Effect of thai plant extracts on p-glycoprotein function and viability in paclitaxel-resistant HepG2 cells

Drug Metabolism and Pharmacokinetics

Volumn 25, Issue 2, 2010, Pages 155-162

  Kawami, Masashi ^a   Yumoto, Ryoko ^a   Nagai, Junya ^a   Junyaprasert, Varaporn Buraphacheep ^b   Soonthornchareonnon, Noppamas ^b   Patanasethanont, Denpong ^c   Sripanidkulchai, Bung Orn ^c   Mikihisa, Takano ^a  

^a HIROSHIMA UNIVERSITY   (Japan)

^b MAHIDOL UNIVERSITY   (Thailand)

^c KHON KAEN UNIVERSITY   (Thailand)

Author keywords

Multidrug resistance; P glycoprotein (MDR1 ABCB1); Paclitaxel; Paclitaxel resistant HepG2 cells; Rhodamine 123; Thai plant extracts

Indexed keywords

AGANOSMA MARGINATA EXTRACT; ALCOHOL; ANCISTROCLADUS TECTORIUS EXTRACT; BERGAPTEN; CRATOXYLUM FORMOSUM EXTRACT; ELLIPEIOPSIS CHERREVENSIS EXTRACT; EURYCOMALACTONE; GARCINIA COWA EXTRACT; GLYCOPROTEIN P; HERBACEOUS AGENT; LUPINIFOLIN; MICROCOS TOMENTOSA EXTRACT; MICROMELUM MINUTUM EXTRACT; OSTHOLE; PACLITAXEL; POLYALTHIA EVECTA EXTRACT; RHODAMINE 123; RICE EXTRACT; UNCLASSIFIED DRUG;

AGANOSMA MARGINATA; ANCISTROCLADUS TECTORIUS; ARTICLE; CANCER RESISTANCE; CELL STRAIN HEPG2; CELL VIABILITY; COMBINATION CHEMOTHERAPY; CONTROLLED STUDY; CRATOXYLUM FORMOSUM; CYTOTOXICITY; DRUG POTENCY; DRUG POTENTIATION; DRUG UPTAKE; ELLIPEIOPSIS CHERREVENSIS; GARCINIA COWA; HUMAN; HUMAN CELL; IC 50; MEDICINAL PLANT; MICROCOS TOMENTOSA; MICROMELUM MINUTUM; MONOTHERAPY; MULTIDRUG RESISTANCE; POLYALTHIA EVECTA; PROTEIN FUNCTION; RICE; SOLVENT EXTRACTION; WILD TYPE;

EID: 77952614428     PISSN: 13474367     EISSN: 18800920     Source Type: Journal    
DOI: 10.2133/dmpk.25.155     Document Type: Article

References (30)

