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Volumn 24, Issue 3, 2010, Pages 891-905

Transcriptional regulation of the small GTPase RhoB gene by TGFβ-induced signaling pathways

Author keywords

Cell migration; DU145; ERK; HaCaT; NF Y; Smad

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE; RHOB GUANINE NUCLEOTIDE BINDING PROTEIN; SMAD3 PROTEIN; SMALL INTERFERING RNA; TRANSFORMING GROWTH FACTOR BETA; 1,3 BUTADIENE DERIVATIVE; 1,3 DIOXOLANE DERIVATIVE; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; 4 (5 BENZO(1,3)DIOXOL 5 YL 4 PYRIDIN 2 YL 1H IMIDAZOL 2 YL)BENZAMIDE; 4-(5-BENZO(1,3)DIOXOL-5-YL-4-PYRIDIN-2-YL-1H-IMIDAZOL-2-YL)BENZAMIDE; ACTIN; BENZAMIDE DERIVATIVE; MAP2K1 PROTEIN, HUMAN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE KINASE 1; NITRILE; PROTEIN P53; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; SMAD PROTEIN; TRANSFORMING GROWTH FACTOR BETA RECEPTOR;

EID: 77952295086     PISSN: 08926638     EISSN: 15306860     Source Type: Journal    
DOI: 10.1096/fj.09-134742     Document Type: Article
Times cited : (46)

References (52)
  • 1
    • 27944479854 scopus 로고    scopus 로고
    • Rho GTPases: Biochemistry and biology
    • Jaffe, A. B., and Hall, A. (2005) Rho GTPases: biochemistry and biology. Annu. Rev. Cell. Dev. Biol. 21, 247-269
    • (2005) Annu. Rev. Cell. Dev. Biol. , vol.21 , pp. 247-269
    • Jaffe, A.B.1    Hall, A.2
  • 2
    • 44449178868 scopus 로고    scopus 로고
    • Rho GTPases in cancer cell biology
    • Vega, F. M., and Ridley, A. J. (2008) Rho GTPases in cancer cell biology. FEBS Lett. 582, 2093-2101
    • (2008) FEBS Lett. , vol.582 , pp. 2093-2101
    • Vega, F.M.1    Ridley, A.J.2
  • 3
    • 2342418629 scopus 로고    scopus 로고
    • Rho-family GTPases: It's not only Rac and Rho (and I like it)
    • Wennerberg, K., and Der, C. J. (2004) Rho-family GTPases: it's not only Rac and Rho (and I like it). J. Cell Sci. 117, 1301-1312
    • (2004) J. Cell Sci. , vol.117 , pp. 1301-1312
    • Wennerberg, K.1    Der, C.J.2
  • 4
    • 6344231714 scopus 로고    scopus 로고
    • Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility
    • Wheeler, A. P., and Ridley, A. J. (2004) Why three Rho proteins? RhoA, RhoB, RhoC, and cell motility. Exp. Cell. Res. 301, 43-49
    • (2004) Exp. Cell. Res. , vol.301 , pp. 43-49
    • Wheeler, A.P.1    Ridley, A.J.2
  • 5
    • 0035523359 scopus 로고    scopus 로고
    • Actin' up: RhoB in cancer and apoptosis
    • Prendergast, G. C. (2001) Actin' up: RhoB in cancer and apoptosis. Nat. Rev. 1, 162-168
    • (2001) Nat. Rev. , vol.1 , pp. 162-168
    • Prendergast, G.C.1
  • 8
    • 0642306119 scopus 로고    scopus 로고
    • Transforming growth factor beta-regulated gene expression in a mouse mammary gland epithelial cell line
    • Xie, L., Law, B. K., Aakre, M. E., Edgerton, M., Shyr, Y., Bhowmick, N. A., and Moses, H. L. (2003) Transforming growth factor beta-regulated gene expression in a mouse mammary gland epithelial cell line. Breast Cancer Res. 5, R187-R198
    • (2003) Breast Cancer Res. , vol.5
    • Xie, L.1    Law, B.K.2    Aakre, M.E.3    Edgerton, M.4    Shyr, Y.5    Bhowmick, N.A.6    Moses, H.L.7
  • 9
    • 0037458654 scopus 로고    scopus 로고
    • Characterization of the transforming growth factor-beta 1-induced apoptotic transcriptome in FaO hepatoma cells
