Inhibitors of metabolism rescue cell death in Huntington's disease models

Proceedings of the National Academy of Sciences of the United States of America

Volumn 104, Issue 36, 2007, Pages 14525-14530

  Varma, Hemant ^a   Cheng, Richard ^a   Voisine, Cindy ^b   Hart, Anne C ^b   Stockwell, Brent R ^a  

^a Och Spine at New York Presbyterian Hospitals   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Caspase; Drugs; ERK; Neurodegeneration; Survival signaling

Indexed keywords

2,4 DINITROPHENOL; ADENOSINE TRIPHOSPHATE; CASPASE 3; CASPASE 7; EPIDERMAL GROWTH FACTOR; FLUORIDE SODIUM; GLUCOSE; HUNTINGTIN; MITOGEN ACTIVATED PROTEIN KINASE; OLIGOMYCIN; PROTEIN KINASE B; REACTIVE OXYGEN METABOLITE; ROTENONE; SOMATOMEDIN C; TUBULIN; CASPASE; NICOTINAMIDE ADENINE DINUCLEOTIDE;

ANIMAL CELL; ARTICLE; CAENORHABDITIS ELEGANS; CELL DEATH; CELL METABOLISM; CELL SURVIVAL; CONTROLLED STUDY; DEGENERATIVE DISEASE; ENZYME ACTIVATION; GLUCOSE METABOLISM; GLYCOLYSIS; HUNTINGTON CHOREA; MITOCHONDRION; NERVE CELL NECROSIS; NEUROLOGIC DISEASE; NONHUMAN; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; ANIMAL; CELL LINE; DISEASE MODEL; DROSOPHILA MELANOGASTER; DRUG EFFECT; GENETICS; METABOLISM; MUTATION; NERVE CELL; PATHOLOGY;

ADENOSINE TRIPHOSPHATE; ANIMALS; CASPASES; CELL DEATH; CELL LINE; DISEASE MODELS, ANIMAL; DROSOPHILA MELANOGASTER; ENZYME ACTIVATION; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLYCOLYSIS; HUNTINGTON DISEASE; MITOCHONDRIA; MUTATION; NAD; NEURONS; PROTO-ONCOGENE PROTEINS C-AKT; REACTIVE OXYGEN SPECIES; ROTENONE; SIGNAL TRANSDUCTION;

EID: 35448935240     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0704482104     Document Type: Article

References (55)

