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Volumn 22, Issue 3, 2010, Pages 307-312

Recent advances in the genetics and genomics of asthma and related traits

Author keywords

Asthma; Genetics; Genome wide association; Genomics; Single nucleotide polymorphism

Indexed keywords

BETA 2 ADRENERGIC RECEPTOR; CASPASE RECRUITMENT DOMAIN PROTEIN 15; CD14 ANTIGEN; GAMMA INTERFERON; GLUCOCORTICOID; GLUTATHIONE TRANSFERASE M1; GLUTATHIONE TRANSFERASE P1; GLUTATHIONE TRANSFERASE T1; IMMUNOGLOBULIN E; INTERLEUKIN 1 RECEPTOR ASSOCIATED KINASE 3; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 4 RECEPTOR; NEURONAL NITRIC OXIDE SYNTHASE; RAD50 PROTEIN; STAT6 PROTEIN; TOBACCO SMOKE; TRANSFORMING GROWTH FACTOR BETA1;

EID: 77952401861     PISSN: 10408703     EISSN: None     Source Type: Journal    
DOI: 10.1097/MOP.0b013e328339553d     Document Type: Review
Times cited : (14)

References (62)
  • 2
    • 0034501284 scopus 로고    scopus 로고
    • Trends in the cost of illness for asthma in the United States, 1985-1994
    • Weiss KB, Sullivan SD, Lyttle CS. Trends in the cost of illness for asthma in the United States, 1985-1994. J Allergy Clin Immunol 2000; 106:493-499.
    • (2000) J Allergy Clin Immunol , vol.106 , pp. 493-499
    • Weiss, K.B.1    Sullivan, S.D.2    Lyttle, C.S.3
  • 5
    • 3543035759 scopus 로고    scopus 로고
    • Worldwide variations in the prevalence of asthma symptoms: The international study of asthma and allergies in childhood (ISAAC)
    • Worldwide variations in the prevalence of asthma symptoms: the International Study of Asthma and Allergies in Childhood (ISAAC). Eur Respir J 1998; 12:315-335.
    • (1998) Eur Respir J , vol.12 , pp. 315-335
  • 8
    • 0035179870 scopus 로고    scopus 로고
    • McLeod HL pharmacogenetics: More than skin deep
    • McLeod HL Pharmacogenetics: more than skin deep. Nat Genet 2001; 29:247-248.
    • (2001) Nat Genet , vol.29 , pp. 247-248
  • 10
    • 25444464092 scopus 로고    scopus 로고
    • Pharmacogenetics, pharmacogenomics and airway disease
    • Hall IP. Pharmacogenetics, pharmacogenomics and airway disease. Respir Res 2002; 3:10.
    • (2002) Respir Res , vol.3 , pp. 10
    • Hall, I.P.1
  • 11
    • 1942494043 scopus 로고    scopus 로고
    • Association studies for asthma and atopic diseases: A comprehensive review of the literature
    • Hoffjan S, Nicolae D, Ober C. Association studies for asthma and atopic diseases: a comprehensive review of the literature. Respir Res 2003; 4:14.
    • (2003) Respir Res , vol.4 , pp. 14
    • Hoffjan, S.1    Nicolae, D.2    Ober, C.3
  • 12
    • 0347595284 scopus 로고    scopus 로고
    • Recent development in genomic and proteomic research for asthma
    • Halapi E, Hakonarson H. Recent development in genomic and proteomic research for asthma. Curr Opin Pulm Med 2004; 10:22-30.
    • (2004) Curr opin Pulm Med , vol.10 , pp. 22-30
    • Halapi, E.1    Hakonarson, H.2
  • 13
    • 0034981949 scopus 로고    scopus 로고
    • Current concepts on the genetics of asthma
    • Hakonarson H, Wjst M. Current concepts on the genetics of asthma. Curr Opin Pediatr 2001; 13:267-277.
