Microsomal prostaglandin e synthase-1 contributes to ischaemic excitotoxicity through prostaglandin E2 EP3 receptors

British Journal of Pharmacology

Volumn 160, Issue 4, 2010, Pages 847-859

  Ikeda Matsuo, Y ^a   Tanji, H ^a   Ota, A ^a   Hirayama, Y ^a   Uematsu, S ^b   Akira, S ^b   Sasaki, Y ^a  

^a KITASATO UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

Author keywords

Excitotoxicity; Ischaemia; MPGES 1; Prostaglandin E synthase; Rho kinase

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; EP3 RECEPTOR; FASUDIL; GLUTAMIC ACID; MESSENGER RNA; PERTUSSIS TOXIN; PROSTAGLANDIN E RECEPTOR; PROSTAGLANDIN E SYNTHASE 1; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; PROSTAGLANDIN RECEPTOR STIMULATING AGENT; RHO KINASE; UNCLASSIFIED DRUG; AMINO ACID RECEPTOR AFFECTING AGENT; ISOMERASE; PROSTAGLANDIN E RECEPTOR 3; PROSTAGLANDIN E SYNTHASE; PTGER3 PROTEIN, HUMAN; PTGER3 PROTEIN, MOUSE; PTGER3 PROTEIN, RAT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INFARCTION SIZE; BRAIN ISCHEMIA; CEREBROVASCULAR ACCIDENT; CONTROLLED STUDY; DISEASE EXACERBATION; ENZYME ACTIVATION; EXCITOTOXICITY; HIPPOCAMPUS; MOUSE; NERVE CELL LESION; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; RAT; WILD TYPE; AGONISTS; ANIMAL; ANTAGONISTS AND INHIBITORS; BRAIN EDEMA; C57BL MOUSE; DRUG EFFECTS; ENZYMOLOGY; FEMALE; GENETICS; HIPPOCAMPAL CA1 REGION; IN VITRO STUDY; INFARCTION, MIDDLE CEREBRAL ARTERY; ISCHEMIC ATTACK, TRANSIENT; KNOCKOUT MOUSE; MALE; METABOLISM; MICROSOME; NERVE CELL; PATHOPHYSIOLOGY; REPERFUSION INJURY; SIGNAL TRANSDUCTION; TOXICITY; WISTAR RAT;

ANIMALS; BRAIN EDEMA; BRAIN ISCHEMIA; CA1 REGION, HIPPOCAMPAL; EXCITATORY AMINO ACID AGENTS; FEMALE; IN VITRO TECHNIQUES; INFARCTION, MIDDLE CEREBRAL ARTERY; INTRAMOLECULAR OXIDOREDUCTASES; ISCHEMIC ATTACK, TRANSIENT; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICROSOMES; NEURONS; RATS; RATS, WISTAR; RECEPTORS, PROSTAGLANDIN E; RECEPTORS, PROSTAGLANDIN E, EP3 SUBTYPE; REPERFUSION INJURY; RHO-ASSOCIATED KINASES; RNA, MESSENGER; SIGNAL TRANSDUCTION;

EID: 77952819880     PISSN: 00071188     EISSN: 14765381     Source Type: Journal    
DOI: 10.1111/j.1476-5381.2010.00711.x     Document Type: Article

References (52)

