Does wine prevent dementia?

International Journal of Wine Research

Volumn 1, Issue 1, 2009, Pages 41-52

  Pinder, Roger M ^a  

^a Pharma Consultant   (United Kingdom)

Author keywords

Alcohol; Alzheimer's disease; Dementia; Epidemiology; Polyphenols; Wine

Indexed keywords

EID: 77952833017     PISSN: None     EISSN: 11791403     Source Type: Journal    
DOI: 10.2147/IJWR.S4691     Document Type: Review

References (105)

1. Norrie PA. The history of wine as a medicine. In: Sandler M, Pinder R, editors. Wine. A Scientific Exploration. London: Taylor and Francis; 2003. p. 21-55.
2. Sandler M, Pinder R, editors. Wine. A Scientific Exploration. London: Taylor and Francis; 2003.
3. Di Castelnuovo A, Rotondo S, Iacoviello L, et al. Meta-analysis of wine and beer consumption in relation to vascular risk. Circulation. 2002;105:2836-2844.
4. Klatsky AL, Friedman GD, Armstrong MA, et al. Wine, liquor, beer and mortality. Am J Epidemiol. 2003;158:585-595.
5. Klatsky AL. Wine, alcohol and cardiovascular disease. In: Sandler M, Pinder R, editors. Wine. A Scientific Exploration. London: Taylor and Francis; 2003. p. 108-139.
6. Di Castelnuovo A, Costanzo S, Bagnardi V, et al. Alcohol dosing and total mortality in men and women. An updated meta-analysis of 34 prospective studies. Arch Intern Med. 2006;166:2437-2445.
7. Beulens JWJ, Rimm E, Aschiero A, et al. Alcohol consumption and risk for coronary heart disease among men with hypertension. Arch Intern Med. 2007;146:10-19.
8. Djoussé L, Gaziano JM. Alcohol consumption and heart failure in hypertensive US male physicians. Am J Cardiol. 2008;102:593-597.
9. Reynolds K, Lewis LB, Nolen JDJ, et al. Alcohol and the risk of stroke. A meta-analysis. JAMA. 2003;289:579-588.
10. Pinder RM, Sandler M. Alcohol, wine and mental health: focus on dementia and stroke. J Psychopharmacol. 2004;18:449-456.
11. Carlsson S, Hammar N, Grill V, et al. Alcohol consumption and the incidence of type 2 diabetes. A 20-year follow-up of the Finnish twin cohort. Diabetes Care. 2002;26:2785-2790.
12. Koppes LJ, Bouter LM, Dekker JM, et al. Moderate alcohol consumption lowers the risk of type 2 diabetes. A meta-analysis of prospective observational studies. Diabetes Care. 2005;28:719-725.
13. Davies MJ, Baer DJ, Judd JT, et al. Effects of moderate alcohol intake on fasting insulin and glucose concentrations and insulin sensitivity in postmenopausal women. A randomized controlled trial. JAMA. 2002;287:2559-2562.
14. Klatsky AL. Is it the drink or the drinker? Circumstantial evidence only raises a probability. Am J Clin Nutr. 1999;69:2-3.
15. Solfrizzi V, D'Introno A, Colacicco AM, et al. Alcohol consumption, mild cognitive impairment, and progression to dementia. Neurology. 2007;68:1790-1799.
16. Peters R, Peters J, Warner J, et al. Alcohol, dementia and cognitive decline in the elderly: a systematic review. Age Ageing. 2008;37:505-512.
17. World Health Organization, World Federation of Neurology. Atlas of Country Resources for Neurological Disorders. Geneva: WHO; 2004.
18. Husain MM, Trevino K, Siddique H, et al. Present and prospective clinical therapeutic regimens for Alzheimer's disease. Neuropsychiat Dis Treat. 2008;4:765-777.
19. Pinder RM. Is Alzheimer's a preventable disease? Ann Gen Psychiatry. 2008;7(Suppl 1):S59.
20. Solfrizzi V, Capurso C, D'Introno A, et al. Lifestyle-related factors in predementia and dementia syndromes. Expert Rev Neurother. 2008;8:133-158.
