Mucosal cytokine and antigen-specific responses to Cryptosporidium parvum in IL-12p40 KO mice

Parasite Immunology

Volumn 27, Issue 1-2, 2005, Pages 17-28

  Ehigiator, H N ^b   Romagnoli, P ^a,b   Borgelt, K ^a   Fernandez, M ^a   McNair, N ^a   Secor, W E ^c   Mead, Jan R ^a,b  

^a ATLANTA VA MEDICAL CENTER   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c NATL CENTER FOR INFECTIOUS DISEASES   (United States)

Author keywords

Cellular response; Cryptosporidium parvum; Cytokine; IL 12p40 knockout; Mouse; Real time PCR

Indexed keywords

BETA ACTIN; CD19 ANTIGEN; CD4 ANTIGEN; CD8 ANTIGEN; CYTOKINE; GAMMA INTERFERON; INTERLEUKIN 12P40; INTERLEUKIN 15; INTERLEUKIN 18; INTERLEUKIN 4; INTERLEUKIN 6; MESSENGER RNA; PADGEM PROTEIN; PLASMID DNA; T LYMPHOCYTE RECEPTOR ALPHA CHAIN; T LYMPHOCYTE RECEPTOR BETA CHAIN; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL MODEL; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM PARVUM; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; GENE EXPRESSION; IMMUNE RESPONSE; IMMUNOPHENOTYPING; KNOCKOUT MOUSE; LYMPH NODE CELL; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION; SPLEEN CELL;

ANIMALS; CRYPTOSPORIDIOSIS; CRYPTOSPORIDIUM PARVUM; CYTOKINES; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION PROFILING; IMMUNITY, CELLULAR; IMMUNITY, MUCOSAL; INTERLEUKIN-12; INTERLEUKIN-12 SUBUNIT P40; INTESTINES; LYMPH NODES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PROTEIN SUBUNITS; SPLEEN;

EID: 17144367001     PISSN: 01419838     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-3024.2005.00736.x     Document Type: Article

References (60)

