Selective agonists at group II metabotropic glutamate receptors: Synthesis, stereochemistry, and molecular pharmacology of (S)- and (R)-2-amino-4-(4-hydroxy[1,2,5]thiadiazol-3-yl)butyric acid

Journal of Medicinal Chemistry

Volumn 45, Issue 19, 2002, Pages 4240-4245

  Clausen, Rasmus P ^a   Bräuner Osborne, Hans ^a   Greenwood, Jeremy R ^a   Hermit, Mette B ^a   Stensbøl, Tine B ^a   Nielsen, Birgitte ^a   Krogsgaard Larsen, Povl ^a  

^a UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

2 AMINO 3 (4 HYDROXY[1,2,5]THIADIAZOL 3 YL)PROPIONIC ACID; 2 AMINO 4 (4 HYDROXY[1,2,5]THIADIAZOL 3 YL)BUTYRIC ACID; 4 AMINO 2 OXABICYCLO[3.1.0]HEXANE 4,6 DICARBOXYLIC ACID; AMPA RECEPTOR; AMPA RECEPTOR AGONIST; METABOTROPIC RECEPTOR; METABOTROPIC RECEPTOR AGONIST; RECEPTOR SUBTYPE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CHEMICAL MODIFICATION; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CONFORMATION; DRUG MECHANISM; DRUG POTENCY; DRUG RECEPTOR BINDING; DRUG SELECTIVITY; DRUG SPECIFICITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENANTIOMER; MOLECULAR DYNAMICS; NONHUMAN; RAT; STEREOCHEMISTRY; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

AMINO ACIDS; ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BINDING SITES; CEREBRAL CORTEX; MODELS, MOLECULAR; RADIOLIGAND ASSAY; RATS; RECEPTORS, METABOTROPIC GLUTAMATE; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; THIADIAZOLES;

EID: 0037068631     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm020122x     Document Type: Article

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