Polymeric Drug Nanoparticles Prepared by an Aerosol Flow Reactor Method

Pharmaceutical Research

Volumn 21, Issue 1, 2004, Pages 136-143

  Eerikäinen, Hannele ^a,d   Kauppinen, Esko I ^a,b   Kansikas, Jarno ^c  

^a AALTO UNIVERSITY   (Finland)

^b Aerosol Technology Group   (Finland)

^c UNIVERSITY OF HELSINKI   (Finland)

^d ORION CORPORATION   (Finland)

Author keywords

Amorphous; Eudragit; Nanoparticles; Nanospheres; Polymer

Indexed keywords

EUDRAGIT; KETOPROFEN; NANOPARTICLE; NAPROXEN;

ARTICLE; CONTROLLED DRUG RELEASE; CRYSTALLIZATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG RELEASE; DRUG SOLUBILITY; DRUG STRUCTURE; DRUG SYNTHESIS; DRY POWDER; ELECTRON MICROSCOPY; HUMAN; MUCOSA INFLAMMATION; PARTICLE SIZE; PRIORITY JOURNAL; REACTOR; STOMACH MUCOSA; STOMACH ULCER; X RAY DIFFRACTION;

AEROSOLS; CALORIMETRY, DIFFERENTIAL SCANNING; MICROSCOPY, ELECTRON, SCANNING; NANOTECHNOLOGY; PARTICLE SIZE; POLYMERS; POWDERS; TECHNOLOGY, PHARMACEUTICAL;

EID: 1642457352     PISSN: 07248741     EISSN: None     Source Type: Journal    
DOI: 10.1023/B:PHAM.0000012161.58738.25     Document Type: Article

References (30)