    • (2001) Curr opin Pediatr , vol.13 , pp. 267-277
    • Hakonarson, H.1    Wjst, M.2
  • 14
    • 0036888556 scopus 로고    scopus 로고
    • Present status on the genetic studies of asthma
    • Hoffjan S, Ober C. Present status on the genetic studies of asthma. Curr Opin Immunol 2002; 14:709-717.
    • (2002) Curr opin Immunol , vol.14 , pp. 709-717
    • Hoffjan, S.1    Ober, C.2
  • 16
    • 33748676135 scopus 로고    scopus 로고
    • ADAM33 is not essential for growth and development and does not modulate allergic asthma in mice
    • Chen C, Huang X, Sheppard D. ADAM33 is not essential for growth and development and does not modulate allergic asthma in mice. Mol Cell Biol 2006; 26:6950-6956.
    • (2006) Mol Cell Biol , vol.26 , pp. 6950-6956
    • Chen, C.1    Huang, X.2    Sheppard, D.3
  • 17
    • 0037173639 scopus 로고    scopus 로고
    • Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness
    • Van Eerdewegh P, Little RD, Dupuis J, et al. Association of the ADAM33 gene with asthma and bronchial hyperresponsiveness. Nature 2002; 418:426-430.
    • (2002) Nature , vol.418 , pp. 426-430
    • Van Eerdewegh, P.1    Little, R.D.2    Dupuis, J.3
  • 18
    • 16844365903 scopus 로고    scopus 로고
    • Contribution of ADAM33 polymorphisms to the population risk of asthma
    • Blakey J, Halapi E, Bjornsdottir US, et al. Contribution of ADAM33 polymorphisms to the population risk of asthma. Thorax 2005; 60:274-276.
    • (2005) Thorax , vol.60 , pp. 274-276
    • Blakey, J.1    Halapi, E.2    Bjornsdottir, U.S.3
  • 19
    • 11144357144 scopus 로고    scopus 로고
    • Characterization of a common susceptibility locus for asthma-related traits
    • Laitinen T, Polvi A, Rydman P, et al. Characterization of a common susceptibility locus for asthma-related traits. Science 2004; 304:300-304.
    • (2004) Science , vol.304 , pp. 300-304
    • Laitinen, T.1    Polvi, A.2    Rydman, P.3
  • 20
    • 27644522293 scopus 로고    scopus 로고
    • Candidate gene association studies and evidence for gene-by-gene interactions
    • Kabesch M. Candidate gene association studies and evidence for gene-by-gene interactions. Immunol Allergy Clin North Am 2005; 25:681-708.
    • (2005) Immunol Allergy Clin North Am , vol.25 , pp. 681-708
    • Kabesch, M.1
  • 21
    • 40049100646 scopus 로고    scopus 로고
    • Discovering susceptibility genes for asthma and allergy
    • Vercelli D. Discovering susceptibility genes for asthma and allergy. Nat Rev Immunol 2008; 8:169-182.
    • (2008) Nat Rev Immunol , vol.8 , pp. 169-182
    • Vercelli, D.1
  • 22
    • 0028850663 scopus 로고
    • Genetics of beta 2-adrenergic receptor variants in asthma
    • discussion 95-86
    • Liggett SB. Genetics of beta 2-adrenergic receptor variants in asthma. Clin Exp Allergy 1995; 25 (Suppl 2):89-94; discussion 95-86.
    • (1995) Clin Exp Allergy , vol.25 , Issue.SUPPL. 2 , pp. 89-94
    • Liggett, S.B.1
  • 23
    • 0031466866 scopus 로고    scopus 로고
    • Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing
    • Martinez FD, Graves PE, Baldini M, et al. Association between genetic polymorphisms of the beta2-adrenoceptor and response to albuterol in children with and without a history of wheezing. J Clin Invest 1997; 100: 3184-3188.
    • (1997) J Clin Invest , vol.100 , pp. 3184-3188
    • Martinez, F.D.1    Graves, P.E.2    Baldini, M.3
  • 24
    • 0027518052 scopus 로고
    • Genetic polymorphism of the beta-2 adrenergic receptor in atopic and nonatopic subjects
    • Potter PC, Van Wyk L, Martin M, et al. Genetic polymorphism of the beta-2 adrenergic receptor in atopic and nonatopic subjects. Clin Exp Allergy 1993; 23:874-877.
