Differential regulation of caspase-9 by ionizing radiation- and UV-induced apoptotic pathways in thymic cells

Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis

Volumn 688, Issue 1-2, 2010, Pages 78-87

  Okamoto, Mayumi ^a   Koga, Satomi ^a   Tatsuka, Masaaki ^a  

^a PREFECTURAL UNIVERSITY OF HIROSHIMA   (Japan)

Author keywords

Apoptosome; Caspases; Ionizing radiation; UV

Indexed keywords

APOPTOSOME; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 3; CASPASE 8; CASPASE 9; CYTOCHROME C; DNA; PROTEIN BCL XL; PROTEIN BID;

ANIMAL CELL; APOPTOSIS; ARTICLE; B CELL LYMPHOMA; CANCER CELL CULTURE; CELL ACTIVATION; CELL FRACTIONATION; CONTROLLED STUDY; DNA DAMAGE; ENZYME ACTIVATION; ENZYME REGULATION; IONIZING RADIATION; MOLECULAR MECHANICS; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN LOCALIZATION; PROTEIN SECRETION; SIGNAL TRANSDUCTION; THYMOCYTE; ULTRAVIOLET IRRADIATION; ULTRAVIOLET RADIATION;

ANIMALS; APOPTOSIS; CASPASE 3; CASPASE 9; CELL FRACTIONATION; CELLS, CULTURED; CYTOCHROMES C; ENZYME ACTIVATION; MICE; MITOCHONDRIA; RADIATION, IONIZING; THYMUS GLAND; ULTRAVIOLET RAYS;

EID: 77952875366     PISSN: 00275107     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrfmmm.2010.03.012     Document Type: Article

References (50)