1. Takano, M., Yumoto, R. and Murakami, T.: Expression and function of efflux drug transporters in the intestine. Pharmacol. Ther., 109: 137-161 (2006).
2. Kim, A. E., Dintaman, J. M., Waddell, D. S. and Silverman, J. A.: Saquinavir, an HIV protease inhibitor, is transported by P-glycoprotein. J. Pharmacol. Exp. Ther., 286: 1439-1445 (1998).
3. Masuda, S. and Inui, K.: An up-date review on individualized dosage adjustment of calcineurin inhibitors in organ transplant patients. Pharmacol. Ther., 112: 184-198 (2006).
4. Krishna, R. and Mayer, L. D.: Multidrug resistance (MDR) in cancer. Mechanisms, reversal using modulators of MDR and the role of MDR modulators in influencing the pharmacokinetics of anticancer drugs. Eur. J. Pharm. Sci., 11: 265-283 (2000).
5. te Boekhorst, P. A., van Kapel, J., Schoester, M. and Sonneveld, P.: Reversal of typical multidrug resistance by cyclosporin and its non-immunosuppressive analogue SDZ PSC 833 in Chinese hamster ovary cells expressing the mdr1 phenotype. Cancer Chemother. Pharmacol., 30: 238-242 (1992).
6. van Zuylen, L., Nooter, K., Sparreboom, A. and Verweij, J.: Development of multidrug-resistance convertors: sense or non-sense? Invest. New Drugs, 18: 205-220 (2000).
7. Thomas, H. and Coley, H. M.: Overcoming multidrug resistance in cancer: an update on the clinical strategy of inhibiting P-glycoprotein. Cancer Control., 10: 159-165 (2003).
8. Zhou, S., Lim, L. Y. and Chowbay, B.: Herbal modulation of P-glycoprotein. Drug Metab. Rev., 36: 57-104 (2004).
9. Aszalos A.: Role of ATP-binding cassette (ABC) transporters in interactions between natural products and drugs. Curr. Drug Metab., 9: 1010-1018 (2008).
10. Patanasethanont, D., Nagai, J., Matsuura, C., Fukui, K., Sutthanut, K., Sripanidkulchai, B.-O., Yenjai, C., Yumoto, R. and Takano, M.: Modulation of function of multidrug resistance associated-proteins by Kaempferia parviflora extracts and their components. Eur. J. Pharmacol., 566: 67-74 (2007).
11. Patanasethanont, D., Nagai, J., Yumoto, R., Murakami, T., Sutthanut, K., Sripanidkulchai, B.-O., Yenjai, C. and Takano, M.: Effects of Kaempferia parviflora extracts and their flavone constituents on P-glycoprotein function. J. Pharm. Sci., 96: 223-233 (2007).
12. Takano, M., Otani, Y., Tanda, M., Kawami, M., Nagai, J. and Yumoto, R.: Paclitaxel-resistance conferred by altered expression of efflux and influx transporters for paclitaxel in human hepatoma cell line HepG2. Drug Metab. Pharmacokinet., 24: 418-427 (2009).
13. Ikehata, M., Yumoto, R., Nakamura, K., Nagai, J. and Takano, M.: Comparison of albumin uptake in rat alveolar type II and type I-like epithelial cells in primary culture. Pharm. Res., 25: 913-922 (2008).
14. Lowry, O., Rosebrough, N. J., Farr, A. L. and Randall, R. J.: Protein measurement with the Folin phenol reagent. J. Biol. Chem., 193: 265-275 (1951).
15. Bradford, M. M.: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem., 72: 248-254 (1976).
16. Synold, T. W., Dussault, I. and Forman, B. M.: The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat. Med., 7: 584-590 (2001).
17. Murakami, T. and Takano, M.: Intestinal efflux transporters and drug absorption. Expert Opin. Drug Metab. Toxicol., 4: 923-939 (2008).
18. Masereeuw, R., Moons, M. M. and Russel, F. G.: Rhodamine 123 accumulates extensively in the isolated perfused rat kidney and is secreted by the organic cation system. Eur. J. Pharmacol., 321: 315-323 (1997).
19. Heemskerk, S., Wouterse, A. C., Russel, F. G. and Masereeuw, R.: Nitric oxide down-regulates the expression of organic cation transporters (OCT) 1 and 2 in rat kidney during endotoxemia. Eur. J. Pharmacol., 584: 390-397 (2008).
20. Dias, V. and Ribeiro, V.: The expression of the solute carriers NTCP and OCT-1 is regulated by cholesterol in HepG2 cells. Fundam. Clin. Pharmacol., 21: 445-450 (2007).
21. Smith, N. F., Acharya, M. R., Desai, N., Figg, W. D. and Sparreboom, A.: Identification of OATP1B3 as a high-affinity hepatocellular transporter of paclitaxel. Cancer Biol. Ther., 4: 815-818 (2005).
22. Libra, A., Fernetti, C., Lorusso, V., Visigalli, M., Anelli, P. L., Staud, F., Tiribelli, C. and Pascolo, L.: Molecular determinants in the transport of a bile acid-derived diagnostic agent in tumoral and nontumoral cell lines of human liver. J. Pharmacol. Exp. Ther., 319: 809-817 (2006).
23. Litman, T., Brangi, M., Hudson, E., Fetsch, P., Abati, A., Ross, D. D., Miyake, K., Resau, J. H. and Bates, S. E.: The multidrug-resistant phenotype associated with overexpression of the new ABC half-transporter, MXR (ABCG2). J. Cell Sci., 113: 2011-2021 (2000).
24. Sharom, F. J.: ABC multidrug transporters: structure, function and role in chemoresistance. Pharmacogenomics, 9: 105-127 (2008).
25. Prayong, P., Barusrux, S. and Weerapreeyakul, N.: Cytotoxic activity screening of some indigenous Thai plants. Fitoterapia, 79: 598-601 (2008).
26. Wirasathien, L., Pengsuparp, T., Moriyasu, M., Kawanishi, K. and Suttisri, R.: Cytotoxic C-benzylated chalcone and other constituents of Ellipeiopsis cherrevensis. Arch. Pharm. Res., 29: 497-502 (2006).
27. Wandel, C., Kim, R. B., Kajiji, S., Guengerich, P., Wilkinson, G. R. and Wood, A. J.: P-glycoprotein and cytochrome P-450 3A in-hibition: dissociation of inhibitory potencies. Cancer Res., 59: 3944-3948 (1999).
28. Pusztai, L., Wagner, P., Ibrahim, N., Rivera, E., Theriault, R., Booser, D., Symmans, F. W., Wong, F., Blumenschein, G., Fleming, D. R., Rouzier, R., Boniface, G. and Hortobagyi, G. N.: Phase II study of tariquidar, a selective P-glycoprotein inhibitor, in patients with chemotherapy-resistant, advanced breast carcinoma. Cancer, 104: 682-691 (2005).
29. Modok, S., Mellor, H. R. and Callaghan, R.: Modulation of multidrug resistance efflux pump activity to overcome chemoresistance in cancer. Curr. Opin. Pharmacol., 6: 350-354 (2006).
30. Fox, E. and Bates, S. E.: Tariquidar (XR9576): a P-glycoprotein drug efflux pump inhibitor. Expert Rev. Anticancer Ther., 7: 447-459 (2007).