1. Brouillet E, Condâe F, Beal MF, Hantraye P (1999) Prog Neurobiol 59:427-468.
2. Ross CA (2002) Neuron 35:819-822.
3. Rigamonti D, Bauer JH, De-Fraja C, Conti L, Sipione S, Sciorati C, Clementi E, Hackam A, Hayden MR, Li Y, et al. (2000) J Neurosci 20:3705-3713.
4. Varma H, Voisine C, DeMarco CT, Cattaneo E, Lo DC, Hart AC, Stockwell BR (2007) Nat Chem Biol 3:99-100.
5. Scheffler IE (2001) Adv Drug Deliv Rev 49:3-26.
6. Gutekunst CA, Li SH, Yi H, Mulroy JS, Kuemmerle S, Jones R, Rye D, Ferrante RJ, Hersch SM, Li XJ (1999) J Neurosci 19:2522-2534.
7. Hodgson JG, Agopyan N, Gutekunst CA, Leavitt BR, LePiane F, Singaraja R, Smith DJ, Bissada N, McCutcheon K, Nasir J, et al. (1999) Neuron 23:181-192.
8. Penefsky HS (1985) Proc Natl Acad Sci USA 82:1589-1593.
9. Harper JA, Dickinson K, Brand MD (2001) Obes Rev 2:255-265.
10. Gumiânska M, Sterkowicz J (1976) Acta Biochim Pol 23:285-291.
11. Faber PW, Voisine C, King DC, Bates EA, Hart AC (2002) Proc Natl Acad Sci USA 99:17131-17136.
12. Dillin A, Hsu AL, Arantes-Oliveira N, Lehrer-Graiwer J, Hsin H, Fraser AG, Kamath RS, Ahringer J, Kenyon C (2002) Science 298:2398-2401.
13. Troulinaki K, Tavernarakis N (2005) Mech Aging Dev 126:23-33.
14. Jackson GR, Salecker I, Dong X, Yao X, Arnheim N, Faber PW, MacDonald ME, Zipursky SL (1998) Neuron 21:633-642.
15. Steffan JS, Bodai L, Pallos J, Poelman M, McCampbell A, Apostol BL, Kazantsev A, Schmidt E, Zhu YZ, Greenwald M, et al. (2001) Nature 413:739-743.
16. Ferrante RJ, Kubilus JK, Lee J, Ryu H, Beesen A, Zucker B, Smith K, Kowall NW, Ratan RR, Luthi-Carter R, et al. (2003) J Neurosci 23:9418-9427.
17. Sanchez Mejia RO, Friedlander RM (2001) Neuroscientist 7:480-489.
18. Graham RK, Deng Y, Slow EJ, Haigh B, Bissada N, Lu G, Pearson J, Shehadeh J, Bertram L, Murphy Z, et al. (2006) Cell 125:1179-1191.
19. Stefanelli C, Bonavita F, Stanic I, Farruggia G, Falcieri E, Robuffo I, Pignatti C, Muscari C, Rossoni C, Guarnieri C, et al. (1997) Biochem J 322:909-917.
20. Nicotera P, Leist M (1997) Cell Death Differ 4:435-442.
21. Sestili P, Brambilla L, Cantoni O (1999) FEBS Lett 457:139-143.
22. Vrablic AS, Albright CD, Craciunescu CN, Salganik RI, Zeisel SH (2001) FASEB J 15:1739-1744.
23. Wang J, Zhai Q, Chen Y, Lin E, Gu W, McBurney MW, He Z (2005) J Cell Biol 170:349-355.
24. Apostol BL, Illes K, Pallos J, Bodai L, Wu J, Strand A, Schweitzer ES, Olson JM, Kazantsev A, Marsh JL, et al. (2006) Hum Mol Genet 15:273-285.
25. Liâevens JC, Rival T, Ichâe M, Chneiweiss H, Birman S (2005) Hum Mol Genet 14:713-724.
26. Colin E, Râegulier E, Perrin V, Dèurr A, Brice A, Aebischer P, Dâeglon N, Humbert S, Saudou F (2005) Eur J Neurosci 21:1478-1488.
27. Humbert S, Bryson EA, Cordeliáeres FP, Connors NC, Datta SR, Finkbeiner S, Greenberg ME, Saudou F (2002) Dev Cell 2:831-837.
28. Dâeas O, Dumont C, MacFarlane M, Rouleau M, Hebib C, Harper F, Hirsch F, Charpentier B, Cohen GM, Senik A (1998) J Immunol 161:3375-3383.
29. King MP, Attardi G (1996) Methods Enzymol 264:304-313.
30. King MP, Attardi G (1989) Science 246:500-503.
31. Hougardy BM, Maduro JH, van der Zee AG, Willemse PH, de Jong S, de Vries EG (2005) Lancet Oncol 6:589-598.
32. Henson ES, Gibson SB (2006) Cell Signal 18:2089-2097.
33. Grèunewald T, Beal MF (1999) Ann NY Acad Sci 893:203-213.
34. Powers WJ, Videen TO, Markham J, McGee-Minnich L, Antenor-Dorsey JV, Hershey T, Perlmutter JS (2007) Proc Natl Acad Sci USA 104:2945-2949.
35. Guidetti P, Charles V, Chen EY, Reddy PH, Kordower JH, Whetsell WO, Jr, Schwarcz R, Tagle DA (2001) Exp Neurol 169:340-350.
36. Pratley RE, Salbe AD, Ravussin E, Caviness JN (2000) Ann Neurol 47:64-70.
37. Gaba AM, Zhang K, Marder K, Moskowitz CB, Werner P, Boozer CN (2005) Am J Clin Nutr 81:1335-1341.
38. Panov AV, Lund S, Greenamyre JT (2005) Mol Cell Biochem 269:143-152.
39. Hickey MA, Morton AJ (2000) J Neuro Chem 75:2163-2171.
40. Madapallimattam AG, Law L, Jeejeebhoy KN (2002) Am J Clin Nutr 76:1031-1039.
41. Feuers RJ (1998) Ann NY Acad Sci 854:192-201.
42. Duan W, Guo Z, Jiang H, Ware M, Li XJ, Mattson MP (2003) Proc Natl Acad Sci USA 100:2911-2916.
43. Underwood BR, Broadhurst D, Dunn WB, Ellis DI, Michell AW, Vacher C, Mosedale DE, Kell DB, Barker RA, Grainger DJ, et al. (2006) Brain 129:877-886.
44. Pattison LR, Kotter MR, Fraga D, Bonelli RM (2006) J Neurol 253:1137-1142.
45. Kurmasheva RT, Houghton PJ (2006) Biochim Biophys Acta 1766:1-22.
46. Newmeyer DD, Ferguson-Miller S (2003) Cell 112:481-490.
47. Liu Z, Butow RA (2006) Annu Rev Genet 40:159-185.
48. Song C, Perides G, Liu YF (2002) J Biol Chem 277:6703-6707.
49. Mattiasson G, Shamloo M, Gido G, Mathi K, Tomasevic G, Yi S, Warden CH, Castilho RF, Melcher T, Gonzalez-Zulueta M, et al. (2003) Nat Med 9:1062-1068.
50. Mullenix PJ, Denbesten PK, Schunior A, Kernan WJ (1995) Neurotoxicol Teratol 17:169-177.
51. Rubin CD, Pak CY, Adams-Huet B, Genant HK, Li J, Rao DS (2001) Arch Intern Med 161:2325-2333.
52. Favata MF, Horiuchi KY, Manos EJ, Daulerio AJ, Stradley DA, Feeser WS, Van Dyk DE, Pitts WJ, Earl RA, Hobbs F, et al. (1998) J Biol Chem 273:18623-18632.
53. Wityak J, Hobbs FW, Gardner DS, Santella JB, III, Petraitis JJ, Sun JH, Favata MF, Daulerio AJ, Horiuchi KY, Copeland RA, et al. (2004) Bioorg Med Chem Lett 14:1483-1486.
54. Vlahos CJ, Matter WF, Hui KY, Brown RF (1994) J Biol Chem 269:5241-5248.
55. Voisine C, Varma H, Walker N, Bates EA, Stockwell BR, Hart AC (2007) PLoS One 2:e504.