21. ADAPT Research Group. Naproxen and celecoxib do not prevent AD in early results from a randomized controlled trial. Neurology. 2007;68:1800-1808.
22. ADAPT Research Group. Cognitive function over time in the Alzheimer's Disease Anti-inflammatory Prevention Trial (ADAPT). Arch Neurol. 2008;65:896-905.
23. Garibotto V, Borroni B, Kalbe E, et al. Education and occupation as proxies for reserve in aMCI converters and AD. Neurology. 2008; 71:1342-1349.
24. Sofi F, Cesari F, Abbate R, et al. Adherence to Mediterranean diet and health status: meta-analysis. BMJ. 2008;337:a1344.
25. Scarmeas N, Stern Y, Tang M-X, et al. Mediterranean diet and risk for Alzheimer's disease. Ann Neurol. 2006;59:912-921.
26. Scarmeas N, Luchsinger JA, Mayeux R, et al. Mediterranean diet and Alzheimer disease mortality. Neurology. 2007;69:1084-1093.
27. Barberger-Gateau P, Raffaitin C, Letenneur L, et al. Dietary patterns and risk of dementia. The Three-City Cohort Study. Neurology. 2008;69:1921-1930.
28. Larrieu S, Letenneur L, Helmer C. et al. Nutritional factors and risk of incident dementia in the PAQUID longitudinal cohort. J Nutr Health Aging. 2004;8:150-154.
29. Bobak M, Marmot M. Wine and heart disease: a statistical approach. In: Sandler M, Pinder R, editors. Wine. A Scientific Exploration. London: Taylor and Francis; 2003. p. 92-107.
30. Letenneur L. Moderate alcohol consumption and risk of developing dementia in the elderly: the contribution of prospective studies. Ann Epidemiol. 2007;17:S43-S45.
31. Mukamal KJ, Conigrave KM, Mittleman MA, et al. Role of drinking pattern and type of alcohol consumed in coronary heart disease in men. N Engl J Med. 2003;348:109-118.
32. Mukamal KJ, Jensen KJ, Grønbæk M, et al. Drinking frequency, mediating biomarkers, and risk of myocardial infarction in women and men. Circulation. 2005;112:1406-1413.
33. Mukamal KJ, Ascherio A, Mittleman MA, et al. Alcohol and risk for ischemic stroke in men; The role of drinking patterns and usual beverage. Ann Intern Med. 2005;142:11-19.
34. Mukamal KJ, Maclure M, Muller JE, et al. Binge drinking and mortality after acute myocardial infarction. Circulation. 2005;112: 3839-3845.
35. Jarvenpaa T, Rinne JO, Koskenvuo M, et al. Binge drinking in midlife and dementia risk. Epidemiology. 2005;16:766-771.
36. St Leger AS, Cochrane AL, Moore F. Factors associated with cardiac mortality in developed countries with particular reference to the consumption of wine. Lancet. 1979;1:1017-1020.
37. Hébert R, Scherr PA, Beckett LA, et al. Relation of smoking and alcohol consumption to incident Alzheimer's disease. Am J Epidemiol. 1992;135:347-355.
38. Hébert R, Lindsay J, Verreault R, et al. Vascular dementia: Incidence and risk factors in the Canadian Study of Health and Aging. Stroke. 2000;31:1487-1493.
39. Broe GA, Creasy H, Jorm AF, et al. Health habits and risk of cognitive impairnment and dementia in old age: A prospective study on the effects of exercise, smoking and alcohol consumption. Austral NZ J Publ Health. 2008;22:621-623.
40. Yoshitake T, Kiyohara Y, Kato I, et al. Incidence and risk factors of vascular dementia and Alzheimer's disease in a defined elderly Japanese population: the Hisayama Study. Neurology. 1995;45:1161-1168.
41. Simons LA, Simons J, McCallum J, et al. Lifestyle factors and risk of dementia: the Dubbo Study of the elderly. Med J Aust. 2006;184:68-70.
