Induction of Parkinson disease-related proteins in motor neurons after transient spinal cord ischemia in rabbits

Journal of Cerebral Blood Flow and Metabolism

Volumn 29, Issue 4, 2009, Pages 752-758

  Sakurai, Masahiro ^a   Kawamura, Takae ^a   Nishimura, Hidekazu ^a   Suzuki, Hiroyoshi ^a   Tezuka, Fumiaki ^b   Abe, Koji ^b  

^a NATIONAL HOSPITAL ORGANIZATION   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

Author keywords

Ischemia; Parkinsons disease; Spinal cord; Stress response

Indexed keywords

ALPHA SYNUCLEIN; DJ 1 PROTEIN; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE; PTEN INDUCED KINASE 1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BALLOON CATHETER; BRAIN PERFUSION; CELL DEATH; CELL LABELING; CONTROLLED STUDY; EXPERIMENTAL RABBIT; FLUORESCENCE ANALYSIS; IMMUNOCYTOCHEMISTRY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MOTONEURON; NONHUMAN; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN INDUCTION; REPERFUSION; SHAM PROCEDURE; SPINAL CORD ISCHEMIA; WESTERN BLOTTING;

ALPHA-SYNUCLEIN; ANIMALS; IMMUNOASSAY; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MOTOR NEURONS; ONCOGENE PROTEINS; PARKINSON DISEASE; PROTEIN KINASES; RABBITS; REPERFUSION; SPINAL CORD ISCHEMIA; TRANSCRIPTIONAL ACTIVATION;

EID: 63949084954     PISSN: 0271678X     EISSN: None     Source Type: Journal    
DOI: 10.1038/jcbfm.2008.167     Document Type: Article

References (34)

