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Volumn 28, Issue 6, 2010, Pages 1115-1123

Genome-wide case/control studies in hypertension: Only the 'tip of the iceberg'

Author keywords

Association; Genomics; Hypertension

Indexed keywords

BODY MASS; CHROMOSOME 12Q; DIASTOLIC BLOOD PRESSURE; EPISTASIS; ESSENTIAL HYPERTENSION; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENE MAPPING; GENETIC ASSOCIATION; GENETIC LINKAGE; GENETIC PREDISPOSITION; GENETIC SUSCEPTIBILITY; GENOMICS; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; HYPERTENSION; PRIORITY JOURNAL; REVIEW; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTOLIC BLOOD PRESSURE;

EID: 77952553812     PISSN: 02636352     EISSN: None     Source Type: Journal    
DOI: 10.1097/HJH.0b013e328337f6bc     Document Type: Review
Times cited : (30)

References (68)
  • 1
    • 33846857559 scopus 로고    scopus 로고
    • Heart disease and stroke statistics-2007 update: A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee
    • Rosamond W, Flegal K, Friday G, Furie K, Go A, Greenlund K, et al. Heart disease and stroke statistics-2007 update: a report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation 2007; 115:e69-e171.
    • Circulation , vol.2007 , Issue.115
    • Rosamond, W.1    Flegal, K.2    Friday, G.3    Furie, K.4    Go, A.5    Greenlund, K.6
  • 2
    • 33646147809 scopus 로고    scopus 로고
    • Emergence ofnovel genetic effects on blood pressure and hemodynamics in adolescence: The Georgia Cardiovascular Twin study
    • KupperN,Ge D,Treiber FA, Snieder H. Emergence ofnovel genetic effects on blood pressure and hemodynamics in adolescence: the Georgia Cardiovascular Twin study. Hypertension 2006; 47:948-954.
    • (2006) Hypertension , vol.47 , pp. 948-954
    • Kupper, N.1    Ge, D.2    Treiber, F.A.3    Snieder, H.4
  • 3
    • 20444499360 scopus 로고    scopus 로고
    • Mapping the new frontier: Complex genetic disorders
    • Mayeux R. Mapping the new frontier: complex genetic disorders. J Clin Invest 2005; 115:1404-1407.
    • (2005) J Clin Invest , vol.115 , pp. 1404-1407
    • Mayeux, R.1
  • 4
    • 0035936780 scopus 로고    scopus 로고
    • Molecular mechanisms of human hypertension
    • Lifton RP, Gharavi AG, Geller DS. Molecular mechanisms of human hypertension. Cell 2001; 104:545-556.
    • (2001) Cell , vol.104 , pp. 545-556
    • Lifton, R.P.1    Gharavi, A.G.2    Geller, D.S.3
  • 5
    • 0029741063 scopus 로고    scopus 로고
    • The future of genetic studies of complex human diseases
    • Risch N, Merikangas K. The future of genetic studies of complex human diseases. Science 1996; 273:1516-1517.
    • (1996) Science , vol.273 , pp. 1516-1517
    • Risch, N.1    Merikangas, K.2
  • 6
    • 0031750743 scopus 로고    scopus 로고
    • The relative power of linkage and association studies for the detection of genes involved in hypertension
    • Jones HB. The relative power of linkage and association studies for the detection of genes involved in hypertension. Kidney Int 1998; 53:1446-1448.
    • (1998) Kidney Int , vol.53 , pp. 1446-1448
    • Jones, H.B.1
  • 7
    • 0035451780 scopus 로고    scopus 로고
    • On the allelic spectrum of human disease
    • Reich DE, Lander ES. On the allelic spectrum of human disease. Trends Genet 2001; 17:502-510.
    • (2001) Trends Genet , vol.17 , pp. 502-510
    • Reich, D.E.1    Lander, E.S.2
  • 8
    • 0036799545 scopus 로고    scopus 로고
    • The allelic architecture of human disease genes: Common disease-common variant (or not?)
    • Pritchard JK, Cox NJ. The allelic architecture of human disease genes: common disease-common variant (or not? Hum Mol Genet 2002; 11:2417-2423.
