Regulation of avilamycin biosynthesis in Streptomyces viridochromogenes: Effects of glucose, ammonium ion, and inorganic phosphate

Applied Microbiology and Biotechnology

Volumn 73, Issue 5, 2007, Pages 1031-1038

  Zhu, Chuan He ^a,b   Lu, Fu Ping ^a   He, Ya Nan ^a   Han, Zhen Lin ^a   Du, Lian Xiang ^a  

^a TIANJIN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

^b SHANDONG AGRICULTURAL UNIVERSITY   (China)

Author keywords

Avilamycin; Biosynthesis; Regulation; Streptomyces viridochromogenes AS4.126

Indexed keywords

ANTIBIOTICS; BIOSYNTHESIS; ENZYMES; GENES; GLUCOSE;

ADENOSINE TRIPHOSPHATE; AMMONIUM IONS; AVILAMYCIN; STREPTOMYCES VIRIDOCHROMOGENES AS4 126;

PROTEINS;

3 METHYLGLUCOSE; ADENOSINE TRIPHOSPHATE; AMMONIA; AMMONIUM SULFATE; AVILAMYCIN; DEOXYGLUCOSE; GLUCOSE; GLUCOSE 6 PHOSPHATE; GLUCOSE 6 PHOSPHATE DEHYDROGENASE; PHOSPHATE; SUCCINATE DEHYDROGENASE; VALINE DEHYDROGENASE;

AMMONIUM; ANTIBIOTICS; BACTERIUM; ENZYME ACTIVITY; GLUCOSE; MICROBIAL ACTIVITY; PHOSPHATE (INORGANIC);

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG SYNTHESIS; NONHUMAN; STREPTOMYCES; STREPTOMYCES VIRIDOCHROMOGENES;

3-O-METHYLGLUCOSE; CULTURE MEDIA; DEOXYGLUCOSE; ENZYME INHIBITORS; GLUCOSE; OLIGOSACCHARIDES; PHOSPHATES; PHOSPHORIC MONOESTER HYDROLASES; QUATERNARY AMMONIUM COMPOUNDS; STREPTOMYCES; VALINE DEHYDROGENASE (NADP+);

STREPTOMYCES VIRIDOCHROMOGENES;

EID: 33845760536     PISSN: 01757598     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00253-006-0572-6     Document Type: Article

References (42)