    • (1993) Clin Exp Allergy , vol.23 , pp. 874-877
    • Potter, P.C.1    Van Wyk, L.2    Martin, M.3
  • 25
    • 0028789831 scopus 로고
    • Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy
    • discussion 95-96
    • Rosenwasser LJ, Klemm DJ, Dresback JK, et al. Promoter polymorphisms in the chromosome 5 gene cluster in asthma and atopy. Clin Exp Allergy 1995; 25 (Suppl 2):74-78; discussion 95-96.
    • (1995) Clin Exp Allergy , vol.25 , Issue.SUPPL. 2 , pp. 74-78
    • Rosenwasser, L.J.1    Klemm, D.J.2    Dresback, J.K.3
  • 26
    • 0034142166 scopus 로고    scopus 로고
    • Atopy and asthma: Genetic variants of IL-4 and IL-13 signalling
    • Shirakawa I, Deichmann KA, Izuhara I, et al. Atopy and asthma: genetic variants of IL-4 and IL-13 signalling. Immunol Today 2000; 21:60-64.
    • (2000) Immunol Today , vol.21 , pp. 60-64
    • Shirakawa, I.1    Deichmann, K.A.2    Izuhara, I.3
  • 27
    • 0034808223 scopus 로고    scopus 로고
    • Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population
    • Howard TD, Whittaker PA, Zaiman AL, et al. Identification and association of polymorphisms in the interleukin-13 gene with asthma and atopy in a Dutch population. Am J Respir Cell Mol Biol 2001; 25:377-384.
    • (2001) Am J Respir Cell Mol Biol , vol.25 , pp. 377-384
    • Howard, T.D.1    Whittaker, P.A.2    Zaiman, A.L.3
  • 28
    • 0034162827 scopus 로고    scopus 로고
    • Genetic variants of IL-13 signalling and human asthma and atopy
    • Heinzmann A, Mao XQ, Akaiwa M, et al. Genetic variants of IL-13 signalling and human asthma and atopy. Hum Mol Genet 2000; 9:549-559.
    • (2000) Hum Mol Genet , vol.9 , pp. 549-559
    • Heinzmann, A.1    Mao, X.Q.2    Akaiwa, M.3
  • 29
    • 33644774556 scopus 로고    scopus 로고
    • Asthma genetics 2006: The long and winding road to gene discovery
    • Ober C, Hoffjan S. Asthma genetics 2006: the long and winding road to gene discovery. Genes Immun 2006; 7:95-100.
    • (2006) Genes Immun , vol.7 , pp. 95-100
    • Ober, C.1    Hoffjan, S.2
  • 31
    • 84969213492 scopus 로고    scopus 로고
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
    • Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature 2007; 447:661-678.
    • (2007) Nature , vol.447 , pp. 661-678
  • 32
    • 34347341846 scopus 로고    scopus 로고
    • Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes
    • Todd JA, Walker NM, Cooper JD, et al. Robust associations of four new chromosome regions from genome-wide analyses of type 1 diabetes. Nat Genet 2007; 39:857-864.
    • (2007) Nat Genet , vol.39 , pp. 857-864
    • Todd, J.A.1    Walker, N.M.2    Cooper, J.D.3
  • 33
    • 34547621758 scopus 로고    scopus 로고
    • A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene
    • Hakonarson H, Grant S, Bradfield J, et al. A genome-wide association study identifies KIAA0350 as a type 1 diabetes gene. Nature 2007; 448:591-594.
    • (2007) Nature , vol.448 , pp. 591-594
    • Hakonarson, H.1    Grant, S.2    Bradfield, J.3
  • 34
    • 33847176604 scopus 로고    scopus 로고
    • A genome-wide association study identifies novel risk loci for type 2 diabetes
    • Sladek R, Rocheleau G, Rung J, et al. A genome-wide association study identifies novel risk loci for type 2 diabetes. Nature 2007; 445:881-885.
