PTEN attenuates PIP3/Akt signaling in the cochlea of the aging CBA/J mouse

Hearing Research

Volumn 264, Issue 1-2, 2010, Pages 86-92

  Sha, Su Hua ^a   Chen, Fu Quan ^a,b   Schacht, Jochen ^a  

^a UNIVERSITY OF MICHIGAN HEALTH SYSTEM   (United States)

^b FOURTH MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Aging cochlea; Akt; Outer hair cells; PIP3; PTEN

Indexed keywords

MESSENGER RNA; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE B; SERINE; THREONINE; PHOSPHATIDYLINOSITOL 3,4,5-TRIPHOSPHATE; POLYPHOSPHOINOSITIDE; PTEN PROTEIN, MOUSE;

AGING; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUDITORY THRESHOLD; CBA MOUSE; CELL LEVEL; CELL SURVIVAL; COCHLEA; CONTROLLED STUDY; ENZYME DEGRADATION; ENZYME LOCALIZATION; ENZYME PHOSPHORYLATION; EVOKED AUDITORY RESPONSE; EVOKED BRAIN STEM RESPONSE; GENE EXPRESSION REGULATION; HAIR CELL; IMMUNOHISTOCHEMISTRY; MAGNOCELLULAR NUCLEUS; MALE; MOUSE; NONHUMAN; PERCEPTION DEAFNESS; PRESBYACUSIS; PRIORITY JOURNAL; SIGNAL TRANSDUCTION; AGE; ANIMAL; AUDITORY STIMULATION; GENETICS; METABOLISM; PATHOLOGY; PHOSPHORYLATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ACOUSTIC STIMULATION; AGE FACTORS; AGING; ANIMALS; AUDITORY THRESHOLD; BLOTTING, WESTERN; CELL SURVIVAL; COCHLEA; HAIR CELLS, AUDITORY, OUTER; IMMUNOHISTOCHEMISTRY; MALE; MICE; MICE, INBRED CBA; PHOSPHATIDYLINOSITOL PHOSPHATES; PHOSPHORYLATION; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; THREONINE;

EID: 77952668622     PISSN: 03785955     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.heares.2009.09.002     Document Type: Article

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