle E, Hansen HJ, Goldenberg DM (1993) Epitope specificity of the anti-B cell lymphoma monoclonal antibody, LL2. Cancer Immunol Immunother 37: 293-298
45. Stein R, Goldenberg DM, Thorpe SR, Basu A, Mattes MJ (1995) Effects of radiolabeling monoclonal antibodies with a residualizing iodine radiolabel on the accretion of radioisotope in tumors. Cancer Res 55: 3132-3139
46. Stern P, Hagan P, Halpern S, Chen A, David G, Adams T, Desmond W, Brautigam K, Royston I (1982) In: Mitchell MS, Oettgen HF (eds) Hybridomas in cancer diagnosis and treatment. Raven Press, New York, p 245
47. Weadock KS, Sharkey RM, Varga DC, Goldenberg DM (1990) Evaluation of a remote radioiodination system for radioimmunotherapy. J Nucl Med 31: 508-511