    • (2002) Hum Mol Genet , vol.11 , pp. 2417-2423
    • Pritchard, J.K.1    Cox, N.J.2
  • 9
    • 44349132708 scopus 로고    scopus 로고
    • Common and rare variants in multifactorial susceptibility to common diseases
    • Bodmer W, Bonilla C. Common and rare variants in multifactorial susceptibility to common diseases. Nat Genet 2008; 40:695-701.
    • (2008) Nat Genet , vol.40 , pp. 695-701
    • Bodmer, W.1    Bonilla, C.2
  • 10
    • 45849144004 scopus 로고    scopus 로고
    • Hereditary determinants of human hypertension: Strategies in the setting of genetic complexity
    • Shih PA, O'Connor DT. Hereditary determinants of human hypertension: strategies in the setting of genetic complexity. Hypertension 2008; 51:1456-1464.
    • (2008) Hypertension , vol.51 , pp. 1456-1464
    • Shih, P.A.1    O'Connor, D.T.2
  • 11
    • 42649139571 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies 20 loci that influence adult height
    • Weedon MN, Lango H, Lindgren CM, Wallace C, Evans DM, Mangino M, et al. Genome-wide association analysis identifies 20 loci that influence adult height. Nat Genet 2008; 40:575-583.
    • (2008) Nat Genet , vol.40 , pp. 575-583
    • Weedon, M.N.1    Lango, H.2    Lindgren, C.M.3    Wallace, C.4    Evans, D.M.5    Mangino, M.6
  • 13
    • 79959524146 scopus 로고    scopus 로고
    • A haplotype map of the human genome
    • International HapMap Consortium
    • International HapMap Consortium. A haplotype map of the human genome. Nature 2005; 437:1299-1320.
    • (2005) Nature , vol.437 , pp. 1299-1320
  • 15
    • 70449649375 scopus 로고    scopus 로고
    • HapMap and mapping genes for cardiovascular disease
    • Musunuru KKS. HapMap and mapping genes for cardiovascular disease. Circ Cardiovasc Genet 2008; 1:66-71.
    • (2008) Circ Cardiovasc Genet , vol.1 , pp. 66-71
    • Musunuru, K.K.S.1
  • 17
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • Wellcome Trust Case Control Consortium
    • Wellcome Trust Case Control Consortium. Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447:661-678.
    • (2007) Nature , vol.447 , pp. 661-678
  • 18
    • 56749149825 scopus 로고    scopus 로고
    • Replication of the Wellcome Trust genome-wide association study of essential hypertension: The Family Blood Pressure Program
    • Ehret GB, Morrison AC, O'Connor AA, Grove ML, Baird L, Schwander K, et al. Replication of the Wellcome Trust genome-wide association study of essential hypertension: the Family Blood Pressure Program. Eur J Hum Genet 2008; 16:1507-1511.
    • (2008) Eur J Hum Genet , vol.16 , pp. 1507-1511
    • Ehret, G.B.1    Morrison, A.C.2    O'Connor, A.A.3    Grove, M.L.4    Baird, L.5    Schwander, K.6
  • 19
    • 67650520178 scopus 로고    scopus 로고
    • Replication of the Wellcome Trust genome-wide association study on essential hypertension in a Korean population
    • Hong KW, Jin HS, Cho YS, Lee JY, Lee JE, Cho NH, et al. Replication of the Wellcome Trust genome-wide association study on essential hypertension in a Korean population. Hypertens Res 2009; 32:570-574.
    • (2009) Hypertens Res , vol.32 , pp. 570-574
    • Hong, K.W.1    Jin, H.S.2    Cho, Y.S.3    Lee, J.Y.4    Lee, J.E.5    Cho, N.H.6
  • 20
    • 67349085063 scopus 로고    scopus 로고
    • Genome-wide association study identifies eight loci associated with blood pressure
    • Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L, et al. Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet 2009; 41:666-676.
    • (2009) Nat Genet , vol.41 , pp. 666-676
    • Newton-Cheh, C.1    Johnson, T.2    Gateva, V.3    Tobin, M.D.4    Bochud, M.5    Coin, L.6
  • 21
    • 35748962317 scopus 로고    scopus 로고
    • Framingham HeartStudy100K Project: Genome-wide associations for blood pressure and arterial stiffness
    • LevyD,LarsonMG, BenjaminEJ, Newton-ChehC,Wang TJ,Hwang SJ,etal. Framingham HeartStudy100K Project: genome-wide associations for blood pressure and arterial stiffness. BMC Med Genet 2007; 8 (Suppl 1):S3.