    • (2007) Nature , vol.445 , pp. 881-885
    • Sladek, R.1    Rocheleau, G.2    Rung, J.3
  • 35
    • 34249888775 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels
    • Saxena R, Voight BF, Lyssenko V, et al. Genome-wide association analysis identifies loci for type 2 diabetes and triglyceride levels. Science 2007; 316:1331-1336.
    • (2007) Science , vol.316 , pp. 1331-1336
    • Saxena, R.1    Voight, B.F.2    Lyssenko, V.3
  • 36
    • 34249895023 scopus 로고    scopus 로고
    • Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes
    • Zeggini E, Weedon MN, Lindgren CM, et al. Replication of genome-wide association signals in UK samples reveals risk loci for type 2 diabetes. Science 2007; 316:1336-1341.
    • (2007) Science , vol.316 , pp. 1336-1341
    • Zeggini, E.1    Weedon, M.N.2    Lindgren, C.M.3
  • 37
    • 34249885875 scopus 로고    scopus 로고
    • A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants
    • Scott LJ, Mohlke KL, Bonnycastle LL, et al. A genome-wide association study of type 2 diabetes in Finns detects multiple susceptibility variants. Science 2007; 316:1341-1345.
    • (2007) Science , vol.316 , pp. 1341-1345
    • Scott, L.J.1    Mohlke, K.L.2    Bonnycastle, L.L.3
  • 38
    • 20244380171 scopus 로고    scopus 로고
    • Complement factor H polymorphism in age-related macular degeneration
    • Klein RJ, Zeiss C, Chew EY, et al. Complement factor H polymorphism in age-related macular degeneration. Science 2005; 308:385-389.
    • (2005) Science , vol.308 , pp. 385-389
    • Klein, R.J.1    Zeiss, C.2    Chew, E.Y.3
  • 39
    • 33845340501 scopus 로고    scopus 로고
    • A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
    • Duerr RH, Taylor KD, Brant SR, et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 2006; 314:1461-1463.
    • (2006) Science , vol.314 , pp. 1461-1463
    • Duerr, R.H.1    Taylor, K.D.2    Brant, S.R.3
  • 41
    • 34249996115 scopus 로고    scopus 로고
    • A common allele on chromosome 9 associated with coronary heart disease
    • McPherson R, Pertsemlidis A, Kavaslar N, et al. A common allele on chromosome 9 associated with coronary heart disease. Science 2007; 316:1488-1491.
    • (2007) Science , vol.316 , pp. 1488-1491
    • McPherson, R.1    Pertsemlidis, A.2    Kavaslar, N.3
  • 42
    • 34250006413 scopus 로고    scopus 로고
    • Genome-wide association study identifies novel breast cancer susceptibility loci
    • Easton DF, Pooley KA, Dunning AM, et al. Genome-wide association study identifies novel breast cancer susceptibility loci. Nature 2007; 447:1087-1093.
    • (2007) Nature , vol.447 , pp. 1087-1093
    • Easton, D.F.1    Pooley, K.A.2    Dunning, A.M.3
  • 43
    • 34547216747 scopus 로고    scopus 로고
    • Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma
    • Moffatt M, Kabesch M, Liang L, et al. Genetic variants regulating ORMDL3 expression contribute to the risk of childhood asthma. Nature 2007; 448:470-473.
    • (2007) Nature , vol.448 , pp. 470-473
    • Moffatt, M.1    Kabesch, M.2    Liang, L.3
  • 44
    • 44449150336 scopus 로고    scopus 로고
    • ORMDL3 gene is associated with asthma in three ethnically diverse populations
    • Galanter J, Choudhry S, Eng C, et al. ORMDL3 gene is associated with asthma in three ethnically diverse populations. Am J Respir Crit Care Med 2008; 11:1194-1200.
