Phenyl ureas of creatinine as mGluR5 antagonists. A structure-activity relationship study of fenobam analogues

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 5, 2006, Pages 1142-1145

  Wållberg, Andreas ^a   Nilsson, Karolina ^a   Österlund, Krister ^a   Peterson, Alecia ^b   Elg, Susanne ^a   Raboisson, Patrick ^c   Bauer, Udo ^a   Hammerland, Lance G ^b   Mattsson, Jan P ^a  

^a ASTRAZENECA R AND D   (Sweden)

^b NPS Pharmaceutical Inc   (United States)

^c ASTRAZENECA R AND D   (Sweden)

Author keywords

Anxiolytic; Fenobam; Metabotropic glutamate receptor; mGluR5

Indexed keywords

ANXIOLYTIC AGENT; CARBANILAMIDE DERIVATIVE; CREATININE; FENOBAM; METABOTROPIC RECEPTOR 5; METABOTROPIC RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG; UREA DERIVATIVE;

ANTICONVULSANT ACTIVITY; ARTICLE; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IC 50; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

AMIDES; CHLORIDES; CREATININE; IMIDAZOLES; INHIBITORY CONCENTRATION 50; MOLECULAR STRUCTURE; RECEPTORS, METABOTROPIC GLUTAMATE; STRUCTURE-ACTIVITY RELATIONSHIP; UREA;

EID: 31344432963     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.11.092     Document Type: Article

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