Apoptosis in UV-C light irradiated p53 wild-type, apaf-1 and p53 knockout mouse embryonic fibroblasts: Interplay of receptor and mitochondrial pathway

Apoptosis

Volumn 10, Issue 6, 2005, Pages 1295-1304

  Tomicic, M T ^a   Christmann, M ^a   Kaina, B ^a  

^a JOHANNES GUTENBERG UNIVERSITY   (Germany)

Author keywords

Apaf 1; Bcl 2; DNA repair; Fas; Fasl; p53; UV C

Indexed keywords

APOPTOTIC PROTEASE ACTIVATING FACTOR 1; CASPASE 3; CASPASE 8; CASPASE 9; DNA; FAS ANTIGEN; FAS LIGAND; MESSENGER RNA; PROTEIN BCL 2; PROTEIN P53;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL VIABILITY; DNA DAMAGE; EMBRYO; ENZYME ACTIVATION; FIBROBLAST; KNOCKOUT MOUSE; LIGHT IRRADIANCE; MITOCHONDRION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN DETERMINATION; PROTEIN INDUCTION; SENSITIVITY ANALYSIS; STATISTICAL SIGNIFICANCE; ULTRAVIOLET C RADIATION; UPREGULATION; WILD TYPE;

ANIMALS; APOPTOSIS; APOPTOTIC PROTEASE-ACTIVATING FACTOR 1; CASPASES; CELL CYCLE; CELL SURVIVAL; EMBRYO, MAMMALIAN; ENZYME ACTIVATION; FAS-ASSOCIATED DEATH DOMAIN PROTEIN; FIBROBLASTS; GENES, DOMINANT; MICE; MICE, KNOCKOUT; MITOCHONDRIA; NECROSIS; PYRIMIDINE DIMERS; RECEPTORS, CELL SURFACE; THERMODYNAMICS; TRANS-ACTIVATION (GENETICS); TRANSFECTION; TUMOR SUPPRESSOR PROTEIN P53; ULTRAVIOLET RAYS;

ANIMALIA;

EID: 30944454672     PISSN: 13608185     EISSN: 1573675X     Source Type: Journal    
DOI: 10.1007/s10495-005-1392-3     Document Type: Article

References (31)