    • (2007) BMC Med Genet , vol.8 , Issue.SUPPL. 1
    • Levy, D.1    Larson, M.G.2    Benjamin, E.J.3    Newton-Cheh, C.4    Wang, T.J.5    Hwang, S.J.6
  • 23
    • 58549108489 scopus 로고    scopus 로고
    • From the cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene
    • Wang Y, O'Connell JR, McArdle PF, Wade JB, Dorff SE, Shah SJ, et al. From the cover: whole-genome association study identifies STK39 as a hypertension susceptibility gene. Proc Natl Acad Sci USA 2009; 106:226-231.
    • (2009) Proc Natl Acad Sci USA , vol.106 , pp. 226-231
    • Wang, Y.1    O'Connell, J.R.2    McArdle, P.F.3    Wade, J.B.4    Dorff, S.E.5    Shah, S.J.6
  • 24
    • 67349188883 scopus 로고    scopus 로고
    • A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits
    • Cho YS, Go MJ, Kim YJ, Heo JY, Oh JH, Ban HJ, et al. A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits. Nat Genet 2009; 41:527-534.
    • (2009) Nat Genet , vol.41 , pp. 527-534
    • Cho, Y.S.1    Go, M.J.2    Kim, Y.J.3    Heo, J.Y.4    Oh, J.H.5    Ban, H.J.6
  • 25
    • 68249107559 scopus 로고    scopus 로고
    • A genome-wide association study of hypertension and blood pressure in African Americans
    • Adeyemo A, Gerry N, Chen G, Herbert A, Doumatey A, Huang H, et al. A genome-wide association study of hypertension and blood pressure in African Americans. PLoS Genet 2009; 5:e1000564.
    • (2009) PLoS Genet , vol.5
    • Adeyemo, A.1    Gerry, N.2    Chen, G.3    Herbert, A.4    Doumatey, A.5    Huang, H.6
  • 26
    • 66149105886 scopus 로고    scopus 로고
    • Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations
    • Org E, Eyheramendy S, Juhanson P, Gieger C, Lichtner P, Klopp N, et al. Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations. Hum Mol Genet 2009; 18:2288-2296.
    • (2009) Hum Mol Genet , vol.18 , pp. 2288-2296
    • Org, E.1    Eyheramendy, S.2    Juhanson, P.3    Gieger, C.4    Lichtner, P.5    Klopp, N.6
  • 27
    • 33645775067 scopus 로고    scopus 로고
    • An utter refutation of the 'Fundamental Theorem of the HapMap'
    • Terwilliger JD, Hiekkalinna T. An utter refutation of the 'Fundamental Theorem of the HapMap'. Eur J Hum Genet 2006; 14:426-437.
    • (2006) Eur J Hum Genet , vol.14 , pp. 426-437
    • Terwilliger, J.D.1    Hiekkalinna, T.2
  • 29
    • 0029892711 scopus 로고    scopus 로고
    • The genetic contribution to stature
    • Preece MA. The genetic contribution to stature. Horm Res 1996; 45 (Suppl 2):56-58.
    • (1996) Horm Res , vol.45 , Issue.SUPPL. 2 , pp. 56-58
    • Preece, M.A.1
  • 30
    • 58149163142 scopus 로고    scopus 로고
    • Six new loci associated with body mass index highlight a neuronal influence on body weight regulation
    • Willer CJ, Speliotes EK, Loos RJ, Li S, Lindgren CM, Heid IM, et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet 2009; 41:25-34.
    • (2009) Nat Genet , vol.41 , pp. 25-34
    • Willer, C.J.1    Speliotes, E.K.2    Loos, R.J.3    Li, S.4    Lindgren, C.M.5    Heid, I.M.6
  • 31
    • 33846100236 scopus 로고    scopus 로고
    • C-reactive protein, an 'intermediate phenotype' for inflammation: Human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta-adrenergic pathway loci
    • Wessel J, Moratorio G, Rao F, Mahata M, Zhang L, Greene W, et al. C-reactive protein, an 'intermediate phenotype' for inflammation: human twin studies reveal heritability, association with blood pressure and the metabolic syndrome, and the influence of common polymorphism at catecholaminergic/beta- adrenergic pathway loci. J Hypertens 2007; 25:329-343.
