메뉴 건너뛰기




Volumn 3, Issue 2, 2010, Pages 406-418

Deregulation of interferon signaling in malignant cells

Author keywords

Cancer; Interferon; Signaling pathways

Indexed keywords

ALPHA INTERFERON RECEPTOR; GAMMA INTERFERON; INTERFERON; INTERFERON RECEPTOR; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PROTEIN KINASE B; PROTEIN KINASE TYK2; RECOMBINANT INTERFERON; STAT PROTEIN; STAT1 PROTEIN; STAT3 PROTEIN; STAT5 PROTEIN;

EID: 77952231814     PISSN: None     EISSN: 14248247     Source Type: Journal    
DOI: 10.3390/ph3020406     Document Type: Review
Times cited : (28)

References (103)
  • 2
    • 31344461659 scopus 로고    scopus 로고
    • Innate immune recognition of viral infection
    • Kawai, T.; Akira, S. Innate immune recognition of viral infection. Nat. Immunol. 2006, 7, 131-137.
    • (2006) Nat. Immunol , vol.7 , pp. 131-137
    • Kawai, T.1    Akira, S.2
  • 4
    • 9644262469 scopus 로고    scopus 로고
    • Interferons, interferon-like cytokines, and their receptors
    • Pestka, S.; Krause, C.D.; Walter, M.R. Interferons, interferon-like cytokines, and their receptors. Immunol. Rev. 2004, 202, 8-32.
    • (2004) Immunol. Rev , vol.202 , pp. 8-32
    • Pestka, S.1    Krause, C.D.2    Walter, M.R.3
  • 5
    • 0036715591 scopus 로고    scopus 로고
    • Viruses and interferon: A fight for supremacy
    • Katze, M.G.; He, Y.; Gale, M. Viruses and interferon: a fight for supremacy. Nat. Rev. Immunol. 2002, 2, 675-687.
    • (2002) Nat. Rev. Immunol , vol.2 , pp. 675-687
    • Katze, M.G.1    He, Y.2    Gale, M.3
  • 6
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • Darnell, J.E.; Kerr, I.M.; Stark, G.R. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 1994, 264, 1415-1421.
    • (1994) Science , vol.264 , pp. 1415-1421
    • Darnell, J.E.1    Kerr, I.M.2    Stark, G.R.3
  • 7
    • 18844457095 scopus 로고    scopus 로고
    • Mechanisms of type-I- and type-II-interferon-mediated signalling
    • Platanias, L.C. Mechanisms of type-I- and type-II-interferon-mediated signalling. Nat. Rev. Immunol. 2005, 5, 375-386.
    • (2005) Nat. Rev. Immunol , vol.5 , pp. 375-386
    • Platanias, L.C.1
  • 8
    • 31144463847 scopus 로고    scopus 로고
    • Cytokines as critical co-stimulatory molecules in modulating the immune response of natural killer cells
    • Young, H.A.; Ortaldo, J. Cytokines as critical co-stimulatory molecules in modulating the immune response of natural killer cells. Cell Res. 2006, 16, 20-24.
    • (2006) Cell Res , vol.16 , pp. 20-24
    • Young, H.A.1    Ortaldo, J.2
  • 10
    • 34547099363 scopus 로고    scopus 로고
    • The interferons: 50 years after their discovery, there is much more to learn
    • Pestka, S. The interferons: 50 years after their discovery, there is much more to learn. J. Biol. Chem. 2007, 282, 20047-20051.
    • (2007) J. Biol. Chem , vol.282 , pp. 20047-20051
    • Pestka, S.1
  • 11
    • 0038792224 scopus 로고    scopus 로고
    • Map kinase signaling pathways and hematologic malignancies
    • Platanias, L.C. Map kinase signaling pathways and hematologic malignancies. Blood 2003, 101, 4667-4679.
    • (2003) Blood , vol.101 , pp. 4667-4679
    • Platanias, L.C.1
  • 12
    • 0344304443 scopus 로고    scopus 로고
    • Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1
    • Nusinzon, I.; Horvath, C.M. Interferon-stimulated transcription and innate antiviral immunity require deacetylase activity and histone deacetylase 1. Proc. Natl. Acad. Sci. USA 2003, 100, 14742-14747.
