Inhibition of glucometabolism by a novel dehydroabielylamine derivative, DHAA-urea, in human hepatoma HepG2 cells

Journal of China Pharmaceutical University

Volumn 41, Issue 2, 2010, Pages 160-165

  Xie, Jian Xiang ^a,b   He, Ling ^a   Zang, Lu Yong ^a   Rao, Xiao Ping ^c   Song, Zhan Qian ^c  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b NANJING MEDICAL UNIVERSITY   (China)

^c RESEARCH INSTITUTE OF FORESTRY   (China)

Author keywords

Adenosine triphosphate; Dehydroabietylamine derivatives; Glucolysis; Glycometabolism; HepG2 human hepatocellular carcinoma cells

Indexed keywords

ADENOSINE TRIPHOSPHATE; DEHYDROAHIETYLAMINE UREA; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; LACTATE DEHYDROGENASE; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ARTICLE; CELL STRAIN HEPG2; CELL VIABILITY; COLORIMETRY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DOSE RESPONSE; DRUG STRUCTURE; ENZYME ACTIVITY; GLUCOSE METABOLISM; GLYCOLYSIS; HEPATOMA CELL; HUMAN; HUMAN CELL; HYPOXIA; HYPOXIC CELL; INCUBATION TIME; TIME;

EID: 77952526087     PISSN: 10005048     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (21)

1. Rolfe DF, Brown GC. Cellular energy utilization and molecular origin of standard metabolic rate in mammals[J]. Physiol Rev, 1997,77(3):731-758.
2. Harris AL. Hypoxia - a key regulatory factor in tumour growth [J]. Nat Rev Cancer,2002,2(1):38-47.
3. Dachs GU, Tozer GM. Hypoxia modulated gene expression: angiogenesis, metastasis and therapeutic exploitation [J]. Eur J Cancer,2000,36(13):1649-1660.
4. Tretter L, Adam-Vizi V. Alpha-ketoglutarate dehydrogenase:a target and generator of oxidative stress [J]. Philos Trans R Soc Land B Biol Sci,2005,360(1464):2335-2345.
5. Coy JF, Dressler D, Wilde J, et al. Mutations in the transketolase-like gene TKTL1: clinical implications for neurodegenerative diseases, diabetes and cancer[J]. Clin Lab, 2005,51(5-6):257-273.
6. Greiner EF, Guppy M, Brand K. Glucose is essential for proliferation and the glycolytic enzyme induction that provokes a transition to glycolytic energy production[J]. J Biol Chem, 1994,269 (50):31484-31490. (Pubitemid 24379505)
7. Zhong H, DeMarzo AM, Laughner E, et al. Overexpression of hypoxia-inducible factor 1α in common human cancer and their metastases[J]. Cancer Res, 1999,59:5830-5835.
8. Izyumov DS, Avetisyan AV, Pletjushkina OY, et al. "Wages of fear": transient threefold in intracellular ATP level imposes apoptosis[J]. Biochim Biophys Acta,2004,1658(1-2):141-147.
9. Rao XP, Song ZQ, Gao H. Research and application progress on dehydroabietylamine derivatives [J]. Chemistry, 2006,3(69): 168-172.
10. Wilkerson WW, Galbraith W, Delucca I, et al. Topical anti-inflammatory dehydroabietylamine derivatives. IV[J]. Bioorg Med Chem Lett, 1993,3(10):2087-2092. (Pubitemid 23349760)
11. Li F, He L, Song ZQ, et al. Cytotoxic effects and pro-apoptotic mechanism of TBIDOM, a novel dehydroabietylamine derivative, on human hepatocellular carcinoma SMMC-7721 Cells[J]. JPP, 2008,60(2):205-211. (Pubitemid 351211836)
12. Zhu CH, Lu FP, He YN, et al. Regulation of avilamycin biosynthesis in Streptomyces viridochromogenes: effects of glucose, ammonium ion, and inorganic phosphate [J]. Appl Microbiol Biotechnol ,2007,73(5):1031-1038.
13. Alcazar O, Tiedge M, Lenzen S. Importance of lactate dehydrogenase for the regulation of glycolytic flux and insulin secretion in insulin-producing cells[J]. Biochem ,2000,352(2):373-380. (Pubitemid 32011431)
14. William CM, Richard CS,Jr. ,John WB, et al. Menadione causes endothelial barrier failure by a direct effect on intracellular thiols, independent of reactive oxygen production [J]. Biochim Biophys Acta ,2003,1641(1):43-53.
15. Warburg O. On the origin of cancer cells[J]. Science, 1956,123 (3191):309-314.
16. Medina RA, Owen GI. Glucose transporters: expression, regulation and cancer[J]. Biol Res, 2002,35(1):9-26.
17. Rider MH, Bertrand L, Vertommen D, et al. 6-Phosphofructo-2-kinase/ fructose-2,6-bisphosphatase:head-to-head with a bifunctional enzyme that controls glucolysis [J]. Biochem, 2004,381 (3):561-579.
18. Calvo MN, Bartrons R, Castano E, et al. PFKFB3 gene silencing decreases glucolysis, induces cell-cycle delay and inhibits anchorage-independent growth in HeLa cells [J]. FEBS Lett, 2006,580(13):3308-3314. (Pubitemid 44251000)
19. Hamilton CA, Taylor GJ, Good AG. Vacuolar H(+)-ATPase, but not mitochondrial F(1)F(0)-ATPase, is required for NaCl tolerance in Saccharomyces cerevisiae [J]. FEMS Microbiol Lett, 2002,208(2):227-232.
20. Langbein S, Zerilli M, Zur HA, et al. Expression of transketolase TKTL1 predicts colon and urothelial cancer patient survival: Warburg effect reinterpreted [J]. Br J Cancer, 2006,94(4):578-585.
21. Serkova N, Boros LG, Serkova N, et al. Detection of resistance to imatinib by metabolic profiling: clinical and drug development implications [J]. Am J Pharmacogenomics, 2005,5(5):293-302. (Pubitemid 41425607)