1. Friedberg E.C., Walker G.C., Siede W. DNA Repair and Mutagenesis 2006, American Society for Microbiology, Washigton, DC. second ed.
2. Warmerdam D.O., Freire R., Kanaar R., Smits V.A. Cell cycle-dependent processing of DNA lesions controls localization of Rad9 to sites of genotoxic stress. Cell Cycle 2009, 8:1765-1774.
3. Kaina B. DNA damage-triggered apoptosis: critical role of DNA repair, double-strand breaks, cell proliferation and signaling. Biochem. Pharmacol. 2003, 66:1547-1554.
4. Roos W.P., Kaina B. DNA damage-induced cell death by apoptosis. Trends Mol. Med. 2006, 12:440-450.
5. Kim S.T., Lim D.S., Canman C.E., Kastan M.B. Substrate specificities and identification of putative substrates of ATM kinase family members. J Biol. Chem. 1999, 274:37538-37543.
6. Woo M., Hakem R., Soengas M.S., Duncan G.S., Shahinian A., Kagi D., Hakem A., McCurrach M., Khoo W., Kaufman S.A., Senaldi G., Howard T., Lowe S.W., Mak T.W. Essential contribution of caspase 3/CPP32 to apoptosis and its associated nuclear changes. Genes Dev. 1998, 12:806-819.
7. Maruyama Y., Feola J.M. Relative radiosensitivities of the tymus, spleen, and lymphohemopoietic systems. Advances in Radiation Biology 1987, vol. 12:1-82. Academic Press, New York.
8. Yamada T., Ohyama H. Radiation-induced interphase death of rat thymocytes is internally programmed (apoptosis). Int. J. Radiat. Biol. Relat. Stud. Phys. Chem. Med. 1988, 53:65-75.
9. Yamada T., Ohyama H. Characteristics of radiation-induced apoptosis in thymocytes. Radiation Research 1895-1995 1996, vol. 2:645-648. Universitätsdruckerei H. Stürtz, Würzburg, Germany.
10. Lowe S.W., Schmitt E.M., Smith S.W., Osborne B.A., Jacks T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 1993, 362:847-849.
11. Clarke A.R., Purdie C.A., Harrison D.J., Morris R.G., Bird C.C., Hooper M.L., Wyllie A.H. Thymocyte apoptosis induced by p53-dependent and independent pathways. Nature 1993, 362:849-852.
12. Lotem J., Sachs L. Hematopoietic cells from mice deficient in wild-type p53 are more resistant to induction of apoptosis by some agents. Blood 1993, 82:1092-1096.
13. Kawai H., Kitamura Y., Nikaido O., Tatsuka M., Hama-Inaba H., Muto M., Ohyama H., Suzuki F. Isolation and characterization of apoptosis-resistant mutants from a radiosensitive mouse lymphoma cell line. Radiat. Res. 1998, 149:41-51.
14. Lu X., Lane D.P. Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?. Cell 1993, 75:765-778.
15. Hakem R., Hakem A., Duncan G.S., Henderson J.T., Woo M., Soengas M.S., Elia A., de la Pompa J.L., Kagi D., Khoo W., Potter J., Yoshida R., Kaufman S.A., Lowe S.W., Penninger J.M., Mak T.W. Differential requirement for caspase 9 in apoptotic pathways in vivo. Cell 1998, 94:339-352.
16. Schamberger C.J., Gerner C., Cerni C. Caspase-9 plays a marginal role in serum starvation-induced apoptosis. Exp. Cell Res. 2005, 302:115-128.
17. Green D.R., Reed J.C. Mitochondria and apoptosis. Science 1998, 281:1309-1312.
18. Li P., Nijhawan D., Budihardjo I., Srinivasula S.M., Ahmad M., Alnemri E.S., Wang X. Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade. Cell 1997, 91:479-489.
19. Hu Y., Benedict M.A., Ding L., Nunez G. Role of cytochrome c and dATP/ATP hydrolysis in Apaf-1-mediated caspase-9 activation and apoptosis. EMBO J. 1999, 18:3586-3595.
20. Thornberry N.A., Lazebnik Y. Caspases: enemies within. Science 1998, 281:1312-1316.
21. Zou H., Li Y., Liu X., Wang X. An APAF-1.cytochrome c multimeric complex is a functional apoptosome that activates procaspase-9. J. Biol. Chem. 1999, 274:11549-11556.
22. Sasai K., Yajima H., Suzuki F. Suppression of postmitochondrial signaling and delayed response to UV-induced nuclear apoptosis in HeLa cells. Jpn. J. Cancer Res. 2002, 93:275-283.
23. Scoltock A.B., Cidlowski J.A. Activation of intrinsic and extrinsic pathways in apoptotic signaling during UV-C-induced death of Jurkat cells: the role of caspase inhibition. Exp. Cell Res. 2004, 297:212-223.
24. Vu C.C., Bortner C.D., Cidlowski J.A. Differential involvement of initiator caspases in apoptotic volume decrease and potassium efflux during Fas- and UV-induced cell death. J. Biol. Chem. 2001, 276:37602-37611.
25. Kawai H., Yamada Y., Tatsuka M., Niwa O., Yamamoto K., Suzuki F. Down-regulation of nuclear factor kappaB is required for p53-dependent apoptosis in X-ray-irradiated mouse lymphoma cells and thymocytes. Cancer Res. 1999, 59:6038-6041.