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 14742-14747
    • Nusinzon, I.1    Horvath, C.M.2
  • 14
    • 0742322159 scopus 로고    scopus 로고
    • Interferons: Mechanisms of action and clinical applications
    • Parmar, S.; Platanias, L.C. Interferons: Mechanisms of action and clinical applications. Curr. Opin. Oncol. 2003, 15, 431-439.
    • (2003) Curr. Opin. Oncol , vol.15 , pp. 431-439
    • Parmar, S.1    Platanias, L.C.2
  • 15
    • 0037204953 scopus 로고    scopus 로고
    • A road map for those who don't know JAK-STAT
    • Aaronson, D.S.; Horvath, C.M. A road map for those who don't know JAK-STAT. Science 2002, 296, 1653-1655.
    • (2002) Science , vol.296 , pp. 1653-1655
    • Aaronson, D.S.1    Horvath, C.M.2
  • 16
  • 17
    • 0035953308 scopus 로고    scopus 로고
    • IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity
    • Shankaran, V.; Ikeda, H.; Bruce, A.T.; White, J.M.; Swanson, P.E.; Old, L.J.; Schreiber, R.D., IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature 2001, 410, 1107-1111.
    • (2001) Nature , vol.410 , pp. 1107-1111
    • Shankaran, V.1    Ikeda, H.2    Bruce, A.T.3    White, J.M.4    Swanson, P.E.5    Old, L.J.6    Schreiber, R.D.7
  • 19
    • 34547097764 scopus 로고    scopus 로고
    • The RAS/Raf1/MEK/ERK signaling pathway facilitates VSV-mediated oncolysis: Implication for the defective interferon response in cancer cells
    • Noser, J.A.; Mael, A.A.; Sakuma, R.; Ohmine, S.; Marcato, P.; Lee, P.W.; Ikeda, Y. The RAS/Raf1/MEK/ERK signaling pathway facilitates VSV-mediated oncolysis: Implication for the defective interferon response in cancer cells. Mol. Ther. 2007, 15, 1531-1536.
    • (2007) Mol. Ther , vol.15 , pp. 1531-1536
    • Noser, J.A.1    Mael, A.A.2    Sakuma, R.3    Ohmine, S.4    Marcato, P.5    Lee, P.W.6    Ikeda, Y.7
  • 22
    • 2542441665 scopus 로고    scopus 로고
    • The BCR-ABL story: Bench to bedside and back
    • Wong, S.; Witte, O.N. The BCR-ABL story: Bench to bedside and back. Annu. Rev. Immunol. 2004, 22, 247-306.
    • (2004) Annu. Rev. Immunol , vol.22 , pp. 247-306
    • Wong, S.1    Witte, O.N.2
  • 24
    • 0033973215 scopus 로고    scopus 로고
    • Defective Jak-STAT signal transduction pathway in melanoma cells resistant to growth inhibition by interferon-alpha
    • Pansky, A.; Hildebrand, P.; Fasler-Kan, E.; Baselgia, L.; Ketterer, S.; Beglinger, C.; Heim, M.H. Defective Jak-STAT signal transduction pathway in melanoma cells resistant to growth inhibition by interferon-alpha. Int. J. Cancer 2000, 85, 720-725.
    • (2000) Int. J. Cancer , vol.85 , pp. 720-725
    • Pansky, A.1    Hildebrand, P.2    Fasler-Kan, E.3    Baselgia, L.4    Ketterer, S.5    Beglinger, C.6    Heim, M.H.7
  • 25
    • 52949089050 scopus 로고    scopus 로고
    • JAKs in pathology: Role of Janus kinases in hematopoietic malignancies and immunodeficiencies
    • Vainchenker, W.; Dusa, A.; Constantinescu, S.N. JAKs in pathology: Role of Janus kinases in hematopoietic malignancies and immunodeficiencies. Semin. Cell Dev. Biol. 2008, 19, 385-393.
    • (2008) Semin. Cell Dev. Biol , vol.19 , pp. 385-393
    • Vainchenker, W.1    Dusa, A.2    Constantinescu, S.N.3
  • 26
    • 34248583886 scopus 로고    scopus 로고
    • MAP kinase signalling pathways in cancer
    • Dhillon, A.S.; Hagan, S.; Rath, O.; Kolch, W. MAP kinase signalling pathways in cancer. Oncogene 2007, 26, 3279-3290.