1. Egger M, Mausezahl D, Odermatt P, Marti HP & Tanner M. Symptoms and transmissions of intestinal cryptosporidiosis. Arch Dis Child 1990; 65: 445-447.
2. Guerrant RL. Cryptosporidiosis: An emerging, highly infectious threat. Emerg Infect Dis 1997; 3: 51-57.
3. Frisby HR, Addiss DG, Reiser WJ, et al. Clinical and epidemiological features of a massive waterborne outbreak of cryptosporidiosis in persons with HIV infection. J Acquir Immune Defic Syndr Hum Retrovirol 1997; 16: 367-373.
4. Hoxie NJ, Davis JP, Vergeront JM, Nashold RD & Blair KA. Cryptosporidiosis-associated mortality following a massive waterborne outbreak in Milwaukee, Wisconsin. Am J Public Health 1997; 87: 2032-2035.
5. DuPont HL, Chappell CL, Sterling CR, Okhuysen PC, Rose JB & Jakubowski W. The infectivity of Cryptosporidium parvum in healthy volunteers. N Engl J Med 1995; 332: 855-859.
6. Okhuysen PC, Chappell CL, Sterling CR, Jakubowski W & DuPont HL. Susceptibility and serological response of healthy adults to reinfection with Cryptosporidium parvum. Infect Immun 1998; 66: 441-443.
7. McDonald V & Bancroft GJ. Immunological control of Cryptosporidium infection. Chem Immun 1998; 70: 103-123.
8. Gookin JL, Nordone SK & Argenzio RA. Host responses to Cryptosporidium infection. J Vet Intern Med 2002; 16: 12-21.
9. Riggs MW. Recent advances in cryptosporidiosis: the immune response. Microbes Infect 2002; 4: 1067-1080.
10. McDonald SAC, O'Grady JE, Bajaj-Elliot M, et al. Protection against the early acute phase of Cryptosporidium parvum infection conferred by interleukin-4-induced expression of T helper 1 cytokines. J Infect Dis 2004; 190: 1019-1025.
11. Canals A, Pasquali P, Zarlenga DS, Payer R, Almeria S & Gasbarre LC. Local ileal cytokine responses in cattle during a primary infection with Cryptosporidium parvum. J Parasitol 1998; 84: 125-130.
12. Gomez-Morales MA, La-Rosa G, Ludovisi A, Mochi-Onori A & Pozio E. Cytokine profile induced by Cryptosporidium antigen in peripheral blood mononuclear cells from immunocompetent and immunosuppressed persons with cryptosporidiosis. J Infect Dis 1999; 179: 967-973.
13. Lacroix S, Mancassola R, Naciri M & Laurent F. Cryptosporidium parvum-specific mucosal immune response in C57BL/6 neonatal and gamma interferon-deficient mice: role of tumor necrosis factor alpha in protection. Infect Immun 2001; 69: 1635-1642.
14. Lacroix-Lamandé S. Mancassola R, Naciri M & Laurent F. Role of gamma interferon in chemokine expression in the ileum of mice and in a murine intestinal epithelial cell line after Cryptosporidium parvum infection. Infect Immun 2002; 70: 2090-2099.
15. Maillot C, Gargala G, Delaunay A, et al. Cryptosporidium parvum infection stimulates the secretion of TGF-beta, IL-8 and RANTES by Caco-2 cell line. Parasitol Res 2000; 86: 947-949.
16. Robinson P, Okhuysen PC, Chappell CL, et al. Transforming growth factor β1 is expressed in the jejunum after experimental Cryptosporidium parvum infection in humans. Infect Immun 2000; 68: 5405-5407.
17. Robinson P, Okhuysen PC, Chappell CL, et al. Expression of IL-15 and IL-4 in IFN-gamma-independent control of experimental human Cryptosporidium parvum infection. Cytokine 2001; 15: 39-46.
18. Smith LM, Bonafonte M-T & Mead JR. Cytokine expression and specific lymphocyte proliferation in two strains of Cryptosporidium parvum-infected gamma-interferon knockout mice. J Parasitol 2000; 86: 300-307.
19. Tilley M, McDonald V & Bancroft GJ. Resolution of cryptosporidial infection in mice correlates with parasite-specific lymphocyte proliferation associated with both Th1 and Th2 cytokine secretion. Parasite Immunol 1995; 17: 459-464.
20. Griffiths JK, Theodos C, Paris M & Tzipori S. The gamma interferon gene knockout mouse: a highly sensitive model for evaluation of therapeutic agents against Cryptosporidium parvum. J Clin Microbiol 1998; 36: 2503-2508.