    • Coyle, B., Freathy, C., Gant, T. W., Roberts, R. A., and Cain, K. (2003) Characterization of the transforming growth factor-beta 1-induced apoptotic transcriptome in FaO hepatoma cells. J. Biol. Chem. 278, 5920-5928
    • (2003) J. Biol. Chem. , vol.278 , pp. 5920-5928
    • Coyle, B.1    Freathy, C.2    Gant, T.W.3    Roberts, R.A.4    Cain, K.5
  • 10
    • 0035907240 scopus 로고    scopus 로고
    • Identification of novel TGF-beta/Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach
    • Verrecchia, F., Chu, M. L., and Mauviel, A. (2001) Identification of novel TGF-beta/Smad gene targets in dermal fibroblasts using a combined cDNA microarray/promoter transactivation approach. J. Biol. Chem. 276, 17058-17062
    • (2001) J. Biol. Chem. , vol.276 , pp. 17058-17062
    • Verrecchia, F.1    Chu, M.L.2    Mauviel, A.3
  • 11
    • 44449149171 scopus 로고    scopus 로고
    • Dynamic control of TGF-beta signaling and its links to the cytoskeleton
    • Moustakas, A., and Heldin, C. H. (2008) Dynamic control of TGF-beta signaling and its links to the cytoskeleton. FEBS Lett. 582, 2051-2065
    • (2008) FEBS Lett. , vol.582 , pp. 2051-2065
    • Moustakas, A.1    Heldin, C.H.2
  • 12
    • 33646562542 scopus 로고    scopus 로고
    • The logic of TGFbeta signaling
    • Massague, J., and Gomis, R. R. (2006) The logic of TGFbeta signaling. FEBS Lett. 580, 2811-2820
    • (2006) FEBS Lett. , vol.580 , pp. 2811-2820
    • Massague, J.1    Gomis, R.R.2
  • 13
    • 2342488852 scopus 로고    scopus 로고
    • New insights into TGF-beta-Smad signalling
    • Ten Dijke, P., and Hill, C. S. (2004) New insights into TGF-beta-Smad signalling. Trends Biochem. Sci. 29, 265-273
    • (2004) Trends Biochem. Sci. , vol.29 , pp. 265-273
    • Ten Dijke, P.1    Hill, C.S.2
  • 14
    • 34548386720 scopus 로고    scopus 로고
    • TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA
    • Lee, M. K., Pardoux, C., Hall, M. C., Lee, P. S., Warburton, D., Qing, J., Smith, S. M., and Derynck, R. (2007) TGF-beta activates Erk MAP kinase signalling through direct phosphorylation of ShcA. EMBO J. 26, 3957-3967
    • (2007) EMBO J. , vol.26 , pp. 3957-3967
    • Lee, M.K.1    Pardoux, C.2    Hall, M.C.3    Lee, P.S.4    Warburton, D.5    Qing, J.6    Smith, S.M.7    Derynck, R.8
  • 15
    • 15744394838 scopus 로고    scopus 로고
    • LIM-kinase 2 and cofilin phosphorylation mediate actin cytoskeleton reorganization induced by transforming growth factor-beta
    • Vardouli, L., Moustakas, A., and Stournaras, C. (2005) LIM-kinase 2 and cofilin phosphorylation mediate actin cytoskeleton reorganization induced by transforming growth factor-beta. J. Biol. Chem. 280, 11448-11457
    • (2005) J. Biol. Chem. , vol.280 , pp. 11448-11457
    • Vardouli, L.1    Moustakas, A.2    Stournaras, C.3
  • 16
    • 0033377867 scopus 로고    scopus 로고
    • TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells
    • Piek, E., Moustakas, A., Kurisaki, A., Heldin, C. H., and ten Dijke, P. (1999) TGF-(beta) type I receptor/ALK-5 and Smad proteins mediate epithelial to mesenchymal transdifferentiation in NMuMG breast epithelial cells. J. Cell Sci. 112(Pt. 24), 4557-4568
    • (1999) J. Cell Sci. , vol.112 , Issue.PART 24 , pp. 4557-4568
    • Piek, E.1    Moustakas, A.2    Kurisaki, A.3    Heldin, C.H.4    Ten Dijke, P.5
  • 18