    • (2007) Oncogene , vol.26 , pp. 3279-3290
    • Dhillon, A.S.1    Hagan, S.2    Rath, O.3    Kolch, W.4
  • 28
    • 61849126356 scopus 로고    scopus 로고
    • Human interferon-lambda3 is a potent member of the type III interferon family
    • Dellgren, C.; Gad, H.H.; Hamming, O.J.; Melchjorsen, J.; Hartmann, R. Human interferon-lambda3 is a potent member of the type III interferon family. Genes Immun. 2009, 10, 125-131.
    • (2009) Genes Immun , vol.10 , pp. 125-131
    • Dellgren, C.1    Gad, H.H.2    Hamming, O.J.3    Melchjorsen, J.4    Hartmann, R.5
  • 30
    • 0025376590 scopus 로고
    • The regulation of beta-interferon gene expression
    • Goodbourn, S. The regulation of beta-interferon gene expression. Semin. Cancer Biol. 1990, 1, 89-95.
    • (1990) Semin. Cancer Biol , vol.1 , pp. 89-95
    • Goodbourn, S.1
  • 31
    • 0023506134 scopus 로고
    • Multiple interferon subtypes: The phenomenon and its relevance
    • Rubinstein, M. Multiple interferon subtypes: The phenomenon and its relevance. J. Interferon Res. 1987, 7, 545-551.
    • (1987) J. Interferon Res , vol.7 , pp. 545-551
    • Rubinstein, M.1
  • 32
    • 0035858379 scopus 로고    scopus 로고
    • Improvements in protein PEGylation: Pegylated interferons for treatment of hepatitis C
    • Kozlowski, A.; Harris, J.M. Improvements in protein PEGylation: Pegylated interferons for treatment of hepatitis C. J. Control Release 2001, 72, 217-224.
    • (2001) J. Control Release , vol.72 , pp. 217-224
    • Kozlowski, A.1    Harris, J.M.2
  • 33
    • 51549092094 scopus 로고    scopus 로고
    • The impact of PEGylation on biological therapies
    • Veronese, F.M.; Mero, A. The impact of PEGylation on biological therapies. BioDrugs 2008, 22, 315-329.
    • (2008) BioDrugs , vol.22 , pp. 315-329
    • Veronese, F.M.1    Mero, A.2
  • 34
    • 0036233585 scopus 로고    scopus 로고
    • Cytokine signaling in 2002: New surprises in the Jak/Stat pathway
    • O'Shea, J.J.; Gadina, M.; Schreiber, R.D. Cytokine signaling in 2002: New surprises in the Jak/Stat pathway. Cell 2002, 109, 121-131.
    • (2002) Cell , vol.109 , pp. 121-131
    • O'Shea, J.J.1    Gadina, M.2    Schreiber, R.D.3
  • 35
    • 34547116656 scopus 로고    scopus 로고
    • Type I interferon receptors: Biochemistry and biological functions
    • de Weerd, N.A.; Samarajiwa, S.A.; Hertzog, P.J. Type I interferon receptors: Biochemistry and biological functions. J. Biol. Chem. 2007, 282, 20053-20057.
    • (2007) J. Biol. Chem , vol.282 , pp. 20053-20057
    • de Weerd, N.A.1    Samarajiwa, S.A.2    Hertzog, P.J.3
  • 37
    • 0030889207 scopus 로고    scopus 로고
    • The IFN gamma receptor: A paradigm for cytokine receptor signaling
    • Bach, E.A.; Aguet, M.; Schreiber, R.D. The IFN gamma receptor: A paradigm for cytokine receptor signaling. Annu. Rev. Immunol. 1997, 15, 563-591.