1. R. H. Müller and K. Peters. Nanosuspensions for the formulation of poorly soluble drugs I. Preparation by a size-reduction technique. Int. J. Pharm. 160:229-237 (1998).
2. E. Merisko-Liversidge, P. Sarpotdar, J. Bruno, S. Hajj, L. Wei, N. Peltier, J. Rake, J. M. Shaw, S. Pugh, L. Polin, J. Jones, T. Corbett, E. Cooper, and G. G. Liversidge. Formulation and antitumor activity evaluation of nanocrystalline suspensions of poorly soluble anticancer drugs. Pharm. Res. 13:272-278 (1996).
3. G. G. Liversidge and P. Conzentino. Drug particle size reduction for decreasing gastric irritancy and enhancing absorption of naproxen in rates. Int. J. Pharm. 125:309-313 (1995).
4. J-C. Leroux, E. Allémann, E. Doelker, and R. Gurny. New approach for the preparation of nanoparticles by an emulsification-diffusion method. Eur. J. Pharm. Biopharm. 41:14-18 (1995).
5. R. Bodmeier and H. Chen. Indomethacin polymeric nanosuspensions prepared by microfluidization. J Controlled Release 12:223-233 (1990).
6. R. H. Müller, C. Jacobs, and O. Kayser. Nanosuspensions as particulate drug formulations in therapy Rationale for development and what can we expect for the future. Adv. Drug Deliv. Rev. 47: 3-19 (2001).
7. N. Kondo, T. Iwao, H. Masuda, K. Yamanouchi, Y. Ishihara, N. Yamada, T. Haga, Y. Ogawa, and K. Yokoyama. Improved oral absorption of a poorly water-soluble drug, HO-221, by wet-bead milling producing particles in a submicron region. Chem. Pharm. Bull. 41:737-740 (1993).
8. J-O. Waltersson and P. Lundgren. The effect of mechanical comminution on drug stability. Acta Pharm. Suec. 22:291-300 (1985).
9. R. Arshady. Preparation of biodegradable microspheres and microcapsules: 2. Polylactides and related polyesters. J Controlled Release 17:1-22 (1991).
10. R. Bodmeier, H. Chen, P. Tyle, and P. Jarosz. Spontaneous formation of drug-containing acrylic nanoparticles. J Microencaps. 8:161-170 (1991).
11. C. Schmidt and R. Bodmeier. Incorporation of polymeric nanoparticles into solid dosage forms. J Controlled Release 57:115-125 (1999).
12. L. S. Tu, F. Dehghani, and N. R. Forster. Micronization and microencapsulation of pharmaceuticals using a carbon dioxide antisolvent. Powder Tech. 126:134-149 (2002).
13. E. Reverchon and G. Delia Porta. Production of antibiotic micro-and nano-particles by supercritical antisolvent precipitation. Powder Tech. 106:23-29 (1999).
14. R. Bodmeier, H. Wang, D. J. Dixon, S. Mawson, and K. P. Johnston. Polymeric microspheres prepared by spraying into compressed carbon dioxide. Pharm. Res. 12:1211-1217 (1995).
15. E. Reverchon, G. Della Porta, and M. G. Falivene. Process parameters and morphology in amoxicillin micro and submicro particles generation by supercritical antisolvent precipitation. J Supercrit Fluids. 17:239-248 (2000).
16. G. F. Palmieri, G. Bonacucina, P. Di Martino, and S. Martelli. Gastro-resistant microspheres containing ketoprofen. J Microencaps. 19:111-119 (2002).
17. J-H. Kim, T. E. Paxton, and D. L. Tomasko. Microencapsulation of naproxen using rapid expansion of supercritical solutions. Biotech Prog. 12:650-661 (1996).
18. F. De Jaeghere, E. Allémann, E. Doelker, and R. Gurny. pH-dependent dissolving nano-and microparticles for improved peroral delivery of a highly lipophilic compound in dogs. AAPS Pharmsci. 3:Article 8 (2001). http://aapspharmsci.org/ps0301/ ps030108/ps030108.pdf, pages 1-8.
19. A. J. Shukla. Polymethacrylates. In: A. Wade and P. J. Weller (eds.), Handbook of Pharmaceutical Excipients. American Pharmaceutical Association, Pharmaceutical Press, Washington, DC, 1994.
20. R. E. Hillamo and E. I. Kauppinen. On the performance of the Berner low pressure impactor. Aeros. Sci. Tech. 14:33-47 (1991).
21. K. Hartke (ed.). Kommentar zum Europäischen Arzneibuch. Wissenschafliche Verlagsgesellschaft mbH, Govi-Verlag, Stuttgart, Eschborn, Germany, 1993-2000.
22. US Pharmacopeia XXV, 〈724〉 Drug Release. United States Pharmacopeial Convention, Rockville, MD, 2001.
23. TSI Incorporated. TSI Model 3075/3076 Constant Output Atomizer Instruction Manual. TSI Incorporated, St. Paul, MN, 2000.
24. I. Brigger, C. Dubernet, and P. Couvreur. Nanoparticles in cancer therapy and diagnosis. Adv. Drug Deliv. Rev. 54:631-651 (2002).
25. A. H. El-Kamel, M. S. Sokar, S. S. Al Gamal, and Y. F. Naggar. Preparation and evaluation of ketoprofen floating oral delivery system. Int. J. Pharm. 220:13-21 (2001).
26. C. Wu and J. W. McGinity. Non-traditional plasticization of polymeric films. Int. J. Pharm. 177:15-27 (1999).
27. C. Wu and J. W. McGinity. Influence of Ibuprofen as a Solid-State Plasticizer in Eudragit RS 30 D on the Physicochemical Properties of Coated Beads, AAPS PharmSciTech. 2:Article 24 (2001). http:aapspharmscitech.org/pt0204/ pt020424/pt020424.pdf, pages 1-9.
28. M. R. Jenquin, S. M. Liebowitz, R. E. Sarabia, and J. W. McGinity. Physical and chemical factors influencing the release of drugs from acrylic resin films. J. Pharm. Sci. 79:811-816 (1990).
29. R. Pignatello, M. Ferro, and G. Puglisi. Preparation of solid dispersions of nonsteroidal anti-inflammatory drugs with acrylic polymers and studies on mechanisms of drug-polymer interactions. AAPS PharmSciTech. 3: Article 10 (2002). http:// www.aapspharmscitech.org/pt0302/pt030210/pt030210. pdf, pages 1-11.
30. C. Dubernet. Thermoanalysis of microspheres. Thermochim Acta 248:259-269 (1995).