Role of folylpolygutamate synthetase (FPGS) in antifolate chemotherapy; a biochemical and clinical update

Leukemia and Lymphoma

Volumn 21, Issue 1-2, 1996, Pages 9-15

  Synold, Timothy W ^a   Willits, Elizabeth M ^d   Barredo, Julio C ^b,c  

^a CITY OF HOPE NATIONAL MEDICAL CENTER   (United States)

^b MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^c MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

^d NONE

Author keywords

Antifolates; Chemotherapy; FPGS; Polyglutamylation

Indexed keywords

ALKYLATING AGENT; DNA TOPOISOMERASE; ENZYME INHIBITOR; FLUOROURACIL; FOLIC ACID ANTAGONIST; FOLINIC ACID; FOLYLPOLYGLUTAMATE SYNTHASE; LOMETREXOL; METHOTREXATE; PEMETREXED; RALTITREXED; THYMIDYLATE SYNTHASE; ANTINEOPLASTIC ANTIMETABOLITE; FOLIC ACID; PEPTIDE SYNTHASE;

ACUTE LYMPHOBLASTIC LEUKEMIA; ANTINEOPLASTIC ACTIVITY; CANCER; DRUG ACTIVATION; DRUG SAFETY; HUMAN; METABOLISM; NONHUMAN; PRIORITY JOURNAL; PURINE SYNTHESIS; REVIEW; ANIMAL; BIOTRANSFORMATION;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; BIOTRANSFORMATION; FOLIC ACID; FOLIC ACID ANTAGONISTS; HUMANS; PEPTIDE SYNTHASES;

EID: 0029658749     PISSN: 10428194     EISSN: None     Source Type: Journal    
DOI: 10.3109/10428199609067573     Document Type: Article

References (56)