1. 4 receptor agonist protects against acute neurotoxicity. Brain Res 1066 : 71 77.
2. 1 receptor contributes to excitotoxicity and focal ischemic brain damage. Toxicol Sci 89 : 265 270.
3. 3 receptors exacerbates stroke and excitotoxic injury. J Neuroimmunol 184 : 172 179. (Pubitemid 46365999)
4. Alexander SPH, Mathie A, Peters JA (2009). Guide to Receptors and Channels (GRAC), 4th edn. Br J Pharmacol 158 (Suppl. 1 S1 S254.
5. 3 signaling regulates tumor-associated angiogenesis and tumor growth. J Exp Med 197 : 221 232.
6. 2. Am J Physiol 277 : H924 H930.
7. Barone FC, Feuerstein GZ (1999). Inflammatory mediators and stroke: new opportunities for novel therapeutics. J Cereb Blood Flow Metab 19 : 819 834.
8. Butcher SP, Bullock R, Graham DI, McCulloch J (1990). Correlation between amino acid release and neuropathologic outcome in rat brain following middle cerebral artery occlusion. Stroke 21 : 1727 1733.
9. Dávalos A, Shuaib A, Wahlgren NG (2000). Neurotransmitters and pathophysiology of stroke: evidence for the release of glutamate and other transmitters/mediators in animals and humans. J Stroke Cerebrovasc Dis 9 : 2 8.
10. Dirnagl U, Iadecola C, Moskowitz MA (1999). Pathobiology of ischaemic stroke: an integrated view. Trends Neurosci 22 : 391 397.
11. 3 receptor signaling. J Biochem 131 : 781 784.
12. Hayashi S, Ueyama T, Kajimoto T, Yagi K, Kohmura E, Saito N (2005). Involvement of gamma protein kinase C in estrogen-induced neuroprotection against focal brain ischemia through G protein-coupled estrogen receptor. J Neurochem 93 : 883 891.
13. Iadecola C, Niwa K, Nogawa S, Zhao X, Nagayama M, Araki E et al 2001). Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate- mediated neurotoxicity in cyclooxygenase-2-deficient mice. Proc Natl Acad Sci USA 98 : 1294 1299.
14. 2 receptor. Jpn J Pharmacol 84 : 140 145.
15. 2 production. J Neurochem 94 : 1546 1558.
16. Ikeda-Matsuo Y, Ota A, Fukada T, Uematsu S, Akira S, Sasaki Y (2006). Microsomal prostaglndin E synthase-1 is a critical factor of stroke-reperfusion injury. Proc Natl Acad Sci USA 103 : 11790 11795.
17. Ikeda-Matsuo Y, Hirayama Y, Ota A, Uematsu S, Akira S, Sasaki Y (2010). Microsomal prostaglandin E synthase-1 and cyclooxygenase-2 are both required for ischaemic excitotoxicity. Br J Pharmacol 159 : 1174 1186.
18. i in cDNA-transfected Chinese hamster ovary cells. Biochem Biophys Res Commun 204 : 303 309.
19. 2-induced constriction of porcine large cerebral arteries. J Cereb Blood Flow Metab 24 : 1305 1316.
20. Jakobsson PJ, Thoren S, Morgenstern R, Samuelsson B (1999). Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc Natl Acad Sci USA 96 : 7220 7225.
21. 4 suppresses colitis, mucosal damage and CD4 cell activation in the gut. J Clin Invest 109 : 883 893.
22. 3 subtype induces neurite retraction via small GTPase Rho. J Biol Chem 271 : 29780 29784.
23. Kaufmann WE, Andreasson KI, Isakson PC, Worley PF (1997). Cyclooxygenases and the central nervous system. Prostaglandins 54 : 601 624.
24. 1 receptors: downstream effectors of COX-2 neurotoxicity. Nat Med 12 : 225 229.
25. Kempski O, Shohami E, von Lubitz D, Hallenbeck JM, Feuerstein G (1987). Postischemic production of eicosanoids in gerbil brain. Stroke 18 : 111 119.
26. Lee JJ, Li L, Jung HH, Zuo Z (2008). Postconditioning with isoflurane reduced ischemia-induced brain injury in rats. Anesthesiology 108 : 1055 1062.
27. Lee JM, Zipfel GJ, Choi DW (1999). The changing landscape of ischaemic brain injury mechanisms. Nature 399 : A7 A14.
28. 2 receptor agonist, protects against cerebral ischemia. Neurosci Lett 438 : 210 215.
29. Li Q, Huang XJ, He W, Ding J, Jia JT, Fu G et al 2009). Neuroprotective potential of fasudil mesylate in brain ischemia-reperfusion injury of rats. Cell Mol Neurobiol 29 : 169 180.
30. 3 a, b, and g receptor variants reduce tumor cell proliferation and tumorigenesis in vivo. J Biol Chem 283 : 12538 12545.
31. 2 receptor in cerebral ischemia. J Neurosci 24 : 257 268.
32. 3 subtype. Biochem Biophys Res Commun 338 : 550 557.
33. Murakami M, Nakatani Y, Tanioka T, Kudo I (2002). Prostaglandin E synthase. Prostaglandins Other Lipid Mediat 68-69 : 383 399.
34. 3 receptor in the rat nervous system. J Comp Neurol 421 : 543 569.
35. Narumiya S, Sugimoto Y, Ushikubi F (1999). Prostanoid receptors: structures, properties, and functions. Physiol Rev 79 : 1193 1226.
36. Nogawa S, Zhang F, Ross ME, Iadecola C (1997). Cyclo-oxygenase-2 gene expression in neurons contributes to ischemic brain damage. J Neurosci 17 : 2746 2755.
37. Nomura Y (1998). A transient brain ischemia- and bacterial endotoxin-induced glial iNOS expression and NO-induced neuronal apoptosis. Toxicol Lett 102-103 : 65 69.
38. 3 receptors. J Physiol 551 : 945 954.
39. Rikitake Y, Kim HH, Huang Z, Seto M, Yano K, Asano T et al 2005). Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. Stroke 36 : 2251 2257.
40. 3 receptor-deficient mice after cerebral ischemia. J Neuroimmunol 208 : 87 93.
41. Sasaki T, Kitagawa K, Yamagata K, Takemiya T, Tanaka S, Omura-Matsuoka E et al 2004). Amelioration of hippocampal neuronal damage after transient forebrain ischemia in cyclooxygenase-2-deficient mice. J Cereb Blood Flow Metab 24 : 107 113.
42. Shah ZA, Namiranian K, Klaus J, Kibler K, Dore S (2006). Use of an optimized transient occlusion of the middle cerebral artery protocol for the mouse stroke model. J Stroke Cerebrovasc Dis 15 : 133 138.
43. 3 receptor agonists. Br J Pharmacol 139 : 1449 1461.
44. 3 receptor in excitotoxic lesions in the rat striatum. Neurochem Int 45 : 653 660.
45. 4) in bone resorption: an analysis using specific agonists for the respective EPs. Endocrinology 141 : 1554 1559.
46. 2 receptors in cultured hippocampal neurons. Neurochem Int 45 : 713 719.
47. 2 treated rats. Brain Res 825 : 36 45.
48. 2 synthase gene induced by the Toll-like receptor 4/MyD88/NF-IL6 pathway. J Immunol 168 : 5811 5816.
49. 3. Nature 395 : 281 284.
50. Watanabe K, Kawamori T, Nakatsugi S, Ohta T, Ohuchida S, Yamamoto H et al 2000). Inhibitory effect of a prostaglandin E receptor subtype EP(1) selective antagonist, ONO-8713, on development of azoxymethane-induced aberrant crypt foci in mice. Cancer Lett 156 : 57 61.
51. 2 and β-actin at membrane microdomain. J Cell Physiol 220 : 748 755.
52. Yamashita K, Kotani Y, Nakajima Y, Shimazawa M, Yoshimura S, Nakashima S et al 2007). Fasudil, a Rho kinase (ROCK) inhibitor, protects against ischemic neuronal damage in vitro and in vivo by acting directly on neurons. Brain Res 1154 : 215 224.