34kDa MOMP of Shigella flexneri promotes TLR2 mediated macrophage activation with the engagement of NF-κB and p38 MAP kinase signaling

Molecular Immunology

Volumn 47, Issue 9, 2010, Pages 1739-1746

  Pore, Debasis ^a   Mahata, Nibedita ^a   Pal, Amit ^a   Chakrabarti, Manoj K ^a  

^a NATIONAL INSTITUTE OF CHOLERA AND ENTERIC DISEASES   (India)

Author keywords

Macrophages; Major outer membrane protein; NF B; P38 MAP kinase; Toll like receptors

Indexed keywords

B7 ANTIGEN; CHEMOKINE; CYTOKINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE P38; MYELOID DIFFERENTIATION FACTOR 88; OUTER MEMBRANE PROTEIN; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 6; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6; HLA ANTIGEN CLASS 2; I A(B) ANTIGEN, MOUSE; I-A(B) ANTIGEN, MOUSE; TLR2 PROTEIN, MOUSE;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; ENZYME ACTIVATION; GENE EXPRESSION REGULATION; HOST PATHOGEN INTERACTION; IMMUNE RESPONSE; INNATE IMMUNITY; MACROPHAGE ACTIVATION; MOUSE; NONHUMAN; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN TRANSPORT; SHIGELLA FLEXNERI; SIGNAL TRANSDUCTION; ACTIVE TRANSPORT; ANIMAL; BAGG ALBINO MOUSE; CELL CULTURE; CELL NUCLEUS; CHEMISTRY; CYTOLOGY; DRUG EFFECT; GENETICS; IMMUNOBLOTTING; METABOLISM; MOLECULAR WEIGHT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

BACTERIA (MICROORGANISMS); MURINAE; MUS; SHIGELLA FLEXNERI; SHIGELLA FLEXNERI 2A;

ACTIVE TRANSPORT, CELL NUCLEUS; ANIMALS; ANTIGENS, CD80; BACTERIAL OUTER MEMBRANE PROTEINS; CELL NUCLEUS; CELLS, CULTURED; CHEMOKINES; CYTOKINES; HISTOCOMPATIBILITY ANTIGENS CLASS II; IMMUNOBLOTTING; MACROPHAGE ACTIVATION; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED BALB C; MOLECULAR WEIGHT; MYELOID DIFFERENTIATION FACTOR 88; NF-KAPPA B; P38 MITOGEN-ACTIVATED PROTEIN KINASES; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SHIGELLA FLEXNERI; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 6; TOLL-LIKE RECEPTOR 2;

EID: 77952320309     PISSN: 01615890     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.molimm.2010.03.001     Document Type: Article

References (41)