1. Niemeyer, C. M., Hitchcock, B. S., and Sallan, S. E. (1985) Comparative analysis of treatment programs for childhood acute lymphoblastic leukemia. Seminars in Oncology, 12, 122-30.
2. Keyomarsi, K. and Moran, R. G. (1988) Mechanism of the cytotoxic synergism of fluoropyrimidines and folinic acid in mouse leukemic cells. Journal of Biological Chemistry, 263, 14402-9.
3. Arbuck, S. G. (1989) Overview of clinical trials using 5-fluorouracil and leucovorin for the treatment of colorectal cancer. [Review]. Cancer, 63, 1036-44.
4. Boffetta, P. and Kaldor, J. M. (1994) Secondary malignancies following cancer chemotherapy. [Review]. Acta Oncologica, 33, 591-8.
5. Ochs, J. and Mulhern, R. (1994) Long-term sequelae of therapy for childhood acute lymphoblastic leukaemia. [Review]. Baillieres Clinical Haematology, 7, 365-76.
6. Chabner, B. A., et al. (1985) Polyglutamation of methotrexate. Is methotrexate a prodrug?. [Review]. Journal of Clinical Investigation, 76, 907-12.
7. Baldwin, S. W., et al. (1991) Structural features of 5,10-dideaza5,6,7,8-tetrahydrofolate that determine inhibition of mammalian glycinamide ribonucleotide formyltransferase. Biochemistry, 30, 1997-2006.
8. Jackman, A. L., et al. (1991) ICI D1694, a quinazoline antifolate thymidylate synthase inhibitor that is a potent inhibitor of L1210 tumor cell growth in vitro and in vivo: a new agent for clinical study. Cancer Research, 51, 5579-86.
9. Moran, R. G., Shih, C., Taylor, E. C., and Grindey, G. B. (1992) Are classical antifolates directed at thymidylate synthase and purine synthesis prodrugs? (Meeting abstract). Proc Seventh NCI-EORTC Symposium on New Drugs in Cancer Therapy, p. 91. Amsterdam: NCI-EPRTC.
10. Schroder, H. (1986) Methotrexate pharmacokinetics in age-fractionated erythrocytes. Cancer Chemotherapy & Pharmacology, 18, 203-7.
11. Barredo, J. and Moran, R. G. (1992) Determinants of antifolate cytotoxicity: folylpolyglutamate synthetase activity during cellular proliferation and development. Molecular Pharmacology, 42, 687-94.
12. Schmiegelow, K., et al. (1995) Risk of relapse in childhood acute lymphoblastic leukemia is related to rbc methotrexate and mercaptopurine metabolites during maintenance chemotherapy. Journal of Clinical Oncology, 13, 345-351.
13. Freisheim, J. H., Price, E. M., and Ratnam, M. (1989) Folate coenzyme and antifolate transport proteins in normal and neoplastic cells. Advances in Enzyme Regulation, 29, 13-26.
14. Kamen, B. A., Wang, M. T., Streckfuss, A. J., Peryea, X., and Anderson, R. G. (1988) Delivery of folates to the cytoplasm of MA104 cells is mediated by a surface membrane receptor that recycles. Journal of Biological Chemistry, 263, 13602-9.
15. Kim, J. S., Lowe, K. E., and Shane, B. (1993) Regulation of folate and one-carbon metabolism in mammalian cells. IV. Role of folylpoly-gamma-glutamate synthetase in methotrexate metabolism and cytotoxicity. Journal of Biological Chemistry, 268, 21680-5.
16. Allegra, C. J. (1990) ANTIFOLATES. [Review]. Cancer Chemotherapy: Principles and Practice. Chabner B and Collins J eds., Philadelphia, Lippincott, pp. 110-53. Philadelphia: JB Lippincott.
17. Henderson, G. B. and Strauss, B. P. (1990) Characteristics of a novel transport system for folate compounds in wild-type and methotrexate-resistant L1210 cells. Cancer Research, 50, 1709-14.
18. McGuire, J. J., Hsieh, P., and Bertino, J. R. (1984) Enzymatic synthesis of polyglutamate derivatives of 7-hydroxymethotrexate. Biochemical Pharmacology, 33, 1355-61.
19. Bognar, A. L., Osborne, C., Shane, B., Singer, S. C., and Ferone, R. (1985) Folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase. Cloning and high expression of the Escherichia coli folC gene and purification and properties of the gene product. Journal of Biological Chemistry, 260, 5625-30.
20. Bognar, A. L. and Shane, B. (1983) Purification and properties of Lactobacillus casei folylpoly-gamma-glutamate synthetase. Journal of Biological Chemistry, 258, 12574-81.
21. Garrow, T. A., Admon, A., and Shane, B. (1992) Expression cloning of a human cDNA encoding folylpoly(gamma-glutamate) synthetase and determination of its primary structure. Proceedings of the National Academy of Sciences of the United States of America, 89, 9151-5.
22. Shane, B. (1989) Folylpolyglutamate synthesis and role in the regulation of one-carbon metabolism. [Review]. Vitamins & Hormones, 45, 263-335.
23. Moran, R. G. and Colman, P. D. (1984) Measurement of folylpolyglutamate synthetase in mammalian tissues. Analytical Biochemistry, 140, 326-42.
24. McBurney, M. W. and Whitmore, G. F. (1974) Isolation and biochemical characterization of folate deficient mutants of Chinese hamster cells. Cell, 2, 173-82.
25. Barredo, J. and Moran, R. G. (1992) Determinants of antifolate cytotoxicity: folylpolyglutamate synthetase activity during cellular proliferation and development. Molecular Pharmacology, 42, 687-94.
26. Barredo, J. and Moran, R. G. (1991) Folypolyglutamate synthetase (FPGS) activity during proliferation, differentiation and development (meeting abstract). Proc Annu Meet Am Assoc Cancer Res.
27. Lenz, H. J., et al. (1993) A polymerase chain reaction (PCR) assay for folylpolyglutamate synthetase (FPGS) gene expression: marked variation in human leukemia blast samples (Meeting abstract). Proc Annu Meet Am Assoc Cancer Res.
28. Li, W. W., et al. (1992) Mechanisms of natural resistance to antifolates in human soft tissue sarcomas. Cancer Research, 52, 1434-8.
29. Barredo, J. C., et al. (1993) In vivo changes of folylpolyglutamate synthetase (FPGS) activity in blasts from children with ALL after methotrexate (MTX) therapy (Meeting abstract). Proc Annu Meet Am Assoc Cancer Res.
30. Fort, D. W., et al. (1993) Accumulation of 5-methyltetrahydrofolic acid and folylpolyglutamate synthetase expression by mitogen stimulated human lymphocytes. British Journal of Haematology, 84, 595-601.