42. Kivipelto M, Helkala E-L, Laakso MP, et al. Midlife vascular risk factors and Alzheimer's disease in later life: longitudinal, populationbased study. BMJ. 2001;322:1447-1451.
43. Anttila T, Helkala E-L, Viitanen M, et al. Alcohol drinking in middle age and subsequent risk of mild cognitive impairment and dementia in old age: a prospective population-based study. BMJ. 2004;329:539-544.
44. Orgogozo JM, Dartigues JF, Lafont S, et al. Wine consumption and dementia in the elderly: a prospective community study in the Bordeaux area. Rev Neurol. 1997;153:185-192.
45. Leibovici, D, Ritchie K, Ledesert L, et al. The effects of wine and tobacco consumption on cognitive performance in the eldely: a longitudal study of relative risk. Int J Epidemiol. 1999;28:77-81.
46. Ruitenberg A, van Swieten JC, Witteman JC, et al. Alcohol consumption and risk of dementia: the Rotterdam study. Lancet. 2002;359: 281-286.
47. Luchsinger J, Tang MX, Siddiqui M, et al. Alcohol intake and risk of dementia. J Am Geriatr Soc. 2004;52:540-546.
48. Lindsay J, Laurin D, Verreault R, et al. Risk factors for Alzheimer's disease: A prospective analysis of the Canadian Study of Health and Aging. Am J Epidemiol. 2002;156:445-453.
49. Huang W, Qiu C, Winblad B, et al. Alcohol consumption and incidence of dementia in a community sample aged 75 years and older. J Clin Epidemiol. 2002;55:959-964.
50. Deng J, Zhou DH, Li J, et al. A 2-year follow-up study of alcohol consumption and risk of dementia. Clin Neurol Neurosurg. 2006;108:378-383.
51. Zhou DHD, Wang JYJ, Li J, et al. Study on frequency and predictors of dementia after ischaemic stroke. J Neurol. 2004;251:421-427.
52. Mukamal KJ, Kuller L, Fitzpatrick A, et al. Prospective study of alcohol consumption and risk of dementia in older adults, JAMA. 2003b; 289:1405-1413.
53. Truelsen T, Thudium D, Grønbæk M. Amount and type of alcohol and risk of dementia. The Copenhagen Heart Study. Neurology. 2002;59:1313-1319.
54. Mehlig K, Skoog I, Guo X, et al. Alcoholic beverages and incidence of dementia: 34-year follow-up of the Prospective Population Study of Women in Göteborg. Am J Epidemiol. 2008;167:684-691.
55. Zuccala G, Onder G, Pedone C, et al. Dose-related impact of alcohol consumption on cognitive function in advanced age: results of a multicentre survey. Alcohol Clin Exp Res. 2001;25:1743-1748.
56. Hébert LE, Scherr PA, Beckett LA, et al. Relation of smoking and low-to-moderate alcohol consumption to change in cognitive function: A longitudinal study in a defined community of older persons. Am J Epidemiol. 1993;137:881-891.
57. Dufouil C, Ducimetiere P, Alperovitch A. Sex differences in the association between alcohol consumption and cognitive performance. EVA Study Group. Epidemiology of Vascular Aging. Am J Epidemiol. 1997;146:405-412.
58. Elias PK, Elias MF, D'Agostino RB, et al. Alcohol consumption and cognitive performance in the Framingham Heart Study. Am J Epidemiol. 1999;150:580-589.
59. Kalmijn S, van Boxtel MPJ, Verschuren MWM, et al. Cigarette smoking and alcohol consumption in relation to cognitive performance in middle age. Am J Epidemiol. 2002;156:936-944.
60. Launer LJ, Feskens EJ, Kalmijn S, et al. Smoking, drinking and thinking. The Zutphen Elderly Study. Am J Epidemiol. 1996;143:219-227.
61. Leroi I, Sheppard J-M, Lyketsos G. Cognitive function after 11.5 years of alcohol use: Relation to alcohol use. Am J Epidemiol. 2002; 156:747-752.