    • (2008) Am J Respir Crit Care Med , vol.11 , pp. 1194-1200
    • Galanter, J.1    Choudhry, S.2    Eng, C.3
  • 45
    • 57149129440 scopus 로고    scopus 로고
    • ORMDL3 variants associated with asthma susceptibility in North Americans of European ancestry
    • Sleiman PM, Annaiah K, Imielinski M, et al. ORMDL3 variants associated with asthma susceptibility in North Americans of European ancestry. J Allergy Clin Immunol 2008; 6:1225-1227.
    • (2008) J Allergy Clin Immunol , vol.6 , pp. 1225-1227
    • Sleiman, P.M.1    Annaiah, K.2    Imielinski, M.3
  • 46
    • 41549111983 scopus 로고    scopus 로고
    • A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications
    • Tavendale R, Macgregor D, Mukhopadhyay S, Palmer C. A polymorphism controlling ORMDL3 expression is associated with asthma that is poorly controlled by current medications. J Allergy Clin Immunol 2008; 121:860-863.
    • (2008) J Allergy Clin Immunol , vol.121 , pp. 860-863
    • Tavendale, R.1    Macgregor, D.2    Mukhopadhyay, S.3    Palmer, C.4
  • 47
    • 61449154539 scopus 로고    scopus 로고
    • Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood
    • Bisgaard H, Bonnelykke K, Sleiman PM, et al. Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood. Am J Respir Crit Care Med 2009; 179:179-185.
    • (2009) Am J Respir Crit Care Med , vol.179 , pp. 179-185
    • Bisgaard, H.1    Bonnelykke, K.2    Sleiman, P.M.3
  • 48
    • 76049112976 scopus 로고    scopus 로고
    • A genome-wide association study on African-ancestry populations for asthma
    • Mathias RA, Grant AV, Rafaels N, et al. A genome-wide association study on African-ancestry populations for asthma. J Allergy Clin Immunol 2009; 2: 336-346.
    • (2009) J Allergy Clin Immunol , vol.2 , pp. 336-346
    • Mathias, R.A.1    Grant, A.V.2    Rafaels, N.3
  • 49
    • 57349101088 scopus 로고    scopus 로고
    • Effect of 17q21 variants and smoking exposure in early-onset asthma
    • Bouzigon E, Corda E, Aschard H, et al. Effect of 17q21 variants and smoking exposure in early-onset asthma. N Engl J Med 2008; 19:1985-1994.
    • (2008) N Engl J Med , vol.19 , pp. 1985-1994
    • Bouzigon, E.1    Corda, E.2    Aschard, H.3
  • 50
    • 65549123032 scopus 로고    scopus 로고
    • Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene
    • Himes BE, Hunninghake GM, Baurley JW, et al. Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene. Am J Hum Genet 2009; 84:581-593.
    • (2009) Am J Hum Genet , vol.84 , pp. 581-593
    • Himes, B.E.1    Hunninghake, G.M.2    Baurley, J.W.3
  • 51
    • 67449108071 scopus 로고    scopus 로고
    • Assessing the reproducibility of asthma candidate gene associations using genome-wide data
    • Rogers AJ, Raby BA, Lasky-Su JA, et al. Assessing the reproducibility of asthma candidate gene associations using genome-wide data. Am J Respir Crit Care Med 2009; 12:1084-1090.
    • (2009) Am J Respir Crit Care Med , vol.12 , pp. 1084-1090
    • Rogers, A.J.1    Raby, B.A.2    Lasky-Su, J.A.3
  • 52
    • 70149094161 scopus 로고    scopus 로고
    • Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in Mexican children
    • Hancock DB, Romieu I, Shi M, et al. Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in Mexican children. PLoS Genet 2009; 5:e1000623.
    • (2009) PLoS Genet , vol.5
    • Hancock, D.B.1    Romieu, I.2    Shi, M.3
  • 53
    • 74049129976 scopus 로고    scopus 로고
    • Variants of DENND1 B associated with asthma in children
    • Sleiman PM, Flory J, Imielinski M, et al. Variants of DENND1 B associated with asthma in children. N Engl J Med 2010; 362:36-44.