    • (2007) J Hypertens , vol.25 , pp. 329-343
    • Wessel, J.1    Moratorio, G.2    Rao, F.3    Mahata, M.4    Zhang, L.5    Greene, W.6
  • 33
    • 12244264435 scopus 로고    scopus 로고
    • Genetic power calculator: Design of linkage and association genetic mapping studies of complex traits
    • Purcell S, Cherny SS, Sham PC. Genetic power calculator: design of linkage and association genetic mapping studies of complex traits. Bioinformatics 2003; 19:149-150.
    • (2003) Bioinformatics , vol.19 , pp. 149-150
    • Purcell, S.1    Cherny, S.S.2    Sham, P.C.3
  • 34
    • 55449120805 scopus 로고    scopus 로고
    • Genetic mapping in human disease
    • Altshuler D, Daly MJ, Lander ES. Genetic mapping in human disease. Science 2008; 322:881-888.
    • (2008) Science , vol.322 , pp. 881-888
    • Altshuler, D.1    Daly, M.J.2    Lander, E.S.3
  • 35
    • 34247617824 scopus 로고    scopus 로고
    • Catecholamine release-inhibitory peptide catestatin (chromogranin A (352-372)): Naturally occurring amino acid variant Gly364Ser causes profound changes in human autonomic activity and alters risk for hypertension
    • Rao F, Wen G, Gayen JR, Das M, Vaingankar SM, Rana BK, et al. Catecholamine release-inhibitory peptide catestatin (chromogranin A (352-372)): naturally occurring amino acid variant Gly364Ser causes profound changes in human autonomic activity and alters risk for hypertension. Circulation 2007; 115:2271-2281.
    • (2007) Circulation , vol.115 , pp. 2271-2281
    • Rao, F.1    Wen, G.2    Gayen, J.R.3    Das, M.4    Vaingankar, S.M.5    Rana, B.K.6
  • 36
    • 41149176472 scopus 로고    scopus 로고
    • Haplotypic analysis of Wellcome Trust Case Control Consortium data
    • Browning BL, Browning SR. Haplotypic analysis of Wellcome Trust Case Control Consortium data. Hum Genet 2008; 123:273-280.
    • (2008) Hum Genet , vol.123 , pp. 273-280
    • Browning, B.L.1    Browning, S.R.2
  • 37
    • 53649098737 scopus 로고    scopus 로고
    • Pathway analysis of seven common diseases assessed by genome-wide association
    • Torkamani A, Topol EJ, Schork NJ. Pathway analysis of seven common diseases assessed by genome-wide association. Genomics 2008; 92:265-272.
    • (2008) Genomics , vol.92 , pp. 265-272
    • Torkamani, A.1    Topol, E.J.2    Schork, N.J.3
  • 39
    • 67650747514 scopus 로고    scopus 로고
    • Blood pressure genetics: Time to focus
    • Harrap SB. Blood pressure genetics: time to focus. J Am Soc Hypertens 2009; 3:231-237.
    • (2009) J Am Soc Hypertens , vol.3 , pp. 231-237
    • Harrap, S.B.1
  • 40
    • 42649084334 scopus 로고    scopus 로고
    • Rare independent mutations in renal salt handling genes contribute to blood pressure variation
    • Ji W, Foo JN, O'Roak BJ, Zhao H, Larson MG, Simon DB, et al. Rare independent mutations in renal salt handling genes contribute to blood pressure variation. Nat Genet 2008; 40:592-599.