    • (1997) Annu. Rev. Immunol , vol.15 , pp. 563-591
    • Bach, E.A.1    Aguet, M.2    Schreiber, R.D.3
  • 41
    • 34447273319 scopus 로고    scopus 로고
    • Type III interferon(IFN) induces a type I IFN-like response in a restricted subset of cells through signaling pathways involving both the Jak-STAT pathway and the mitogen-activated protein kinases
    • Zhou, Z.; Hamming, O.J.; Ank, N.; Paludan, S.R.; Nielsen, A.L.; Hartmann, R. Type III interferon(IFN) induces a type I IFN-like response in a restricted subset of cells through signaling pathways involving both the Jak-STAT pathway and the mitogen-activated protein kinases. J. Virol. 2007, 81, 7749-7758.
    • (2007) J. Virol , vol.81 , pp. 7749-7758
    • Zhou, Z.1    Hamming, O.J.2    Ank, N.3    Paludan, S.R.4    Nielsen, A.L.5    Hartmann, R.6
  • 42
    • 0032754656 scopus 로고    scopus 로고
    • Serum levels of soluble interferon Alfa/Beta receptor as an inhibitory factor of interferon in the patients with chronic hepatitis C
    • Mizukoshi, E.; Kaneko, S.; Kaji, K.; Terasaki, S.; Matsushita, E.; Muraguchi, M.; Ohmoto, Y.; Kobayashi, K. Serum levels of soluble interferon Alfa/Beta receptor as an inhibitory factor of interferon in the patients with chronic hepatitis C. Hepatology 1999, 30, 1325-1331.
    • (1999) Hepatology , vol.30 , pp. 1325-1331
    • Mizukoshi, E.1    Kaneko, S.2    Kaji, K.3    Terasaki, S.4    Matsushita, E.5    Muraguchi, M.6    Ohmoto, Y.7    Kobayashi, K.8
  • 45
    • 0035863894 scopus 로고    scopus 로고
    • The soluble murine type I interferon receptor Ifnar-2 is present in serum, is independently regulated, and has both agonistic and antagonistic properties
    • Hardy, M.P.; Owczarek, C.M.; Trajanovska, S.; Liu, X.; Kola, I.; Hertzog, P.J. The soluble murine type I interferon receptor Ifnar-2 is present in serum, is independently regulated, and has both agonistic and antagonistic properties. Blood 2001, 97, 473-482.
    • (2001) Blood , vol.97 , pp. 473-482
    • Hardy, M.P.1    Owczarek, C.M.2    Trajanovska, S.3    Liu, X.4    Kola, I.5    Hertzog, P.J.6
  • 46
    • 0142105396 scopus 로고    scopus 로고
    • SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor
    • Kumar, K.G.; Tang, W.; Ravindranath, A.K.; Clark, W.A.; Croze, E.; Fuchs, S.Y. SCF(HOS) ubiquitin ligase mediates the ligand-induced down-regulation of the interferon-alpha receptor. EMBO J. 2003, 22, 5480-5490.
    • (2003) EMBO J , vol.22 , pp. 5480-5490
    • Kumar, K.G.1    Tang, W.2    Ravindranath, A.K.3    Clark, W.A.4    Croze, E.5    Fuchs, S.Y.6
  • 50
    • 41849116690 scopus 로고    scopus 로고
    • Roles of unphosphorylated STATs in signaling
    • Yang, J.; Stark, G.R. Roles of unphosphorylated STATs in signaling. Cell Res. 2008, 18, 443-451.
    • (2008) Cell Res , vol.18 , pp. 443-451
    • Yang, J.1    Stark, G.R.2
  • 51
    • 36849082588 scopus 로고    scopus 로고
    • Non-conventional signal transduction by type 1 interferons: The NF-kappaB pathway
    • Du, Z.; Wei, L.; Murti, A.; Pfeffer, S.R.; Fan, M.; Yang, C.H.; Pfeffer, L.M. Non-conventional signal transduction by type 1 interferons: The NF-kappaB pathway. J. Cell Biochem. 2007, 102, 1087-1094.
    • (2007) J. Cell Biochem , vol.102 , pp. 1087-1094
    • Du, Z.1    Wei, L.2    Murti, A.3    Pfeffer, S.R.4    Fan, M.5    Yang, C.H.6    Pfeffer, L.M.7
  • 52
    • 0026632288 scopus 로고
    • A protein tyrosine kinase in the interferon alpha/beta signaling pathway
    • Velazquez, L.; Fellous, M.; Stark, G.R.; Pellegrini, S. A protein tyrosine kinase in the interferon alpha/beta signaling pathway. Cell 1992, 70, 313-322.