    • 35348854570 scopus 로고    scopus 로고
    • Physical and functional interactions between liver X receptor/retinoid X receptor and Sp1 modulate the transcriptional induction of the human ATP binding cassette transporter A1 gene by oxysterols and retinoids
    • Thymiakou, E., Zannis, V. I., and Kardassis, D. (2007) Physical and functional interactions between liver X receptor/retinoid X receptor and Sp1 modulate the transcriptional induction of the human ATP binding cassette transporter A1 gene by oxysterols and retinoids. Biochemistry 46, 11473-11483
    • (2007) Biochemistry , vol.46 , pp. 11473-11483
    • Thymiakou, E.1    Zannis, V.I.2    Kardassis, D.3
  • 20
    • 21444453507 scopus 로고    scopus 로고
    • Characterization of a novel transcriptionally active domain in the transforming growth factor beta-regulated Smad3 protein
    • Prokova, V., Mavridou, S., Papakosta, P., and Kardassis, D. (2005) Characterization of a novel transcriptionally active domain in the transforming growth factor beta-regulated Smad3 protein. Nucleic Acids Res. 33, 3708-3721
    • (2005) Nucleic Acids Res. , vol.33 , pp. 3708-3721
    • Prokova, V.1    Mavridou, S.2    Papakosta, P.3    Kardassis, D.4
  • 21
    • 0032499789 scopus 로고    scopus 로고
    • Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members
    • Moustakas, A., and Kardassis, D. (1998) Regulation of the human p21/WAF1/Cip1 promoter in hepatic cells by functional interactions between Sp1 and Smad family members. Proc. Natl. Acad. Sci. U. S. A. 95, 6733-6738
    • (1998) Proc. Natl. Acad. Sci. U. S. A. , vol.95 , pp. 6733-6738
    • Moustakas, A.1    Kardassis, D.2
  • 22
    • 0032101178 scopus 로고    scopus 로고
    • Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene
    • Dennler, S., Itoh, S., Vivien, D., ten Dijke, P., Huet, S., and Gauthier, J. M. (1998) Direct binding of Smad3 and Smad4 to critical TGF beta-inducible elements in the promoter of human plasminogen activator inhibitor-type 1 gene. EMBO J. 17, 3091-3100
    • (1998) EMBO J. , vol.17 , pp. 3091-3100
    • Dennler, S.1    Itoh, S.2    Vivien, D.3    Ten Dijke, P.4    Huet, S.5    Gauthier, J.M.6
  • 23
    • 0025831433 scopus 로고
    • The ras-related gene rhoB is an immediate-early gene inducible by v-Fps, epidermal growth factor, and platelet-derived growth factor in rat fibroblasts
    • Jahner, D., and Hunter, T. (1991) The ras-related gene rhoB is an immediate-early gene inducible by v-Fps, epidermal growth factor, and platelet-derived growth factor in rat fibroblasts. Mol. Cell. Biol. 11, 3682-3690 (Pubitemid 21895755)
    • (1991) Molecular and Cellular Biology , vol.11 , Issue.7 , pp. 3682-3690
    • Jahner, D.1    Hunter, T.2
  • 24
    • 0036467496 scopus 로고    scopus 로고
    • TGF-beta signaling: Positive and negative effects on tumorigenesis
    • Wakefield, L. M., and Roberts, A. B. (2002) TGF-beta signaling: positive and negative effects on tumorigenesis. Curr. Opin. Genet. Dev. 12, 22-29
    • (2002) Curr. Opin. Genet. Dev. , vol.12 , pp. 22-29
    • Wakefield, L.M.1    Roberts, A.B.2
  • 25
    • 34249845879 scopus 로고    scopus 로고
    • Transforming growth factor-beta receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways
    • Pannu, J., Nakerakanti, S., Smith, E., ten Dijke, P., and Trojanowska, M. (2007) Transforming growth factor-beta receptor type I-dependent fibrogenic gene program is mediated via activation of Smad1 and ERK1/2 pathways. J. Biol. Chem. 282, 10405-10413
    • (2007) J. Biol. Chem. , vol.282 , pp. 10405-10413
    • Pannu, J.1    Nakerakanti, S.2    Smith, E.3    Ten Dijke, P.4    Trojanowska, M.5
  • 26
    • 64049089837 scopus 로고    scopus 로고
    • SB-431542 inhibition of scar formation after filtration surgery and its potential mechanism
    • Xiao, Y. Q., Liu, K., Shen, J. F., Xu, G. T., and Ye, W. (2009) SB-431542 inhibition of scar formation after filtration surgery and its potential mechanism. Investig. Ophthalmol. Vis. Sci. 50, 1698-1706
    • (2009) Investig. Ophthalmol. Vis. Sci. , vol.50 , pp. 1698-1706
    • Xiao, Y.Q.1    Liu, K.2    Shen, J.F.3    Xu, G.T.4    Ye, W.5
  • 27
    • 0035253673 scopus 로고    scopus 로고
    • Transcriptional activation of the small GTPase gene rhoB by genotoxic stress is regulated via a CCAAT element
    • Fritz, G., and Kaina, B. (2001) Transcriptional activation of the small GTPase gene rhoB by genotoxic stress is regulated via a CCAAT element. Nucleic Acids Res. 29, 792-798 (Pubitemid 32124392)
    • (2001) Nucleic Acids Research , vol.29 , Issue.3 , pp. 792-798
    • Fritz, G.1    Kaina, B.2
  • 28
    • 0034618406 scopus 로고    scopus 로고
    • Functional consequences of tumorigenic missense mutations in the amino-terminal domain of Smad4
    • Moren, A., Itoh, S., Moustakas, A., Dijke, P., and Heldin, C. H. (2000) Functional consequences of tumorigenic missense mutations in the amino-terminal domain of Smad4. Oncogene 19, 4396-4404
    • (2000) Oncogene , vol.19 , pp. 4396-4404
    • Moren, A.1    Itoh, S.2    Moustakas, A.3    Dijke, P.4    Heldin, C.H.5
  • 29
    • 0028920041 scopus 로고
    • Recombinant rat CBF-C, the third subunit of CBF/NFY, allows formation of a protein-DNA complex with CBF-A and CBF-B and with yeast HAP2 and HAP3
    • Sinha, S., Maity, S. N., Lu, J., and de Crombrugghe, B. (1995) Recombinant rat CBF-C, the third subunit of CBF/NFY, allows formation of a protein-DNA complex with CBF-A and CBF-B and with yeast HAP2 and HAP3. Proc. Natl. Acad. Sci. U. S. A. 92, 1624-1628
    • (1995) Proc. Natl. Acad. Sci. U. S. A. , vol.92 , pp. 1624-1628
    • Sinha, S.1    Maity, S.N.2    Lu, J.3    De Crombrugghe, B.4
  • 33
    • 0032540280 scopus 로고    scopus 로고
    • RhoB is stabilized by transforming growth factor beta and antagonizes transcriptional activation
    • Engel, M. E., Datta, P. K., and Moses, H. L. (1998) RhoB is stabilized by transforming growth factor beta and antagonizes transcriptional activation. J. Biol. Chem. 273, 9921-9926
    • (1998) J. Biol. Chem. , vol.273 , pp. 9921-9926
    • Engel, M.E.1    Datta, P.K.2    Moses, H.L.3
  • 34
    • 0028900073 scopus 로고
    • The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation
    • Zubiaga, A. M., Belasco, J. G., and Greenberg, M. E. (1995) The nonamer UUAUUUAUU is the key AU-rich sequence motif that mediates mRNA degradation. Mol. Cell. Biol. 15, 2219-2230
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 2219-2230
    • Zubiaga, A.M.1    Belasco, J.G.2    Greenberg, M.E.3
  • 35
    • 59349117376 scopus 로고    scopus 로고
    • Graded Smad2/3 activation is converted directly into levels of target gene expression in embryonic stem cells