    • (2008) Nat Genet , vol.40 , pp. 592-599
    • Ji, W.1    Foo, J.N.2    O'Roak, B.J.3    Zhao, H.4    Larson, M.G.5    Simon, D.B.6
  • 42
    • 32444441330 scopus 로고    scopus 로고
    • Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels
    • Cohen JC, Pertsemlidis A, FahmiS, Esmail S, Vega GL, Grundy SM, Hobbs HH. Multiple rare variants in NPC1L1 associated with reduced sterol absorption and plasma low-density lipoprotein levels. Proc Natl Acad Sci USA 2006; 103:1810-1815.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 1810-1815
    • Cohen, J.C.1    Pertsemlidis, A.2    Fahmis Esmail, S.3    Vega, G.L.4    Grundy, S.M.5    Hobbs, H.H.6
  • 44
    • 13944265645 scopus 로고    scopus 로고
    • Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9
    • Cohen J, Pertsemlidis A, Kotowski IK, Graham R, Garcia CK, Hobbs HH. Low LDL cholesterol in individuals of African descent resulting from frequent nonsense mutations in PCSK9. Nat Genet 2005; 37:161-165.
    • (2005) Nat Genet , vol.37 , pp. 161-165
    • Cohen, J.1    Pertsemlidis, A.2    Kotowski, I.K.3    Graham, R.4    Garcia, C.K.5    Hobbs, H.H.6
  • 45
  • 48
    • 45249084746 scopus 로고    scopus 로고
    • Common genetic variants in the chromogranin A promoter alter autonomic activity and blood pressure
    • Chen Y, Rao F, Rodriguez-Flores JL, Mahapatra NR, Mahata M, Wen G, et al. Common genetic variants in the chromogranin A promoter alter autonomic activity and blood pressure. Kidney Int 2008; 74:115-125.
    • (2008) Kidney Int , vol.74 , pp. 115-125
    • Chen, Y.1    Rao, F.2    Rodriguez-Flores, J.L.3    Mahapatra, N.R.4    Mahata, M.5    Wen, G.6
  • 49
    • 76649137391 scopus 로고    scopus 로고
    • Autonomic function in hypertension: Role of genetic variation at the catecholamine storage vesicle protein chromogranin B (CHGB)
    • Zhang K, Rao F, Rana BK, Gayen JR, Calegari F, King A, et al. Autonomic function in hypertension: role of genetic variation at the catecholamine storage vesicle protein chromogranin B (CHGB). Circ Cardiovasc Genet 2009; 2:46-56.
    • (2009) Circ Cardiovasc Genet , vol.2 , pp. 46-56
    • Zhang, K.1    Rao, F.2    Rana, B.K.3    Gayen, J.R.4    Calegari, F.5    King, A.6
  • 50
    • 34547743350 scopus 로고    scopus 로고
    • An ancestral variant of Secretogranin II confers regulation by PHOX2 transcription factors and association with hypertension
    • Wen G, Wessel J, Zhou W, Ehret GB, Rao F, Stridsberg M, et al. An ancestral variant of Secretogranin II confers regulation by PHOX2 transcription factors and association with hypertension. Hum Mol Genet 2007; 16:1752-1764.
    • (2007) Hum Mol Genet , vol.16 , pp. 1752-1764
    • Wen, G.1    Wessel, J.2    Zhou, W.3    Ehret, G.B.4    Rao, F.5    Stridsberg, M.6
  • 51
    • 34548202734 scopus 로고    scopus 로고
    • Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis: Discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo
    • Rao F, Zhang L, Wessel J, Zhang K, Wen G, Kennedy BP, et al. Tyrosine hydroxylase, the rate-limiting enzyme in catecholamine biosynthesis: discovery of common human genetic variants governing transcription, autonomic activity, and blood pressure in vivo. Circulation 2007; 116:993-1006.
    • (2007) Circulation , vol.116 , pp. 993-1006
    • Rao, F.1    Zhang, L.2    Wessel, J.3    Zhang, K.4    Wen, G.5    Kennedy, B.P.6
  • 52
    • 73849108040 scopus 로고    scopus 로고
    • Human dopamine beta-hydroxylase (DBH) regulatory polymorphism that influences enzymatic activity, autonomic function, and blood pressure
    • Chen Y, Wen G, Rao F, Zhang K, Wang L, Rodriguez-Flores JL, et al. Human dopamine beta-hydroxylase (DBH) regulatory polymorphism that influences enzymatic activity, autonomic function, and blood pressure. J Hypertens 2010; 28:76-86.