31. Barredo, J. C., et al. (1994) Differences in constitutive and postmethotrexate folylpolyglutamate synthetase activity in B-lineage and T-lineage leukemia. Blood, 84, 564-9.
32. Li, W. W., Lin, J. T., Schweitzer, B., Brennan, M. F., and Bertino, J. R. (1990) Inherent resistance to methotrexate in human soft tissue sarcoma (HSTS) cell lines (meeting abstract). Proc Annu Meet Am Assoc Cancer Res.
33. Lenz, H. J., et al. (1994) Quantitative analysis of folylpolyglutamate synthetase gene expression in tumor tissues by the polymerase chain reaction - marked variation of expression among leukemia patients. Oncology Research, 6, 329-335.
34. Goker, E., et al. (1993) Decreased polyglutamylation of methotrexate in acute lymphoblastic leukemia blasts in adults compared to children with this disease. Leukemia, 7, 1000-4.
35. Rosenblatt, D. S., et al. (1978) Prolonged inhibition of DNA synthesis associated with the accumulation of methotrexate polyglutamates by cultured human cells. Molecular Pharmacology, 14, 1143-7.
36. Galivan, J. (1980) Evidence for the cytotoxic activity of polyglutamate derivatives of methotrexate. Molecular Pharmacology, 17, 105-10.
37. Jolivet, J. and Chabner, B. A. (1983) Intracellular pharmacokinetics of methotrexate polyglutamates in human breast cancer cells. Selective retention and less dissociable binding of 4-NH2-10-CH3-pteroylglutamate4 and 4-NH2-10-CH3-pteroylglutamate5 to dihydrofolate reductase. Journal of Clinical Investigation, 72, 773-8.
38. Jackman, A. L., et al. (1991) Thymidylate synthase inhibitors: the in vitro activity of a series of heterocyclic benzoyl ring modified 2-desamino-2-methyl-N10-substituted-5,8-dideazafolates. [Review]. Advances in Enzyme Regulation, 31, 13-27.
39. Bertino, J. R. (1993) Karnofsky memorial lecture. Ode to methotrexate. [Review]. Journal of Clinical Oncology, 11, 5-14.
40. Whitehead, V. M., Rosenblatt, D. S., Vuchich, M. J., and Beaulieu, D. (1987) Methotrexate polyglutamate synthesis in lymphoblasts from children with acute lymphoblastic leukemia. Developmental Pharmacology & Therapeutics, 10, 443-8.
41. Samuels, L. L., Feinberg, A., Moccio, D. M., Sirotnak, F. M., and Rosen, G. (1984) Detection by high-performance liquid chromatography of methotrexate and its metabolites in tumor tissue from osteosarcoma patients treated with high-dose methotrexate/leucovorin rescue. Biochemical Pharmacology, 33, 2711-4.
42. Winick, N. J., et al. (1987) Folate and methotrexate polyglutamate tissue levels in rhesus monkeys following chronic low-dose methotrexate. Cancer Drug Delivery, 4, 25-31.
43. Allegra, C. J., et al. (1985) Enhanced inhibition of thymidylate synthase by methotrexate polyglutamates. Journal of Biological Chemistry, 260, 9720-6.
44. Allegra, C. J., Drake, J. C., Jolivet, J., and Chabner, B. A. (1985) Inhibition of phosphoribosylaminoimidazolecarboxamide transformylase by methotrexate and dihydrofolic acid polyglutamates. Proceedings of the National Academy of Sciences of the United States of America, 82, 4881-5.
45. Masson, E., et al. (1995) Inhibition of de novo purine synthesis is related to long-chain methotrexate polyglutamate concentrations in lymphoblasts. Proc Annu Meet Am Assoc Cancer Res.
46. Beardsley, G. P., Moroson, B. A., Taylor, E. C., and Moran, R. G. (1989) A new folate antimetabolite, 5,10-dideaza-5,6,7,8-tetrahydrofolate is a potent inhibitor of de novo purine synthesis. Journal of Biological Chemistry, 264, 328-33.
47. Jackman, A. L., et al. (1991) Thymidylate synthase inhibitors: the in vitro activity of a series of heterocyclic benzoyl ring modified 2-desamino-2-methyl-N10-substituted-5,8-dideazafolates. [Review]. Advances in Enzyme Regulation, 31, 13-27.
48. Lu, K., McGuire, J. J., and Rustum, Y. M. (1995) Characterization of a folylpolyglutamate synthesis deficient, ZD1694-resistant/methotrexate sensitive HCT-8 human ileocecal adenocarcinoma subline (meeting abstract). Proc Annu Meet Am Assoc Cancer Res..
49. Rosowsky, A., Forsch, R. A., and Moran, R. G. (1993) Optimization of folate analogues with an ornithine side chain as folyl-polyglutamate synthetase (FPGS) inhibitors (Meeting abstract). Proc Annu Meet Am Assoc Cancer Res..
50. Rosowsky, A., et al. (1986) Methotrexate analogues. 26. Inhibition of dihydrofolate reductase and folylpolyglutamate synthetase activity and in vitro tumor cell growth by methotrexate and aminopterin analogues containing a basic amino acid side chain. Journal of Medicinal Chemistry, 29, 655-60.
51. Whitehead, V. M., et al. (1990) Accumulation of methotrexate and methotrexate polyglutamates in lymphoblasts at diagnosis of childhood acute lymphoblastic leukemia: a pilot prognostic factor analysis. Blood, 76, 44-9.
52. Synold, T. W., et al. (1994) Blast cell methotrexate-polyglutamate accumulation in vivo differs by lineage, ploidy, and methotrexate dose in acute lymphoblastic leukemia. Journal of Clinical Investigation, 94, 1996-2001.
53. Galpin, A. J., et al. (1994) Differences in folylpolyglutamate synthetase (FPGS) mRNA expression in B-lineage and T-lineage acute lymphoblastic leukemia (ALL) (Meeting abstract). Proc Annu Meet Am Soc Clin Oncol.
54. McCloskey, D. E., et al. (1991) Decreased folylpolyglutamate synthetase activity as a mechanism of methotrexate resistance in CCRF-CEM human leukemia sublines. Journal of Biological Chemistry, 266, 6181-7.
55. Ciaiolo, C., et al. (1988) Enhancement of methotrexate cytotoxicity by modulation of proliferative activity in normal and neoplastic T lymphocytes and in a myeloid leukemia cell line. Tumori, 74, 537-42.
56. Rumberger, B. G., Barrueco, J. R., and Sirotnak, F. M. (1990) Differing specificities for 4-aminofolate analogues of folylpolyglutamyl synthetase from tumors and proliferative intestinal epithelium of the mouse with significance for selective antitumor action. Cancer Research, 50, 4639-43.