26. Zhou X., Suto S., Ota T., Tatsuka M. Nuclear translocation of cleaved LyGDI dissociated from Rho and Rac during Trp53-dependent ionizing radiation-induced apoptosis of thymus cells in vitro. Radiat. Res. 2004, 162:287-295.
27. Tatsuka M., Sato S., Kanda A., Miki T., Kamata N., Kitajima S., Kudo Y., Takata T. Oncogenic role of nuclear accumulated Aurora-A. Mol. Carcinog. 2009.
28. Chao D.T., Korsmeyer S.J. BCL-2 family: regulators of cell death. Annu. Rev. Immunol. 1998, 16:395-419.
29. Pan G., O'Rourke K., Dixit V.M. Caspase-9, Bcl-XL, and Apaf-1 form a ternary complex. J. Biol. Chem. 1998, 273:5841-5845.
30. Hu Y., Benedict M.A., Wu D., Inohara N., Nunez G. Bcl-XL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation. Proc. Natl. Acad. Sci. U. S. A. 1998, 95:4386-4391.
31. Moriishi K., Huang D.C., Cory S., Adams J.M. Bcl-2 family members do not inhibit apoptosis by binding the caspase activator Apaf-1. Proc. Natl. Acad. Sci. U. S. A. 1999, 96:9683-9688.
32. Conus S., Rosse T., Borner C. Failure of Bcl-2 family members to interact with Apaf-1 in normal and apoptotic cells. Cell Death Differ. 2000, 7:947-954.
33. Yajima H., Suzuki F. Identification of a Bcl-XL binding region within the ATPase domain of Apaf-1. Biochem. Biophys. Res. Commun. 2003, 309:520-527.
34. Dunkern T.R., Fritz G., Kaina B. Ultraviolet light-induced DNA damage triggers apoptosis in nucleotide excision repair-deficient cells via Bcl-2 decline and caspase-3/-8 activation. Oncogene 2001, 20:6026-6038.
35. Ferguson H.A., Marietta P.M., Van Den Berg C.L. UV-induced apoptosis is mediated independent of caspase-9 in MCF-7 cells: a model for cytochrome c resistance. J. Biol. Chem. 2003, 278:45793-45800.
36. Tomicic M.T., Christmann M., Kaina B. Apoptosis in UV-C light irradiated p53 wild-type, apaf-1 and p53 knockout mouse embryonic fibroblasts: interplay of receptor and mitochondrial pathway. Apoptosis 2005, 10:1295-1304.
37. Luo X., Budihardjo I., Zou H., Slaughter C., Wang X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 1998, 94:481-490.
38. Jin Z., El-Deiry W.S. Overview of cell death signaling pathways. Cancer Biol. Ther. 2005, 4:139-163.
39. Razandi M., Pedram A., Levin E.R. Plasma membrane estrogen receptors signal to antiapoptosis in breast cancer. Mol. Endocrinol. 2000, 14:1434-1447.
40. Besse B., Cande C., Spano J.P., Martin A., Khayat D., Le Chevalier T., Tursz T., Sabatier L., Soria J.C., Kroemer G. Nuclear localization of apoptosis protease activating factor-1 predicts survival after tumor resection in early-stage non-small cell lung cancer. Clin. Cancer Res. 2004, 10:5665-5669.
41. Chinnaiyan A.M., O'Rourke K., Lane B.R., Dixit V.M. Interaction of CED-4 with CED-3 and CED-9: a molecular framework for cell death. Science 1997, 275:1122-1126.
42. Newmeyer D.D., Bossy-Wetzel E., Kluck R.M., Wolf B.B., Beere H.M., Green D.R. Bcl-xL does not inhibit the function of Apaf-1. Cell Death Differ. 2000, 7:402-407.
43. Gao J., Wu D., Guo T.B., Ruan Q., Li T., Lu Z., Xu M., Dai W., Lu L. K(+) channel activity and redox status are differentially required for JNK activation by UV and reactive oxygen species. Exp. Cell Res. 2004, 297:461-471.
44. Hajra K.M., Liu J.R. Apoptosome dysfunction in human cancer. Apoptosis 2004, 9:691-704.
45. Karki P., Seong C., Kim J.E., Hur K., Shin S.Y., Lee J.S., Cho B., Park I.S. Intracellular K(+) inhibits apoptosis by suppressing the Apaf-1 apoptosome formation and subsequent downstream pathways but not cytochrome c release. Cell Death Differ. 2007, 14:2068-2075.
46. Cain K., Langlais C., Sun X.M., Brown D.G., Cohen G.M. Physiological concentrations of K+ inhibit cytochrome c-dependent formation of the apoptosome. J. Biol. Chem. 2001, 276:41985-41990.
47. Desagher S., Osen-Sand A., Nichols A., Eskes R., Montessuit S., Lauper S., Maundrell K., Antonsson B., Martinou J.C. Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis. J. Cell Biol. 1999, 144:891-901.
48. Kim T.H., Zhao Y., Barber M.J., Kuharsky D.K., Yin X.M. Bid-induced cytochrome c release is mediated by a pathway independent of mitochondrial permeability transition pore and Bax. J. Biol. Chem. 2000, 275:39474-39481.
49. Sheikh M.S., Antinore M.J., Huang Y., Fornace A.J. Ultraviolet-irradiation-induced apoptosis is mediated via ligand independent activation of tumor necrosis factor receptor 1. Oncogene 1998, 17:2555-2563.
50. Alam A., Cohen L.Y., Aouad S., Sekaly R.P. Early activation of caspases during T lymphocyte stimulation results in selective substrate cleavage in nonapoptotic cells. J. Exp. Med. 1999, 190:1879-1890.