1. Adam-Vizi V (2005) Production of reactive oxygen species in brain mitochondria: contribution by electron transport chain and non-electron transport chain sources. Antioxid Redox Signal 7:1140-9
2. Aleyasin H, Rousseaux MW, Phillips M, Kim RH, Bland RJ, Callaghan S, Slack RS, During MJ, Mak TW, Park DS (2007) The Parkinson's disease gene DJ-1 is also a key regulator of stroke-induced damage. Proc Natl Acad Sci USA 104:18748-53
3. Alves da Costa C, Paitel E, Vincent B, Checler F (2002) Alpha-synuclein lowers p53-dependent apoptotic of neuronal cell: abolishment by6-hydroxydopamine and implication for Parkinson's disease. J Bio Chem 277:50980-4
4. Bonifati V, Rizzu P, van Baren MJ, Schaap O, Breedveld GJ, Krieger E, Dekker MC, Squitieri F, Ibanez P, Joosse M, van Dongen JW, Vanacore N, van Swieten JC, Brice A, Meco G, van Duijn CM, Oostra BA, Heutink P (2003) Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science 299:256-9
5. Canet-Aviles RM, Wilson MA, Millwe DW, Ahmad R, McLendon C, Bandyopadhyay S, Baptista MJ, Ringe D, Petsko GA, Cookson MR (2004) The Parkinson's disease protein DJ-1 is neuroprotective due to cysteine-sulfinic acid-driven mitochondrial localization. Proc Natl Acad Sci USA 101:9103-8
6. Chandra S, Fornai F, Kwon HB, Yazdani U, Atasoy D, Liu X, Hammer RE, Battaglia G, German DC, Castillo PE, Sudhof TC (2004) Double-knockout mice for alpha- and beta-synucleins: effect on synaptic functions. Proc Natl Acad Sci USA 101:14966-71
7. Cho S, Park EM, Febbraio M, Anrather J, Park L, Racchumi G, Silverstein RL, Iadecola C (2005) The class B scavenger receptor CD36 mediates free radical production and tissue injury in cerebral ischemia. J Neurosci 25:2504-12
8. Chung YH, Joo KM, Kim MJ, Cha CI (2003) Immunohistochemical study on the distribution of alpha-synuclein in the central nervous system of the transgenic mice expressing a human Cu/Zn superoxide dismutase mutation. Neurosci Lett 342:151-4
9. Dorerty MJ, Bird TD, Leverenz JB (2004) Alpha-synuclein in motor neuron disease: an immunohistologic study. Acta Neuropathol 107:169-75
10. Giasson BI, Duda JE, Quinn SM, Zhang B, Trojanowski JQ, Lee VM (2002) Neuronal α-synucleinopathy with severe movement disorder in mice expressing A53T human α-synuclein. Neuron 34:521-33
11. Goedert M (2001) Alpha-synuclein and neurodegenerative diseases. Nat Rev Neurosci 2:492-501
12. Islekel S, Islekel H, Guner G, Ozdamar N (1999) Alterations in superoxide dismutase, glutathione peroxidase and catalase activities in experimental cerebral ischemiareperfusion. Res Exp Med (Berl) 199:167-76
13. Iwata A, Murayama M, Kanazawa I, Nukina N (2001) a-synuclein affects the MAPK pathway and accelerates cell death. J Bio Chem 276:45320-9
14. Kato T, Katagiri T, Hirano A, Kawanami T, Sasakii H (1989) Lewy body-like hyaline inclusions in sporadic motor neuron disease are ubiquitinated. Acta Neuropathol 77:391-6
15. Kim RH, Peters M, Jang Y, Shi W, Pintilie M, Fletcher GC, DeLuca C, Liepa J, Zhou L, Snow B, Binari RC, Manoukian , Bray MR, Liu FF, Tsao MS, Mak TW (2005a) DJ-1, a novel regulator of the tumor suppressor PTEN. Cancer Cell 7:263-73
16. Kim RH, Smith PD, Aleyasin H, Heylay S, Mount MP, Pownall S, Wakeham A, You-Ten AJ, Kalia SK, Horne P, Westaway D, Lozano AM, Anisman H, Park DS, Mak TW (2005b) Hypersensitivity of DJ-1-deficient mice to 1-methyl-4-phenyl-1,2,3,6- tetrahydropyrindine (MPTP) and oxidative stress. Proc Natl Acad Sci USA 102:5215-20
17. Martin LJ, Pan Y, Price AC, Sterling W, Copeland NG, Jenkins NA, Price DL, Lee MK (2006) Parkinson's disease α-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. J Neurosci 26:41-50
18. Mitsumoto A, Nakagawa Y, Takeuchi A, Okawa K, Iwamatsu A, Takanezawa Y (2001) Oxidized forms of peroxiredoxins and DJ-1 on two-dimensional gels increased in response to sublethal levels of paraquat. Free Radic Res 35:301-10
19. Moore WM, Hollier LY (1991) The influence of severity of spinal cord ischemia in the etiology of delayed-onset paraplegia. Ann Surg 213:427-32
20. Muqit MM, Abou-Sleiman PM, Saurin AT, Harvey K, Gandhi S, Deas E, Eaton S, Payne Smith MD, Venner K, Matilla A, Healy DG, Gliks WP, Lee AJ, Holton J, Revesz T, Parker PJ, Harvey RJ, Wood NW, Latchman DS (2006) Altered cleavage and localization of PINK1 to aggresomes in the presence of proteasomal stress. J Neurochem 98:156-69
21. Nagakubo D, Taira T, Kitaura H, Ikeda M, Tamai K, Iguti-Ariga SM, Ariga H (1997) DJ-1, a novel oncogene which transforms mouse NIH3T3 cells in cooperation with ras. Biochem Biophys Res Commun 231:509-13
22. Niki T, Takahashi-Niki K, Taira T, Iguchi-Ariga SM, Ariga H (2003) DJBP: a novel DJ-1-binding protein, negatively regulates the androgen receptor by recruiting histone deacetylase complex, and DJ-1 antagonizes this inhibition by abrogation of this complex. Mol Cancer Res 1:247-61
23. Petit A, Kawarai T, Paitel E, Sanjo N, Maj M, Scheid M, Chen F, Gu Y, Hasegawa H, Salehi-Rad S, Wang L, Rogaeva E, Fraser P, Robinson B, St George-Hyslop P, Tandon A (2005) Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations. J Biol Chem 280:34025-32
24. Sakurai M, Fukuyama N, Takizawa S, Abe K, Hayashi T, Shinohara Y, Nakazawa Tabayashi K (1998) Inductions of 3-L-nitrotyrosine in motor neurons after transient spinal cord ischemia in rabbits. J Cereb Blood Flow Metab 18:1233-8
25. Sakurai M, Hayashi T, Abe K, Itoyama Y, Tabayashi K (2000) Cyclin D1 and cdk 4 protein inductions in motor neurons after spinal cord ischemia in rabbits. Stroke 31:200-7
26. Sakurai M, Nagata T, Abe K, Horinouchi T, Itoyama Y, Tabayashi K (2003a) Oxidative damage and reduction of redox factor-1 expression after transient spinal cord ischemia in rabbits. J Vasc Surg 37:446-52
27. Sakurai M, Nagata T, Abe K, Horinouchi T, Itoyama Y, Tabayashi K (2003b) Survival- and death promoting events after transient spinal cord ischemia in rabbits: induction of Akt and caspase3 in motor neurons. J Thorac Cardiovasc Surg 125:370-7
28. Sakurai M, Takahashi G, Abe K, Horinouchi T, Itoyama Y, Tabayashi K (2005) Endoplasmic reticulum stress induced in motor neurons by transient spinal cord ischemia in rabbits. J Thorac Cardiovasc Surg 130:640-5
29. Starkov AA, Chinopoulos C, Fiskum G (2004) Mitochondrial calcium and oxidative stress as mediators of ischemic brain injury. Cell Calcium 36:257-64
30. Sugawara T, Chan PH (2003) Reactive oxygen radicals and pathogenesis of neuronal death after cerebral ischemia. Antioxid Redox Signal 5:597-607
31. Unoki M, Nakamura Y (2001) Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway. Oncogene 20:4457-65
32. Valente EM, Abou-Sleiman PM, Caputo V, Muqit MM, Harvey K, Gispert S, Ali Z, Del Turco D, Bentivoglio AR, Healy DG, Albanse A, Nussbaum R, Gonzalez- Maldonado R, Deller T, Salvi S, Cortelli P, Gilks WP, Latchman DS, Harvey RJ, Dallapiccola B, Auburger G, Wood NW (2004) Hereditary early-onset Parkinson's disease caused by mutations in PINK1. Science 304:1158-60
33. Yamauchi T, Sakurai M, Abe K, Sawa Y (2008) Ubiquitinmediated stress response in the spinal cord after transient ischemia. Stroke 39:1883-9
34. Yanagisawa D, Kitamura Y, Inden M, Takata K, Taniguchi T, Morikawa S, Morita M, Inubushi T, Tooyama I, Taira T, Iguchi-Ariga SM, Akaie A, Ariga H (2008) DJ-1 protects against neurodegeneration caused by focal cerebral ischemia and reperfusion in rats. J Cereb Blood Flow Metab 28:563-78