Do we need genomic research for the prevention of common diseases with environmental causes?

American Journal of Epidemiology

Volumn 161, Issue 9, 2005, Pages 799-805

  Khoury, Muin J ^a   Davis, Robert ^a   Gwinn, Marta ^a   Lindegren, Mary Lou ^a   Yoon, Paula ^a  

^a NATIONAL CENTER ON BIRTH DEFECTS AND DEVELOPMENTAL DISABILITIES   (United States)

Author keywords

Environment; Epidemiology; Genomics; Health promotion; Medicine; Preventive health services; Preventive medicine; Public health

Indexed keywords

ENVIRONMENTAL RISK; HEALTH RISK;

ENVIRONMENTAL FACTOR; EPIDEMIOLOGY; GENETIC ANALYSIS; GENETIC RISK; GENETIC SUSCEPTIBILITY; GENOMICS; HEALTH PROMOTION; HEALTH SERVICE; HUMAN; MEDICAL RESEARCH; PREVENTIVE MEDICINE; PUBLIC HEALTH; REVIEW; RISK ASSESSMENT; RISK FACTOR; RISK REDUCTION;

ENVIRONMENTAL ILLNESS; GENOMICS; HEALTH PROMOTION; HUMANS; PUBLIC HEALTH; RESEARCH;

EID: 17744373679     PISSN: 00029262     EISSN: None     Source Type: Journal    
DOI: 10.1093/aje/kwi113     Document Type: Review

References (52)