    • (2010) J Hypertens , vol.28 , pp. 76-86
    • Chen, Y.1    Wen, G.2    Rao, F.3    Zhang, K.4    Wang, L.5    Rodriguez-Flores, J.L.6
  • 53
    • 68949191193 scopus 로고    scopus 로고
    • Neuropeptide Y(1) receptor NPY1R: Discovery of naturally occurring human genetic variants governing gene expression in cella as well as pleiotropic effects on autonomic activity and blood pressure in vivo
    • Wang L, Rao F, Zhang K, Mahata M, Rodriguez-Flores JL, Fung MM, et al. Neuropeptide Y(1) receptor NPY1R: discovery of naturally occurring human genetic variants governing gene expression in cella as well as pleiotropic effects on autonomic activity and blood pressure in vivo. J Am Coll Cardiol 2009; 54:944-954.
    • (2009) J Am Coll Cardiol , vol.54 , pp. 944-954
    • Wang, L.1    Rao, F.2    Zhang, K.3    Mahata, M.4    Rodriguez-Flores, J.L.5    Fung, M.M.6
  • 54
    • 52949096084 scopus 로고    scopus 로고
    • Next-generation DNA sequencing methods
    • Mardis ER. Next-generation DNA sequencing methods. Annu Rev Genomics Hum Genet 2008; 9:387-402.
    • (2008) Annu Rev Genomics Hum Genet , vol.9 , pp. 387-402
    • Mardis, E.R.1
  • 55
    • 0033759719 scopus 로고    scopus 로고
    • FallinD,ChakravartiA.Linkage disequilibrium analysis of biallelic DNA markers, human quantitative trait loci, and threshold-defined case and control subjects
    • Schork NJ, Nath SK, FallinD,ChakravartiA.Linkage disequilibrium analysis of biallelic DNA markers, human quantitative trait loci, and threshold-defined case and control subjects. Am J Hum Genet 2000; 67:1208-1218.
    • (2000) Am J Hum Genet , vol.67 , pp. 1208-1218
    • Schork, N.J.1    Nath, S.K.2
  • 56
    • 33847609151 scopus 로고    scopus 로고
    • Population-based sample reveals gene-gender interactions in blood pressure in White Americans
    • Rana BK, Insel PA, Payne SH, Abel K, Beutler E, Ziegler MG, et al. Population-based sample reveals gene-gender interactions in blood pressure in White Americans. Hypertension 2007; 49:96-106.
    • (2007) Hypertension , vol.49 , pp. 96-106
    • Rana, B.K.1    Insel, P.A.2    Payne, S.H.3    Abel, K.4    Beutler, E.5    Ziegler, M.G.6
  • 57
    • 16244398035 scopus 로고    scopus 로고
    • Mapping quantitative trait loci using linkage disequilibrium: Marker-versus trait-based methods
    • Tenesa A, Visscher PM, Carothers AD, Knott SA. Mapping quantitative trait loci using linkage disequilibrium: marker-versus trait-based methods. Behav Genet 2005; 35:219-228.
    • (2005) Behav Genet , vol.35 , pp. 219-228
    • Tenesa, A.1    Visscher, P.M.2    Carothers, A.D.3    Knott, S.A.4
  • 59
    • 0347601668 scopus 로고    scopus 로고
    • Cardiovascular haemodynamic response to repeated mental stress in normotensive subjects at genetic risk of hypertension: Evidence of enhanced reactivity, blunted adaptation, and delayed recovery
    • Schneider GM, Jacobs DW, Gevirtz RN, O'Connor DT. Cardiovascular haemodynamic response to repeated mental stress in normotensive subjects at genetic risk of hypertension: evidence of enhanced reactivity, blunted adaptation, and delayed recovery. J Hum Hypertens 2003; 17:829-840.
    • (2003) J Hum Hypertens , vol.17 , pp. 829-840
    • Schneider, G.M.1    Jacobs, D.W.2    Gevirtz, R.N.3    O'Connor, D.T.4
  • 60
    • 0027448840 scopus 로고
    • Early structural changes in hypertension: Pathophysiology and clinical consequences
    • Folkow B. Early structural changes in hypertension: pathophysiology and clinical consequences. J Cardiovasc Pharmacol 1993; 22 (Suppl 1):S1-S6.