62. Britton A, Singh-Manoux A, Marmot M. Alcohol consumption and cognitive function in the Whitehall Study. Am J Epidemiol. 2004;160:240-247.
63. Stampfer MJ, Kang JH, Chen J, et al. Effects of moderate alcohol consumption on cognitive function in women. N Engl J Med. 2005;352:245-253.
64. Espeland MA, Gu L, Masaki KH, et al. Association between reported alcohol intake and cognition: Results from the Women's Health Initiative Memory Study. Am J Epidemiol. 2005;161:228-238.
65. Wright CB, Elkind MSV, Luo X, et al. Reported alcohol consumption and cogntive decline: The Northern Manhattan Study. Neuroepidemiology. 2006;27:201-207.
66. Byles J, Young A, Furuya H, et al. A drink to healthy aging: The association between older women's use of alcohol and their healthrelated quality of life. J Am Geriatr Soc. 2006;54:1341-1347.
67. Ngandu T, Helkala E-L, Soinen H, et al. Alcohol drinking and cognitive functions: Findings from the Cardiovascular Risk Factors Aging and Dementia (CAIDE) Study. Dement Geriatr Cogn Disord. 2007; 23:140-149.
68. Ganguli M, Van der Bilt J, Saxton JA, et al. Alcohol consumption and cognitive function in late life. A longitudinal community study. Neurology. 2005;65:1210-1217.
69. Lindeman RD, Wayne SJ, Baumgartner RN, et al. Cognitive function in drinkers compared to abstainers in the New Mexico Elder Health Study. J Gerontol Series A. 2005;60:1065-1070.
70. Rasmussen HB, Bagger YZ, Tanko LB, et al. Cognitive impairment in elderly women: the relative importance of selected genes, lifestyle factors, and co-morbidities. Neuropsychiat Dis Treat. 2006;2:227-233.
71. Dawe B, Procter A, Philpot M. Concepts of mild cognitive impairment in the elderly and their relationship to dementia: A review. Int J Geriatr Psychiatry. 1992;7:473-479.
72. DeCarli C, Miller BL, Swan GE, et al. Cerebrovascular and brain morphological correlates of mild cognitive impairment in the National Heart, Lung, and Blood Institute Twin Study. Arch Neurol. 2001;58:643-647.
73. Mukamal KJ, Kronmal RA, Mittleman MA, et al. Alcohol consumption and carotid atherosclerosis in older adults. The Cardiovascular Health Study. Arterioscler Thromb Vasc Biol. 2003c;23:2252-2259.
74. Den Heijer T, Vermeer SE, Van Dijk EJ, et al. Alcohol intake in relation to brain magnetic resonance imaging findings in older persons without dementia. Am J Clin Nutr. 2004;80:992-997.
75. Rönnemaa E, Zethelius B, Sundelöf J, et al. Impaired insulin secretion increases the risk of Alzheimer disease. Neurology. 2008;71:1065-1071.
76. Beeri MS, Schmeidler J, Silverman JM, et al. Insulin in combination with other diabetes medication is associated with less Alzheimer neuropathology. Neurology. 2008;71:750-757.
77. Zhao W-Q, De Felice FG, Fernandez S, et al. Amyloid beta oligomers induce impairment of neuronal insulin receptors. FASEB J. 2008;22:246-260.
78. Simonyi A, Woods D, Sun AY, et al. Grape polyphenols inhibit chronic ethanol-induced COX-2 mRNA expression in rat brain. Alcohol Clin Exp Res. 2002;26:352-357.
79. Aisen WL. Inflammation and Alzheimer's disease: mechanisms and therapeutic strategies. Gerontology. 1997;43:143-149.
80. Akiyama H, Barger S, Barnum S. Inflammation and Alzheimer's disease. Neurobiol Aging. 2000;21:383-421.
81. McGeer PL, Schulzer M, McGeer EG. Arthritis and anti-inflammatory agents as possible protective factors for Alzheimer's disease. Neurology. 1996;47:425-432.