    • (1992) Cell , vol.70 , pp. 313-322
    • Velazquez, L.1    Fellous, M.2    Stark, G.R.3    Pellegrini, S.4
  • 53
    • 0035823201 scopus 로고    scopus 로고
    • A region encompassing the FERM domain of Jak1 is necessary for binding to the cytokine receptor gp130
    • Hilkens, C.M.; Is'harc, H.; Lillemeier, B.F.; Strobl, B.; Bates, P.A.; Behrmann, I.; Kerr, I.M. A region encompassing the FERM domain of Jak1 is necessary for binding to the cytokine receptor gp130. FEBS Lett. 2001, 505, 87-91.
    • (2001) FEBS Lett , vol.505 , pp. 87-91
    • Hilkens, C.M.1    Is'harc, H.2    Lillemeier, B.F.3    Strobl, B.4    Bates, P.A.5    Behrmann, I.6    Kerr, I.M.7
  • 59
    • 0028244396 scopus 로고
    • Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells
    • Witthuhn, B.A.; Silvennoinen, O.; Miura, O.; Lai, K.S.; Cwik, C.; Liu, E.T.; Ihle, J.N. Involvement of the Jak-3 Janus kinase in signalling by interleukins 2 and 4 in lymphoid and myeloid cells. Nature 1994, 370, 153-157.
    • (1994) Nature , vol.370 , pp. 153-157
    • Witthuhn, B.A.1    Silvennoinen, O.2    Miura, O.3    Lai, K.S.4    Cwik, C.5    Liu, E.T.6    Ihle, J.N.7
  • 60
    • 26244463218 scopus 로고    scopus 로고
    • Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: Inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells
    • Lin, Q.; Lai, R.; Chirieac, L.R.; Li, C.; Thomazy, V.A.; Grammatikakis, I.; Rassidakis, G.Z.; Zhang, W.; Fujio, Y.; Kunisada, K.; Hamilton, S.R.; Amin, H.M. Constitutive activation of JAK3/STAT3 in colon carcinoma tumors and cell lines: Inhibition of JAK3/STAT3 signaling induces apoptosis and cell cycle arrest of colon carcinoma cells. Am. J. Pathol. 2005, 167, 969-980.
    • (2005) Am. J. Pathol , vol.167 , pp. 969-980
    • Lin, Q.1    Lai, R.2    Chirieac, L.R.3    Li, C.4    Thomazy, V.A.5    Grammatikakis, I.6    Rassidakis, G.Z.7    Zhang, W.8    Fujio, Y.9    Kunisada, K.10    Hamilton, S.R.11    Amin, H.M.12
  • 66
    • 34548240698 scopus 로고    scopus 로고
    • Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders. Nat
    • Levine, R.L.; Pardanani, A.; Tefferi, A.; Gilliland, D.G. Role of JAK2 in the pathogenesis and therapy of myeloproliferative disorders. Nat. Rev. Cancer 2007, 7, 673-683.
    • (2007) Rev. Cancer , vol.7 , pp. 673-683
    • Levine, R.L.1    Pardanani, A.2    Tefferi, A.3    Gilliland, D.G.4
  • 67
    • 70350494529 scopus 로고    scopus 로고
    • JAK2 gets histone H3 rolling
    • Sattler, M.; Griffin, J.D. JAK2 gets histone H3 rolling. Cancer Cell 2009, 16, 365-366.
    • (2009) Cancer Cell , vol.16 , pp. 365-366
    • Sattler, M.1    Griffin, J.D.2
  • 69
    • 0033559793 scopus 로고    scopus 로고
    • Autosomal SCID caused by a point mutation in the N-terminus of Jak3: Mapping of the Jak3-receptor interaction domain
    • Cacalano, N.A.; Migone, T.S.; Bazan, F.; Hanson, E.P.; Chen, M.; Candotti, F.; O'Shea, J.J.; Johnston, J.A. Autosomal SCID caused by a point mutation in the N-terminus of Jak3: Mapping of the Jak3-receptor interaction domain. EMBO J. 1999, 18, 1549-1558.
