The respective N-hydroxypyrazole analogues of the classical glutamate receptor ligands ibotenic acid and (RS)-2-amino-2-(3-hydroxy-5-methyl-4- isoxazolyl)acetic acid

European Journal of Pharmacology

Volumn 499, Issue 1-2, 2004, Pages 35-44

  Clausen, Rasmus P ^a   Hansen, Kasper B ^a,b   Calí, Patrizia ^a   Nielsen, Birgitte ^a   Greenwood, Jeremy R ^a   Begtrup, Mikael ^a   Egebjerg, Jan ^b   Bräuner Osborne, Hans ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

^b H LUNDBECK A S   (Denmark)

Author keywords

Docking; Glutamate receptor; Ibotenic acid; Metabotropic glutamate receptor; N Hydroxypyrazole; Partial agonism

Indexed keywords

ACETIC ACID DERIVATIVE; GLUTAMATE RECEPTOR; IBOTENIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR BLOCKING AGENT; N METHYL DEXTRO ASPARTIC ACID RECEPTOR STIMULATING AGENT; PYRAZOLE DERIVATIVE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG ANTAGONISM; DRUG EFFICACY; DRUG POTENCY; DRUG POTENTIATION; DRUG RECEPTOR BINDING; NONHUMAN; PRIORITY JOURNAL; RAT; SUBSTITUTION REACTION;

2-AMINO-5-PHOSPHONOVALERATE; ALANINE; ALPHA-AMINO-3-HYDROXY-5-METHYL-4-ISOXAZOLEPROPIONIC ACID; ANIMALS; BINDING SITES; BINDING, COMPETITIVE; BRAIN; CELL MEMBRANE; CHO CELLS; CRICETINAE; CRICETULUS; DOSE-RESPONSE RELATIONSHIP, DRUG; EXCITATORY AMINO ACID AGONISTS; GLUTAMIC ACID; IBOTENIC ACID; KAINIC ACID; LIGANDS; MEMBRANE POTENTIALS; MODELS, MOLECULAR; N-METHYLASPARTATE; PYRAZOLES; RATS; RECEPTORS, GLUTAMATE; RECEPTORS, N-METHYL-D-ASPARTATE; THERMODYNAMICS; TRITIUM;

EID: 19344374946     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2004.07.049     Document Type: Article

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