Prodrug activation by Cryptosporidium thymidine kinase

Journal of Biological Chemistry

Volumn 285, Issue 21, 2010, Pages 15916-15922

  Sun, Xin E ^a   Sharling, Lisa ^b   Muthalagi, Mani ^b   Mudeppa, Devaraja G ^c   Pankiewicz, Krzysztof W ^d   Felczak, Krzysztof ^d   Rathod, Pradipsinh K ^c   Mead, Jan ^e   Striepen, Boris ^b   Hedstrom, Lizbeth ^a  

^a BRANDEIS UNIVERSITY   (United States)

^b UNIVERSITY OF GEORGIA   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

^d UNIVERSITY OF MINNESOTA   (United States)

^e EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM; CRYPTOSPORIDIUM SPP; DIHYDROFOLATE REDUCTASE; GASTROINTESTINAL DISEASE; GASTROINTESTINAL TRACT; GENOMIC STUDIES; IN-VITRO; MOUSE MODELS; PARASITE GROWTH; PRODRUG ACTIVATION; PROTOZOAN PARASITES; PYRIMIDINE BIOSYNTHESIS; STABLE TRIMERS; THYMIDINE KINASE; THYMIDYLATE SYNTHASE; TRIFLUOROMETHYL;

BIOCHEMISTRY; CHEMOTHERAPY; PROTOZOA;

CHEMICAL ACTIVATION;

ACICLOVIR; BROXURIDINE; CYTARABINE; DEOXYCYTIDINE TRIPHOSPHATE; DEOXYNUCLEOSIDE KINASE; DIHYDROFOLATE REDUCTASE; FLOXURIDINE; KP 1283; KP 1308; KP 1309; KP 275; KP 296 8; KP 330; KP 332 4; NUCLEOSIDE ANALOG; PAROMOMYCIN; PHOSPHOTRANSFERASE; PRODRUG; PYRIMIDINE; STAVUDINE; THYMIDINE; THYMIDINE DERIVATIVE; THYMIDINE KINASE; THYMIDINE PHOSPHATE; THYMIDYLATE SYNTHASE; THYMINE ARABINOSIDE; TRIFLUOROMETHYL THYMIDINE; TRIFLURIDINE; UNCLASSIFIED DRUG; UNINDEXED DRUG; ZIDOVUDINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM PARVUM; DRUG ACTIVATION; DRUG EFFICACY; ENZYME SUBSTRATE; GASTROINTESTINAL TRACT; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PYRIMIDINE SYNTHESIS;

ANIMALS; ANTIPROTOZOAL AGENTS; CELL LINE, TUMOR; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM PARVUM; DISEASE MODELS, ANIMAL; FLOXURIDINE; GENOME, PROTOZOAN; HUMANS; MICE; MICE, KNOCKOUT; PRODRUGS; PROTOZOAN PROTEINS; PYRIMIDINES; RECOMBINANT PROTEINS; THYMIDINE KINASE;

CRYPTOSPORIDIUM; CRYPTOSPORIDIUM PARVUM; PROTOZOA;

EID: 77952364996     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.101543     Document Type: Article

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