82. De Craen AJM, Gussekloo J, Vrijsen B, et al. Meta-analysis of nonsteroidal antiinflammatory drug use and risk of dementia. Am J Epidemiol. 2005;161:114-120.
83. Vlad SC, Miller DR, Kowall NW, et al. Protective effects of NSAIDs on the development of Alzheimer disease. Neurology. 2008;70: 1672-1677.
84. Aisen PS, Schafer KA, Grundman M, et al. Effects of rofecoxib or naproxen versus placebo on Alzheimer's disease progression: A randomized controlled trial. JAMA. 2003;289:2819-2826.
85. Weggen S, Eriksen H, Das P, et al. A subset of NSAIDs lower amyloidogenic Aβ42 independently of cyclooxygenase activity. Nature. 2001;414:212-216.
86. Hogan DB. Progress update: Pharmacological treatment of Alzheimer's disease. Neuropsychiat Dis Treat. 2007;3:569-578.
87. Fadda F, Rossetti ZL. Chronic ethanol consumption: from neuroadaptation to neurodegeneration. Progr Neurobiol. 1998;56:385-431.
88. Perry E, Walker M, Grace J, et al. Acetylcholine in mind: A neurotransmitter correlate of consciousness? Trends Neurosci. 1999;22: 273-280.
89. Creasy GL, Creasy LL. Grape-derived flavonoids and stilbenes. In: Sandler M, Pinder R, editors. Wine. A Scientific Exploration. London: Taylor and Francis; 2003. p. 199-227.
90. Corder R. The Wine Diet. London: Little, Brown; 2006.
91. Wallerath J, Poleo D, Li H, et al. Red wine increases the expression of human endothelial nitric oxide synthase. J Am Coll Cardiol. 2003;41:471-478.
92. Corder R, Douthwaite JA, Lees DM, et al. Endothelin-1 synthesis reduced by red wine. Nature. 2001;414:663-664.
93. Doré S. Unique properties of polyphenol stilbenes in the brain: More than direct antioxidant actions, gene/protein regulatory activity. Neurosignals. 2005;14:61-70.
94. Mattson MF, Rydel RE. Amyloid ox-tox transducers. Nature. 1996;382:674-675.
95. Thomas T, Thomas G, McLendon C, et al. b-Amyloid-mediated vasoactivity and vascular endothelial damage. Nature. 1996;380:168-171.
96. Anekonda TS, Reddy PH. Neuronal protection by sirtuins in Alzheimer's disease. Int J Neurochem. 2006;96:305-313.
97. Howitz KT, Bitterman KJ, Cohen HY, et al. Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan. Nature. 2003;425:191-196.
98. Lagouge M, Argmann C, Gerhart-Hines Z, et al. Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1α. Cell. 2006;127:1109-1122.
99. Bauer JA, Pearson KJ, Price NL, et al. Resveratrol improves health and survival of mice on a high-calorie diet. Nature. 2006;444:337-342.
100. Barger JL, Kaye T, Vann JM, et al. A low dose of dietary resveratrol partially mimics calorie restriction and retards aging parameters in mice. PLoS ONE. 2008;3(6):e2264. doi:10.1371/journal. pone.0002264.
101. Marambaud P, Zhao H, Davies P. Resveratrol promotes clearance of Alzheimer's disease amyloid-β peptides. J Biol Chem. 2005;280: 37377-37382.
102. Wang J, Ho L, Zhao Z, et al. Moderate consumption of Cabernet Sauvignon attenuates Aβ neuropathology in a mouse model of Alzheimer's disease. FASEB J. 2006;20:2313-2320.
103. Rimm EB, Williams P, Fosher K, et al. Moderate alcohol intake and lower risk of coronary heart disease: meta-analysis of effects on lipids and haemostatic factors. BMJ. 1999;319:1523-1528.
104. Aviram M, Fuhrman B. Wine flavonoids, LDL cholesterol oxidation and atherosclerosis. In: Sandler M, Pinder R, editors. Wine. A Scientific Exploration. London: Taylor and Francis; 2003. p. 140-159.
105. Vogel RA. Vintners and vasodilators. Are French red wines more cardioprotective? J Am Coll Cardiol. 2003;41:479-481.