    • (2010) N Engl J Med , vol.362 , pp. 36-44
    • Sleiman, P.M.1    Flory, J.2    Imielinski, M.3
  • 54
    • 42249103640 scopus 로고    scopus 로고
    • Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function
    • Ober C, Tan Z, Sun Y, et al. Effect of variation in CHI3L1 on serum YKL-40 level, risk of asthma, and lung function. N Engl J Med 2008; 358:1682-1691.
    • (2008) N Engl J Med , vol.358 , pp. 1682-1691
    • Ober, C.1    Tan, Z.2    Sun, Y.3
  • 55
    • 50849120030 scopus 로고    scopus 로고
    • Genome-wide scan on total serum IgE levels identifies FCER1 A as novel susceptibility locus
    • Weidinger S, Gieger C, Rodriguez E, et al. Genome-wide scan on total serum IgE levels identifies FCER1 A as novel susceptibility locus. PLoS Genet 2008; 4:e1000166.
    • (2008) PLoS Genet , vol.4
    • Weidinger, S.1    Gieger, C.2    Rodriguez, E.3
  • 56
    • 61349089164 scopus 로고    scopus 로고
    • Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction
    • Gudbjartsson DF, Bjornsdottir US, Halapi E, et al. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nat Genet 2009; 41:342-347.
    • (2009) Nat Genet , vol.41 , pp. 342-347
    • Gudbjartsson, D.F.1    Bjornsdottir, U.S.2    Halapi, E.3
  • 57
    • 63449101907 scopus 로고    scopus 로고
    • A genome-wide association study in chronic obstructive pulmonary disease (COPD): Identification of two major susceptibility loci
    • Pillai SG, Ge D, Zhu G, et al. A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci. PLoS Genet 2009; 5:e1000421.
    • (2009) PLoS Genet , vol.5
    • Pillai, S.G.1    Ge, D.2    Zhu, G.3
  • 58
    • 63449099623 scopus 로고    scopus 로고
    • A genome-wide association study of pulmonary function measures in the Framingham heart study
    • Wilk JB, Chen TH, Gottlieb DJ, et al. A genome-wide association study of pulmonary function measures in the Framingham Heart Study. PLoS Genet 2009; 5:e1000429.
    • (2009) PLoS Genet , vol.5
    • Wilk, J.B.1    Chen, T.H.2    Gottlieb, D.J.3
  • 59
    • 73349143302 scopus 로고    scopus 로고
    • Genome-wide association study identifies five loci associated with lung function
    • Repapi E, Sayers I, Wain LV, et al. Genome-wide association study identifies five loci associated with lung function. Nat Genet 2010; 42:36-44.
    • (2010) Nat Genet , vol.42 , pp. 36-44
    • Repapi, E.1    Sayers, I.2    Wain, L.V.3
  • 60
    • 73349111257 scopus 로고    scopus 로고
    • Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function
    • Hancock DB, Eijgelsheim M, Wilk JB, et al. Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function. Nat Genet 2010; 42:45-52.
    • (2010) Nat Genet , vol.42 , pp. 45-52
    • Hancock, D.B.1    Eijgelsheim, M.2    Wilk, J.B.3
  • 61
    • 40849097777 scopus 로고    scopus 로고
    • Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking
    • Berrettini W, Yuan X, Tozzi F, et al. Alpha-5/alpha-3 nicotinic receptor subunit alleles increase risk for heavy smoking. Mol Psychiatry 2008; 13:368-373.
    • (2008) Mol Psychiatry , vol.13 , pp. 368-373
    • Berrettini, W.1    Yuan, X.2    Tozzi, F.3
  • 62
    • 33846510020 scopus 로고    scopus 로고
    • Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs
    • Saccone SF, Hinrichs AL, Saccone NL, et al. Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs. Hum Mol Genet 2007; 16:36-49.
    • (2007) Hum Mol Genet , vol.16 , pp. 36-49
    • Saccone, S.F.1    Hinrichs, A.L.2    Saccone, N.L.3


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