    • (1999) EMBO J , vol.18 , pp. 1549-1558
    • Cacalano, N.A.1    Migone, T.S.2    Bazan, F.3    Hanson, E.P.4    Chen, M.5    Candotti, F.6    O'Shea, J.J.7    Johnston, J.A.8
  • 70
    • 34547108380 scopus 로고    scopus 로고
    • JAK-STAT signaling: From interferons to cytokines
    • Schindler, C.; Levy, D.E.; Decker, T. JAK-STAT signaling: From interferons to cytokines. J. Biol. Chem. 2007, 282, 20059-20063.
    • (2007) J. Biol. Chem , vol.282 , pp. 20059-20063
    • Schindler, C.1    Levy, D.E.2    Decker, T.3
  • 71
    • 30444458235 scopus 로고    scopus 로고
    • Stats: Multifaceted regulators of transcription
    • Brierley, M.M.; Fish, E.N. Stats: Multifaceted regulators of transcription. J. Interferon Cytokine Res. 2005, 25, 733-744.
    • (2005) J. Interferon Cytokine Res , vol.25 , pp. 733-744
    • Brierley, M.M.1    Fish, E.N.2
  • 72
    • 0037177813 scopus 로고    scopus 로고
    • Protein kinase C-delta (PKC-delta) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727
    • Uddin, S.; Sassano, A.; Deb, D.K.; Verma, A.; Majchrzak, B.; Rahman, A.; Malik, A.B.; Fish, E.N.; Platanias, L.C. Protein kinase C-delta (PKC-delta) is activated by type I interferons and mediates phosphorylation of Stat1 on serine 727. J. Biol. Chem. 2002, 277, 14408-14416.
    • (2002) J. Biol. Chem , vol.277 , pp. 14408-14416
    • Uddin, S.1    Sassano, A.2    Deb, D.K.3    Verma, A.4    Majchrzak, B.5    Rahman, A.6    Malik, A.B.7    Fish, E.N.8    Platanias, L.C.9
  • 73
    • 0030670639 scopus 로고    scopus 로고
    • Extracellular signal-dependent nuclear import of Stat1 is mediated by nuclear pore-targeting complex formation with NPI-1, but not Rch1
    • Sekimoto, T.; Imamoto, N.; Nakajima, K.; Hirano, T.; Yoneda, Y. Extracellular signal-dependent nuclear import of Stat1 is mediated by nuclear pore-targeting complex formation with NPI-1, but not Rch1. EMBO J. 1997, 16, 7067-7077.
    • (1997) EMBO J , vol.16 , pp. 7067-7077
    • Sekimoto, T.1    Imamoto, N.2    Nakajima, K.3    Hirano, T.4    Yoneda, Y.5
  • 74
    • 0037007207 scopus 로고    scopus 로고
    • Regulated nuclear import of the STAT1 transcription factor by direct binding of importin-alpha
    • McBride, K.M.; Banninger, G.; McDonald, C.; Reich, N.C. Regulated nuclear import of the STAT1 transcription factor by direct binding of importin-alpha. EMBO J. 2002, 21, 1754-1763.
    • (2002) EMBO J , vol.21 , pp. 1754-1763
    • McBride, K.M.1    Banninger, G.2    McDonald, C.3    Reich, N.C.4
  • 75
    • 33746570647 scopus 로고    scopus 로고
    • Tracking STAT nuclear traffic
    • Reich, N.C.; Liu, L. Tracking STAT nuclear traffic. Nat. Rev. Immunol. 2006, 6, 602-612.
    • (2006) Nat. Rev. Immunol , vol.6 , pp. 602-612
    • Reich, N.C.1    Liu, L.2
  • 76
    • 0034669111 scopus 로고    scopus 로고
    • Nuclear export signal located within theDNA- binding domain of the STAT1transcription factor
    • McBride, K.M.; McDonald, C.; Reich, N.C. Nuclear export signal located within theDNA- binding domain of the STAT1transcription factor. EMBO J. 2000, 19, 6196-6206.
    • (2000) EMBO J , vol.19 , pp. 6196-6206
    • McBride, K.M.1    McDonald, C.2    Reich, N.C.3
  • 77
    • 70350500225 scopus 로고    scopus 로고
    • STATs in cancer inflammation and immunity: A leading role for STAT3
    • Yu, H.; Pardoll, D.; Jove, R. STATs in cancer inflammation and immunity: A leading role for STAT3. Nat. Rev. Cancer 2009, 9, 798-809.