1. Buzzetti F, Eisenberg F, Grant HN et al (1968) Avilamycin. Experientia 24:320-324
2. Cao FX (2003) The technology of the secondary production and secondary metabolism. National University of Defense Technology Press, Beijing, China
3. Chauvin CM, Gicquel BA, Perrin GF et al (2005) Use of avilamycin for growth promotion and avilamycin-resistance among Enterococcus faecium from broilers in a matched case-control study in France. Prev Vet Med 70:155-163
4. Chen GB, Zhang JY, Niu JY et al (2003) Studies on regulation of antibiotic AGPM biosynthesis. Chem J Chin Univ 17:521-525
5. Chu J, Li YR (2002) Modern industrial fermentation regulation. Chemical Industry Press, Beijing, China
6. Du LX, Lu FP (1992) Industrial microbiology experiment technique. Tianjin Science and Technology Press, Tianjin, China
7. Fabrizio B, Srdjan J, Marina F et al (2004) Valine influences production and complex composition of glycopeptide antibiotic A40926 in fermentations of Nonomuraea sp. ATCC 39727. J Antibiot 57:37-44
8. Gaisser S, Trefzer A, Sigrid S et al (1997) Cloning of an avilamycin biosynthetic gene cluster from Streptomyces viridochromogenes Tü57. J Bacteriol 179:6271-6278
9. Hofmann C, Boll R, Heitmann B et al (2005) Genes encoding enzymes responsible for biosynthesis of L-Lyxose and attachment of Eurekanate during avilamycin biosynthesis. Chem Biol 12:1137-1143
10. Hulya AK, Tarhan L (2006) Vancomycin antibiotic production and TCA-glyoxalate pathways depending on the glucose concentration in Amycolatopsis orientalis. Enzyme Microb Technol 38:727-734
11. Hyun CG, Kim SS, Park KH et al (2000) Valine dehydrogenase from Streptomyces albus: gene cloning, heterologous expression and identification of active site by site-directed mutagenesis. FEMS Microbiol Lett 182:29-34
12. Irschik H, Reichenbach H (1985) An unusual pattern of carbonhydrate utilization in corallococcus (Myxococcus) coralloides (Myxobacterales). Arch Microbiol 142:40
13. Juan FM (2004) Phosphate control of the biosynthesis of antibiotics and other secondary metabolites is mediated by the PhoR-PhoP system: an unfinished story. J Bacteriol 186:5197-5201
14. Juan FM, Arnold LD (1980) Control of antibiotic biosynthesis. Microbiol Rev 44:230-251
15. Keqian Y, Lei H, Leo CV (1995) Regulation of jadomycin B production in Streptomyces venezuelae ISP5230: involvement of a repressor gene, jadR2. J Bacteriol 177:6111-6117
16. Kuby SA, Noltmann EA (1966) Methods in enzymology, vol 9. Academic, New York, pp 116-125
17. Lebrihi A, Lamsaif D, Lefebvre G et al (1992) Effect of ammonium ions on spiramycin biosynthesis in Streptomyces ambofaciens. Appl Microbiol Biotechnol 37:382-387
18. Levine S, Gregory C, Nguyen T et al (2002) Bioenergetic adaptation of individual human diaphragmatic myofibers to severe COPD. J Appl Physiol 92:1205-1213
19. Li T, Zhang YX, Hutechinson CR (1994) Amino acid catabolism and antibiotic synthesis: valine is a source of precursors for macrolide biosynthesis in Streptomyces ambofaciens and Streptomyces fradiae. J Bacteriol 176:6107-6119
20. Lounes A, Lebrihi A, Benslimane C et al (1995) Regulation of valine catabolism by ammonium in Streptomyces ambofaciens, producer of spiramycin. Can J Microbiol 41:800-808
21. Lounes A, Lebrihi A, Benslimane C et al (1996) Regulation of spiramycin synthesis in Streptomyces ambofaciens: effects of glucose and inorganic phosphate. Appl Microbiol Biotechnol 45:204-211
22. Mardy N, Sprinkmeyer R (1979) Regulation of tylosin synthesis in Streptomeces: effect of glucose analogs and inorganic phosphate. Eur J Appl Microbiol Biotechnol 7:365-370
23. Mosbacher G, Bechthold A, Schulz E (2005) Structure and function of the antibiotic resistance-mediating Methyltransferase AviRb from Streptomyces viridochromogenes. J Mol Biol 345:535-545
24. Nigel D, John A (1989) Purification and catalytic properties of L-valine dehydrogenase from Streptomyces cinnamonensis. Biochem J 261:853-861
25. Noriteru M, Kenji I, Koichi O et al (2004) Exposure to pressure stimulus enhances succinate dehydrogenase activity in L6 myoblasts. Am J Physiol Endocrinol Metabol Gastrointest Physiol 287:1064-1069
26. Novak J, Hajek P, Rezanka T et al (1992) Nitrogen regulation of fatty acids and avermectins biosynthesis in Streptomyces avermitilis. FEMS Microbiol Lett 93:57-61
27. Omura S, Tsuzuki KY, Tanaka H et al (1983) Valine as a precursor of the n-butyrate unit in the biosynthesis of macrolide aglycones. J Antibiot 36:614-616
28. Omura S, Tanaka Y, Mamada R et al (1984a) Effect of ammonium ion, inorganic phosphate and amino acids on the biosynthesis of protylonolide, a precursor of tylosin aglycone. J Antibiot 37:494-502
29. Omura S, Tanaka Y, Mamada R et al (1984b) Ammonium ion suppress the amino acid metabolism involved in the biosynthesis of protylonolide in a mutant of Streptomyces fradiae. J Antibiot 37:1362-1369
30. Orduna RM, Theobald U (2000) Intracellular glucose 6-phosphate content in Streptomyces coelicolor upon environmental changes in a defined medium. J Biotechnol 77:209-218
31. Saier MH Jr (1998) Multiple mechanisms controlling carbon metabolism in bacteria. Biotechnol Bioeng 58:170-174
32. Shikha D, Rup L, Manjit H et al (2005) Effect of antibiotics on growth and laccase production from Cyathus bulleri and Pycnoporus cinnabarinus. Bioresour Technol 96:1415-1418
33. Treede I, Hauser G, Mühlenweg A et al (2005) Genes involved in formation and attachment of a two-carbon chain as a component of Eurekanate, a branched-chain sugar moiety of avilamycin A. Appl Environ Microbiol 71:400-406
34. Wang JY, Zhu SK, Xu ZF (2002) Biochemistry, 3rd edn. Higher Education Press, Beijing, China
35. Wang P, Zhu YP, Chu J et al (2005) Regulatory effects of ammonium ions on the biosynthesis of meilingmycin. Acta Microbiol Sin 45:405-409
36. Weitnauer G, Gaisser S, Trefzer A et al (2001a) An ATP-binding cassette transporter and two rRNA methyltransferases are involved in resistance to avilamycin in the producer organism Streptomyces viridochromogenes Tü57. Antimicrob Agents Chemother 45:690-695
37. Weitnauer G, Mühlenweg A, Trefzer A et al (2001b) Biosynthesis of the orthosomycin antibiotic avilamycin A: deductions from the molecular analysis of the avi biosynthetic gene cluster of Streptomyces viridochromogenes Tü57 and production of new antibiotics. Chem Biol 8:569-581
38. Weitnauer G, Gaisser S, Kellenberger L et al (2002) Analysis of a C-methyltransferase gene (aviG1) involved in avilamycin biosynthesis in Streptomyces viridochromogenes Tü57 and complementation of a Saccharopolyspora erythraea eryBIII mutant by aviG1. Microbiology 148:373-379
39. Wright ED (1979) The orthosomycins, a new family of antibiotics. Tetrahedron 35:1207-1236
40. Xu CD, Yi WY, Quan WH (1998) Approach of phenol-hypochlorite reaction for determination of ammonia. J Wuxi Univ Light Ind 17:34-38
41. Yuan YS, Zhu WH, Chen JH (1995) Biochemical experiments. Advanced Education Press, Beijing, China
42. Zhang XY (2000) The determination of avilamycin premix. J China Vet 35:21-23