    • (1993) J Cardiovasc Pharmacol , vol.22 , Issue.SUPPL. 1
    • Folkow, B.1
  • 61
    • 53249113155 scopus 로고    scopus 로고
    • Gene-environment interactions for complex traits: Definitions, methodological requirements and challenges
    • Dempfle A, Scherag A, Hein R, Beckmann L, Chang-Claude J, Schafer H. Gene-environment interactions for complex traits: definitions, methodological requirements and challenges. Eur J Hum Genet 2008; 16:1164-1172.
    • (2008) Eur J Hum Genet , vol.16 , pp. 1164-1172
    • Dempfle, A.1    Scherag, A.2    Hein, R.3    Beckmann, L.4    Chang-Claude, J.5    Schafer, H.6
  • 62
    • 42249109208 scopus 로고    scopus 로고
    • Sample size requirements for indirect association studies of gene-environment interactions (G x E)
    • Hein R, Beckmann L, Chang-Claude J. Sample size requirements for indirect association studies of gene-environment interactions (G x E). Genet Epidemiol 2008; 32:235-245.
    • (2008) Genet Epidemiol , vol.32 , pp. 235-245
    • Hein, R.1    Beckmann, L.2    Chang-Claude, J.3
  • 63
    • 17744373679 scopus 로고    scopus 로고
    • Do we need genomic research for the prevention of common diseases with environmental causes?
    • Khoury MJ, Davis R, Gwinn M, Lindegren ML, Yoon P. Do we need genomic research for the prevention of common diseases with environmental causes? Am J Epidemiol 2005; 161:799-805.
    • (2005) Am J Epidemiol , vol.161 , pp. 799-805
    • Khoury, M.J.1    Davis, R.2    Gwinn, M.3    Lindegren, M.L.4    Yoon, P.5
  • 64
    • 53949122279 scopus 로고    scopus 로고
    • Naturally occurring human genetic variation in the 3-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion
    • Chen Y, Rao F, Rodriguez-Flores JL, Mahata M, Fung MM, Stridsberg M, et al. Naturally occurring human genetic variation in the 3-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion. J Am Coll Cardiol 2008; 52:1468-1481.
    • (2008) J Am Coll Cardiol , vol.52 , pp. 1468-1481
    • Chen, Y.1    Rao, F.2    Rodriguez-Flores, J.L.3    Mahata, M.4    Fung, M.M.5    Stridsberg, M.6
  • 65
    • 33646164662 scopus 로고    scopus 로고
    • Rho kinase polymorphism influences blood pressure and systemic vascular resistance in human twins: Role of heredity
    • Seasholtz TM, Wessel J, Rao F, Rana BK, Khandrika S, Kennedy BP, et al. Rho kinase polymorphism influences blood pressure and systemic vascular resistance in human twins: role of heredity. Hypertension 2006; 47:937-947.
    • (2006) Hypertension , vol.47 , pp. 937-947
    • Seasholtz, T.M.1    Wessel, J.2    Rao, F.3    Rana, B.K.4    Khandrika, S.5    Kennedy, B.P.6
  • 66
    • 41049113284 scopus 로고    scopus 로고
    • Genetic variation within adrenergic pathways determines in vivo effects of presynaptic stimulation in humans
    • Fung MM, Nguyen C, Mehtani P, Salem RM, Perez B, Thomas B, et al. Genetic variation within adrenergic pathways determines in vivo effects of presynaptic stimulation in humans. Circulation 2008; 117:517-525.
    • (2008) Circulation , vol.117 , pp. 517-525
    • Fung, M.M.1    Nguyen, C.2    Mehtani, P.3    Salem, R.M.4    Perez, B.5    Thomas, B.6
  • 68
    • 56049108812 scopus 로고    scopus 로고
    • Use of monozygotic twins to investigate the relationship between 5HTTLPR genotype, depression and stressful life events: An application of Item Response Theory
    • discussion 59-70
    • Wray NR, Coventry WL, James MR, Montgomery GW, Eaves LJ, Martin NG. Use of monozygotic twins to investigate the relationship between 5HTTLPR genotype, depression and stressful life events: an application of Item Response Theory. Novartis Found Symp 2008; 293:48-59; discussion 59-70.
    • (2008) Novartis Found Symp , vol.293 , pp. 48-59
    • Wray, N.R.1    Coventry, W.L.2    James, M.R.3    Montgomery, G.W.4    Eaves, L.J.5    Martin, N.G.6


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