1. Christmann M, Tomicic MT, Roos WP, Kaina B. Mechanisms of human DNA repair: An update. Toxicology 2003; 193: 3-34.
2. el-Deiry WS, Kern SE, Pietenpol JA, Kinzler KW, Vogelstein B. Definition of a consensus binding site for p53. Nat Genet 1992; 1: 45-49.
3. Maltzman W, Czyzyk L. UV irradiation stimulates levels of p53 cellular tumor antigen in nontransformed mouse cells. Mol Cell Biol 1984; 4: 1689-1694.
4. Chehab NH, Malikzay A, Stavridi ES, Halazonetis TD. Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage. Proc Natl Acad Sci USA 1999; 96: 13777-13782.
5. Khosravi R, Maya R, Gottlieb T, Oren M, Shiloh Y, Shkedy D. Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage. Proc Natl Acad Sci USA 1999; 96: 14973-14977.
6. Lakin ND, Jackson SP. Regulation of p53 in response to DNA damage. Oncogene 1999; 18: 7644-7655.
7. Kastan MB, Onyekwere O, Sidransky D, Vogelstein B, Craig RW. Participation of p53 protein in the cellular response to DNA damage. Cancer Res 1991; 51: 6304-6311.
8. Zhou J, Ahn J, Wilson SH, Prives C. A role for p53 in base excision repair. Embo J 2001; 20: 914-923.
9. Seo YR, Fishel ML, Amundson S, Kelley MR, Smith ML. Implication of p53 in base excision DNA repair: In vivo evidence. Oncogene 2002; 21: 731-737.
10. Susse S, Janz C, Janus F, Deppert W, Wiesmuller L. Role of heteroduplex joints in the functional interactions between human Rad51 and wild-type p53. Oncogene 2000; 19: 4500-4512.
11. Rafferty JA, Clarke AR, Sellappan D, Koref MS, Frayling IM, Margison GP. Induction of murine O6-alkylguanine-DNA-alkyltransferase in response to ionising radiation is p53 gene dose dependent. Oncogene 1996; 12: 693-697.
12. Grombacher T, Eichhorn U, Kaina B. p53 is involved in regulation of the DNA repair gene O6-methylguanine-DNA methyltransferase (MGMT) by DNA damaging agents. Oncogene 1998; 17: 845-851.
13. Smith ML, Ford JM, Hollander MC, et al. p53-mediated DNA repair responses to UV radiation: Studies of mouse cells lacking p53, p21, and/or gadd45 genes. Mol Cell Biol 2000; 20: 3705-3714.
14. Prost S, Ford JM, Taylor C, Doig J, Harrison DJ. Hepatitis B x protein inhibits p53-dependent DNA repair in primary mouse hepatocytes. J Biol Chem 1998; 273: 33327-33332.
15. Lackinger D, Kaina B. Primary mouse fibroblasts deficient for c-Fos, p53 or for both proteins are hypersensitive to UV light and alkylating agent-induced chromosomal breakage and apoptosis. Mutat Res 2000; 457: 113-123.
16. Lackinger D, Eichhorn U, Kaina B. Effect of ultraviolet light, methyl methanesulfonate and ionizing radiation on the genotoxic response and apoptosis of mouse fibroblasts lacking c-Fos, p53 or both. Mutagenesis 2001; 16: 233-241.
17. Dunkern TR, Kaina B. Cell proliferation and DNA breaks are involved in ultraviolet light-induced apoptosis in nucleotide excision repair-deficient Chinese hamster cells. Mol Biol Cell 2002; 13: 348-361.
18. Dunkern TR, Fritz G, Kaina B. Ultraviolet light-induced DNA damage triggers apoptosis in nucleotide excision repair-deficient cells via Bcl-2 decline and caspase-3/-8 activation. Oncogene 2001; 20: 6026-6038.
19. Tomicic MT, Thust R, Kaina B. Ganciclovir-induced apoptosis in HSV-1 thymidine kinase expressing cells: Critical role of DNA breaks, Bcl-2 decline and caspase-9 activation. Oncogene 2002; 21: 2141-2153.
20. Tomicic MT, Kaina B. Hamster Bcl-2 protein is cleaved in vitro and in cells by caspase-9 and caspase-3. Biochem Biophys Res Commun 2001; 281: 404-408.
21. Milosevic J, Hoffarth S, Huber C, Schuler M. The DNA damage-induced decrease of Bcl-2 is secondary to the activation of apoptotic effector caspases. Oncogene 2003; 22: 6852-6856.
22. Christmann M, Kaina B. Nuclear translocation of mismatch repair proteins MSH2 and MSH6 as a response of cells to alkylating agents. J Biol Chem 2000; 275: 36256-36262.
23. Christmann M, Tomicic MT, Kaina B. Phosphorylation of mismatch repair proteins MSH2 and MSH6 affecting MutS{alpha} mismatch-binding activity. Nucl Acids Res 2002; 30: 1959-1966.
24. Fortin A, Cregan SP, MacLaurin JG, et al. APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death. J Cell Biol 2001; 155: 207-216.
25. Muller M, Wilder S, Bannasch D, et al. p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs. J Exp Med 1998; 188: 2033-2045.
26. Brozovic A, Fritz G, Christmann M, et al. Long-term activation of SAPK/JNK, p38 kinase and fas-L expression by cisplatin is attenuated in human carcinoma cells that acquired drug resistance. Int J Cancer 2004; 112: 974-985.
27. Mansouri A, Ridgway LD, Korapati AL, et al. Sustained activation of JNK/p38 MAPK pathways in response to cisplatin leads to Fas ligand induction and cell death in ovarian carcinoma cells. J Biol Chem 2003; 278: 19245-19256.
28. Chinnaiyan AM, O'Rourke K, Tewari M, Dixit VM. FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis. Cell 1995; 81: 505-512.
29. Roos W, Baumgartner M, Kaina B. Apoptosis triggered by DNA damage O6-methylguanine in human lymphocytes requires DNA replication and is mediated by p53 and Fas/CD95/Apo-1. Oncogene 2004; 23: 359-367.
30. Chakraborty M, Qiu SG, Vasudevan KM, Rangnekar VM. Par-4 drives trafficking and activation of Fas and Fasl to induce prostate cancer cell apoptosis and tumor regression. Cancer Res 2001; 61: 7255-7263.
31. Boehrer S, Nowak D, Hochmuth S, et al. Daxx overexpression in T-lymphoblastic Jurkat cells enhances caspase-dependent death receptor- and drug-induced apoptosis in distinct ways. Cell Signal 2005; 17: 581-595.