    • (2009) Nat. Rev. Cancer , vol.9 , pp. 798-809
    • Yu, H.1    Pardoll, D.2    Jove, R.3
  • 78
    • 0038820386 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription proteins in leukemias
    • Benekli, M.; Baer, M.R.; Baumann, H.; Wetzler, M. Signal transducer and activator of transcription proteins in leukemias. Blood 2003, 101, 2940-2954.
    • (2003) Blood , vol.101 , pp. 2940-2954
    • Benekli, M.1    Baer, M.R.2    Baumann, H.3    Wetzler, M.4
  • 80
    • 0036731485 scopus 로고    scopus 로고
    • Stats: Transcriptional control and biological impact
    • Levy, D.E.; Darnell, J.E. Stats: Transcriptional control and biological impact. Nat. Rev. Mol. Cell Biol. 2002, 3, 651-662.
    • (2002) Nat. Rev. Mol. Cell Biol , vol.3 , pp. 651-662
    • Levy, D.E.1    Darnell, J.E.2
  • 81
    • 34548167742 scopus 로고    scopus 로고
    • STAT1- dependent and STAT1-independent gene expression in murine immune cells following stimulation with interferon-alpha
    • Zimmerer, J.M.; Lesinski, G.B.; Radmacher, M.D.; Ruppert, A.; Carson, W.E. STAT1- dependent and STAT1-independent gene expression in murine immune cells following stimulation with interferon-alpha. Cancer Immunol. Immunother. 2007, 56, 1845-1852.
    • (2007) Cancer Immunol. Immunother , vol.56 , pp. 1845-1852
    • Zimmerer, J.M.1    Lesinski, G.B.2    Radmacher, M.D.3    Ruppert, A.4    Carson, W.E.5
  • 84
    • 0034292328 scopus 로고    scopus 로고
    • Distinct requirements for IFNs and STAT1 in NK cell function
    • Lee, C.K.; Rao, D.T.; Gertner, R.; Gimeno, R.; Frey, A.B.; Levy, D.E. Distinct requirements for IFNs and STAT1 in NK cell function. J. Immunol. 2000, 165, 3571-3577.
    • (2000) J. Immunol , vol.165 , pp. 3571-3577
    • Lee, C.K.1    Rao, D.T.2    Gertner, R.3    Gimeno, R.4    Frey, A.B.5    Levy, D.E.6
  • 85
    • 30344461860 scopus 로고    scopus 로고
    • The p38 mitogen-activated protein kinase pathway in interferon signal transduction
    • Katsoulidis, E.; Li, Y.; Mears, H.; Platanias, L.C. The p38 mitogen-activated protein kinase pathway in interferon signal transduction. J. Interferon Cytokine Res. 2005, 25, 749-756.
    • (2005) J. Interferon Cytokine Res , vol.25 , pp. 749-756
    • Katsoulidis, E.1    Li, Y.2    Mears, H.3    Platanias, L.C.4
  • 86
    • 0037406263 scopus 로고    scopus 로고
    • The p38 mitogen-activated protein kinase pathway and its role in interferon signaling. Pharmacol
    • Platanias, L.C. The p38 mitogen-activated protein kinase pathway and its role in interferon signaling. Pharmacol. Ther. 2003, 98, 129-142.
    • (2003) Ther , vol.98 , pp. 129-142
    • Platanias, L.C.1
  • 87
    • 0032727032 scopus 로고    scopus 로고
    • Signaling pathways activated by interferons
    • Platanias, L.C.; Fish, E.N. Signaling pathways activated by interferons. Exp. Hematol. 1999, 27, 1583-1592.
    • (1999) Exp. Hematol , vol.27 , pp. 1583-1592
    • Platanias, L.C.1    Fish, E.N.2
  • 88
    • 0036232326 scopus 로고    scopus 로고
    • Signaling via the interferon-alpha receptor in chronic myelogenous leukemia cells
    • Verma, A.; Platanias, L.C. Signaling via the interferon-alpha receptor in chronic myelogenous leukemia cells. Leuk. Lymphoma 2002, 43, 703-709.