1. Aderem A., Underhill D.M. Mechanisms of phagocytosis in macrophages. Annu. Rev. Immunol. 1999, 17:593-623.
2. Ashkenazi S., Levy I., Kazaronovsky V., Samra Z. Growing antimicrobial resistance of Shigella isolates. J. Antimicrob. Chemother. 2003, 51:427-429.
3. Beutler B. Inferences, questions and possibilities in Toll-like receptor signalling. Nature 2004, 430:257-263.
4. Blaecke A., Delneste Y., Herbault N., Jeannin P., Bonnefoy J.Y., Beck A., Aubry J.P. Measurement of nuclear factor-kappa B translocation on lipopolysaccharide-activated human dendritic cells by confocal microscopy and flow cytometry. Cytometry 2002, 48(2):71-79.
5. Boehm U., Klamp T., Groot M., Howard J.C. Cellular responses to interferon-γ. Annu. Rev. Immunol. 1997, 15:749-795.
6. Caamano J., Hunter C.A. NF-κB family of transcription factors: central regulators of innate and adaptive immune functions. Clin. Microbiol. Rev. 2002, 15(3):414-429.
7. Camussi G., Albano E., Tetta C., Bussolino F. The molecular action of tumor necrosis factor-α. Eur. J. Biochem. 1991, 202:3-14.
8. Cao Z., Henzel W.J., Gao X. IRAK: a kinase associated with the interleukin-1 receptor. Science 1996, 271:1128-1131.
9. Dinarello C.A. Interleukin-1, interleukin-1 receptors and interleukin-1 receptor antagonist. Int. Rev. Immunol. 1998, 16:457-499.
10. Ding J.L., Zhu Y., Ho B. High-performance affinity capture removal of bacterial pyrogen from solutions. J. Chromatogr. B Biomed. Sci. Appl. 2001, 759:237-246.
11. Dixon G.L.J., Newton P.J., Chain B.M., Katz D., Andersen S.R., Wong S., et al. Dendritic cell activation and cytokine production induced by group B Nesseria meningitidis: interleukin-12 production depends on lipoolysaccharide expression in intact bacteria. Infect. Immun. 2001, 69:4351-4357.
12. Gately M.K., Renzentti L.M., Magram J., Stern A.S., Adorini L., Gubler U., Presky D.H. The interleukin-12/interleukin-12 receptor system: role in normal and pathologic immune responses. Ann. Rev. Immunol. 1998, 16:495-521.
13. Guillot L., Le G.R., Bloch S., Escriou N., Akira S., Chignard M., Si-Tahar M. Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus. J. Biol. Chem. 2005, 280:5571-5580.
14. Hayden M.S., Ghosh S. Signaling to NF-κB. Genes Dev. 2004, 18:2195-2224.
15. Hsieh C.S., Macatonia S.E., Tripp C.S., Wolf S.F., O'Garra A., Murphy K.M. Development of TH1 CD4{thorn} T cells through IL-12 produced by Listeria-induced macrophages. Science 1993, 260:547-549.
16. Kaisho T., Akira S. Toll-like receptors as adjuvant receptors. Biochim. Biophys. Acta 2002, 1589:1-13.
17. Kolb-Maurer A., Unkmeir A., Kammerer U., Hubner C., Leimbach T., Stade A., et al. Interaction of Nesseria meningitidis with human dendritic cells. Infect. Immun. 2001, 69:6912-6922.
18. Kopp E., Medzhitov R. Recognition of microbial infection by Toll-like receptors. Curr. Opin. Immunol. 2003, 15:396-401.
19. Kotloff K.L., Winickoff J.P., Ivanoff B., Clemens J.D., Swedlow D.L., Sansonetti P.J., Adak G.K., Levine M.M. Global burden of Shigella infections: implications for vaccine development and implementation of control strategies. Bull. World Health Organ. 1999, 77:651-666.
20. Kuchroo K.S., Das M.P., Brown J.A., Ranger A.M., Zamvil S.S., Sobel H., Weiner l., Nabavi N., Glimcher L.H. B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 development pathway: application to autoimmune disease therapy. Cell 1995, 80:707-718.
21. Latz E., Franko J., Golenbock D.T., Schreiber J.R. Haemophilus influenzae type b-outer membrane protein complex glycoconjugate vaccine induces cytokine production by engaging human Toll-like receptor 2 (TLR2) and requires the presence of TLR for optimal immunogenicity. J. Immunol. 2004, 172:2431-2438.
22. Lien E., Sellati T.J., Yoshimura A., Flo T.H., Rawadi G., Finberg R.W. Toll like receptor 2 functions as a pattern recognition receptor for diverse bacterial products. J. Biol. Chem. 1999, 274:33419-33425.
23. Mantovani A., Sica A., Sozzani S., Allavena P., Vecchi A., Locati M. The chemokine system in diverse forms of macrophage activation and polarization. Trends Immunol. 2004, 25:677-686.
24. Matsuguchi T., Takagi K., Musikacharoen T., Yoshikai Y. Gene expressions of lipopolysaccharide receptors, toll-like receptors 2 and 4, are differently regulated in mouse T lymphocytes. Blood 2000, 95(1378):1385.
25. Mazzoni A., Segal D.M. Controlling the Toll road to dendritic cell polarization. J. Leukoc. Biol. 2004, 75:721-730.
26. Medzhitov R., Janeway C.A.J. Innate immunity: the virtues of a nonclonal system of recognition. Cell 1997, 91:295-298.
27. Medzhitov R., Preston-Hurlburt P., Janeway C.A. A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature 1997, 388:394-397.
28. Medzhitov R., Preston-Hurlburt P., Kopp E., Stadlen A., Chen C., Ghosh S., Janeway C.A. MyD88 is an adaptor protein in the hToll/IL-1 receptor family signaling pathways. Mol. Cell 1998, 2:253-258.
29. Mukhopadhaya A., Mahalanabis D., Chakrabarti M.K. Role of Shigella fexneri 2a 34kDa outer membrane protein in induction of protective immune response. Vaccine 2006, 24:6028-6036.
30. Musikacharoen T., Matsuguchi T., Kikuchi T., Yoshikai Y. NF-kappa B and STAT5 play important roles in the regulation of mouse Toll-like receptor 2 gene expression. J. Immunol. 2001, 166:4516-4524.
31. Muzio M., Ni J., Feng P., Dixit V.M. IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. Science 1997, 278:1612-1615.
32. Ozinsky A., Underhill D.M., Fontenot J.D., Hajjar A.M., Smith K.D., Wilson C.B., Schroeder L., Aderem A. The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors. Proc. Natl. Acad. Sci. U.S.A. 2000, 97:13766-13771.
33. Pore D., Chowdhury P., Mahata N., Pal A., Yamasaki S., Mahalanabis D., Chakrabarti M.K. Purification and characterization of an immunogenic outer membrane protein of Shigella fexneri 2a. Vaccine 2009, 27:5855-5864.
34. Rauh M.J., Ho V., Pereira C., Sham A., Sly L.M., Lam V., et al. SHIP represses the generation of alternatively activated macrophages. Immunity 2005, 23:361-374.
35. Reis e Sousa C. Toll-like receptors and dendritic cells: for whom the bug tolls. Semin. Immunol. 2004, 16:27-34.
36. Standiford T.J., Kunkel S.L., Greenberger M.J., Laichalk L.L., Strieter R.M. Expression and regulation of chemokines in bacterial pneumonia. J. Leukoc. Biol. 1996, 59:24-28.
37. Takeuchi O., kawai T., Muhlradt P.F., Morr M., Radolf J.D., Zychlinsky A., et al. Discrimination of bacterial lipoproteins by Toll-like receptor 6. Int. Immunol. 2001, 13:933-940.
38. Wang C., Deng L., Hong M., Giridhar R.A., Jun-ichiro I., Zhijian J.C. TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 2001, 412:346-351.
39. Wang T., Lafuse W.P., Zwilling B.S. NFkappaB and Sp1 elements are necessary for maximal transcription of toll-like receptor 2 induced by Mycobacterium avium. J. Immunol. 2001, 167:6924-6932.
40. West A.P., Koblansky A.A., Ghosh S. Recognition and signaling by Toll-like receptors. Annu. Rev. Cell Dev. Biol. 2006, 22:409-437.
41. Zlotnik A., Yoshie O. Chemokines: a new classification system and their role in immunity. Immunity 2000, 12(2):121-127.