    • Guzman-Ayala, M., Lee, K. L., Mavrakis, K. J., Goggolidou, P., Norris, D. P., and Episkopou, V. (2009) Graded Smad2/3 activation is converted directly into levels of target gene expression in embryonic stem cells. PloS One 4, e4268
    • (2009) PloS One , vol.4
    • Guzman-Ayala, M.1    Lee, K.L.2    Mavrakis, K.J.3    Goggolidou, P.4    Norris, D.P.5    Episkopou, V.6
  • 36
    • 24944497786 scopus 로고    scopus 로고
    • Non-Smad TGF-beta signals
    • Moustakas, A., and Heldin, C. H. (2005) Non-Smad TGF-beta signals. J. Cell Sci. 118, 3573-3584
    • (2005) J. Cell Sci. , vol.118 , pp. 3573-3584
    • Moustakas, A.1    Heldin, C.H.2
  • 38
    • 26444560222 scopus 로고    scopus 로고
    • Induction of an epithelial to mesenchymal transition in human immortal and malignant keratinocytes by TGF-beta1 involves MAPK, Smad and AP-1 signalling pathways
    • Davies, M., Robinson, M., Smith, E., Huntley, S., Prime, S., and Paterson, I. (2005) Induction of an epithelial to mesenchymal transition in human immortal and malignant keratinocytes by TGF-beta1 involves MAPK, Smad and AP-1 signalling pathways. J. Cell. Biochem. 95, 918-931
    • (2005) J. Cell. Biochem. , vol.95 , pp. 918-931
    • Davies, M.1    Robinson, M.2    Smith, E.3    Huntley, S.4    Prime, S.5    Paterson, I.6
  • 39
    • 0033106484 scopus 로고    scopus 로고
    • A mechanism of repression of TGFfbeta/Smad signaling by oncogenic Ras
    • Kretzschmar, M., Doody, J., Timokhina, I., and Massague, J. (1999) A mechanism of repression of TGFbeta/Smad signaling by oncogenic Ras. Genes Dev. 13, 804-816 (Pubitemid 29169840)
    • (1999) Genes and Development , vol.13 , Issue.7 , pp. 804-816
    • Kretzschmar, M.1    Doody, J.2    Timokhina, I.3    Massague, J.4
  • 40
    • 0029893734 scopus 로고    scopus 로고
    • Extracellular signal-regulated kinase and the small GTP-binding protein, Rac, contribute to the effects of transforming growth factor-beta1 on gene expression
    • DOI 10.1074/jbc.271.28.16567
    • Mucsi, I., Skorecki, K. L., and Goldberg, H. J. (1996) Extracellular signal-regulated kinase and the small GTP-binding protein, Rac, contribute to the effects of transforming growth factor-beta1 on gene expression. J. Biol. Chem. 271, 16567-16572 (Pubitemid 26239011)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.28 , pp. 16567-16572
    • Mucsi, I.1    Skorecki, K.L.2    Goldberg, H.J.3
  • 42
    • 0032030308 scopus 로고    scopus 로고
    • A survey of 178 NF-Y binding CCAAT boxes
    • Mantovani, R. (1998) A survey of 178 NF-Y binding CCAAT boxes. Nucleic Acids Res. 26, 1135-1143
    • (1998) Nucleic Acids Res. , vol.26 , pp. 1135-1143
    • Mantovani, R.1
  • 44
    • 58149236744 scopus 로고    scopus 로고
    • Roles of TGFbeta in metastasis
    • Padua, D., and Massague, J. (2009) Roles of TGFbeta in metastasis. Cell Res. 19, 89-102
    • (2009) Cell Res. , vol.19 , pp. 89-102
    • Padua, D.1    Massague, J.2
  • 45
    • 61749086821 scopus 로고    scopus 로고
    • Transforming growth factor-beta1 increases cell migration and beta1 integrin up-regulation in human lung cancer cells
    • Fong, Y. C., Hsu, S. F., Wu, C. L., Li, T. M., Kao, S. T., Tsai, F. J., Chen, W. C., Liu, S. C., Wu, C. M., and Tang, C. H. (2009) Transforming growth factor-beta1 increases cell migration and beta1 integrin up-regulation in human lung cancer cells. Lung Cancer (Amst.) 64, 13-21