    • (2002) Leuk. Lymphoma , vol.43 , pp. 703-709
    • Verma, A.1    Platanias, L.C.2
  • 90
  • 91
    • 0038264431 scopus 로고    scopus 로고
    • Cell context-specific effects of the BCR-ABL oncogene monitored in hematopoietic progenitors
    • Wong, S.; McLaughlin, J.; Cheng, D.; Witte, O.N. Cell context-specific effects of the BCR-ABL oncogene monitored in hematopoietic progenitors. Blood 2003, 101, 4088-4097.
    • (2003) Blood , vol.101 , pp. 4088-4097
    • Wong, S.1    McLaughlin, J.2    Cheng, D.3    Witte, O.N.4
  • 93
    • 33751257187 scopus 로고    scopus 로고
    • The interferon regulated ubiquitin-like protein, ISG15, in tumorigenesis: Friend or foe?
    • Andersen, J.B.; Hassel, B.A. The interferon regulated ubiquitin-like protein, ISG15, in tumorigenesis: Friend or foe? Cytokine Growth Factor Rev. 2006, 17, 411-421.
    • (2006) Cytokine Growth Factor Rev , vol.17 , pp. 411-421
    • Andersen, J.B.1    Hassel, B.A.2
  • 94
    • 28544435897 scopus 로고    scopus 로고
    • Immunity by ubiquitylation: A reversible process of modification
    • Liu, Y.C.; Penninger, J.; Karin, M. Immunity by ubiquitylation: A reversible process of modification. Nat. Rev. Immunol. 2005, 5, 941-952.
    • (2005) Nat. Rev. Immunol , vol.5 , pp. 941-952
    • Liu, Y.C.1    Penninger, J.2    Karin, M.3
  • 96
    • 0027180655 scopus 로고
    • gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme
    • Kok, K.; Hofstra, R.; Pilz, A.; van den Berg, A.; Terpstra, P.; Buys, C.H.; Carritt, B. A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme. Proc. Natl. Acad. Sci. USA 1993, 90, 6071-6075.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 6071-6075
    • Kok, K.1    Hofstra, R.2    Pilz, A.3    van den Berg, A.4    Terpstra, P.5    Buys, C.H.6    Carritt, B.A.7
  • 98
    • 0035906250 scopus 로고    scopus 로고
    • Cloning and characterization of human ubiquitin-processing protease-43 from terminally differentiated human melanoma cells using a rapid subtraction hybridization protocol RaSH
    • Kang, D.; Jiang, H.; Wu, Q.; Pestka, S.; Fisher, P.B. Cloning and characterization of human ubiquitin-processing protease-43 from terminally differentiated human melanoma cells using a rapid subtraction hybridization protocol RaSH. Gene 2001, 267, 233-242.
    • (2001) Gene , vol.267 , pp. 233-242
    • Kang, D.1    Jiang, H.2    Wu, Q.3    Pestka, S.4    Fisher, P.B.5
  • 100
    • 47749140740 scopus 로고    scopus 로고
    • Akt and mRNA translation by interferons
    • Kaur, S.; Katsoulidis, E.; Platanias, L.C. Akt and mRNA translation by interferons. Cell Cycle 2008, 7, 2112-2116.
    • (2008) Cell Cycle , vol.7 , pp. 2112-2116
    • Kaur, S.1    Katsoulidis, E.2    Platanias, L.C.3
  • 102
    • 47649124617 scopus 로고    scopus 로고
    • Protein kinase C signalling in leukemia
    • Redig, A.J.; Platanias, L.C. Protein kinase C signalling in leukemia. Leuk. Lymphoma 2008, 49, 1255-1262.
    • (2008) Leuk. Lymphoma , vol.49 , pp. 1255-1262
    • Redig, A.J.1    Platanias, L.C.2
  • 103
    • 0036595049 scopus 로고    scopus 로고
    • Suppressors of cytokine signalling (SOCS) in the immune system. Nat
    • Alexander, W.S. Suppressors of cytokine signalling (SOCS) in the immune system. Nat. Rev. Immunol. 2002, 2, 410-416.
    • (2002) Rev. Immunol , vol.2 , pp. 410-416
    • Alexander, W.S.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.