1. Rose G. Sick individuals and sick populations. Int J Epidemiol 1985;14:32-8.
2. Wald NJ, Hackshaw AK, Frost CD. When can a risk factor be used as a worthwhile screening test? BMJ 1999;319:1562-5.
3. Guttmacher AE, Collins FS. Welcome to the genomic era. (Editorial). N Engl J Med 2003;349:996-8.
4. Bell J. Predicting disease using genomics. Nature 2004;429: 453-6.
5. Willet WC. Balancing lifestyle and genomic research for disease prevention. Science 2002;296:695-8.
6. Cooper RS, Psaty BM. Genomics and medicine: distraction, incremental progress or the dawn of a new age. Ann Intern Med 2003;138:576-80.
7. Merikangas KR, Risch N. Genomic priorities and public health. Science 2003;302:599-601.
8. Berrettini W, Bierut L, Crowley TJ, et al. Setting priorities for genomic research. Science 2004;304:1445-7.
9. Rothman KJ. Modern epidemiology. Boston, MA: Little, Brown and Company, 1986:14.
10. National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention. Physical activity and good nutrition: essential elements to prevent chronic diseases and obesity. At A Glance 2004. Atlanta, GA: Centers for Disease Control and Prevention, 2004. (World Wide Web URL: http://www.cdc.gov/nccdphp/aag/aag_dnpa.htm). (Accessed October 4, 2004).
11. Mokdad AH, Ford ES, Bowman BA, et al. Prevalence of obesity, diabetes and obesity-related health risk factors, 2001. JAMA 2003;289:76-9.
12. Ford ES, Giles WH, Mokdad AH. Increasing prevalence of the metabolic syndrome among U.S. adults. Diabetes Care 2004;27:2444-9.
13. Trends in screening for colorectal cancer-United States, 1997 and 1999. MMWR Morb Mortal Wkly Rep 2001;50:162-6. (World Wide Web URL: http://www.cdc.gov/mmwr/preview/mmwrhtml/mm5009a2.htm). (Accessed January 1, 2003).
14. Warden CH, Fisler JS. Complex diseases influenced by environmental risk factors may require complex cures. (Electronic letter). Science 2003;Nov 20. (World Wide Web URL: www.sciencemag.org/cgi/eletters/302/5645/599). (Accessed September 10, 2004).
15. Yoon PW, Scheuner MT, Peterson-Oehlke KL, et al. Can family history be used as a tool for public health and preventive medicine? Genet Med 2002;4:304-10.
16. Hunt SC, Gwinn M, Adams TD. Family history assessment: strategies for prevention of cardiovascular disease. Am J Prev Med 2003;24:136-42.
17. Harrison TA, Hindorff LA, Kim H, et al. Family history of diabetes as a potential public health tool. Am J Prev Med 2003;24:152-9.
18. Yoon PW, Scheuner MT, Khoury MJ. Research priorities for evaluating family history in the prevention of common chronic diseases. Am J Prev Med 2003;24:128-35.
19. Office of Genomics and Disease Prevention, Centers for Disease Control and Prevention. Family history for preventive medicine and public health. Atlanta, GA: Centers for Disease Control and Prevention, 2004. (World Wide Web URL: http://www.cdc.gov/genomics/activities/famhx.htm). (Accessed August 18,2004).
20. Scheuner MT, Wang SJ, Raffel LJ, et al. Family history: a comprehensive genetic risk assessment method for the chronic conditions of adulthood. Am J Med Genet 1997;71:315-24.
21. Tyagi A, Morris J. Using decision analytic methods to assess the utility of family history tools. Am J Prev Med 2003;24:199-207.
22. Department of Health and Human Services. U.S. Surgeon General's Family History Initiative. Washington, DC: Department of Health and Human Services, 2004. (World Wide Web URL: http://www.hhs.gov/familyhistory/). (Accessed November 23, 2004).
23. Khoury MJ, Yang Q, Gwinn M, et al. An epidemiologic assessment of genomic profiling for measuring susceptibility to common diseases and targeting interventions. Genet Med 2004;6:38-47.
24. Collins FS. Shattuck lecture-medical and societal consequences of the Human Genome Project. N Engl J Med 1999;341:28-37.
25. Haga S, Khoury MJ, Burke W. Genomic profiling for lifestyle modification: not ready for prime time. Nat Genet 2003;34:347-50.
26. Khoury MJ. Genetics and genomics in practice: the continuum from genetic disease to genetic information in health and disease. Genet Med 2003;5:261-8.
27. Vineis P. A self-fulfilling prophecy: are we underestimating the role of the environment in gene-environment interaction research? Int J Epidemiol 2004;33:945-6.
28. Olden K. Genomics in environmental health research-opportunities and challenges. Toxicology 2004;198:19-24.
29. Pennie W, Pettit SD, Lord PG. Toxicogenomics in risk assessment: an overview of an HESI collaborative research program. Environ Health Perspect 2004;112:417-19.
30. Hamadeh HK, Bushel PR, Jayadev S, et al. Prediction of compound signature using high density gene expression profiling. Toxicol Sci 2002;67:232-40.
31. Hamadeh HK, Jayadev S, Gaillard ET, et al. Integration of clinical and gene expression endpoints to explore furan-mediated hepatotoxicity. Mutat Res 2004;549:169-83.
32. Campbell CJ, Ghazal P. Molecular signatures for diagnosis of infection: application of microarray technology. J Appl Microbiol 2004;96:18-23.
33. Pesch B, Bruning T, Frentzel-Beyme R, et al. Challenges to environmental toxicology and epidemiology: where do we stand and which way do we go? Toxicol Lett 2004;151:255-66.
34. Vineis P, Schulte PA, Carreon T, et al. Issues of design and analysis in studies of gene-environment interactions. IARC Sci Publ 2004;157:417-35.
35. Khoury MJ, Adams MJ Jr, Flanders WD. An epidemiologic approach to ecogenetics. Am J Hum Genet 1988;42:89-95.
36. Khoury MJ, Little J, Burke W, eds. Human genome epidemiology: a scientific foundation for using genetic information to improve health and prevent disease. New York, NY: Oxford University Press, 2004.
37. Davey Smith G, Ebrahim S. 'Mendelian randomization': can genetic epidemiology contribute to understanding environmental determinants of disease? Int J Epidemiol 2003;32:1-22.
38. Little J, Khoury MJ. Mendelian randomisation: a new spin or real progress? Lancet 2003;362:930-1.
39. Davey Smith G, Ebrahim S. Mendelian randomization: prospects, potentials, and limitations. Int J Epidemiol 2004;33:30-42.
40. Burke W. Genomics as a probe for disease biology. N Engl J Med 2003;349:969-74.
41. Furberg H, Millikan RC, Geradts J, et al. Reproductive factors in relation to breast cancer characterized by p53 protein expression (United States). Cancer Causes Control 2003;14: 609-18.
42. Romieu I, Sienra-Monge JJ, Ramirez-Aguilar M, et al. Genetic polymorphism of GSTM1 and antioxidant supplementation influence lung function in relation to ozone exposure in asthmatic children in Mexico City. Thorax 2004;59:8-10.
43. Lingappa J, Lindegren ML. Genomics and acute public health investigations. In: Genomics and population health: United States 2003. Atlanta, GA: Centers for Disease Control and Prevention, 2003. (World Wide Web URL: http://www.cdc.gov/genomics/activities/ogdp/2003/chap02.htm).
44. Institute of Medicine, National Academy of Sciences. Microbial threats to health: emergence, detection and response. Washington, DC: National Academy Press, 2003.
45. Lingappa J, Kuffner T, Tappero J, et al. HLA-DQ6 and ingestion of contaminated water: possible gene-environment interaction in an outbreak of leptospirosis. Genes Immun 2004;5:197-202.
46. Lin M, Tseng H-K, Trejaut JA, et al. Association of HLA class I with severe acute respiratory syndrome coronavirus infection. BMC Med Genet 2003;4:1-9.
47. Li W, Moore MJ, Vasilieva N, et al. Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus. Nature 2003;426:450-4.
48. Bellamy R. Susceptibility to mycobacterial infections: the importance of host genetics. Genes Immun 2003;4:4-11.
49. Bates I, Fenton C, Gruber J, et al. Vulnerability to malaria, tuberculosis and HIV/AIDS infection and disease. Part 1: determinants operating at the individual and household level. Lancet Inf Dis 2004;4:267-77.
50. Balamurugan A, Sharma SK, Mehra NK. Human leukocyte antigen class I supertypes influence susceptibility and severity of tuberculosis. J Infect Dis 2004;189:805-11.
51. McNicholl JM, Promadej N. Insights into the role of host genetic and T-cell factors in resistance to HIV transmission from studies of highly HIV-exposed Thais. Immunol Res 2004;29:161-74.
52. Hoover RN. Cancer-nature, nurture or both. (Editorial). N Engl J Med 2000;343:135-6.