    • (2009) Lung Cancer (Amst.) , vol.64 , pp. 13-21
    • Fong, Y.C.1    Hsu, S.F.2    Wu, C.L.3    Li, T.M.4    Kao, S.T.5    Tsai, F.J.6    Chen, W.C.7    Liu, S.C.8    Wu, C.M.9    Tang, C.H.10
  • 46
    • 64249147843 scopus 로고    scopus 로고
    • Transforming growth factor-beta induces CD44 cleavage that promotes migration of MDA-MB-435s cells through the up-regulation of membrane type 1-matrix metalloproteinase
    • Kuo, Y. C., Su, C. H., Liu, C. Y., Chen, T. H., Chen, C. P., and Wang, H. S. (2009) Transforming growth factor-beta induces CD44 cleavage that promotes migration of MDA-MB-435s cells through the up-regulation of membrane type 1-matrix metalloproteinase. Int. J. Cancer 124, 2568-2576
    • (2009) Int. J. Cancer , vol.124 , pp. 2568-2576
    • Kuo, Y.C.1    Su, C.H.2    Liu, C.Y.3    Chen, T.H.4    Chen, C.P.5    Wang, H.S.6
  • 47
    • 48249113787 scopus 로고    scopus 로고
    • A novel mechanism of TGFbeta-induced actin reorganization mediated by Smad proteins and Rho GTPases
    • Vardouli, L., Vasilaki, E., Papadimitriou, E., Kardassis, D., and Stournaras, C. (2008) A novel mechanism of TGFbeta-induced actin reorganization mediated by Smad proteins and Rho GTPases. FEBS J. 275, 4074-4087
    • (2008) FEBS J. , vol.275 , pp. 4074-4087
    • Vardouli, L.1    Vasilaki, E.2    Papadimitriou, E.3    Kardassis, D.4    Stournaras, C.5
  • 48
    • 67649202158 scopus 로고    scopus 로고
    • Rho isoforms have distinct and specific functions in the process of epithelial to mesenchymal transition in renal proximal tubular cells
    • Hutchison, N., Hendry, B. M., and Sharpe, C. C. (2009) Rho isoforms have distinct and specific functions in the process of epithelial to mesenchymal transition in renal proximal tubular cells. Cell. Signal. 21, 1522-1531
    • (2009) Cell. Signal. , vol.21 , pp. 1522-1531
    • Hutchison, N.1    Hendry, B.M.2    Sharpe, C.C.3
  • 49
    • 34548621163 scopus 로고    scopus 로고
    • RhoB affects macrophage adhesion, integrin expression and migration
    • Wheeler, A. P., and Ridley, A. J. (2007) RhoB affects macrophage adhesion, integrin expression and migration. Exp. Cell. Res. 313, 3505-3516
    • (2007) Exp. Cell. Res. , vol.313 , pp. 3505-3516
    • Wheeler, A.P.1    Ridley, A.J.2
  • 51
    • 33748211158 scopus 로고    scopus 로고
    • Gain of function of mutant p53: The mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation
    • Di Agostino, S., Strano, S., Emiliozzi, V., Zerbini, V., Mottolese, M., Sacchi, A., Blandino, G., and Piaggio, G. (2006) Gain of function of mutant p53: the mutant p53/NF-Y protein complex reveals an aberrant transcriptional mechanism of cell cycle regulation. Cancer Cell 10, 191-202
    • (2006) Cancer Cell , vol.10 , pp. 191-202
    • Di Agostino, S.1    Strano, S.2    Emiliozzi, V.3    Zerbini, V.4    Mottolese, M.5    Sacchi, A.6    Blandino, G.7    Piaggio, G.8
  • 52
    • 0242499448 scopus 로고    scopus 로고
    • Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer
    • Siegel, P. M., and Massague, J. (2003) Cytostatic and apoptotic actions of TGF-beta in homeostasis and cancer. Nat. Rev. 3, 807-821
    • (2003) Nat. Rev. , vol.3 , pp. 807-821
    • Siegel, P.M.1    Massague, J.2


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