21. Mead JR & You X. Susceptibility differences to Cryptosporidium parvum infection in two strains of gamma interferon knockout mice. J Parasitol 1998; 84: 1045-1048.
22. Theodos CM, Sullivan KL, Griffiths JK & Tzipori S. Profiles of healing and nonhealing Cryptosporidium parvum infection in C57BL/6 mice with functional B and T lymphocytes: The extent of gamma interferon modulation determines the outcome of infection. Infect Immun 1997; 65: 4761-4769.
23. Campbell LD, Stewart JN & Mead JR. Susceptibility to Cryptosporidium parvum infections in cytokine- and chemokine-receptor knockout mice. J Parasitol 2002; 88: 1014-1016.
24. Cooper AM, Kipnis A, Turner J, Magram J, Ferrante J & Orme IM. Mice lacking bioactive IL-12 can generate protective, antigen-specific cellular responses to mycobacterial infection only if the IL-12 p40 subunit is present. J Immunol 2002; 168: 1322-1327.
25. Ehigiator HN, McNair N & Mead JR. IL-12 knockout C57BL/6 mice are protected from re-infection with Cryptosporidium parvum after challenge. J Eukaryot Microbiol 2003; 50: S539-S541.
26. Arrowood MJ & Donaldson K. Improved purification methods for calf-derived Cryptosporidium parvum oocysts using discontinuous sucrose and cesium chloride gradients. J Eukaryot Microbiol 1996; 43: 89S-92S.
27. Arrowood MJ, Kurd MR & Mead JR. A new method for evaluating experimental cryptosporidial parasite loads using immunofluorescent flow cytometry. J Parasitol 1995; 81: 404-409.
28. Muller PY, Janovjak H, Miserez AR & Dobbie Z. Processing of gene expression data generated by quantitative real-time RT-PCR. Biotechniques 2002; 32: 1372-1379. (Erratum in: Biotechniques 2002; 33: 514).
29. Muller PY, Janovjak H, Miserez AR & Dobbie Z. Processing of gene expression data generated by quantitative real-time RT-PCR. Biotechniques 2002; 32: 1372-1379. (Erratum in: Biotechniques 2002; 33: 514).
30. T method. Methods 2001; 25: 402-408.
31. Pearl JE, Khader SA, Solache A, et al. IL-27 signaling compromises control of bacterial growth in Mycobacteria-infected mice. J Immunol 2004; 173: 7490-7496.
32. Ehigiator HN, Stadnyk AW & Lee TDG. Modulation of B cell proliferative response by a soluble extract of N. brasiliensis. Infect Immun 2000; 68: 6154-6161.
33. Mead JR, Arrowood MJ, Sidwell RW & Healey MC. Chronic Cryptosporidium parvum infections in congenitally immunodeficient SCID and nude mice. J Infect Dis 1991; 163: 1297-1304.
34. McDonald V, Deer R, Uni S, Iseki M & Bancroft GJ. Immune responses to Cryptosporidium muris and Cryptosporidium parvum in adult immunocompetent or immunocompromised (nude SCID) mice. Infect Immun 1992; 60: 3325-3331.
35. White AC Jr, Robinson P, Okhuysen PC, et al. Interferon-gamma expression in jejunal biopsies in experimental human cryptosporidiosis correlates with prior sensitization and control of oocyst excretion. J Infect Dis 2000; 181: 701-709.
36. + lymphocytes in gut-associated lymphoid tissue during resolution of infection. J Immunol 1998; 161: 1891-1900.
37. Chai J-Y, Guk S-M, Han H-K & Yun C-K. Role of intraepithelial lymphocytes in mucosal immune responses of mice experimentally infected with Cryptosporidium parvum. J Parasitol 1999; 85: 234-239.
38. Culshaw RJ, Bancroft GJ & McDonald V. Gut intraepithelial lymphocytes induce immunity against Cryptosporidium infection through a mechanism involving gamma interferon production. Infect Immun 1997; 65: 3074-3079.
39. Reinecker HC, MacDermott RP, Mirau S, Dignass A & Podolsky DK. Intestinal epithelial cells both express and respond to IL-15. Gastroenterol 1996; 111: 1706-1713.
40. Artis D, Johnson LM, Joyce K, et al. Early IL-4 production governs the requirement for IL-27-WSX-1 signaling in the development of protective Th1 cytokine responses following Leishmania major infection. J Immunol 2004; 172: 4672-4675.
