Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and pharmacological characterization of γ-aminobutyric acid (GABA) related compounds

Journal of Medicinal Chemistry

Volumn 49, Issue 14, 2006, Pages 4442-4446

  Lolli, Marco L ^a   Hansen, Suzanne L ^b   Rolando, Barbara ^a   Nielsen, Birgitte ^b   Wellendorph, Petrine ^b   Madsen, Karsten ^b   Larsen, Orla Miller ^b   Kristiansen, Uffe ^b   Fruttero, Roberta ^a   Gasco, Alberto ^a   Johansen, Tommy N ^b  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

3 AMINO 2 (3 CARBOXYPROPYL) 6 (4 METHOXYPHENYL)PYRIDAZINIUM BROMIDE; 4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID RECEPTOR; CARBOXYL GROUP; GABOXADOL; HYDROXY 1,2,5 OXADIAZOLYL DERIVATIVE; MUSCIMOL; OXADIAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

4 AMINOBUTYRIC ACID BRAIN LEVEL; ALKYLATION; AMINATION; ARTICLE; BRAIN CORTEX; CONTROLLED STUDY; DRUG SYNTHESIS; IC 50; IONIZATION; NERVE CELL CULTURE; NONHUMAN; PKA; RECEPTOR AFFINITY; SUBSTITUTION REACTION;

ANIMALS; ASTROCYTES; BINDING, COMPETITIVE; CELL LINE; CELLS, CULTURED; CEREBRAL CORTEX; GABA PLASMA MEMBRANE TRANSPORT PROTEINS; GAMMA-AMINOBUTYRIC ACID; HUMANS; MICE; NEURONS; OXADIAZOLES; PATCH-CLAMP TECHNIQUES; RATS; RECEPTORS, GABA-A; RECEPTORS, GABA-B; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33745809867     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm051288b     Document Type: Article

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