41. Lean I-S, McDonald SAC, Bajaj-Elliot M, Pollok RCG, Farthing MJG & McDonald V. Interleukin-4 and Transforming growth factor β have opposing regulatory effects on gamma interferon-mediated inhibition of Cryptosporidium parvum reproduction. Infect Immun 2003; 71: 4580-4585.
42. Ungar BL, Kao TC, Burris JA & Finkelman FD. Cryptosporidium parvum infection in an adult mouse model. Independent roles for IFN-gamma and CD4+ T lymphocytes in protective immunity. J Immunol 1991; 147: 1014-1022.
43. Urban JF Jr, Payer R, Chen SJ, Gause WC, Gately MK & Finkelman FD. IL-12 protects immunocompetent and immunodeficient neonatal mice against infection with Cryptosporidium parvum. J Immunol 1996; 156: 263-268.
44. Bohn E, Sing A, Zumbihl R, et al. IL-18 (IFN-γ-inducing factor) regulates early cytokine production in, and promotes resolution of, bacterial infection in mice. J Immunol 1998; 160: 299-307.
45. Cai G, Kastelein R & Hunter CA. IL-18 enhances innate IL-12-mediated resistance to Toxoplasma gondii. Infect Immun 2000; 68: 6932-6938.
46. Oxenius A, Karrer U, Zinkernagel RM & Hengartner H. IL-12 is not required for induction of type 1-cytokine responses in viral infections. J Immunol 1999; 162: 965-973.
47. Wei X-Q, Leung BP, Niedbala W, et al. Altered immune responses and susceptibility to Leishmania major and Staphylococcus aureus infection in IL-18-deficient mice. J Immunol 1999; 163: 2821-2828.
48. Lieberman LA, Cardillo F, Owyang AM, et al. 1L-23 provides a limited mechanism of resistance to acute toxoplasmosis in the absence of IL-12. J Immunol 2004; 173: 1887-1893.
49. + T cells. Immunity 2002; 16: 779-790.
50. Takeda A, Hamano S, Yamanaka A, et al. Role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment. J Immunol 2003; 170: 4886-4889.
51. Bancroft GJ, Sheehan KCF, Schreiber RD & Unanue ER. Tumor necrosis factor is involved in the T cell-independent pathway of macrophage activation in SCID mice. J Immunol 1989; 143: 127-134.
52. Shibuya K, Robinson D, Zonin F, et al. IL-1α and TNFα are required for IL-12-induced development of Th1 cells producing high levels of IFN-γ in BALB/c but not C57BL/6 mice. J Immunol 1998; 160: 1708-1716.
53. + T cell alloproliferation, IFN-γ responses, and intestinal graft-versus-host disease by IL-12-independent mechanisms. J Immunol 2003; 170: 5082-5088.
54. Robinson P, Okhuysen PC, Chappell CL, et al. Expression of tumor necrosis factor alpha and interleukin 1β in jejuna of volunteers after experimental challenge with Cryptosporidium parvum correlates with exposure but not with symptoms. Infect Immun 2001b; 69: 1172-1174.
55. Hirose K, Suzuki H, Nishimura H, et al. IL-15 may be responsible for early activation of intestinal intraepithelial lymphocytes after oral infection with Listeria monocytogenes in rats. Infect Immun 1998; 66: 5677-5683.
56. Hunter CA, Bermudez L, Beernink H, Waegell W & Remington JS. TGF-β inhibits IL-12-induced production of IFN-γ by natural killer cells: a role for TGF-β in the regulation of T cell-independent resistance to Toxoplasma gondii. Eur J Immunol 1995; 25: 994-1000.
57. Planchon SM, Martins CAP, Guerrant RL & Roche JK. Regulation of intestinal epithelial barrier function by TGF-β. Evidence for its role in abrogating the effect of a T cell cytokine. J Immunol 1994; 153: 5730-5739.
58. Roche JK, Martins CAP, Cosme R, Payer R, & Guerrant RL. Transforming growth factor β1 ameliorates intestinal epithelial barrier disruption by Cryptosporidium parvum in vitro in the absence of mucosal T lymphocytes. Infect Immun 2000; 68: 5635-5644.
59. Martin P, Ruiz SR, Martinez del Hoyo G, et al. Dramatic increase in lymph node dendritic cell number during infection by the mouse mammary tumor virus occurs by a CD62L-dependent blood-borne DC recruitment. Blood 2002; 99: 1282-1288.
60. + cells in murine bone marrow and spleen does not belong to the B cell lineage but has dendritic cell characteristics. Eur J Immunol 2002; 32: 686-692.